Epigenetics And Dermatology

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Epigenetics and Dermatology

Qianjin Lu,Christopher C. Chang,Bruce C. Richardson
Epigenetics and Dermatology Book PDF

Author : Qianjin Lu,Christopher C. Chang,Bruce C. Richardson
Publisher : Academic Press
Page : 520 pages
File Size : 40,9 Mb
Release : 2015-02-16
Category : Science
ISBN : 9780128012727

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Epigenetics and Dermatology by Qianjin Lu,Christopher C. Chang,Bruce C. Richardson Pdf

Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable. Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy

Epigenetic Regulation of Skin Development and Regeneration

Vladimir A. Botchkarev,Sarah E. Millar
Epigenetic Regulation of Skin Development and Regeneration Book PDF

Author : Vladimir A. Botchkarev,Sarah E. Millar
Publisher : Springer
Page : 323 pages
File Size : 54,7 Mb
Release : 2018-09-03
Category : Science
ISBN : 9783319167695

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Epigenetic Regulation of Skin Development and Regeneration by Vladimir A. Botchkarev,Sarah E. Millar Pdf

This indispensable volume highlights recent studies identifying epigenetic mechanisms as essential regulators of skin development, stem cell activity and regeneration. Chapters are contributed by leading experts and promote the skin as an accessible model system for studying mechanisms that control organ development and regeneration. The timely discussions contained throughout are of broad relevance to other areas of biology and medicine and can help inform the development of novel therapeutics for skin disorders as well as new approaches to skin regeneration that target the epigenome. Part of the highly successful Stem Cells and Regenerative Medicine series, Epigenetic Regulation of Skin Development and Regeneration uncovers the fundamental significance of epigenetic mechanisms in skin development and regeneration, and emphasizes the development of new therapies for a number of skin disorders, such as pathological conditions of epidermal differentiation, pigmentation and carcinogenesis. At least six categories of researchers will find this book essential, including stem cell, developmental, hair follicle or molecular biologists, and gerontologists or clinical dermatologists.

Personalized, Evolutionary, and Ecological Dermatology

Robert A. Norman
Personalized Evolutionary and Ecological Dermatology Book PDF

Author : Robert A. Norman
Publisher : Springer
Page : 142 pages
File Size : 48,6 Mb
Release : 2016-09-21
Category : Medical
ISBN : 9783319410883

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Personalized, Evolutionary, and Ecological Dermatology by Robert A. Norman Pdf

This book discusses the exciting potential for dermatology to embrace developments to enhance the profession’s valuable pattern recognition, diagnostic, and treatment skills. Personalized medicine (PM) and genomics are easily accessible and enable the customization of healthcare using molecular analysis to influence medical decisions, practices, and therapies for the individual patient. The evolution of the skin, and the manner in which dermatological conditions are described and managed, reveals the need to consider many aspects on a personal level. New research data are based on the use of evolutionary medicine and genomics to highlight how we can become more successful at finding the most efficacious types of antibiotic or therapy and dosage for a particular disease or pathogen and build a competitive edge by prevention and risk management against invasive viruses, bacteria, or wrongly administered drugs. As more is understood about what grows on us and how it all interacts, along with how the introduction of new antibiotics, biologics, and other therapies affect our skin’s ecological balance, this book aims to create a heightened sense of the importance and offerings of ecological dermatology.

Epigenetics in Allergy and Autoimmunity

Christopher Chang,Qianjin Lu
Epigenetics in Allergy and Autoimmunity Book PDF

Author : Christopher Chang,Qianjin Lu
Publisher : Springer Nature
Page : 408 pages
File Size : 46,6 Mb
Release : 2020-05-22
Category : Medical
ISBN : 9789811534492

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Epigenetics in Allergy and Autoimmunity by Christopher Chang,Qianjin Lu Pdf

This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.

Epigenetics and Reproductive Health

Anonim
Epigenetics and Reproductive Health Book PDF

Author : Anonim
Publisher : Academic Press
Page : 464 pages
File Size : 48,5 Mb
Release : 2020-09-12
Category : Medical
ISBN : 9780128197547

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Epigenetics and Reproductive Health by Anonim Pdf

Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted reproductive technologies. Emphasis is placed on identifying biomarkers for early detection of aberrant epigenetic mechanisms. Later chapters examine the possibility of correcting these epigenetic dysfunctions, as well as current challenges and next steps in research, enabling new translational discoveries and efforts towards developing therapeutics. Thoroughly examines the influence of aberrant epigenetics during gametogenesis and embryogenesis, affecting parents, gametes and embryos, offspring and future generations Explores health outcomes for reproductive senescence, endocrine disruption, testicular cancer, prostrate cancer, breast cancer, ovarian, cancer, endometrial cancer and cervical cancers Features chapter contributions from international researchers in the field

Skin Diseases: New Insights for the Healthcare Professional: 2013 Edition

Anonim
Skin Diseases New Insights for the Healthcare Professional 2013 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 110 pages
File Size : 46,9 Mb
Release : 2013-07-22
Category : Medical
ISBN : 9781481655859

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Skin Diseases: New Insights for the Healthcare Professional: 2013 Edition by Anonim Pdf

Skin Diseases: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Additional Research in a concise format. The editors have built Skin Diseases: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Additional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Skin Diseases: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Medical Epigenetics

Anonim
Medical Epigenetics Book PDF

Author : Anonim
Publisher : Academic Press
Page : 972 pages
File Size : 47,9 Mb
Release : 2021-08-27
Category : Medical
ISBN : 9780128243268

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Medical Epigenetics by Anonim Pdf

Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a broad spectrum of disease categories and specialties, and with a focus on human systems, epigenetic diseases that affect these systems, and evolving modes of epigenetic-based treatment. Here, more than 40 leading researchers examine how each human system is affected by epigenetic maladies, offering an all-in-one resource on medical epigenetics not only for those directly involved with health care, but investigators in life sciences, biotech companies, graduate students, and others who are interested in applied aspects of epigenetics. Incorporating both diagnostic and prognostic epigenetic approaches, this volume also fully supports the application of epigenetics in precision medicine. This second edition of Medical Epigenetics, a volume in the Translational Epigenetics series, has been fully revised to address recent advances in disease epigenetics and role of epigenetics in precision medicine, with all-new chapters on skin cancer epigenetics, network analysis in medical epigenetics, machine learning in epigenetic diseases, and clinical trials of epigenetics drugs. Features chapters from leading researchers and clinicians dedicated to the burgeoning role of epigenetics in medical practice Covers emerging topics, including twin epigenetics, as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Organized from system disorders to multi-system disorders that involve epigenetic aberrations Examines the role of epigenetics in precision medicine

Atopic Dermatitis

Celso Pereira
Atopic Dermatitis Book PDF

Author : Celso Pereira
Publisher : BoD – Books on Demand
Page : 134 pages
File Size : 45,8 Mb
Release : 2021-05-05
Category : Medical
ISBN : 9781839627231

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Atopic Dermatitis by Celso Pereira Pdf

Atopic dermatitis is a chronic skin condition that has a critical impact on patient quality of life. Recently described pathophysiological aspects and new therapeutic approaches have benefitted greatly the management of patients with this condition. This book presents the most current physiopathogenic evidence in atopic dermatitis. It also examines the scientific rationale of currently available treatments as well as potential new options for managing severe forms of the disease. Written by experts in the field, chapters address some of the most important aspects of atopic dermatitis.

A Life Course Approach to Healthy Ageing

Diana Kuh,Rachel Cooper,Rebecca Hardy,Marcus Richards,Yoav Ben-Shlomo
A Life Course Approach to Healthy Ageing Book PDF

Author : Diana Kuh,Rachel Cooper,Rebecca Hardy,Marcus Richards,Yoav Ben-Shlomo
Publisher : OUP Oxford
Page : 288 pages
File Size : 48,8 Mb
Release : 2013-12-19
Category : Medical
ISBN : 9780191008177

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A Life Course Approach to Healthy Ageing by Diana Kuh,Rachel Cooper,Rebecca Hardy,Marcus Richards,Yoav Ben-Shlomo Pdf

Healthy ageing has long been a neglected area of epidemiological research as the traditional focus has been on specific chronic diseases of older life. There is a growing consensus from scientists, research funders and policy makers that ageing itself needs to be studied from an interdisciplinary and life course perspective, to inform strategies for reducing the societal and individual costs of an ageing population. A Life Course Approach to Healthy Ageing is a synthesis of life course perspectives in epidemiology and interdisciplinary perspectives in ageing research. It brings together expert investigators of maturing birth cohort and ageing studies, cross-cutting methodologists, and authorities in ageing research and knowledge transfer from across the world in one wide-ranging volume. Contributors discuss how aspects of healthy ageing are conceptualised, defined and measured; relate to each other; change across life; and are influenced by biological, psychological and social factors operating from early life onwards. They identify research gaps, and suggest how evidence from observational studies can be strengthened through improved study design and longitudinal analysis, thereby increasing the research contribution to practice or policy change. The book considers how we might delay or slow down the progressive, generalised impairment of function that occurs at the individual, body system and cellular levels, as people grow older. It also considers the determinants of wellbeing in older people, including personal fulfilment, positive emotions and social relationships. Broad in scope, discussing topics from genetics to psychological and social wellbeing, A Life Course Approach to Healthy Ageing is a key resource for epidemiologists, social scientists, clinicians, public health physicians, policy makers and practitioners with a research interest in healthy ageing.

Vitiligo

Mauro Picardo,Alain Taïeb
Vitiligo Book PDF

Author : Mauro Picardo,Alain Taïeb
Publisher : Springer Science & Business Media
Page : 483 pages
File Size : 53,5 Mb
Release : 2010-03-26
Category : Medical
ISBN : 9783540693611

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Vitiligo by Mauro Picardo,Alain Taïeb Pdf

Vitiligo has been, until recently, a rather neglected area in dermatology and medicine. Patients complain about this situation, which has offered avenues to quacks, and has led to the near orphan status of the disease. The apparently, simple and poorly symptomatic presentation of the disease has been a strong disadvantage to its study, as compared to other common chronic skin disorders such as psoriasis and atopic dermatitis. Vitiligo is still considered by doctors as a non disease, a simple aesthetic problem. A good skin-based angle of attack is also lacking because generalized vi- ligo is clearly epitomizing the view of skin diseases as simple targets of a systemic unknown dysregulation (diathesis), re? ecting the Hippocratic doctrine. This view has mostly restricted vitiligo to the manifestation of an auto-immune diathesis in the past 30 years. Thus, skin events, which are easily detected using skin biospies in most other situations, have not been precisely recorded, with the argument that a clinical diagnosis was suf? cient for the management (or most commonly absence of mana- ment) of the patient. This book is an international effort to summarize the information gathered about this disorder at the clinical, pathophysiological and therapeutic levels. Its primary aim is to bridge current knowledge at the clinical and investigative level, to point to the many unsolved issues, and to delineate future priorities for research.

Behçet Syndrome

Yusuf Yazici,Gulen Hatemi,Emire Seyahi,Hasan Yazici
Beh et Syndrome Book PDF

Author : Yusuf Yazici,Gulen Hatemi,Emire Seyahi,Hasan Yazici
Publisher : Springer Nature
Page : 328 pages
File Size : 46,8 Mb
Release : 2019-11-05
Category : Medical
ISBN : 9783030241315

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Behçet Syndrome by Yusuf Yazici,Gulen Hatemi,Emire Seyahi,Hasan Yazici Pdf

The expanded second edition of this important work provides an up-to-date and comprehensive overview of Behçet syndrome. New and updated chapters focus on recent advances in the areas of pathogenesis, the microbiome, genetics and epigenetics, clustering of symptoms, disease assessment and new treatment options. The book examines how these developments have changed the way physicians approach diagnosis, treatment, and management of Behçet patients. It also analyzes the wide variety of clinical manifestations of the disease including mucocutaneous lesions, intraocular inflammation, central nervous system involvement, deep vein thrombosis and other forms of major vascular disease. Building on the success of its predecessor, the Second Edition of Behçet Syndrome is an invaluable resource for physicians, residents, fellows, and graduate students in rheumatology, dermatology, ophthalmology, neurology, gastroenterology, and internal medicine.

A Comprehensive Guide to Hidradenitis Suppurativa

Vivian Y. Shi,Jennifer L. Hsiao,Michelle A. Lowes,Iltefat H. Hamzavi
A Comprehensive Guide to Hidradenitis Suppurativa Book PDF

Author : Vivian Y. Shi,Jennifer L. Hsiao,Michelle A. Lowes,Iltefat H. Hamzavi
Publisher : Elsevier Health Sciences
Page : 371 pages
File Size : 44,7 Mb
Release : 2021-10-20
Category : Medical
ISBN : 9780323777254

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A Comprehensive Guide to Hidradenitis Suppurativa by Vivian Y. Shi,Jennifer L. Hsiao,Michelle A. Lowes,Iltefat H. Hamzavi Pdf

Despite being a relatively straightforward clinical diagnosis, recognition of hidradenitis suppurativa (HS) is highly variable, and clinical management is challenging and complex. Written by the world’s leading experts in HS, A Comprehensive Guide to Hidradenitis Suppurativa brings together up-to-date scientific evidence on the diagnosis, patho-mechanisms, comorbidities, and multi-faceted medical and surgical interventions for this debilitating condition—in one convenient reference. Covers every aspect of this complex skin disorder: etiology, pathophysiology, epidemiology, medical, alternative therapies, a range of surgical options, laser treatments, and comorbidities. Discusses specific patient populations such as children, women of childbearing potential, and pregnant and breastfeeding women. Because HS has higher prevalence in people of skin of color, this patient population is well-documented in the text. Offers insights into multi-disciplinary care, patient support and education, patients at risk for rapid disease progression, and clinical and translational research. Features procedural videos covering laser therapies, de-roofing procedures, excisions and closure techniques, cryoinsufflation techniques, and special wound care material selection and techniques. Includes recent FDA-approved drugs as well as those drugs and therapies that show future promise. Identifies evidence gaps that provide a springboard to the future innovations in HS care to come. Edited and authored by global experts who have co-authored 2019 U.S. and Canadian guidelines on hidradenitis suppurativa.

Epigenetics of Aging and Longevity

Alexey Moskalev,Alexander M. Vaiserman
Epigenetics of Aging and Longevity Book PDF

Author : Alexey Moskalev,Alexander M. Vaiserman
Publisher : Academic Press
Page : 544 pages
File Size : 40,7 Mb
Release : 2017-11-17
Category : Medical
ISBN : 9780128110836

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Epigenetics of Aging and Longevity by Alexey Moskalev,Alexander M. Vaiserman Pdf

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan

The Oxford Handbook of Developmental Psychology, Vol. 1

Philip David Zelazo
The Oxford Handbook of Developmental Psychology Vol 1 Book PDF

Author : Philip David Zelazo
Publisher : Oxford University Press
Page : 1049 pages
File Size : 50,9 Mb
Release : 2013-03-21
Category : Medical
ISBN : 9780199958450

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The Oxford Handbook of Developmental Psychology, Vol. 1 by Philip David Zelazo Pdf

This handbook provides a comprehensive survey of what is now known about psychological development, from birth to biological maturity, and it highlights how cultural, social, cognitive, neural, and molecular processes work together to yield human behavior and changes in human behavior.

Handbook of Nutrition, Diet, and Epigenetics

Vinood B. Patel,Victor R. Preedy
Handbook of Nutrition Diet and Epigenetics Book PDF

Author : Vinood B. Patel,Victor R. Preedy
Publisher : Springer
Page : 0 pages
File Size : 53,9 Mb
Release : 2019-02-27
Category : Medical
ISBN : 3319555294

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Handbook of Nutrition, Diet, and Epigenetics by Vinood B. Patel,Victor R. Preedy Pdf

This multivolume reference work addresses the fact that the well being of humankind is predicated not only on individuals receiving adequate nutrition but also on their genetic makeup. The work includes more than 100 chapters organized in the following major sections: Introduction and Overview; Epigenetics of Organs and Diseases in Relation to Diet and Nutrition; Detailed Processes in Epigenetics of Diet and Nutrition; Modulating Epigenetics with Diet and Nutrition; and Practical Techniques. While it is well known that genes may encode proteins responsible for structural and dynamic components, there is an increasing body of evidence to suggest that nutrition itself may alter the way in which genes are expressed via the process of epigenetics. This is where chemically imposed alteration in the DNA sequence occurs or where the functional expression of DNA is modulated. This may include changes in DNA methylation, non-coding RNA, chromatin, histone acetylation or methylation, and genomic imprinting. Knowledge regarding the number of dietary components that impact on epigenetic processes is increasing almost daily. Marshalling all the information on the complex relationships between diet, nutrition, and epigenetic processes is somewhat difficult due to the wide myriad of material. It is for this reason that the present work has been compiled.