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Author : Latha P. Ganesan,Mark S. Cragg,Gestur Vidarsson
Publisher : Frontiers Media SA
Page : 372 pages
File Size : 55,9 Mb
Release : 2020-07-22
Category : Electronic
ISBN : 9782889638758
Author : Marc Daeron,Falk Nimmerjahn
Publisher : Springer
Page : 426 pages
File Size : 54,8 Mb
Release : 2014-08-12
Category : Medical
ISBN : 9783319079110
This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after FcμR and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of FcεRI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcγRIIB and FcαRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes.
Author : Anonim
Publisher : ScholarlyEditions
Page : 23 pages
File Size : 47,7 Mb
Release : 2012-12-26
Category : Medical
ISBN : 9781481634182
Fc Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Fc Receptors in a compact format. The editors have built Fc Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Fc Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Fc Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Arnold Froese,Frixos Paraskevas
Publisher : New York : M. Dekker
Page : 320 pages
File Size : 52,7 Mb
Release : 1983
Category : Nature
ISBN : UOM:39015007497152
Author : Jan G. J. van de Winkel,Peter J. A. Capel
Publisher : Unknown
Page : 266 pages
File Size : 48,5 Mb
Release : 1996
Category : Fc receptors
ISBN : STANFORD:36105019235048
Author : Jan G.J. Winkel,M. Hogarth
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 46,9 Mb
Release : 2012-02-02
Category : Medical
ISBN : 9789401150187
Antibodies are crucial to the fine specificity of the immune system. An effective functioning of these molecules requires interaction with immune cells. Receptors for antibodies, Fc receptors, provide this critical link between the humoral and cellular branches of the immune system. This book presents a comprehensive overview of the different Fc receptors currently recognized. The first part of the book contains state-of-the-art overviews on the biological role of FcR. The latest information on FcR heterogeneity, FcR physiology, FcR-ligand recognition, their crucial coordinating role in immunity, interactions with other immunoreceptors, and the role of FcR in immunoglobulin transport and catabolism are discussed. The clinical importance of FcR is developed in the second part of the book. The well-recognized roles of FcR in allergy, inflammation, infectious diseases, autoimmune disorders, and immunotherapeutic importance are reviewed. The information in this book is easily accessible and should be helpful for researchers and clinical specialists as a convenient overview of the field, as well as a comprehensive introduction for students starting in this area of research.
Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 50,5 Mb
Release : 1989
Category : FC Receptors
ISBN : OCLC:22546896
Author : Wolf H. Fridman
Publisher : S Karger Ag
Page : 0 pages
File Size : 50,7 Mb
Release : 1989
Category : Medical
ISBN : 3805549598
Author : Jeffrey V. Ravetch,Falk Nimmerjahn
Publisher : Springer Nature
Page : 150 pages
File Size : 46,7 Mb
Release : 2019-09-03
Category : Medical
ISBN : 9783030310530
This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.
Author : M. D. Cooper,T. Takai,J.V. Ravetch
Publisher : Springer Science & Business Media
Page : 243 pages
File Size : 48,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9784431539407
A remarkable spectrum of novel immunoreceptors sharing related immunoglobulin-like domains and signaling potential has been identified in recent years. These receptors have attracted widespread interest because they resemble the TCR, BCR, and FcR complexes in their ability to serve as activating or inhibitory receptors on the cells that bear them. Moreover, they are well positioned to affect both innate and adaptive immunity. The full range of ligands for these new receptor families is still not known, and understanding of their physiological roles is far from complete. This volume is the first attempt to summarize and highlight all known aspects of immunoglobulin-like receptors, providing a topical overview of the roles and characteristic features of the immunoglobulin-like receptors and related molecules in the immune system. Researchers in immunology, molecular biology, cell biology, clinical medicine, and pharmacology will find this book invaluable.
Author : Peter Sun
Publisher : Elsevier Inc. Chapters
Page : 358 pages
File Size : 43,6 Mb
Release : 2013-08-06
Category : Medical
ISBN : 9780128060285
Molecular mechanisms of antibody-mediated Fc receptor activation have long been an interest in both Fc receptor biology and antibody therapeutics. The structural efforts to elucidate antibody recognition by Fc receptors have led to the generation of several crystal structures of antibody Fc fragments complexed with Fc receptors. Collectively, these structures revealed a conserved receptor binding mode for IgG and IgE, distinct from those for the neonatal Fc receptor (FcRn), protein A, and protein G. Fcγ receptor recognition in the lower hinge region allows enhanced antigen recognition through dimeric Fabs but obligates immune-complex formation for receptor activation. It also provides the basis for Fcγ receptors to differentiate among IgG subclasses. More recently, pentraxins have also been shown to bind and activate Fc receptors, and structural efforts to elucidate pentraxin Fcγ receptor recognition have revealed surprising similarities between pentraxins and immunoglobulins in Fc receptor recognition. This review summarizes the structural findings that formed the basis of modern antibody–Fc receptor biology and recent advances of shared Fc receptor recognition by innate pentraxins.
Author : Robert M. Anthony
Publisher : Elsevier Inc. Chapters
Page : 358 pages
File Size : 42,7 Mb
Release : 2013-08-06
Category : Medical
ISBN : 9780128060377
IgG antibodies are highly potent molecules, with the unique ability to link foreign particles to innate immune cells. IgG antibodies recognize antigens with high affinity and bind cellular Fc receptors with low affinity individually. These interactions occur in the form of immune complexes, resulting in high-avidity interactions. In fact, the effector functions triggered by IgG antibodies are highly dependent on the type of Fc receptor that is bound; however, many aspects can influence Fc receptor binding by IgG antibodies, including the IgG isotype and the composition of the glycan on the IgG antibody. Further, FcγR expression is not stagnant but instead is affected by the inflammatory milieu. These considerations, and others that affect targeting of IgG Fcs to specific FcγRs to elicit desired effector functions, are discussed herein.
Author : Henry Metzger
Publisher : Amer Society for Microbiology
Page : 368 pages
File Size : 44,9 Mb
Release : 1990-01
Category : Medical
ISBN : 1555810160
Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 46,7 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author : Guido Ferrari,Georgia Tomaras,R. Keith Reeves,Gabriella Scarlatti
Publisher : Frontiers Media SA
Page : 273 pages
File Size : 40,6 Mb
Release : 2020-07-28
Category : Electronic
ISBN : 9782889638901
