Fluorine In Medicinal Chemistry And Chemical Biology

Author : Iwao Ojima
Publisher : John Wiley & Sons
Page : 640 pages
File Size : 52,8 Mb
Release : 2009-03-23
Category : Science
ISBN : 0470744081

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Fluorine in Medicinal Chemistry and Chemical Biology by Iwao Ojima Pdf

The extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is rapidly expanding its biomedical frontiers. With several of the best selling drugs in the world crucially containing fluorine atoms, the incorporation of fluorine to drug leads has become an essential practice in biomedical research, especially for drug design and discovery as well as development. Focusing on the unique and significant roles that fluorine plays in medicinal chemistry and chemical biology, this book reviews recent advances and future prospects in this rapidly developing field. Topics covered include: Discovery and development of fluorine containing drugs and drug candidates. New and efficient synthetic methods for medicinal chemistry and the optimisation of fluorine-containing drug candidates. Structural and chemical biology of fluorinated amino acids and peptides. Fluorine labels as probes in metabolic study, protein engineering and clinical diagnosis. Applications of 19F NMR spectroscopy in biomedical research. An appendix presents an invaluable index of all fluorine-containing drugs that have been approved by the US Food and Drug Administration, including information on structure and pharmaceutical action. Fluorine in Medicinal Chemistry and Chemical Biology will serve as an excellent reference source for graduate students as well as academic and industrial researchers who want to take advantage of fluorine in biomedical research.

Author : Gouverneur Veronique,Muller Klaus
Publisher : World Scientific
Page : 572 pages
File Size : 47,8 Mb
Release : 2012-04-26
Category : Science
ISBN : 9781908977892

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Fluorine In Pharmaceutical And Medicinal Chemistry: From Biophysical Aspects To Clinical Applications by Gouverneur Veronique,Muller Klaus Pdf

Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and clinical environments are also indirectly exposed to fluorine chemistry through the use of fluorinated compounds for imaging.This book provides an overview of the impact that fluorine has made in the life sciences. In the first section, the emphasis is on how fluorine substitution of amino acids, peptides, nucleobases and carbohydrates can provide invaluable information at a molecular level. The following chapters provide answers to the key questions posed on the importance of fluorine in drug discovery and clinical applications. For examples, the reader will discover how fluorine has found its place as a key element improving drug efficacy, with reference to some of the best-selling drugs on the market. Finally, a thorough review on the design, synthesis and use of 18F-radiotracers for positron emission tomography is provided, and this is complemented with a discussion on how 19F NMR has advanced molecular and clinical imaging./a

Author : Jean-Pierre Bégué,Daniele Bonnet-Delpon
Publisher : John Wiley & Sons
Page : 385 pages
File Size : 45,5 Mb
Release : 2008-06-02
Category : Science
ISBN : 9780470281871

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Bioorganic and Medicinal Chemistry of Fluorine by Jean-Pierre Bégué,Daniele Bonnet-Delpon Pdf

Provides a thorough overview of the role of fluorine in pharmaceutical science and development Includes chapters on fluorinated analogues of natural products, fluorinated amino acids and peptides, and derivatives of sugars Classifies marketed and in-development fluorinated pharmaceuticals according to their therapeutic classes

Author : Anonim
Publisher : Unknown
Page : 356 pages
File Size : 42,5 Mb
Release : 1996
Category : Electronic
ISBN : OCLC:1131980031

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Biomedical Frontiers of Fluorine Chemistry by Anonim Pdf

Author : Iwao Ojima,American Chemical Society. Division of Fluorine Chemistry,American Chemical Society. Division of Medicinal Chemistry
Publisher : Unknown
Page : 376 pages
File Size : 52,6 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015037826958

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Biomedical Frontiers of Fluorine Chemistry by Iwao Ojima,American Chemical Society. Division of Fluorine Chemistry,American Chemical Society. Division of Medicinal Chemistry Pdf

Developed from symposia sponsored by the Division of Fluorine Chemistry and the Division of Medicinal Chemistry.

Author : Valentine Nenajdenko
Publisher : Springer
Page : 760 pages
File Size : 43,7 Mb
Release : 2014-07-08
Category : Science
ISBN : 9783319044354

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Fluorine in Heterocyclic Chemistry Volume 2 by Valentine Nenajdenko Pdf

This two-volume work combines comprehensive information on the chemistry of the fluorinated heterocycles. The material has been divided such that the first volume is dedicated to 5-membered fluorinated heterocycles and macrocycles, while the second volume combines data connected with the chemistry of fluorine containing 6-membered heterocycles. Both volumes will be of interest to synthetic organic chemists in general, and particularly for those colleagues working in the fields of heterocyclic-compound chemistry, materials chemistry, medicinal chemistry, and fluorine chemistry. All information is presented and classified clearly to be effective source for broad auditory of chemists. It will be interesting for scientists working in the field of inorganic and coordination chemistry. Fluorinated heterocycles are becoming increasingly important in many areas including the pharmaceutical industry, materials science and agriculture. The presence of fluorine can result in substantial functional changes in the biological as well as physicochemical properties of organic compounds. Incorporation of fluorine into drug molecules can greatly affect their physicochemical properties, such as bond strength, lipophilicity, bioavailability, conformation, electrostatic potential, dipole moment, pKa etc. as well as pharmacokinetic properties, such as tissue distribution, rate of metabolism and pharmacological properties, such as pharmacodynamics and toxicology.

Author : Iwao Ojima
Publisher : World Scientific
Page : 842 pages
File Size : 55,9 Mb
Release : 2019-12-24
Category : Science
ISBN : 9781786347343

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Frontiers Of Organofluorine Chemistry by Iwao Ojima Pdf

This book focuses on the new frontiers of organofluorine chemistry in synthetic, organometallic, bioorganic, medicinal, agricultural, and materials chemistry as well as chemical physics and their applications to biomedical and material sciences. The extraordinary potential of fluorine-containing molecules in biology, pharmaceuticals, agrochemical, materials and their wide range of applications has been recognized by researchers who are not in the traditional fluorine chemistry field, and thus the new wave of organofluorine chemistry is rapidly expanding its frontiers.Featuring major leading researchers from all over the world and their cutting-edge research projects, this title reviews the recent advances and envision the new exciting developments in the future. Frontiers of Organofluorine Chemistry is an excellent reference book for professional researchers, and graduate students, in both industry and academia to get inspirations and new ideas for their projects.

Author : Véronique Gouverneur
Publisher : World Scientific
Page : 571 pages
File Size : 41,8 Mb
Release : 2012
Category : Medical
ISBN : 9781848166349

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Fluorine in Pharmaceutical and Medicinal Chemistry by Véronique Gouverneur Pdf

Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and clinical environments are also indirectly exposed to fluorine chemistry through the use of fluorinated compounds for imaging. This book provides an overview of the impact that fluorine has made in the life sciences. In the first section, the emphasis is on how fluorine substitution of amino acids, peptides, nucleobases and carbohydrates can provide invaluable information at a molecular level. The following chapters provide answers to the key questions posed on the importance of fluorine in drug discovery and clinical applications. For examples, the reader will discover how fluorine has found its place as a key element improving drug efficacy, with reference to some of the best-selling drugs on the market. Finally, a thorough review on the design, synthesis and use of 18F-radiotracers for positron emission tomography is provided, and this is complemented with a discussion on how 19F NMR has advanced molecular and clinical imaging.

Author : Robert Filler,Yoshirō Kobayashi
Publisher : Unknown
Page : 264 pages
File Size : 44,5 Mb
Release : 1982
Category : Fluorine
ISBN : UCAL:B4527612

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Biomedicinal Aspects of Fluorine Chemistry by Robert Filler,Yoshirō Kobayashi Pdf

Author : Robert Filler,Yoshirō Kobayashi,Lev M. Yagupolskii
Publisher : Elsevier Publishing Company
Page : 408 pages
File Size : 54,6 Mb
Release : 1993
Category : Medical
ISBN : UOM:39015031706164

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Organofluorine Compounds in Medicinal Chemistry and Biomedical Applications by Robert Filler,Yoshirō Kobayashi,Lev M. Yagupolskii Pdf

This text examines the role of fluorine in medicinal chemistry, including anticancer and antiviral agents, and provides up-to-date information on volatile aesthetics and central nervous system agents, areas in which fluorine has played a pivotal role.

Author : V Prakash Reddy
Publisher : Newnes
Page : 330 pages
File Size : 46,5 Mb
Release : 2015-01-25
Category : Science
ISBN : 9780444537492

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Organofluorine Compounds in Biology and Medicine by V Prakash Reddy Pdf

This book covers topics on biochemically relevant organofluorine compounds and their synthesis and biochemical pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in this area. Covers the synthesis, biochemical, and therapeutic applications of organofluorine compounds Offers a complete text on biochemically relevant organofluorine compounds and their synthesis and mechanistic pathways Provides one of the first major reference books on the biological and medicinal applications of organofluorine chemistry

Author : Valentine Nenajdenko
Publisher : Springer
Page : 681 pages
File Size : 47,9 Mb
Release : 2014-06-30
Category : Science
ISBN : 9783319043463

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Fluorine in Heterocyclic Chemistry Volume 1 by Valentine Nenajdenko Pdf

This two-volume work combines comprehensive information on the chemistry of the fluorinated heterocycles. The material has been divided such that the first volume is dedicated to 5-membered fluorinated heterocycles and macrocycles, while the second volume combines data connected with the chemistry of fluorine containing 6-membered heterocycles. Both volumes will be of interest to synthetic organic chemists in general, and particularly for those colleagues working in the fields of heterocyclic-compound chemistry, materials chemistry, medicinal chemistry, and fluorine chemistry. All information is presented and classified clearly to be effective source for broad auditory of chemists. It will be interesting for scientists working in the field of inorganic and coordination chemistry. Fluorinated heterocycles are becoming increasingly important in many areas including the pharmaceutical industry, materials science and agriculture. The presence of fluorine can result in substantial functional changes in the biological as well as physicochemical properties of organic compounds. Incorporation of fluorine into drug molecules can greatly affect their physicochemical properties, such as bond strength, lipophilicity, bioavailability, conformation, electrostatic potential, dipole moment, pKa etc. as well as pharmacokinetic properties, such as tissue distribution, rate of metabolism and pharmacological properties, such as pharmacodynamics and toxicology.

Author : Gunter Haufe,Frederic Leroux
Publisher : Academic Press
Page : 686 pages
File Size : 52,7 Mb
Release : 2018-09-19
Category : Science
ISBN : 9780128127346

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Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals by Gunter Haufe,Frederic Leroux Pdf

Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics and Agrochemicals, volume four in Alain Tressaud’s Progress in Fluorine Science series, presents a critical, multidisciplinary overview of the contributions of fluorinated products to solve important global issues in various life science fields, particularly in medicinal chemistry, molecular imaging techniques and agriculture. Edited by recognized experts, this book provides unique coverage of the wide-ranging uses and implications of fluorine and fluorinated compounds. Topics include medicinal monitoring and diagnosis, 19F MRI in medicine and in vivo cell tracking, 18F-labeled radiopharmaceuticals, brain imaging and neurology, risk assessment of reactive metabolites in drug discovery, and more. Edited by Alain Tressaud, past Chair and founder of the CNRS French Fluorine Network, each book in the collection also includes the work of highly-respected volume editors and contributors from both academia and industry who bring valuable and varied content to this active field. Covers a wide range of topics - from organic and physical chemistry, to pharmaceuticals, agrochemicals and medical diagnostics Describes major modern syntheses and unique reaction mechanisms yielding fluorine compounds in these diverse life science settings Features contributions from a wealth of global experts Acts as the fourth volume in Alain Tressaud’s Progress in Fluorine Science

Author : Valery P. Kukhar,Vadim A. Soloshonok
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 41,6 Mb
Release : 1995-04-06
Category : Science
ISBN : UOM:39015033953152

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Fluorine-containing Amino Acids by Valery P. Kukhar,Vadim A. Soloshonok Pdf

In recent years, organo-fluorine chemistry has made a marked impact on the design and synthesis of a large variety of biologically active molecules, such as steroids, carbohydrates, amines, amino acids, peptides and other natural products. Naturally occurring amino acids play a pivotal role in living systems, and therefore synthetic fluorine-containing amino acids have been of significant interest to researchers working towards the understanding and modification of physiological processes. Fluorine-containing Amino Acids: is the first volume devoted to the synthesis and properties of fluorine-containing amino acids pays special attention to the preparation of enantiomerically pure acids (which are essential to the modern pharmaceutical industry) deals with a rapidly expanding field of research has been written by experienced researchers who are responsible for many developments in the field highlights the interdisciplinary nature of this topic Fluorine-containing Amino Acids is the only dedicated reference in this subject and will be essential for researchers in synthetic organic, peptide, natural product, and medicinal chemistry and biochemistry.

Author : Peer Kirsch
Publisher : John Wiley & Sons
Page : 457 pages
File Size : 55,7 Mb
Release : 2013-03-18
Category : Science
ISBN : 9783527651375

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Modern Fluoroorganic Chemistry by Peer Kirsch Pdf

The second edition of this classic reference work has been completely revised and updated, as well as being enlarged by 20% to reflect the latest developments in synthetic organic fluorine chemistry, taking into account new applications in materials science and medicinal chemistry. The new developments in transition-metal-catalyzed methods for the introduction of fluorine and fluorinated groups are discussed. In addition, new chapters have been added on such important applications as organic electronics (OLEDs) and fluorinated dyes. Appendices containing synthetic procedures and conversions round off this comprehensive work. This work is a valuable reference for fluorine chemists that also provides nonspecialists with an introduction to the field. From reviews of the first edition: ''... a well-produced book with attractive graphics, photos and schemes. Throughout the book, coloured electrostatic maps of small organofluorine compounds are used toillustrate charge distributions. These are effective as well as attractive. I would point any organic chemist to this book who wants to learn about and do some fluorine chemistry. It provides uncluttered descriptions and a clear orientation to the literature in this important area of the organic chemistry.'' CHEMBIOCHEM - A European Journal of Chemical Biology