The Developing Genome

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The Developing Genome

David S. Moore
The Developing Genome Book PDF

Author : David S. Moore
Publisher : Oxford University Press
Page : 272 pages
File Size : 53,6 Mb
Release : 2015-01-29
Category : Psychology
ISBN : 9780199922352

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The Developing Genome by David S. Moore Pdf

Why do we grow up to look, act, and feel as we do? Through most of the twentieth century, scientists and laypeople answered this question by referring to two factors alone: our experiences and our genes. But recent discoveries about how genes work have revealed a new way to understand the developmental origins of our characteristics. These discoveries have emerged from the new science of behavioral epigenetics--and just as the whole world has now heard of DNA, "epigenetics" will be a household word in the near future. Behavioral epigenetics is important because it explains how our experiences get under our skin and influence the activity of our genes. Because of breakthroughs in this field, we now know that the genes we're born with don't determine if we'll end up easily stressed, likely to fall ill with cancer, or possessed of a powerful intellect. Instead, what matters is what our genes do. And because research in behavioral epigenetics has shown that our experiences influence how our genes function, this work has changed how scientists think about nature, nurture, and human development. Diets, environmental toxins, parenting styles, and other environmental factors all influence genetic activity through epigenetic mechanisms; this discovery has the potential to alter how doctors treat diseases, and to change how mental health professionals treat conditions from schizophrenia to post-traumatic stress disorder. These advances could also force a reworking of the theory of evolution that dominated twentieth-century biology, and even change how we think about human nature itself. In spite of the importance of this research, behavioral epigenetics is still relatively unknown to non-biologists. The Developing Genome is an introduction to this exciting new discipline; it will allow readers without a background in biology to learn about this work and its revolutionary implications.

The Developing Genome

David Scott Moore
The Developing Genome Book PDF

Author : David Scott Moore
Publisher : Oxford University Press, USA
Page : 321 pages
File Size : 53,7 Mb
Release : 2015
Category : Medical
ISBN : 9780199922345

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The Developing Genome by David Scott Moore Pdf

Includes bibliographical references (pages 275-300) and index

The Dependent Gene

David S. Moore
The Dependent Gene Book PDF

Author : David S. Moore
Publisher : Macmillan
Page : 324 pages
File Size : 54,5 Mb
Release : 2003-02-05
Category : Science
ISBN : 0805072802

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The Dependent Gene by David S. Moore Pdf

This book provides an analysis of the nature vs. nuture debate, arguing for an end to the 'either/or' nature of the discussions in favor of a recognition that environmental and genetic factors interact throughout life to form human traits.

Epigenetics

Benedikt Hallgrimsson Ph.D.,Brian K. Hall Ph.D.
Epigenetics Book PDF

Author : Benedikt Hallgrimsson Ph.D.,Brian K. Hall Ph.D.
Publisher : Univ of California Press
Page : 472 pages
File Size : 40,8 Mb
Release : 2011-04-11
Category : Science
ISBN : 9780520948822

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Epigenetics by Benedikt Hallgrimsson Ph.D.,Brian K. Hall Ph.D. Pdf

Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene. With chapters written by leading authorities, this volume offers a broad integrative survey of epigenetics. Approaching this complex subject from a variety of perspectives, it presents a broad, historically grounded view that demonstrates the utility of this approach for understanding complex biological systems in development, disease, and evolution. Chapters cover such topics as morphogenesis and organ formation, conceptual foundations, and cell differentiation, and together demonstrate that the integration of epigenetics into mainstream developmental biology is essential for answering fundamental questions about how phenotypic traits are produced.

Epigenetic Technological Applications

Yujun George Zheng
Epigenetic Technological Applications Book PDF

Author : Yujun George Zheng
Publisher : Academic Press
Page : 516 pages
File Size : 50,9 Mb
Release : 2015-05-30
Category : Science
ISBN : 9780128013274

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Epigenetic Technological Applications by Yujun George Zheng Pdf

Epigenetic Technological Applications is a compilation of state-of-the-art technologies involved in epigenetic research. Epigenetics is an exciting new field of biology research, and many technologies are invented and developed specifically for epigenetics study. With chapters covering the latest developments in crystallography, computational modeling, the uses of histones, and more, Epigenetic Technological Applications addresses the question of how these new ideas, procedures, and innovations can be applied to current epigenetics research, and how they can keep pushing discovery forward and beyond the epigenetic realm. Discusses technologies that are critical for epigenetic research and application Includes epigenetic applications for state-of-the-art technologies Contains a global perspective on the future of epigenetics

Evolution, Development, and the Predictable Genome

David L. Stern
Evolution Development and the Predictable Genome Book PDF

Author : David L. Stern
Publisher : Roberts Publishers
Page : 294 pages
File Size : 40,8 Mb
Release : 2011
Category : Science
ISBN : STANFORD:36105215333076

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Evolution, Development, and the Predictable Genome by David L. Stern Pdf

Bringing evolutionary and developmental biology together, Evolution, Development, and the Predictable Genome uses the insights from generations of evolutionary and developmental biologists to form a solid foundation for future investigation of the genetic and developmental causes of diversity.

Computational Epigenetics and Diseases

Anonim
Computational Epigenetics and Diseases Book PDF

Author : Anonim
Publisher : Academic Press
Page : 450 pages
File Size : 47,8 Mb
Release : 2019-02-06
Category : Business & Economics
ISBN : 9780128145142

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Computational Epigenetics and Diseases by Anonim Pdf

Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases

Epigenetic Gene Expression and Regulation

Suming Huang,Michael D Litt,C. Ann Blakey
Epigenetic Gene Expression and Regulation Book PDF

Author : Suming Huang,Michael D Litt,C. Ann Blakey
Publisher : Academic Press
Page : 482 pages
File Size : 42,8 Mb
Release : 2015-10-19
Category : Science
ISBN : 9780128004715

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Epigenetic Gene Expression and Regulation by Suming Huang,Michael D Litt,C. Ann Blakey Pdf

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science

Misbehaving Science

Aaron Panofsky
Misbehaving Science Book PDF

Author : Aaron Panofsky
Publisher : University of Chicago Press
Page : 334 pages
File Size : 55,7 Mb
Release : 2014-07-07
Category : Social Science
ISBN : 9780226058597

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Misbehaving Science by Aaron Panofsky Pdf

Behavior genetics has always been a breeding ground for controversies. From the “criminal chromosome” to the “gay gene,” claims about the influence of genes like these have led to often vitriolic national debates about race, class, and inequality. Many behavior geneticists have encountered accusations of racism and have had their scientific authority and credibility questioned, ruining reputations, and threatening their access to coveted resources. In Misbehaving Science, Aaron Panofsky traces the field of behavior genetics back to its origins in the 1950s, telling the story through close looks at five major controversies. In the process, Panofsky argues that persistent, ungovernable controversy in behavior genetics is due to the broken hierarchies within the field. All authority and scientific norms are questioned, while the absence of unanimously accepted methods and theories leaves a foundationless field, where disorder is ongoing. Critics charge behavior geneticists with political motivations; champions say they merely follow the data where they lead. But Panofsky shows how pragmatic coping with repeated controversies drives their scientific actions. Ironically, behavior geneticists’ struggles for scientific authority and efforts to deal with the threats to their legitimacy and autonomy have made controversy inevitable—and in some ways essential—to the study of behavior genetics.

The Concept of the Gene in Development and Evolution

Peter J. Beurton,Raphael Falk,Hans-Jörg Rheinberger
The Concept of the Gene in Development and Evolution Book PDF

Author : Peter J. Beurton,Raphael Falk,Hans-Jörg Rheinberger
Publisher : Cambridge University Press
Page : 405 pages
File Size : 45,7 Mb
Release : 2000-05-29
Category : Philosophy
ISBN : 9780521771870

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The Concept of the Gene in Development and Evolution by Peter J. Beurton,Raphael Falk,Hans-Jörg Rheinberger Pdf

Advances in molecular biological research in the latter half of the twentieth century have made the story of the gene vastly complicated: the more we learn about genes, the less sure we are of what a gene really is. Knowledge about the structure and functioning of genes abounds, but the gene has also become curiously intangible. This collection of essays renews the question: what are genes? Philosophers, historians and working scientists re-evaluate the question in this volume, treating the gene as a focal point of interdisciplinary and international research. It will be of interest to professionals and students in the philosophy and history of science, genetics and molecular biology.

From Neurons to Neighborhoods

National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development
From Neurons to Neighborhoods Book PDF

Author : National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development
Publisher : National Academies Press
Page : 610 pages
File Size : 45,7 Mb
Release : 2000-11-13
Category : Social Science
ISBN : 9780309069885

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From Neurons to Neighborhoods by National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development Pdf

How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

DNA Methylation and Complex Human Disease

Michel Neidhart
DNA Methylation and Complex Human Disease Book PDF

Author : Michel Neidhart
Publisher : Academic Press
Page : 552 pages
File Size : 45,9 Mb
Release : 2015-08-11
Category : Science
ISBN : 9780127999203

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DNA Methylation and Complex Human Disease by Michel Neidhart Pdf

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field Describes wholly new concepts, including the linking of metabolic pathways with epigenetics Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases

The Eukaryote Genome in Development and Evolution

John Bernard
The Eukaryote Genome in Development and Evolution Book PDF

Author : John Bernard
Publisher : Springer Science & Business Media
Page : 432 pages
File Size : 53,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401159913

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The Eukaryote Genome in Development and Evolution by John Bernard Pdf

'The mind unlearns with difficulty what has long been impressed upon it. ' Seneca Reductionism, is, without question, the most successful analytical approach available to the experimental scientist. With the advent of techniques for cloning and sequencing DNA, and the development of a variety of molecular probes for localizing macromolecules in cells and tissues, the biologist now has available the most powerful reductionist tools ever invented. The application of these new technologies has led to a veritable explosion of facts regarding the types and organization of nucleotide sequences present in the genomes of eukaryotes. These data offer a level of precision and predictability which is unparalleled in biology. Recombinant DNA techniques were initially developed to gather information about the structure and organization of the DNA sequences within a genome. The power and potential of these techniques, however, extend far beyond simple data collection of this kind. In an attempt to use the new technology as a basis for analyzing development and evolution, attention was first focused on the topic of gene regulation, an approach that had proven so successful in prokaryotes. It is now clear that this has not been an adequate approach. Lewin (1984) has quoted Brenner as stating 'at the beginning it was said that the answer to the understanding of development was going to come from a knowledge of the molecular mechanisms of gene control. I doubt whether anyone believes this any more.

Welcome to the Genome

Rob DeSalle,Michael Yudell,American Museum of Natural History
Welcome to the Genome Book PDF

Author : Rob DeSalle,Michael Yudell,American Museum of Natural History
Publisher : Wiley
Page : 240 pages
File Size : 54,8 Mb
Release : 2004-09-28
Category : Science
ISBN : 0471453315

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Welcome to the Genome by Rob DeSalle,Michael Yudell,American Museum of Natural History Pdf

A thrilling "user's guide" to the genomics era Welcome to the genome, the miraculous blueprint of your DNA, coiled tight as a spring in the nucleus of each cell of your body. If unwound, the DNA from just one cell, while only a molecule in width, would stretch six feet in length! The information stored in its double helix structure - three billion bits worth - could fill 142 Manhattan phone books. Yet far more amazing than these facts is the impact the study of genomics has had on so many areas of our lives. From the promise of personalized medicine and gene therapy to disputes over the safety of genetically modified (GM) foods, there is little doubt we are in the midst of the Genomic Revolution. Now how do we make sense of it all? Welcome to the Genome takes you right into the thick of today's most cutting-edge science and its far-reaching implications. Authors Rob DeSalle, who curated the highly successful Genomics Revolution exhibit at the American Museum of Natural History in New York, and Michael Yudell, Assistant Professor of Public Health at Drexel University, have written a book which clearly explains the ongoing saga of our attempts to understand the mystery of biology's Rosetta Stone and use its code to better our lives. This reader-friendly book employs an understandable style and eye-popping full-color illustrations to provide real insights into the complex science involved. It delves into the past discoveries that led to the sequencing of the human genome; it presents the challenges facing today's scientists and society and culture in general; and it considers the future possibilities of the developing genome era. Social issues, particularly questions of ethics, receive special attention, covering an important area too often overshadowed by science and technology. If the genome really is the book of life, then we have only just opened to the first of its many pages. Those who triumphantly claim DNA is destiny may have spoken too soon; it is far more likely today's discoveries will lead to insights yet to be imagined. A stirring and informative introduction to a scientific epic still unfolding, Welcome to the Genome is an essential guide for understanding - and participating in - the incredible explorations, discussions, and realizations of the Genomic Revolution.

The Deeper Genome

John Parrington
The Deeper Genome Book PDF

Author : John Parrington
Publisher : Oxford University Press
Page : 369 pages
File Size : 49,9 Mb
Release : 2017
Category : Medical
ISBN : 9780198813095

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The Deeper Genome by John Parrington Pdf

As the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way ... but the emerging picture is if anything far more exciting. Parrington gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals as well as that of chimps about the development of our species.