Fluorine In Pharmaceutical And Medicinal Chemistry From Biophysical Aspects To Clinical Applications

Author : Gouverneur Veronique,Muller Klaus
Publisher : World Scientific
Page : 572 pages
File Size : 47,7 Mb
Release : 2012-04-26
Category : Science
ISBN : 9781908977892

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Fluorine In Pharmaceutical And Medicinal Chemistry: From Biophysical Aspects To Clinical Applications by Gouverneur Veronique,Muller Klaus Pdf

Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and clinical environments are also indirectly exposed to fluorine chemistry through the use of fluorinated compounds for imaging.This book provides an overview of the impact that fluorine has made in the life sciences. In the first section, the emphasis is on how fluorine substitution of amino acids, peptides, nucleobases and carbohydrates can provide invaluable information at a molecular level. The following chapters provide answers to the key questions posed on the importance of fluorine in drug discovery and clinical applications. For examples, the reader will discover how fluorine has found its place as a key element improving drug efficacy, with reference to some of the best-selling drugs on the market. Finally, a thorough review on the design, synthesis and use of 18F-radiotracers for positron emission tomography is provided, and this is complemented with a discussion on how 19F NMR has advanced molecular and clinical imaging./a

Author : Iwao Ojima
Publisher : John Wiley & Sons
Page : 640 pages
File Size : 50,5 Mb
Release : 2009-03-23
Category : Science
ISBN : 0470744081

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Fluorine in Medicinal Chemistry and Chemical Biology by Iwao Ojima Pdf

The extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is rapidly expanding its biomedical frontiers. With several of the best selling drugs in the world crucially containing fluorine atoms, the incorporation of fluorine to drug leads has become an essential practice in biomedical research, especially for drug design and discovery as well as development. Focusing on the unique and significant roles that fluorine plays in medicinal chemistry and chemical biology, this book reviews recent advances and future prospects in this rapidly developing field. Topics covered include: Discovery and development of fluorine containing drugs and drug candidates. New and efficient synthetic methods for medicinal chemistry and the optimisation of fluorine-containing drug candidates. Structural and chemical biology of fluorinated amino acids and peptides. Fluorine labels as probes in metabolic study, protein engineering and clinical diagnosis. Applications of 19F NMR spectroscopy in biomedical research. An appendix presents an invaluable index of all fluorine-containing drugs that have been approved by the US Food and Drug Administration, including information on structure and pharmaceutical action. Fluorine in Medicinal Chemistry and Chemical Biology will serve as an excellent reference source for graduate students as well as academic and industrial researchers who want to take advantage of fluorine in biomedical research.

Author : Gunter Haufe,Frederic Leroux
Publisher : Academic Press
Page : 686 pages
File Size : 41,9 Mb
Release : 2018-09-19
Category : Science
ISBN : 9780128127346

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Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals by Gunter Haufe,Frederic Leroux Pdf

Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics and Agrochemicals, volume four in Alain Tressaud’s Progress in Fluorine Science series, presents a critical, multidisciplinary overview of the contributions of fluorinated products to solve important global issues in various life science fields, particularly in medicinal chemistry, molecular imaging techniques and agriculture. Edited by recognized experts, this book provides unique coverage of the wide-ranging uses and implications of fluorine and fluorinated compounds. Topics include medicinal monitoring and diagnosis, 19F MRI in medicine and in vivo cell tracking, 18F-labeled radiopharmaceuticals, brain imaging and neurology, risk assessment of reactive metabolites in drug discovery, and more. Edited by Alain Tressaud, past Chair and founder of the CNRS French Fluorine Network, each book in the collection also includes the work of highly-respected volume editors and contributors from both academia and industry who bring valuable and varied content to this active field. Covers a wide range of topics - from organic and physical chemistry, to pharmaceuticals, agrochemicals and medical diagnostics Describes major modern syntheses and unique reaction mechanisms yielding fluorine compounds in these diverse life science settings Features contributions from a wealth of global experts Acts as the fourth volume in Alain Tressaud’s Progress in Fluorine Science

Author : Robert Filler,Yoshirō Kobayashi
Publisher : Unknown
Page : 264 pages
File Size : 41,8 Mb
Release : 1982
Category : Fluorine
ISBN : UCAL:B4527612

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Biomedicinal Aspects of Fluorine Chemistry by Robert Filler,Yoshirō Kobayashi Pdf

Author : Iwao Ojima
Publisher : World Scientific
Page : 842 pages
File Size : 51,6 Mb
Release : 2019-12-24
Category : Science
ISBN : 9781786347343

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Frontiers Of Organofluorine Chemistry by Iwao Ojima Pdf

This book focuses on the new frontiers of organofluorine chemistry in synthetic, organometallic, bioorganic, medicinal, agricultural, and materials chemistry as well as chemical physics and their applications to biomedical and material sciences. The extraordinary potential of fluorine-containing molecules in biology, pharmaceuticals, agrochemical, materials and their wide range of applications has been recognized by researchers who are not in the traditional fluorine chemistry field, and thus the new wave of organofluorine chemistry is rapidly expanding its frontiers.Featuring major leading researchers from all over the world and their cutting-edge research projects, this title reviews the recent advances and envision the new exciting developments in the future. Frontiers of Organofluorine Chemistry is an excellent reference book for professional researchers, and graduate students, in both industry and academia to get inspirations and new ideas for their projects.

Author : Bruno Améduri
Publisher : Royal Society of Chemistry
Page : 651 pages
File Size : 42,5 Mb
Release : 2022-08-15
Category : Science
ISBN : 9781839167607

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Perfluoroalkyl Substances by Bruno Améduri Pdf

Perfluoroalkyl substances (PFAS) are a diverse group of human-made chemicals that are used in a wide range of consumer and industrial products. They are under intense scrutiny due to environmental concerns and there is a call to ban new PFASs entering the market. That said, this book is not intended to wave the banner against PFASs per se; rather it provides a balanced overview of the field, from basic synthesis through to applications, why some current PFASs are and may remain the right substance for the job, as well as addressing the challenges and alternatives. Covering organofluorine chemistry to fluoropolymers and their applications in various sectors from biomedical to agrochemical, energy and electrical industries, this book is a solid introduction to the topic and demonstrates why fluorinated products are still useful in many domains. With risk assessment and alternatives to PFASs included, it provides a considered account of both the positive applications of PFASs and the pressing environmental concerns. Suitable for academics and industrial practitioners working in the fields of organic and macromolecular chemistries, it will also appeal to end-users who want to learn about the technology, applications and elimination or recycling of such fluorinated products.

Author : Henri Groult,Frederic Leroux,Alain Tressaud
Publisher : Elsevier
Page : 760 pages
File Size : 44,9 Mb
Release : 2016-11-04
Category : Science
ISBN : 9780128037904

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Modern Synthesis Processes and Reactivity of Fluorinated Compounds by Henri Groult,Frederic Leroux,Alain Tressaud Pdf

Modern Synthesis Processes and Reactivity of Fluorinated Compounds focuses on the exceptional character of fluorine and fluorinated compounds. This comprehensive work explores examples taken from all classes of fluorine chemistry and illustrates the extreme reactivity of fluorinating media and the peculiar synthesis routes to fluorinated materials. The book provides advanced and updated information on the latest synthesis routes to fluorocompounds and the involved reaction mechanisms. Special attention is given to the unique reactivity of fluorine and fluorinated media, along with the correlation of those properties to valuable applications of fluorinated compounds. Contains quality content edited, and contributed, by leading scholars in the field Presents applied guidance on the preparation of original fluorinated compounds, potentially transferable from the lab scale to industrial applications Provides practical synthesis information for a wide audience interested in fluorine compounds in many branches of chemistry, materials science, and physics

Author : Koichi Fukase,Takayuki Doi
Publisher : Springer Nature
Page : 357 pages
File Size : 43,9 Mb
Release : 2021-07-13
Category : Science
ISBN : 9789811624582

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Middle Molecular Strategy by Koichi Fukase,Takayuki Doi Pdf

This book highlights recently discovered aspects of “middle-size molecules,” focusing on (1) their unique bio-functions on the basis of derivatives and conjugates of natural products, saccharides, peptides, and nucleotides; (2) the synthesis of structurally complex natural products; (3) special synthetic methods for π-conjugated functional molecules; and (4) novel synthetic methods using flow chemistry. Given its scope, the book is of interest to industrial researchers and graduate students in the fields of organic chemistry, medicinal chemistry, and materials science.

Author : Huw M. L. Davies,Erick M. Carreira
Publisher : John Wiley & Sons
Page : 462 pages
File Size : 50,6 Mb
Release : 2017-04-24
Category : Science
ISBN : 9781119349020

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Organic Syntheses, Volume 93 by Huw M. L. Davies,Erick M. Carreira Pdf

The current volume continues the tradition of the Organic Syntheses series, providing carefully checked and edited experimental procedures that describe important synthetic methods, transformations, reagents, and synthetic building blocks or intermediates with demonstrated utility in organic synthesis. These significant and interesting procedures should prove worthwhile to many synthetic chemists working in increasingly diverse areas. A trusted guide for professionals in organic and medicinal chemistry in academia, government, and industries, including pharmaceuticals, fine chemicals, agrochemicals, and biotechnological products.

Author : Herbert W. Roesky
Publisher : John Wiley & Sons
Page : 490 pages
File Size : 45,7 Mb
Release : 2012-10-11
Category : Science
ISBN : 9781118409442

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Efficient Preparations of Fluorine Compounds by Herbert W. Roesky Pdf

The definitive guide to creating fluorine-based compounds—and the materials of tomorrow Discovered as an element by the French chemist Henri Moissan in 1886, through electrolysis of potassium fluoride in anhydrous hydrogen fluoride—"le fluor," or fluorine, began its chemical history as a substance both elusive and dangerous. With a slight pale yellow hue, fluorine is at room temperature a poisonous diatomic gas. Resembling a spirit from a chemical netherworld, fluorine is highly reactive, difficult to handle, yet very versatile as a reagent—with the power to form compounds with almost any other element. Comprising 20% of pharmaceutical products and 30% of agrochemical compounds, as well as playing a key role in electric cars, electronic devices, and space technology, compounds containing fluorine have grown in importance across the globe. Learning how to safely handle fluorine in the preparation of innovative new materials—with valuable new properties—is of critical importance to chemists today. Bringing together the research and methods of leading scientists in the fluorine field, Efficient Preparations of Fluorine Compounds is the definitive manual to creating, and understanding the reaction mechanisms integral to a wide variety of fluorine compounds. With sixty-eight contributed chapters, the book's extensive coverage includes: Preparation of Elemental Fluorine Synthesis Methods for Exotic Inorganic Fluorides with Varied Applications Introduction of Fluorine into Compounds via Electrophilic and Nucleophilic Reactions Direct Fluorination of Organic Compounds with Elemental Fluorine Efficient Preparations of Bioorganic Fluorine Compounds Asymmetric Fluorocyclization Reactions Preparations of Rare Earth Fluorosulfides and Oxyfluorosulfides The book offers methods and results that can be reproduced by students involved in advanced studies, as well as practicing chemists, pharmaceutical scientists, biologists, and environmental researchers. The only chemical resource of its kind, Efficient Preparations of Fluorine Compounds—from its first experiment to its last—is a unique window into the centuries old science of fluorine and the limitless universe of fluorine-based compounds.

Author : Anonim
Publisher : Royal Society of Chemistry
Page : 410 pages
File Size : 48,9 Mb
Release : 2014-05-21
Category : Science
ISBN : 9781849738125

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Nuclear Magnetic Resonance by Anonim Pdf

Now in its 43rd volume, the Specialist Periodical Report in Nuclear Magnetic Resonance presents comprehensive and critical reviews of the recent literature, providing the reader with an informed summary of the field from invited authors. Several chapters in this volume are devoted to biochemistry, focussing on carbohydrates, lipids, and proteins and nucleic acids; Malcolm Prior also presents a chapter examining the recent literature of NMR in living systems and Cynthia Jameson reviews the theoretical and physical aspects of nuclear shielding, while Jaroslaw Jazwinski examines the theoretical aspects of spin-spin couplings. The lead volume editor, Krystyna Kamienska-Trela, presents a chapter on the applications of spin-spin couplings. Anyone wishing to update themselves on the recent and hottest developments in NMR will benefit from this volume, which deserves a place in any library or NMR facility. Purchasers of the print edition can register for free access to the electronic edition by returning the enclosed registration card.

Author : Kalman J. Szabo,Nicklas Selander
Publisher : John Wiley & Sons
Page : 464 pages
File Size : 40,5 Mb
Release : 2021-03-22
Category : Science
ISBN : 9783527347117

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Organofluorine Chemistry by Kalman J. Szabo,Nicklas Selander Pdf

By presenting novel methods for the efficient preparation of fluorinated compounds and their application in pharmaceutical and agrochemical chemistry as well as medicine, this is a valuable source of information for all researchers in academia and industry!

Author : Vittorio Pace
Publisher : John Wiley & Sons
Page : 1256 pages
File Size : 41,6 Mb
Release : 2023-05-24
Category : Science
ISBN : 9783527830213

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Homologation Reactions by Vittorio Pace Pdf

Provides a unique summary of homologation strategies in organic synthesis Homologation Reactions presents different concepts underpinning the use of homologating reagents as well as their applications in organic synthesis. It covers in-depth discussions on the rationales governing this kind of transformations with a strong emphasis on mechanistic elements modulating critical aspects (e.g. selectivity) of the processes. In addition, this two-volume work features: Metal carbenoids, ylides, and diazo reagents Homologating agents working under nucleophilic, electrophilic, and radical regime Homologations realized on boron-containing or carbon-centered linchpins Use of highly sensitive fluorinated homologating agents Progressive homologations and the concept of assembly line synthesis Homologation processes followed by rearrangement cascades Construction of cyclic motifs and ring-expansion Homologation reactions with carbon monoxide and carbon dioxide New and/or challenging directions to expect in the future Written by an international team of leaders in the field, the book is a useful guide for designing effective transformations by using homologation reactions. It is a must-read for every synthetic chemist in academia and industry!

Author : Frances Separovic,Akira Naito
Publisher : Royal Society of Chemistry
Page : 128 pages
File Size : 55,5 Mb
Release : 2014-03-17
Category : Science
ISBN : 9781782621195

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Advances in Biological Solid-State NMR by Frances Separovic,Akira Naito Pdf

The complexity and heterogeneity of biological systems has posed an immense challenge in recent years. An increasingly important tool for obtaining molecular and atomic scale information on a range of large biological molecules and cellular components is solid-state NMR. This technique can address fascinating problems in structural biology, including the arrangement of supramolecular complexes and fibril formation in relation to molecular folding, misfolding and aggregation. Advances in Biological Solid-State NMR brings the reader up to date with chapters from international leaders of this growing field, covering the most recent developments in the methodology and applications of solid-state NMR to studies of membrane interactions and molecular motions. A much needed discussion of membrane systems is detailed alongside important developments in in situ analysis. Topics include applications to biological membranes, membrane active peptides, membrane proteins, protein assemblies and in-cell NMR. This exposition of an invaluable technique will interest those working in a range of related spectroscopic and biological fields. A basic introduction invites those interested to familiarise themselves with the basic mathematical and conceptual foundations of solid-state NMR. A thorough and comprehensive discussion of this promising technique follows, which is essential reading for those working or studying at postgraduate level in this exciting field.

Author : Clive R. Wood
Publisher : World Scientific
Page : 490 pages
File Size : 42,8 Mb
Release : 2012
Category : Medical
ISBN : 9781848166295

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Antibody Drug Discovery by Clive R. Wood Pdf

Monoclonal antibodies have become important treatments for cancer, inflammation and a wide range of other diseases, representing an increasing share of the most successful pharmaceutical markets. The technologies to discover these drugs have been developed by select centers of excellence in industry and academia, and are continually being fine tuned in the race to identify the best antibody-based drug candidates and accelerate their paths to patients. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field and to offer specialized perspectives to established researchers. The chapters set into context the significance of key developments and important considerations for selecting different approaches, such as antibody humanization, isotype selection, lead candidate selection criteria and protein production. All contributors to this work are experts in their fields, and many have played pivotal roles in the creation of these technologies.