Evolution Adjusted Tumor Pathophysiology

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Evolution-adjusted Tumor Pathophysiology:

Albrecht Reichle
Evolution adjusted Tumor Pathophysiology Book PDF

Author : Albrecht Reichle
Publisher : Springer Science & Business Media
Page : 438 pages
File Size : 47,6 Mb
Release : 2013-07-01
Category : Medical
ISBN : 9789400768666

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Evolution-adjusted Tumor Pathophysiology: by Albrecht Reichle Pdf

Combined modularized therapies for metastatic cancer are pointing to central problems of communication among ‘systems participators’. A communication theory explains 'social engineering', endogenously induced or by implementing non-normative boundary conditions. Evolution-adjusted tumor pathophysiology is borne by an evolution theory, which contrasts narrative evolution histories. The tool of rationalizations constituting the tumor's normativity (inflammation, immune response etc.) represents the non-genomic counterpart of the tumor genome and should be additionally assessed during tumor staging. Evolution-adjusted tumor pathophysiology allows implementing applied systems biology, a novel clinical and pharmaceutical technology for bioengineering tumor response and personalizing tumor therapy. Combined modularized therapy, evolution-adjusted tumor pathophysiology, and ‘universal’ biomarkers concertedly address genetically based tumor heterogeneity.

Cancer Evolution

Charles Swanton
Cancer Evolution Book PDF

Author : Charles Swanton
Publisher : Perspectives Cshl
Page : 350 pages
File Size : 48,7 Mb
Release : 2017
Category : Medical
ISBN : 1621821439

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Cancer Evolution by Charles Swanton Pdf

Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.

PPARs in Cellular and Whole Body Energy Metabolism

Walter Wahli,Rachel Tee
PPARs in Cellular and Whole Body Energy Metabolism Book PDF

Author : Walter Wahli,Rachel Tee
Publisher : MDPI
Page : 583 pages
File Size : 55,7 Mb
Release : 2019-01-09
Category : Biology (General)
ISBN : 9783038974611

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PPARs in Cellular and Whole Body Energy Metabolism by Walter Wahli,Rachel Tee Pdf

This book is a printed edition of the Special Issue "PPARs in Cellular and Whole Body Energy Metabolism" that was published in IJMS

Gene Therapy for Cancer

Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher
Gene Therapy for Cancer Book PDF

Author : Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher
Publisher : Springer Science & Business Media
Page : 469 pages
File Size : 54,6 Mb
Release : 2007-10-26
Category : Medical
ISBN : 9781597452229

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Gene Therapy for Cancer by Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher Pdf

The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

Tumor Organoids

Shay Soker,Aleksander Skardal
Tumor Organoids Book PDF

Author : Shay Soker,Aleksander Skardal
Publisher : Humana Press
Page : 213 pages
File Size : 53,5 Mb
Release : 2017-10-20
Category : Medical
ISBN : 9783319605111

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Tumor Organoids by Shay Soker,Aleksander Skardal Pdf

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Immunological Surveillance

Macfarlane Burnet
Immunological Surveillance Book PDF

Author : Macfarlane Burnet
Publisher : Elsevier
Page : 288 pages
File Size : 40,5 Mb
Release : 2014-05-17
Category : Health & Fitness
ISBN : 9781483159225

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Immunological Surveillance by Macfarlane Burnet Pdf

Immunological Surveillance

The Shape of Life

Rudolf A. Raff
The Shape of Life Book PDF

Author : Rudolf A. Raff
Publisher : University of Chicago Press
Page : 545 pages
File Size : 43,8 Mb
Release : 2012-12-14
Category : Science
ISBN : 9780226256573

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The Shape of Life by Rudolf A. Raff Pdf

Rudolf Raff is recognized as a pioneer in evolutionary developmental biology. In their 1983 book, Embryos, Genes, and Evolution, Raff and co-author Thomas Kaufman proposed a synthesis of developmental and evolutionary biology. In The Shape of Life, Raff analyzes the rise of this new experimental discipline and lays out new research questions, hypotheses, and approaches to guide its development. Raff uses the evolution of animal body plans to exemplify the interplay between developmental mechanisms and evolutionary patterns. Animal body plans emerged half a billion years ago. Evolution within these body plans during this span of time has resulted in the tremendous diversity of living animal forms. Raff argues for an integrated approach to the study of the intertwined roles of development and evolution involving phylogenetic, comparative, and functional biology. This new synthesis will interest not only scientists working in these areas, but also paleontologists, zoologists, morphologists, molecular biologists, and geneticists.

Immunotherapy of Renal Cell Carcinoma

Frans M.J. Debruyne,Ronald M. Bukowski,J. Edson Pontes,Pieter H.M. de Mulder
Immunotherapy of Renal Cell Carcinoma Book PDF

Author : Frans M.J. Debruyne,Ronald M. Bukowski,J. Edson Pontes,Pieter H.M. de Mulder
Publisher : Springer
Page : 0 pages
File Size : 40,7 Mb
Release : 1991-01-29
Category : Medical
ISBN : 3540528350

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Immunotherapy of Renal Cell Carcinoma by Frans M.J. Debruyne,Ronald M. Bukowski,J. Edson Pontes,Pieter H.M. de Mulder Pdf

With contributions by numerous experts

Applications of Dynamical Systems in Biology and Medicine

Trachette Jackson,Ami Radunskaya
Applications of Dynamical Systems in Biology and Medicine Book PDF

Author : Trachette Jackson,Ami Radunskaya
Publisher : Springer
Page : 233 pages
File Size : 42,7 Mb
Release : 2015-07-06
Category : Mathematics
ISBN : 9781493927821

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Applications of Dynamical Systems in Biology and Medicine by Trachette Jackson,Ami Radunskaya Pdf

This volume highlights problems from a range of biological and medical applications that can be interpreted as questions about system behavior or control. Topics include drug resistance in cancer and malaria, biological fluid dynamics, auto-regulation in the kidney, anti-coagulation therapy, evolutionary diversification and photo-transduction. Mathematical techniques used to describe and investigate these biological and medical problems include ordinary, partial and stochastic differentiation equations, hybrid discrete-continuous approaches, as well as 2 and 3D numerical simulation.

The Material Basis of Evolution

Richard Goldschmidt
The Material Basis of Evolution Book PDF

Author : Richard Goldschmidt
Publisher : Yale University Press
Page : 484 pages
File Size : 45,9 Mb
Release : 1982-01-01
Category : Science
ISBN : 0300028237

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The Material Basis of Evolution by Richard Goldschmidt Pdf

An eminent geneticist examines the Darwinian theory of evolution, analyzes the hereditary differences that produce new species, and suggests changes in evolutionary theory based on his biological research

Molecular Genetic Pathology

Liang Cheng,David Y. Zhang,John N. Eble
Molecular Genetic Pathology Book PDF

Author : Liang Cheng,David Y. Zhang,John N. Eble
Publisher : Springer
Page : 1136 pages
File Size : 45,5 Mb
Release : 2013-03-05
Category : Medical
ISBN : 1461447992

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Molecular Genetic Pathology by Liang Cheng,David Y. Zhang,John N. Eble Pdf

Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharmacogenomics and proteomics, while Part II covers the clinically relevant information of medical genetics, hematology, transfusion medicine, oncology, and forensic pathology. Supplemented with many useful figures and presented in a helpful bullet-point format, Molecular Genetic Pathology, Second Edition provides a unique reference for practicing pathologists, oncologists, internists, and medical genetisists. Furthermore, a book with concise overview of the field and highlights of clinical applications will certainly help those trainees, including pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, and medical technologists in preparing for their board examination/certification.

Adenocarcinoma of the Prostate

Andrew W. Bruce,John Trachtenberg
Adenocarcinoma of the Prostate Book PDF

Author : Andrew W. Bruce,John Trachtenberg
Publisher : Springer Science & Business Media
Page : 225 pages
File Size : 42,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781447113980

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Adenocarcinoma of the Prostate by Andrew W. Bruce,John Trachtenberg Pdf

Carcinoma of the prostate increasingly dominates the attention of urologists for both scientific and clinical reasons. The search for an explanation and the prediction of the variable behaviour of the malignant prostatic cell continues unabated. The search for more precise tumour staging and more effective treatment is equally vigorous. Editors Andrew Bruce and John Trachtenberg have assembled acknowledged leaders in prostate cancer to present those areas of direct interest to the clinician. There are a number of other topics that might have been considered but most of these, such as experimental tumour models or biochemical factors affecting cell growth, still lack immediate application for the clinician. Carcinoma of the prostate continues to have its highest incidence in the western world, and the difference in comparison with the incidence in the Far East appears to be real and not masked by diagnostic or other factors. A number of other epidemiological aspects need careful analysis: Is the incidence increasing? Is the survival improving? Is the prognosis worse in the younger patient? Epidemiological data are easily misused and misinterpreted so that a precise analysis of the known facts makes an important opening chapter to this book.

Evolving Treatment Paradigms in Renal Cancer, An Issue of Urologic Clinics - E-Book

William C. Huang,Samir S. Taneja
Evolving Treatment Paradigms in Renal Cancer An Issue of Urologic Clinics E Book Book PDF

Author : William C. Huang,Samir S. Taneja
Publisher : Elsevier Health Sciences
Page : 153 pages
File Size : 44,5 Mb
Release : 2012-05-08
Category : Medical
ISBN : 9781455744442

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Evolving Treatment Paradigms in Renal Cancer, An Issue of Urologic Clinics - E-Book by William C. Huang,Samir S. Taneja Pdf

This issue of the Urologic Clinics provides a timely update on Renal Cancer and the evolving treatment standards in urology. Articles include Contemporary Imaging of the Renal Mass, Surgical Approach to Multifocal Renal Cancers, and Systemic Therapy Prior to Surgery. Effects of the various existing surgical approaches on long-term renal function is also discussed, along with a review of the current trends in surgical management of renal cancers with specific attention to utilization of laparoscopic approach, partial nephrectomy, ablative technologies and observation.

Branching Process Models of Cancer

Richard Durrett
Branching Process Models of Cancer Book PDF

Author : Richard Durrett
Publisher : Springer
Page : 63 pages
File Size : 43,5 Mb
Release : 2015-06-20
Category : Mathematics
ISBN : 9783319160658

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Branching Process Models of Cancer by Richard Durrett Pdf

This volume develops results on continuous time branching processes and applies them to study rate of tumor growth, extending classic work on the Luria-Delbruck distribution. As a consequence, the author calculate the probability that mutations that confer resistance to treatment are present at detection and quantify the extent of tumor heterogeneity. As applications, the author evaluate ovarian cancer screening strategies and give rigorous proofs for results of Heano and Michor concerning tumor metastasis. These notes should be accessible to students who are familiar with Poisson processes and continuous time Markov chains. Richard Durrett is a mathematics professor at Duke University, USA. He is the author of 8 books, over 200 journal articles, and has supervised more than 40 Ph.D students. Most of his current research concerns the applications of probability to biology: ecology, genetics and most recently cancer.

Childhood Acute Lymphoblastic Leukemia

Ajay Vora
Childhood Acute Lymphoblastic Leukemia Book PDF

Author : Ajay Vora
Publisher : Springer
Page : 342 pages
File Size : 48,5 Mb
Release : 2017-04-21
Category : Medical
ISBN : 9783319397085

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Childhood Acute Lymphoblastic Leukemia by Ajay Vora Pdf

This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.