Activating And Inhibitory Immunoglobulin Like Receptors

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Activating and Inhibitory Immunoglobulin-like Receptors

M. D. Cooper,T. Takai,J.V. Ravetch
Activating and Inhibitory Immunoglobulin like Receptors Book PDF

Author : M. D. Cooper,T. Takai,J.V. Ravetch
Publisher : Springer Science & Business Media
Page : 243 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9784431539407

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Activating and Inhibitory Immunoglobulin-like Receptors by M. D. Cooper,T. Takai,J.V. Ravetch Pdf

A remarkable spectrum of novel immunoreceptors sharing related immunoglobulin-like domains and signaling potential has been identified in recent years. These receptors have attracted widespread interest because they resemble the TCR, BCR, and FcR complexes in their ability to serve as activating or inhibitory receptors on the cells that bear them. Moreover, they are well positioned to affect both innate and adaptive immunity. The full range of ligands for these new receptor families is still not known, and understanding of their physiological roles is far from complete. This volume is the first attempt to summarize and highlight all known aspects of immunoglobulin-like receptors, providing a topical overview of the roles and characteristic features of the immunoglobulin-like receptors and related molecules in the immune system. Researchers in immunology, molecular biology, cell biology, clinical medicine, and pharmacology will find this book invaluable.

Innovative Medicine

Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Innovative Medicine Book PDF

Author : Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Publisher : Springer
Page : 330 pages
File Size : 46,6 Mb
Release : 2015-10-13
Category : Science
ISBN : 9784431556510

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Innovative Medicine by Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto Pdf

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Antibody Fc

Margaret Ackerman,Falk Nimmerjahn
Antibody Fc Book PDF

Author : Margaret Ackerman,Falk Nimmerjahn
Publisher : Academic Press
Page : 376 pages
File Size : 50,8 Mb
Release : 2013-08-06
Category : Medical
ISBN : 9780123948182

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Antibody Fc by Margaret Ackerman,Falk Nimmerjahn Pdf

Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies Color illustrations enhance explanations of the immune system

Models of Protection Against HIV/SIV

Gianfranco Pancino,Guido Silvestri,Keith Fowke
Models of Protection Against HIV SIV Book PDF

Author : Gianfranco Pancino,Guido Silvestri,Keith Fowke
Publisher : Academic Press
Page : 362 pages
File Size : 40,5 Mb
Release : 2011-12-02
Category : Medical
ISBN : 9780123877154

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Models of Protection Against HIV/SIV by Gianfranco Pancino,Guido Silvestri,Keith Fowke Pdf

A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field

Janeway's Immunobiology

Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Janeway s Immunobiology Book PDF

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 49,6 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Toll-Like Receptors (TLRs) and Innate Immunity

Stefan Bauer,Gunther Hartmann
Toll Like Receptors TLRs and Innate Immunity Book PDF

Author : Stefan Bauer,Gunther Hartmann
Publisher : Springer Science & Business Media
Page : 240 pages
File Size : 51,5 Mb
Release : 2007-12-11
Category : Medical
ISBN : 9783540721673

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Toll-Like Receptors (TLRs) and Innate Immunity by Stefan Bauer,Gunther Hartmann Pdf

Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.

Blood and Bone Marrow Pathology

Anna Porwit,Jeffrey J. McCullough,Wendy N. Erber
Blood and Bone Marrow Pathology Book PDF

Author : Anna Porwit,Jeffrey J. McCullough,Wendy N. Erber
Publisher : Unknown
Page : 0 pages
File Size : 53,6 Mb
Release : 2011
Category : Blood
ISBN : 070203147X

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Blood and Bone Marrow Pathology by Anna Porwit,Jeffrey J. McCullough,Wendy N. Erber Pdf

Already a standard reference work in the field, the new edition of Blood and Bone Marrow Pathology incorporates the latest WHO classification schemes and the latest ancillary diagnostic techniques in immunohistochemistry and molecular biology in order to provide a comprehensive, well balanced and authoritative guide to the interpretation and diagnosis of neoplastic and non-neoplastic diseases of blood and bone marrow. The text is lavishly illustrated with high quality colour images that demonstrate the relevant pathological,features and immunohistochemical and molecular markers. The text features a well-organized approach that incorporates practical tips and clues to help avoid pitfalls and to ensure optimal diagnosis The book is lavishly illustrated with high quality color images that demonstrate the relevant pathological features and immunohistochemical and molecular markers. The text features a well-organized approach that incorporates practical tips and clues to help avoid pitfalls and to ensure optimal diagnosis. Chapters have been totally rewritten and new chapters have been added, especially on myeloid malignancies. The chapters on hematological malignancies have been written so that the reader can apply the latest WHO Classifications in their routine daily practice (especially the 2008 WHO Classification of Tumors of Hemopoietic and Lymphoid Tissues) All chapters have been revised to include new aspects of molecular biology and flow cytometry diagnostics. Many new schematic diagrams and color illustrations have been added to illustrate blood and bone marrow pathology. Access the full text online and download images via Expert Consult. Chapters have been totally rewritten and some new chapters have been added especially on myeloid malignancies, in line with the WHO 2008 Classification All chapters have been revised to include new aspects of molecular biology and updated concerning flow cytometry diagnostics Greater emphasis on practical diagnostic aspects for all disorders Brand new editorial and contributing author team. Full Online text through Expert Consult. Full downloadable Image Bank Already a standard reference work in the field, the new edition of Blood and Bone Marrow Pathology incorporates the latest WHO classification schemes and the latest ancillary diagnostic techniques in immunohistochemistry and molecular biology in order to provide a comprehensive, well balanced and authoritative guide to the interpretation and diagnosis of neoplastic and non-neoplastic diseases of blood and bone marrow. The text is lavishly illustrated with high quality colour images that demonstrate the relevant pathological,features and immunohistochemical and molecular markers. The text features a well-organized approach that incorporates practical tips and clues to help avoid pitfalls and to ensure optimal diagnosis

Mechanisms of Lymphocyte Activation and Immune Regulation VII

Sudhir Gupta,Alan Sher,Rafi Ahmed
Mechanisms of Lymphocyte Activation and Immune Regulation VII Book PDF

Author : Sudhir Gupta,Alan Sher,Rafi Ahmed
Publisher : Springer
Page : 0 pages
File Size : 47,9 Mb
Release : 2012-10-23
Category : Medical
ISBN : 146137443X

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Mechanisms of Lymphocyte Activation and Immune Regulation VII by Sudhir Gupta,Alan Sher,Rafi Ahmed Pdf

Proceedings of the Seventh International Conference held in New Port Beach, California, February 6-8, 1998

NK Cell Subsets in Health and Disease: New Developments

Emanuela Marcenaro,Luigi D. Notarangelo,Jordan S. Orange,Eric Vivier
NK Cell Subsets in Health and Disease New Developments Book PDF

Author : Emanuela Marcenaro,Luigi D. Notarangelo,Jordan S. Orange,Eric Vivier
Publisher : Frontiers Media SA
Page : 245 pages
File Size : 50,8 Mb
Release : 2017-11-29
Category : Electronic book
ISBN : 9782889453504

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NK Cell Subsets in Health and Disease: New Developments by Emanuela Marcenaro,Luigi D. Notarangelo,Jordan S. Orange,Eric Vivier Pdf

Natural Killer (NK) cells were discovered ca 1975, as the first group of lymphoid cells that were neither T cells nor B cells. Since then, the dissection of the biology of NK cells has been growing exponentially with many seminal discoveries from the identification of MHC class I-specific inhibitory receptors to the discovery of receptor-ligand pairs involved in NK cell activation and to the manipulation of NK cells in cancer. In this research topic, we asked a group of thought leaders in NK cell biology to review recent advances in their origins and biology, and their roles in cancer, infection and inflammation. Together, these 25 articles provide a timely survey of NK cells as critical immunologic components of health and disease. They will hopefully prompt further dialogue and developments in basic and translational immunology.

Structural Biology in Immunology

Chaim Putterman,David Cowburn,Steven Almo
Structural Biology in Immunology Book PDF

Author : Chaim Putterman,David Cowburn,Steven Almo
Publisher : Academic Press
Page : 192 pages
File Size : 45,8 Mb
Release : 2018-05-14
Category : Medical
ISBN : 9780128033708

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Structural Biology in Immunology by Chaim Putterman,David Cowburn,Steven Almo Pdf

Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease. Describes novel/recently discovered immunomodulatory proteins, including antibodies and co-stimulatory or co-inhibitory molecules Emphasizes new biologic and small molecule drug design through the exploration of structure-function relationship Features a collaborative editorial effort, involving clinical immunologists and structural biologists Provides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunology Gives interested parties a bridge to learn about computer modeling and structure based design principles

B Cell Receptor Signaling

Tomohiro Kurosaki,Jürgen Wienands
B Cell Receptor Signaling Book PDF

Author : Tomohiro Kurosaki,Jürgen Wienands
Publisher : Springer
Page : 231 pages
File Size : 43,5 Mb
Release : 2015-12-26
Category : Medical
ISBN : 9783319261331

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B Cell Receptor Signaling by Tomohiro Kurosaki,Jürgen Wienands Pdf

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.

Natural Killer Cell Protocols

Kerry S. Campbell,Marco Colonna
Natural Killer Cell Protocols Book PDF

Author : Kerry S. Campbell,Marco Colonna
Publisher : Springer Science & Business Media
Page : 394 pages
File Size : 40,8 Mb
Release : 2008-02-03
Category : Medical
ISBN : 9781592590445

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Natural Killer Cell Protocols by Kerry S. Campbell,Marco Colonna Pdf

In Natural Killer Cell Protocols: Cellular and Molecular Methods, Kerry S. Campbell and Marco Colonna have assembled a comprehensive collection of readily reproducible methods designed to study natural killer (NK) cells from the broadest variety of viewpoints. These include not only classic techniques, but also new approaches to standard methods, newly evolved techniques that have become valuable for specific applications, and unique models for manipulating and studying NK cells. Among the advanced methods covered are those for in vitro transendothelial migration, in vivo detection of cells migrating into tumors, immunofluorescence staining of intracellular cytokines, and in vitro NK cell development. Valuable techniques for specific applications include vaccinia virus protein expression, soluble KIR-Fc fusions for HLA class I binding assays, calcium mobilization in cell conjugates, and identification of heterodimeric receptor complexes using cDNA library expression cloning. No less important are accounts of such classic methods as hybrid resistance, ADCC, viral defense, target cell cytotoxicity assays, cloning and culturing, tumor immunotherapy, and generation of HLA class I transfected target cells. Natural Killer Cell Protocols: Cellular and Molecular Methods offers immunologists, cancer researchers, virologists, and cell biologists today's most comprehensive collection of both established and cutting-edge techniques, methods that will contribute significantly to advancing our understanding of this fascinating and critically important class of cells.

Avian Immunology

Bernd Kaspers,Karel A. Schat
Avian Immunology Book PDF

Author : Bernd Kaspers,Karel A. Schat
Publisher : Academic Press
Page : 456 pages
File Size : 47,9 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780123972729

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Avian Immunology by Bernd Kaspers,Karel A. Schat Pdf

The second edition of Avian Immunology provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, the book encompasses all aspects of innate and adaptive immunity in chickens. In addition, chapters are devoted to the immunology of other commercially important species such as turkeys and ducks, and to ecoimmunology summarizing the knowledge of immune responses in free-living birds often in relation to reproductive success. The book contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies. The world-wide importance of poultry protein for the human diet, as well as the threat of avian influenza pandemics like H5N1 and heavy reliance on vaccination to protect commercial flocks makes this book a vital resource. This book provides crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology. With contributions from 33 of the foremost international experts in the field, this book provides the most up-to-date review of avian immunology so far Contains a detailed description of the avian innate immune system reviewing constitutive barriers, chemical and cellular responses; it includes a comprehensive review of avian Toll-like receptors Contains a wide-ranging review of the "ecoimmunology" of free-living avian species, as applied to studies of population dynamics, and reviews methods and resources available for carrying out such research

Immunoreceptor Tyrosine-based Inhibition Motifs

Marc Daeron,Eric Vivier
Immunoreceptor Tyrosine based Inhibition Motifs Book PDF

Author : Marc Daeron,Eric Vivier
Publisher : Springer Science & Business Media
Page : 182 pages
File Size : 50,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642585371

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Immunoreceptor Tyrosine-based Inhibition Motifs by Marc Daeron,Eric Vivier Pdf

Novel molecular motifs named Immunoreceptor Tyrosine-based Inhibition Motifs (ITIMs) have recently been recognized in the intracytoplasmic domains of a still-increasing number of receptors which control cell activation and proliferation. Research on ITIM-bearing molecules has developed exponentially during the last three years, generating new concepts with important consequences in basic research and with exciting potential clinical applications. The present volume contains 15 reviews written by authors who all made significant contributions to the identification of ITIM-bearing molecules and the study of their biological properties. It constitutes the first synthesis ever published that is specifically devoted to this emerging topic.

Encyclopedia of Inflammatory Diseases

Anonim
Encyclopedia of Inflammatory Diseases Book PDF

Author : Anonim
Publisher : Birkhäuser
Page : 0 pages
File Size : 50,5 Mb
Release : 2016-09-15
Category : Medical
ISBN : 3764385308

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Encyclopedia of Inflammatory Diseases by Anonim Pdf

Inflammation has become one of the most exciting and rewarding areas of medical research. Recent years have seen a revolution in our understanding of how blood and tissue cells interact and of the intracellular mechanisms controlling their activation. This has revealed the underlying inflammatory pathology of many diseases and provided multiple new targets for anti-inflammatory and immunomodulatory therapy. The Encyclopedia of Inflammatory Diseases will cover the following areas: Inflammatory Processes and Cells Inflammatory Diseases Mediators of Inflammation Pharmacology of Inflammation Since inflammatory diseases and their therapy cover a broad range of scientific and medical fields, the encyclopedia will be co-edited by four international experts, a clinician and three researchers from the disciplines of immunology, biochemistry, and pharmacology, in this way providing students, basic and clinical scientists and practitioners in academia, hospitals and industry with valuable interlinked information. This living project will serve as a reliable and comprehensive data pool for everybody working in inflammation research. Owing to its dynamic nature, it will grow with time and future editions, becoming an indispensible source of information for academia, clinical practitioners and industry.