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Epilepsy Towards the Next Decade by Pasquale Striano Pdf
A comprehensive collection of the most recent knowledge on the biological bases of various kinds of epilepsies and modern clinical approaches to their treatment. Epilepsy affects about 0.5-1% of the world's population (about 50,000,000 individuals) and the main goal of its treatment is to eliminate seizures without creating side effects. Despite numerous advances in the treatment of epilepsy and the approval of several new antiepileptic drugs, about 30% of patients continue to experience recurrent seizures which are medically, physically, and/or socially disabling. The editor of this volume hopes that by bridging the gap between the fundamental biology of epilepsy and its clinical implications he might spur further research and treatment options.
Institute of Medicine,Board on Health Sciences Policy,Committee on the Public Health Dimensions of the Epilepsies
Author : Institute of Medicine,Board on Health Sciences Policy,Committee on the Public Health Dimensions of the Epilepsies Publisher : National Academies Press Page : 568 pages File Size : 46,8 Mb Release : 2012-07-29 Category : Medical ISBN : 9780309259538
Epilepsy Across the Spectrum by Institute of Medicine,Board on Health Sciences Policy,Committee on the Public Health Dimensions of the Epilepsies Pdf
Although epilepsy is one of the nation's most common neurological disorders, public understanding of it is limited. Many people do not know the causes of epilepsy or what they should do if they see someone having a seizure. Epilepsy is a complex spectrum of disorders that affects an estimated 2.2 million Americans in a variety of ways, and is characterized by unpredictable seizures that differ in type, cause, and severity. Yet living with epilepsy is about much more than just seizures; the disorder is often defined in practical terms, such as challenges in school, uncertainties about social situations and employment, limitations on driving, and questions about independent living. The Institute of Medicine was asked to examine the public health dimensions of the epilepsies, focusing on public health surveillance and data collection; population and public health research; health policy, health care, and human services; and education for people with the disorder and their families, health care providers, and the public. In Epilepsy Across the Spectrum, the IOM makes recommendations ranging from the expansion of collaborative epilepsy surveillance efforts, to the coordination of public awareness efforts, to the engagement of people with epilepsy and their families in education, dissemination, and advocacy for improved care and services. Taking action across multiple dimensions will improve the lives of people with epilepsy and their families. The realistic, feasible, and action-oriented recommendations in this report can help enable short- and long-term improvements for people with epilepsy. For all epilepsy organizations and advocates, local, state, and federal agencies, researchers, health care professionals, people with epilepsy, as well as the public, Epilepsy Across the Spectrum is an essential resource.
Translational Research in Traumatic Brain Injury by Daniel Laskowitz,Gerald Grant Pdf
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.
The Epilepsies by Chrysostomos P. Panayiotopoulos Pdf
This book gives an exhaustive account of the classification and management of epileptic disorders. It provides clear didactic guidance on the diagnosis and treatment of epileptic syndromes and seizures through thirteen chapters, complemented by a pharmacopoeia and CD ROM of video-EEGs.
Jasper's Basic Mechanisms of the Epilepsies by Jeffrey L. Noebels,Massimo Avoli Pdf
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Pharmacoresistance in Epilepsy by Luisa Rocha,Esper A. Cavalheiro Pdf
Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoesistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they’re studying epilepsy in the lab or treating it in a doctor’s office.”
The compelling story of an acclaimed journalist and New York Times bestselling author’s ongoing struggle with epilepsy—how, through personal resilience and the support of loved ones, he overcame medical incompetence and institutional discrimination to achieve once unthinkable success. With a new afterword • “REMARKABLE . . . inspirational in the true sense of the word.”—The New York Times Book Review This is the story of one man’s battle to pursue his dreams despite an often incapacitating brain disorder. From his early experiences of fear and denial to his exasperating search for treatment, Kurt Eichenwald provides a deeply candid account of his years facing this misunderstood and often stigmatized condition. He details his encounters with the doctors whose negligence could have killed him, but for the heroic actions of a brilliant neurologist and the family and friends who fought for him. Ultimately, A Mind Unraveled is an inspirational story, one that chronicles how Eichenwald, faced often with his own mortality, transformed trauma into a guide for reaching the future he desired. Praise for A Mind Unraveled “An intimate journey . . . bravely illuminating the trials of living inside a body always poised to betray itself.”—O: The Oprah Magazine “Poignant and infuriating . . . merges elements of medical drama, anti-discrimination fable, and coming-of-age memoir.”—The New Yorker “One of the best thrillers I’ve read in years, yet there are no detectives, no corpses, no guns or knives.”—Minneapolis Star-Tribune “Terrific . . . Eichenwald’s narrative is a suspenseful medical thriller about a condition that makes everyday life a mine field, a fierce indictment of a callous medical establishment, and an against-the-odds recovery saga.”—Publishers Weekly (starred review) “Riveting . . . Eichenwald has created a universal tale of resilience wrapped in a primal scream against the far-too-savage world."—Booklist (starred review) “An extraordinary book.”—Harriet Lerner, Ph.D., New York Times bestselling author of The Dance of Anger
Clinical Electroencephalography by Oriano Mecarelli Pdf
This book describes the developments and improvements in electroencephalography (EEG). In recent years, digital technology has replaced analog equipments, and it is now possible to easily record and store EEG tracings and to quickly recall previously acquired material for subsequent analysis. In addition, not only static figures, but also electronic supplementary materials can be included in books, enabling EEGs to be viewed in real-time. In clinical practice, EEG still represents the most important functional examination in the study CNS development and its anatomical and physiological integrity throughout life. In the pathological context, EEG provides indispensable diagnostic information for classification of epileptic syndromes, and it is also valuable in all the other CNS diseases (infectious, cerebrovascular, neurodegenerative, etc). Furthermore, monitoring EEG can be widely used in emergency settings, such as emergency departments or intensive care units. In comatose patients, EEG provides information regarding prognosis and evaluation of the sedative effect of anesthetic drugs. Written by a group of leading national and international experts, it offers a substantial, yet practical, EEG compendium, which serves as a reference resource for physicians and neurodiagnostic technologists as well as physicians-in-training, researchers, practicing electroencephalographers and students.
The Mesial Temporal Lobe Epilepsies by Felix Rosenow,Philippe Ryvlin,Hans O. Lüders Pdf
This work is the result of a recently held International Epilepsy Colloquium on the mesial temporal lobe epilepsies (MTLE) which covered all aspects of this specific group of syndromes (or constellations), from animal model to treatment strategies. Written by international experts from different fields, it aims to provide professionals from neuroscientists to clinical neurologists, neurosurgeons and neuropaedia-tricians dealing with mesial temporal lobe epilepsy, with a concise overview on the current body of knowledge and on emerging concepts and findings.
Perhaps the most important achievements in the field of epileptology in the past two decades have been in the neuroimaging and genetic breakthroughs as applied to patients with epilepsy. Indeed, neuroimaging has become a vital part in the study of epilepsy, affecting broad aspects of the disorder ranging from diagnosis and classification to treatment and prognosis. Neuroimaging in epilepsy encompasses many different approaches that have reached various levels of expertise across epilepsy centers worldwide. This book discusses every imaging modality used to gather information on epilepsy. Each technique is described by world experts and epilepsy centers worldwide.
Jasper's Basic Mechanisms of the Epilepsies by Jeffrey Noebels,Massimo Avoli,Michael Rogawski,Richard Olsen,Antonio Delgado-Escueta Pdf
H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.
Nearly three million people in the United States live with epilepsy every day and another 180,000 Americans develop epilepsy every year. Around the world, more than 60 million people have epilepsy. Epilepsy impacts everyone in different ways, as well as their families, friends and professional caregivers. With the Brainstorms series, one of the world's leading authorities on epilepsy, Dr. Steven C. Schachter has gathered together the personal testimonies of patients, family members, and professional caregivers to create a poignant and gripping series of books on this misunderstood and often devastating disorder. This volume, Epilepsy in Our Words, features 68 personal accounts of seizure activity from people with epilepsy that illustrates the wide range of experiences associated with seizures and living with epilepsy. Many have had epilepsy for yers, and their passages are heartfelt and realistic. An introductory section explains epilepsy and different seizure types from a medical perspective. An index helps readers focus on particular symptoms and other specific aspects of seizures, such as seizure warnings and triggers.
