Fas Signaling

Author : Harald Wajant
Publisher : Springer Science & Business Media
Page : 169 pages
File Size : 44,6 Mb
Release : 2007-04-03
Category : Medical
ISBN : 9780387345734

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Fas Signaling by Harald Wajant Pdf

Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of this book cover, besides the well recognized apoptosis-related functions of Fas, its emerging role as a proinflammatory cytokine and as an inducer of alternative forms of cell death. Fas Signaling aims to provide the reader with an up-to-date survey of the various aspects of Fas biology and the open questions of the field are addressed. This title is intended for Ph.D and post-doctoral students starting to work in the field, but is also useful for everyone with an interest in the biology of this exciting molecule.

Author : J. Silvio Gutkind
Publisher : Springer Science & Business Media
Page : 579 pages
File Size : 43,9 Mb
Release : 2000-04-14
Category : Medical
ISBN : 9781592592180

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Signaling Networks and Cell Cycle Control by J. Silvio Gutkind Pdf

Leading scientists summarize the latest findings on signal transduction and cell cycle regulation and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules. Cutting-edge and highly suggestive, Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases presents a wealth of information on the emerging principles of the field, as well as an invaluable guide for all experimental and clinical investigators of cell regulation and its rapidly emerging pharmacological opportunities today.

Author : Pierre-Alain Clavien
Publisher : Springer Science & Business Media
Page : 398 pages
File Size : 54,9 Mb
Release : 2005
Category : Medical
ISBN : 3540229345

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Signaling Pathways in Liver Diseases by Pierre-Alain Clavien Pdf

Recent advances have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo surgery obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis and ischemia/reperfusion injury is essential. This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets of novel therapeutic strategies. It is our goal to stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room.

Author : Wen-Xing Ding,Xiao-Ming Yin
Publisher : Springer
Page : 290 pages
File Size : 42,7 Mb
Release : 2017-08-02
Category : Science
ISBN : 9783319581064

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Molecules, Systems and Signaling in Liver Injury by Wen-Xing Ding,Xiao-Ming Yin Pdf

This essential volume presents comprehensive information on cell death and autophagy in liver diseases, including the role and molecular signaling pathways of cell death in alcohol and non-alcoholic fatty liver disease, bile acids, hepatitis C virus and drug-induced liver injury. The book starts with a discussion of lipotoxicity in non-parenchymal cells, followed by a discussion of cell death and autophagy in cholangiocytes, hepatic stellate cells and Kupffer cells in hepatic biliary diseases, fibrosis and liver inflammation. The book also covers Bcl-2 family proteins, beta-catenin and HMGB1 signaling in regulating cell death in the liver as well as mitochondria, ER stress and gut microbiota on liver injury. The Cell Death in Biology and Diseases series has recruited world experts ranging from basic scientists to clinicians on cell death in liver diseases. Likewise the contributors of this volume are leaders in their fields with worldwide expertise and perspective. Molecul es, Systems and Signaling in Liver Injury is an essential companion to Hepatocytes and Non-Parenchymal Cells and Diseases. It is beneficial for both clinicians and basic scientists and is relevant to those working on drug discovery for preventing and treating liver diseases by targeting cell death and autophagy pathways.

Author : Jean-Francois Dufour,Pierre-Alain Clavien
Publisher : John Wiley & Sons
Page : 520 pages
File Size : 55,9 Mb
Release : 2015-08-31
Category : Medical
ISBN : 9781118663356

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Signaling Pathways in Liver Diseases by Jean-Francois Dufour,Pierre-Alain Clavien Pdf

Signaling Pathways in Liver Diseases, Third Edition again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signaling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however, the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format. With increased focus on the comprehension of cellular mechanisms involved in steatohepatitis, cirrhosis, and liver tumors, which has led to changes in the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as: Autophagy Notch Pathway P13K/PTEN Signaling in Liver Diseases Sirtuins Hepcidin and Iron Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis Oxidative Stress and Signaling in the Liver. Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom has provided clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge. Signaling Pathways in Liver Disease, Third Edition is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist.

Author : Cristian Roberto Smulski,Marta Rizzi,Olivier Micheau
Publisher : Frontiers Media SA
Page : 132 pages
File Size : 55,8 Mb
Release : 2021-06-08
Category : Science
ISBN : 9782889668465

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TNFR Superfamily Oligomerization and Signaling by Cristian Roberto Smulski,Marta Rizzi,Olivier Micheau Pdf

Author : Masayuki Mizui,Kunihiro Ichinose,Christian Michael Hedrich,Vaishali R. Moulton
Publisher : Frontiers Media SA
Page : 123 pages
File Size : 42,8 Mb
Release : 2021-11-01
Category : Medical
ISBN : 9782889714179

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Focusing on T-cells for Novel Treatments of Systemic Lupus Erythematosus by Masayuki Mizui,Kunihiro Ichinose,Christian Michael Hedrich,Vaishali R. Moulton Pdf

Author : Katherine A. Fitzgerald,Luke A.J. O'Neill,Andy J.H. Gearing,Robin E. Callard
Publisher : Elsevier
Page : 526 pages
File Size : 44,9 Mb
Release : 2001-09-03
Category : Medical
ISBN : 9780080530208

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The Cytokine Factsbook and Webfacts by Katherine A. Fitzgerald,Luke A.J. O'Neill,Andy J.H. Gearing,Robin E. Callard Pdf

Completely revised and expanded, this second edition of The Cytokine FactsBook is the most up-to-date reference manual available for all current well-characterized interleukins, cytokines, and their receptors. An additional 52 cytokines are included, doubling the number of entries from the previous edition. The key properties of each cytokine are described and presented in a very accessible format with diagrams for each of the receptors. The Cytokine FactsBook includes free online access to the regularly updated Cytokine Webfacts. Cytokine Webfacts is a web-based comprehensive compendium of facts about cytokines and their receptors that includes a variety of data representations, such as text, signal pathway diagrams and 3D images. This exciting resource is integrated into other databases via hypertext links to provide a unique network, and contains a web-enabled version of RasMol for viewing structures.

Author : Anonim
Publisher : Unknown
Page : 516 pages
File Size : 55,5 Mb
Release : 2009
Category : Cancer
ISBN : MINN:31951P01062472K

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Journal of the National Cancer Institute by Anonim Pdf

Author : R. Jeffrey Chang
Publisher : Springer Science & Business Media
Page : 387 pages
File Size : 52,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461384830

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Polycystic Ovary Syndrome by R. Jeffrey Chang Pdf

The term polycystic ovary syndrome (peOS) is meant to describe a clinical endocrinopathy characterized by menstrual irregularity and evidence of hyperandrogenism. While recognized since the 1800s, a clinical composite was not constructed until 1935 when Stein and Leventhal reported their findings of seven women with infertility, menstrual dysfunction, hirsutism, and enlarged ovaries. Notably, the ovaries contained numerous multiple cysts and the ovarian capsule was thickened. At the time, this preciseness of definition was sufficient to entitle the entity Stein-Leventhal syndrome. Subsequently, over the intervening years as investigators attempted to un ravel the pathophysiology and genesis of this disorder and the number of reported studies increased, there ensued a gradual and distinct terminologic conversion to polycystic ovary syndrome, which, whether intentional or not, connoted a less well-defined condition. Perhaps this is appropriately so, given the seemingly broadening spectrum of clinical presentations and the continuing debate over what constitutes peos. The expansive new knowledge about peos was discussed to a significant degree at an international symposium organized by Serono Symposia USA and held in Boston in the late spring of 1995. Ovarian physiology, including the fate of the follicular unit, was a central focus with several presentations on the genesis, growth, and death of ovarian cellular components. A discus sion of the regulation of ovarian cell function was also highlighted and comprised a major portion of the program.

Author : Anonim
Publisher : ScholarlyEditions
Page : 153 pages
File Size : 45,5 Mb
Release : 2012-01-09
Category : Science
ISBN : 9781464927065

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Nuclear Proteins: Advances in Research and Application: 2011 Edition by Anonim Pdf

Nuclear Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Nuclear Proteins. The editors have built Nuclear Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nuclear Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nuclear Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 41,6 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Author : Han-Ming Shen,Peter Vandenabeele
Publisher : Springer Science & Business Media
Page : 402 pages
File Size : 40,6 Mb
Release : 2014-03-29
Category : Science
ISBN : 9781461482208

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Necrotic Cell Death by Han-Ming Shen,Peter Vandenabeele Pdf

Starting with discussion of basic concepts and the molecular mechanisms of necrosis, this book looks first at several forms of necrotic cell death that have been identified, including necroptosis, autophagic cell death, and PARP-mediated cell death. As necrotic cell death is increasingly known to play a critical role in many physiological processes, the next chapters discuss its effect on metabolism, inflammation, immunity, and development. Necrotic cell death is closely implicated in human diseases like cancer, so the next chapters examine its relevance to human diseases, and final chapters cover methodologies for measuring necrosis. This book presents comprehensive coverage of necrosis from recognized experts from leading academic and medical institutions around the world. ​In contrast to apoptosis, well-defined as a form of programmed cell death, necrosis used to be considered as accidental (i.e., non-programmed) cell death, usually in response to a severe injury. Accumulating evidence now suggests, however, that necrosis is also programmed and controlled by distinctive "death machinery" in response to various stimuli like oxidative stress or DNA damage.

Author : Katharina Lückerath
Publisher : Sudwestdeutscher Verlag Fur Hochschulschriften AG
Page : 144 pages
File Size : 48,9 Mb
Release : 2011-04
Category : Electronic
ISBN : 3838124871

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Fas Ligand Reverse Signaling by Katharina Lückerath Pdf

Binding of Fas Ligand (FasL) to the Fas receptor triggers apoptosis of the receptor-bearing cell, which plays a pivotal role for homeostasis of the immune system and during acute immune responses. Similar to other TNF family members, the intracellular FasL domain is able to transmit signals into the FasL-bearing cell ("reverse signaling"). Recently, we have described a Notch-like proteolytic processing of FasL by the proteases ADAM10 and SPPL2a, which leads to the release of the intracellular domain (FICD) into the cytoplasm. Following the cleavage event, FICD translocates to the nucleus and influences gene transcription. To study the physiological importance of FasL reverse signaling in vivo on the level of the endogenous proteins, we have established a knockout/knockin mouse model in which wildtype FasL was replaced with a deletion mutant lacking the intracellular portion (FasL Intra). Our ex vivo and in vivo findings demonstrate that FasL reverse signaling is a negative modulator of certain immune responses. It is tempting to speculate that FasL reverse signaling might be a fine-tuning mechanism to prevent autoimmune diseases.

Author : Anonim
Publisher : ScholarlyEditions
Page : 902 pages
File Size : 51,7 Mb
Release : 2013-06-21
Category : Medical
ISBN : 9781481688864

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Immunoglobulins—Advances in Research and Application: 2013 Edition by Anonim Pdf

Immunoglobulins—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Immunoglobulin Subunits. The editors have built Immunoglobulins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Immunoglobulin Subunits in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Immunoglobulins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.