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Brain, Behavior and Epigenetics

Arturas Petronis,Jonathan Mill

Author : Arturas Petronis,Jonathan Mill
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 52,7 Mb
Release : 2011-05-19
Category : Medical
ISBN : 9783642174261

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Brain, Behavior and Epigenetics by Arturas Petronis,Jonathan Mill Pdf

Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease? If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment? Over the last couple of decades, epigenetics has undergone a significant metamorphosis from an abstract developmental theory to a very dynamic and rapidly developing branch of molecular biology. This volume represents a compilation of our current understanding about the key aspects of epigenetic processes in the brain and their role in behavior. The chapters in this book bring together some of the leading researchers in the field of behavioral epigenetics. They explore many of the epigenetic processes which operate or may be operating to mediate neurobiological functions in the brain and describe how perturbations to these systems may play a key role in mediating behavior and the origin of brain diseases.

Epigenetics, Brain and Behavior

Paolo Sassone Corsi,Yves Christen

Author : Paolo Sassone Corsi,Yves Christen
Publisher : Springer Science & Business Media
Page : 171 pages
File Size : 42,7 Mb
Release : 2012-08-28
Category : Medical
ISBN : 9783642279126

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Epigenetics, Brain and Behavior by Paolo Sassone Corsi,Yves Christen Pdf

What lies at the heart of neuronal plasticity? Accumulating evidence points to epigenetics. This word originally indicated potentially heritable modifications in gene expression that do not involve changes in DNA sequence. Today this definition is much less strict, and epigenetic control is thought to include DNA methylation, histone modifications, histone variants, microRNA metabolic pathways and non-histone proteins modifications. Thus, while neuronal plasticity is rightly thought to be intimately associated to genomic control, it is critical to appreciate that there is much more to the genome than DNA sequence. Recent years have seen spectacular advances in the field of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigenetic regulation to brain functions has been accumulating. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molecular mechanisms implicated in epigenetic control and how these may operate in concert. It will be critical to unravel how specificity is achieved. Importantly, specific modifications seem to mediate both developmental processes and adult brain functions, such as synaptic plasticity and memory. Many aspects of the research in neurosciences and endocrinology during the upcoming decade will be dominated by the deciphering of epigenetic control. This book constitutes a compendium of the most updated views in the field.

Brain, Behavior and Epigenetics

Arturas Petronis,Jonathan Mill

Author : Arturas Petronis,Jonathan Mill
Publisher : Springer
Page : 320 pages
File Size : 49,6 Mb
Release : 2011-08-10
Category : Medical
ISBN : 3642174272

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Brain, Behavior and Epigenetics by Arturas Petronis,Jonathan Mill Pdf

Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease? If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment? Over the last couple of decades, epigenetics has undergone a significant metamorphosis from an abstract developmental theory to a very dynamic and rapidly developing branch of molecular biology. This volume represents a compilation of our current understanding about the key aspects of epigenetic processes in the brain and their role in behavior. The chapters in this book bring together some of the leading researchers in the field of behavioral epigenetics. They explore many of the epigenetic processes which operate or may be operating to mediate neurobiological functions in the brain and describe how perturbations to these systems may play a key role in mediating behavior and the origin of brain diseases.

Epigenetics and Neuroplasticity - Evidence and Debate

Anonim

Author : Anonim
Publisher : Academic Press
Page : 250 pages
File Size : 50,8 Mb
Release : 2014-11-05
Category : Science
ISBN : 9780128010853

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Epigenetics and Neuroplasticity - Evidence and Debate by Anonim Pdf

The ‘epi-(Greek for ‘over’, ‘above’)genome’, with its rich cache of highly regulated, structural modifications—including DNA methylation, histone modifications and histone variants—defines the moldings and three-dimensional structures of the genomic material inside the cell nucleus and serves, literally, as a molecular bridge linking the environment to the genetic materials in our brain cells. Due to technological and scientific advances in the field, the field of neuroepigenetics is currently one of the hottest topics in the basic and clinical neurosciences. The volume captures some of this vibrant and exciting new research, and conveys to the reader an up-to-date discussion on the role of epigenetics across the lifespan of the human brain in health and disease. Topics cover the entire lifespan of the brain, from transgenerational epigenetics to neurodevelopmental disease to disorders of the aging brain. All chapters are written with dual intent, to provide the reader with a timely update on the field, and a discussion of provocative or controversial findings in the field with the potential of great impact for future developments in the field.

The Neurobiological Basis of Suicide

Yogesh Dwivedi

Author : Yogesh Dwivedi
Publisher : CRC Press
Page : 485 pages
File Size : 44,7 Mb
Release : 2012-06-25
Category : Medical
ISBN : 9781439838815

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The Neurobiological Basis of Suicide by Yogesh Dwivedi Pdf

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Epigenetic Regulation in the Nervous System

J. David Sweatt,Michael J. Meaney,Eric J. Nestler,Schahram Akbarian

Author : J. David Sweatt,Michael J. Meaney,Eric J. Nestler,Schahram Akbarian
Publisher : Academic Press
Page : 374 pages
File Size : 41,5 Mb
Release : 2012-12-31
Category : Science
ISBN : 9780123944054

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Epigenetic Regulation in the Nervous System by J. David Sweatt,Michael J. Meaney,Eric J. Nestler,Schahram Akbarian Pdf

Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. BMA Medical Book Awards 2014 - Highly Commended, Neurology, British Medical Association BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics

Epigenetics for Beginners and Intermediate (2 Books in 1)

Frank Brown

Author : Frank Brown
Publisher : Youcanprint
Page : 330 pages
File Size : 51,9 Mb
Release : 2021-09-15
Category : Medical
ISBN : 9791220357999

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Epigenetics for Beginners and Intermediate (2 Books in 1) by Frank Brown Pdf

You Are About To Develop A Comprehensive Understanding Of The Concept Of Epigenetics, Its Place In Modern Day Medicine, And Health Optimization And Why It Is Literally Changing How We Approach The Treatment Of Various Health Problems! Modern research has now confirmed that the behavior of your genes doesn't always depend on their DNA sequence, but also on factors referred to epigenetics, and that changes in these factors can play a critical role in disease, life structures, behavior and all aspects of life. And that's not all; research also shows that therapies based on these factors have proven effective in reversing some conditions, boosting the immune system, optimizing psychology and human adaptation. Epigenetics have thus taken the center stage in understanding human biology at a deeper level, life, and evolution. But what are epigenetics, and how to they work? How does the environment affect them, and how is this "remembered" in the body? How does epigenetic therapy work? What does it treat? Isn't it risky? What is the relationship between epigenetics and the human psychology? How can we benefit from the discovery and understanding of epigenetics? If you have these and other related questions, this 2 in 1 book is for you so keep reading. Here is a bit of what you'll learn from this 2 in 1 book: • What epigenetics are, why they're important and how they work • How epigenetics relate with our experiences • How cells divide, and how genes control the growth and division of cells • The difference between the DNA, gene and chromosomes • The existing evidence of epigenetic changes, including in transgenerational epigenetic inheritance • The ins and outs of epigenetics mechanisms • The types of epigenetic therapies available today, including their risks, benefits and research on them • The effect of epigenetic control in transcriptional regulation in pluripotency and early differentiation, DNA methylation and Demethylation, nucleosome remodeling and chromatin looping • How epigenetics work at the molecular level and the effect of DNA damage in epigenetic change • The functions of epigenetics, and how they boost mindfulness training, healthy eating and exercise • How epigenetic therapy and modifications affects diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia, mesothelioma and many more • How epigenetic modifications are used in understanding plant and animal evolution • How epigenetic mechanisms are used in understanding human adaptation, boosting memory formation, growth and reinforcing infant neurobehavior. • The role of epigenetic mechanisms in maternal care • The role of environmental chemicals in epigenetics • How epigenetics are involved in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more. • The role of environmental exposures in pathophysiology of IPF • Modulation of epigenetic marks by environmental exposures • How epigenetic regulation affects the immune system …And so much more! Whether you are a beginner or an intermediate in epigenetics, you will find this book educative, as you learn the A-Z of factors that are quickly changing our understanding of the structure of life. Don't wait…. Scroll up and click Buy Now with 1-Click or Buy Now to get started!

Developmental Human Behavioral Epigenetics

Livio Provenzi,Rosario Montirosso

Author : Livio Provenzi,Rosario Montirosso
Publisher : Academic Press
Page : 188 pages
File Size : 42,5 Mb
Release : 2020-12-02
Category : Science
ISBN : 9780128192627

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Developmental Human Behavioral Epigenetics by Livio Provenzi,Rosario Montirosso Pdf

Developmental Human Behavioral Epigenetics: Principles, Methods, Evidence, and Future Directions, Volume 23, a new volume in the Translational Epigenetics series, offers the first systematic account of theoretical G79 frameworks, methodological approaches, findings, and future directions in the field of human behavioral epigenetics. Featuring contributions from leading scientists and international researchers, this book provides a comprehensive overview of human behavioral epigenetics, with a close examination of evidence gathered to-date from animal models, challenges of human-based research and clinical translation, pathways towards drug discovery, and next steps in research. Areas of focus include prenatal stress exposures, preterm behavioral epigenetics, intergenerational exposures, trauma and neglect, socio-economic conditions, maternal caregiving and attachment, study design, and epigenetics and psychotherapy. Enables more effective study design and methods application in behavioral epigenetics research across human and animal models Examines findings in human behavioral epigenetics to-date Features contributions from leading international researchers in behavioral epigenetics

Epigenetic Epidemiology

Karin B. Michels

Author : Karin B. Michels
Publisher : Springer Science & Business Media
Page : 450 pages
File Size : 53,5 Mb
Release : 2012-01-02
Category : Medical
ISBN : 9789400724952

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Epigenetic Epidemiology by Karin B. Michels Pdf

The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored.This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!

The Developing Genome

David Scott Moore

Author : David Scott Moore
Publisher : Oxford University Press, USA
Page : 321 pages
File Size : 53,6 Mb
Release : 2015
Category : Medical
ISBN : 9780199922345

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The Developing Genome by David Scott Moore Pdf

Includes bibliographical references (pages 275-300) and index

The Promise of Adolescence

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Division of Behavioral and Social Sciences and Education,Board on Children, Youth, and Families,Committee on the Neurobiological and Socio-behavioral Science of Adolescent Development and Its Applications

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Division of Behavioral and Social Sciences and Education,Board on Children, Youth, and Families,Committee on the Neurobiological and Socio-behavioral Science of Adolescent Development and Its Applications
Publisher : National Academies Press
Page : 493 pages
File Size : 47,6 Mb
Release : 2019-07-26
Category : Social Science
ISBN : 9780309490115

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The Promise of Adolescence by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Division of Behavioral and Social Sciences and Education,Board on Children, Youth, and Families,Committee on the Neurobiological and Socio-behavioral Science of Adolescent Development and Its Applications Pdf

Adolescenceâ€"beginning with the onset of puberty and ending in the mid-20sâ€"is a critical period of development during which key areas of the brain mature and develop. These changes in brain structure, function, and connectivity mark adolescence as a period of opportunity to discover new vistas, to form relationships with peers and adults, and to explore one's developing identity. It is also a period of resilience that can ameliorate childhood setbacks and set the stage for a thriving trajectory over the life course. Because adolescents comprise nearly one-fourth of the entire U.S. population, the nation needs policies and practices that will better leverage these developmental opportunities to harness the promise of adolescenceâ€"rather than focusing myopically on containing its risks. This report examines the neurobiological and socio-behavioral science of adolescent development and outlines how this knowledge can be applied, both to promote adolescent well-being, resilience, and development, and to rectify structural barriers and inequalities in opportunity, enabling all adolescents to flourish.

Introduction to Psychology

Jennifer Walinga,Charles Stangor

Author : Jennifer Walinga,Charles Stangor
Publisher : Hasanraza Ansari
Page : 810 pages
File Size : 50,8 Mb
Release : 2024-06-18
Category : Body, Mind & Spirit
ISBN : 8210379456XXX

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Introduction to Psychology by Jennifer Walinga,Charles Stangor Pdf

This book is designed to help students organize their thinking about psychology at a conceptual level. The focus on behaviour and empiricism has produced a text that is better organized, has fewer chapters, and is somewhat shorter than many of the leading books. The beginning of each section includes learning objectives; throughout the body of each section are key terms in bold followed by their definitions in italics; key takeaways, and exercises and critical thinking activities end each section.

Epigenetics of Aging

Trygve O. Tollefsbol

Author : Trygve O. Tollefsbol
Publisher : Springer Science & Business Media
Page : 469 pages
File Size : 54,8 Mb
Release : 2009-11-11
Category : Medical
ISBN : 9781441906397

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Epigenetics of Aging by Trygve O. Tollefsbol Pdf

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Environmental Epigenetics

L. Joseph Su,Tung-chin Chiang

Author : L. Joseph Su,Tung-chin Chiang
Publisher : Springer
Page : 321 pages
File Size : 54,7 Mb
Release : 2015-05-18
Category : Medical
ISBN : 9781447166788

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Environmental Epigenetics by L. Joseph Su,Tung-chin Chiang Pdf

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Epigenetics in Psychiatry

Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos

Author : Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos
Publisher : Academic Press
Page : 848 pages
File Size : 44,9 Mb
Release : 2021-08-21
Category : Science
ISBN : 9780128235782

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Epigenetics in Psychiatry by Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos Pdf

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field

Epigenetics Brain And Behavior

Brain, Behavior and Epigenetics by Arturas Petronis,Jonathan Mill Pdf

Epigenetics, Brain and Behavior by Paolo Sassone Corsi,Yves Christen Pdf

Brain, Behavior and Epigenetics by Arturas Petronis,Jonathan Mill Pdf

Epigenetics and Neuroplasticity - Evidence and Debate by Anonim Pdf

The Neurobiological Basis of Suicide by Yogesh Dwivedi Pdf

Epigenetic Regulation in the Nervous System by J. David Sweatt,Michael J. Meaney,Eric J. Nestler,Schahram Akbarian Pdf

Epigenetics for Beginners and Intermediate (2 Books in 1) by Frank Brown Pdf

Developmental Human Behavioral Epigenetics by Livio Provenzi,Rosario Montirosso Pdf

Epigenetic Epidemiology by Karin B. Michels Pdf

The Developing Genome by David Scott Moore Pdf

Introduction to Psychology by Jennifer Walinga,Charles Stangor Pdf

Epigenetics of Aging by Trygve O. Tollefsbol Pdf

Environmental Epigenetics by L. Joseph Su,Tung-chin Chiang Pdf

Epigenetics in Psychiatry by Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos Pdf

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