Fluorine In Life Sciences Pharmaceuticals Medicinal Diagnostics And Agrochemicals

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Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals

Gunter Haufe,Frederic Leroux
Fluorine in Life Sciences Pharmaceuticals Medicinal Diagnostics and Agrochemicals Book PDF

Author : Gunter Haufe,Frederic Leroux
Publisher : Academic Press
Page : 686 pages
File Size : 45,6 Mb
Release : 2018-09-19
Category : Science
ISBN : 9780128127346

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Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals by Gunter Haufe,Frederic Leroux Pdf

Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics and Agrochemicals, volume four in Alain Tressaud’s Progress in Fluorine Science series, presents a critical, multidisciplinary overview of the contributions of fluorinated products to solve important global issues in various life science fields, particularly in medicinal chemistry, molecular imaging techniques and agriculture. Edited by recognized experts, this book provides unique coverage of the wide-ranging uses and implications of fluorine and fluorinated compounds. Topics include medicinal monitoring and diagnosis, 19F MRI in medicine and in vivo cell tracking, 18F-labeled radiopharmaceuticals, brain imaging and neurology, risk assessment of reactive metabolites in drug discovery, and more. Edited by Alain Tressaud, past Chair and founder of the CNRS French Fluorine Network, each book in the collection also includes the work of highly-respected volume editors and contributors from both academia and industry who bring valuable and varied content to this active field. Covers a wide range of topics - from organic and physical chemistry, to pharmaceuticals, agrochemicals and medical diagnostics Describes major modern syntheses and unique reaction mechanisms yielding fluorine compounds in these diverse life science settings Features contributions from a wealth of global experts Acts as the fourth volume in Alain Tressaud’s Progress in Fluorine Science

Fluorine in Medicinal Chemistry and Chemical Biology

Iwao Ojima
Fluorine in Medicinal Chemistry and Chemical Biology Book PDF

Author : Iwao Ojima
Publisher : John Wiley & Sons
Page : 640 pages
File Size : 49,8 Mb
Release : 2009-03-23
Category : Science
ISBN : 0470744081

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Fluorine in Medicinal Chemistry and Chemical Biology by Iwao Ojima Pdf

The extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is rapidly expanding its biomedical frontiers. With several of the best selling drugs in the world crucially containing fluorine atoms, the incorporation of fluorine to drug leads has become an essential practice in biomedical research, especially for drug design and discovery as well as development. Focusing on the unique and significant roles that fluorine plays in medicinal chemistry and chemical biology, this book reviews recent advances and future prospects in this rapidly developing field. Topics covered include: Discovery and development of fluorine containing drugs and drug candidates. New and efficient synthetic methods for medicinal chemistry and the optimisation of fluorine-containing drug candidates. Structural and chemical biology of fluorinated amino acids and peptides. Fluorine labels as probes in metabolic study, protein engineering and clinical diagnosis. Applications of 19F NMR spectroscopy in biomedical research. An appendix presents an invaluable index of all fluorine-containing drugs that have been approved by the US Food and Drug Administration, including information on structure and pharmaceutical action. Fluorine in Medicinal Chemistry and Chemical Biology will serve as an excellent reference source for graduate students as well as academic and industrial researchers who want to take advantage of fluorine in biomedical research.

Frontiers Of Organofluorine Chemistry

Iwao Ojima
Frontiers Of Organofluorine Chemistry Book PDF

Author : Iwao Ojima
Publisher : World Scientific
Page : 842 pages
File Size : 53,9 Mb
Release : 2019-12-24
Category : Science
ISBN : 9781786347343

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Frontiers Of Organofluorine Chemistry by Iwao Ojima Pdf

This book focuses on the new frontiers of organofluorine chemistry in synthetic, organometallic, bioorganic, medicinal, agricultural, and materials chemistry as well as chemical physics and their applications to biomedical and material sciences. The extraordinary potential of fluorine-containing molecules in biology, pharmaceuticals, agrochemical, materials and their wide range of applications has been recognized by researchers who are not in the traditional fluorine chemistry field, and thus the new wave of organofluorine chemistry is rapidly expanding its frontiers.Featuring major leading researchers from all over the world and their cutting-edge research projects, this title reviews the recent advances and envision the new exciting developments in the future. Frontiers of Organofluorine Chemistry is an excellent reference book for professional researchers, and graduate students, in both industry and academia to get inspirations and new ideas for their projects.

Organofluorine Chemistry

Kalman J. Szabo,Nicklas Selander
Organofluorine Chemistry Book PDF

Author : Kalman J. Szabo,Nicklas Selander
Publisher : John Wiley & Sons
Page : 464 pages
File Size : 47,7 Mb
Release : 2021-03-22
Category : Science
ISBN : 9783527347117

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Organofluorine Chemistry by Kalman J. Szabo,Nicklas Selander Pdf

By presenting novel methods for the efficient preparation of fluorinated compounds and their application in pharmaceutical and agrochemical chemistry as well as medicine, this is a valuable source of information for all researchers in academia and industry!

Perfluoroalkyl Substances

Bruno Améduri
Perfluoroalkyl Substances Book PDF

Author : Bruno Améduri
Publisher : Royal Society of Chemistry
Page : 651 pages
File Size : 43,5 Mb
Release : 2022-08-15
Category : Science
ISBN : 9781839167607

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Perfluoroalkyl Substances by Bruno Améduri Pdf

Perfluoroalkyl substances (PFAS) are a diverse group of human-made chemicals that are used in a wide range of consumer and industrial products. They are under intense scrutiny due to environmental concerns and there is a call to ban new PFASs entering the market. That said, this book is not intended to wave the banner against PFASs per se; rather it provides a balanced overview of the field, from basic synthesis through to applications, why some current PFASs are and may remain the right substance for the job, as well as addressing the challenges and alternatives. Covering organofluorine chemistry to fluoropolymers and their applications in various sectors from biomedical to agrochemical, energy and electrical industries, this book is a solid introduction to the topic and demonstrates why fluorinated products are still useful in many domains. With risk assessment and alternatives to PFASs included, it provides a considered account of both the positive applications of PFASs and the pressing environmental concerns. Suitable for academics and industrial practitioners working in the fields of organic and macromolecular chemistries, it will also appeal to end-users who want to learn about the technology, applications and elimination or recycling of such fluorinated products.

Middle Molecular Strategy

Koichi Fukase,Takayuki Doi
Middle Molecular Strategy Book PDF

Author : Koichi Fukase,Takayuki Doi
Publisher : Springer Nature
Page : 357 pages
File Size : 50,7 Mb
Release : 2021-07-13
Category : Science
ISBN : 9789811624582

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Middle Molecular Strategy by Koichi Fukase,Takayuki Doi Pdf

This book highlights recently discovered aspects of “middle-size molecules,” focusing on (1) their unique bio-functions on the basis of derivatives and conjugates of natural products, saccharides, peptides, and nucleotides; (2) the synthesis of structurally complex natural products; (3) special synthetic methods for π-conjugated functional molecules; and (4) novel synthetic methods using flow chemistry. Given its scope, the book is of interest to industrial researchers and graduate students in the fields of organic chemistry, medicinal chemistry, and materials science.

Proceedings of 6th International Conference and Exhibition on Materials Science and Chemistry 2018

ConferenceSeries
Proceedings of 6th International Conference and Exhibition on Materials Science and Chemistry 2018 Book PDF

Author : ConferenceSeries
Publisher : ConferenceSeries
Page : 105 pages
File Size : 50,7 Mb
Release : 2024-06-17
Category : Electronic
ISBN : 8210379456XXX

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Proceedings of 6th International Conference and Exhibition on Materials Science and Chemistry 2018 by ConferenceSeries Pdf

May 17-18, 2018 Rome, Italy Key Topics : Materials Science and Chemistry, Materials Science and Engineering, Materials Chemistry in Developing Areas, Materials Synthesis and Characterization, Analytical Techniques and Instrumentation in Materials Chemistry, Polymeric Materials, Nanomaterials, Inorganic Materials Chemistry, Organic Materials Chemistry, Applied Materials Chemistry, Materials Chemistry and Physics, Science and Technology of Advanced Materials,

Fluorine

Alain Tressaud
Fluorine Book PDF

Author : Alain Tressaud
Publisher : Academic Press
Page : 271 pages
File Size : 49,9 Mb
Release : 2018-10-06
Category : Science
ISBN : 9780128129913

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Fluorine by Alain Tressaud Pdf

Fluorine: A Paradoxical Element, Volume Five, deals with the link between fluorine, humanity and the environment. It is divided into three main sections, including i) The history and developmental stages of fluorinated products, ii) Awareness of its importance in our environment, and iii) Recent contributions of fluoride products in medicine, pharmacy and our daily lives. Made engaging through interesting figures and accessible language, and written by a leading expert, Professor Tressaud, the book supports the work of scientists working in materials, toxicology and environmental science. It complements the author’s edited series, Progress in Fluorine Science, covering recent advances. Describes background and contextual information regarding the history, development of understanding, and applications of this important element Explores the impacts of fluorine, both positive and negative, in the environment and biological systems Includes applied, real-world information from agencies, such as CNRS, NASA, HWS and DOH

Advances in Heterocyclic Chemistry

Eric F.V. Scriven,Christopher A. Ramsden
Advances in Heterocyclic Chemistry Book PDF

Author : Eric F.V. Scriven,Christopher A. Ramsden
Publisher : Elsevier
Page : 332 pages
File Size : 47,7 Mb
Release : 2023-03-28
Category : Science
ISBN : 9780443193170

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Advances in Heterocyclic Chemistry by Eric F.V. Scriven,Christopher A. Ramsden Pdf

Advances in Heterocyclic Chemistry, Volume 140 is the latest release in this definitive series in the field of heterocyclic chemistry, one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. Chapters in this new release include The chemistry of citrazinic acid (2,6-dihydroxyisonicotinic acid), Aza-Diels-Alder Reaction in the Synthesis of Tetrahyroquinoline Structures, and more. Additional chapters delve into Recent Developments in the Synthesis of 4-, 5-, 6- and 7-Azaindoles, Fluoroheterocycle formation using fluoroalkynes and their synthetic equivalents, Advances in applications of dihydropyridines in organic chemistry, and Recent Developments in the Chemistry of Triphyrins (2.1.1). Considered the definitive serial in the field of heterocyclic chemistry Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists Provides the latest comprehensive reviews written by established authorities in the field Combines descriptive synthetic chemistry and mechanistic insights to enhance understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds

The Curious World of Fluorinated Molecules

Konrad Seppelt
The Curious World of Fluorinated Molecules Book PDF

Author : Konrad Seppelt
Publisher : Elsevier
Page : 456 pages
File Size : 45,6 Mb
Release : 2020-10-30
Category : Science
ISBN : 9780128198759

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The Curious World of Fluorinated Molecules by Konrad Seppelt Pdf

The Curious World of Fluorinated Molecules: Molecules Containing Fluorine is the sixth volume in the Progress in Fluorine Science series and is edited by the world-renowned scientist Konrad Seppelt. Dr. Seppelt brings together a team of global experts to uncover the multifaceted nature of the most electronegative element in the Periodic Table. The book explores the fascinating world of unpredictable, fluorine-containing molecules through their discoveries, path to recognition, current state of the art, and impact on the broader fields of fluorinated materials development. This volume will inspire and energize researchers, future scientists, and educators working in fluorine chemistry. Highlights the current state of fundamental research of fluorinated molecules that either helped to rewrite the fundamental rules of chemistry or impacted modern material technologies Features contributions from a global team of leading experts in the field Provides a unique combination of the historical and current examples that explain the unique role that fluorine can play in advancing our understanding of the scientific method at large

Recent Highlights in the Discovery and Optimization of Crop Protection Products

Peter Maienfisch,Ir. Sven Mangelinckx
Recent Highlights in the Discovery and Optimization of Crop Protection Products Book PDF

Author : Peter Maienfisch,Ir. Sven Mangelinckx
Publisher : Academic Press
Page : 647 pages
File Size : 41,5 Mb
Release : 2021-03-24
Category : Technology & Engineering
ISBN : 9780128210369

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Recent Highlights in the Discovery and Optimization of Crop Protection Products by Peter Maienfisch,Ir. Sven Mangelinckx Pdf

Recent Highlights in the Discovery and Optimization of Crop Protection Products highlights the most prominent, recent results in the search for safe and effective new crop protection products. With a focus on the design, synthesis, optimization and/or structure-activity relationships of new chemistries targeting insect, disease, weed, nematode, vector and animal parasite control, the book also includes recent developments in crop enhancement chemistries and new approaches to crop protection products. The inclusion of information on testing tools, green chemistry approaches, and the latest discovery tools, like modeling, structure-based design, and testing tools makes this volume complete. Based on key presentations given at the 14th International IUPAC conference on Crop Protection, May 19-24, 2019 in Ghent, Belgium, this book includes the many exciting new discoveries and findings reported. It is designed to inspire additional research and advancement in the field. Based on science presented at the 2019 International Union of Pure and Applied Chemistry Conference on Crop Protection Provides real-world perspectives on pesticide and disease control progress Presents scientific developments from an international array of contributing authors

Modern Synthesis Processes and Reactivity of Fluorinated Compounds

Henri Groult,Frederic Leroux,Alain Tressaud
Modern Synthesis Processes and Reactivity of Fluorinated Compounds Book PDF

Author : Henri Groult,Frederic Leroux,Alain Tressaud
Publisher : Elsevier
Page : 760 pages
File Size : 55,8 Mb
Release : 2016-11-04
Category : Science
ISBN : 9780128037904

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Modern Synthesis Processes and Reactivity of Fluorinated Compounds by Henri Groult,Frederic Leroux,Alain Tressaud Pdf

Modern Synthesis Processes and Reactivity of Fluorinated Compounds focuses on the exceptional character of fluorine and fluorinated compounds. This comprehensive work explores examples taken from all classes of fluorine chemistry and illustrates the extreme reactivity of fluorinating media and the peculiar synthesis routes to fluorinated materials. The book provides advanced and updated information on the latest synthesis routes to fluorocompounds and the involved reaction mechanisms. Special attention is given to the unique reactivity of fluorine and fluorinated media, along with the correlation of those properties to valuable applications of fluorinated compounds. Contains quality content edited, and contributed, by leading scholars in the field Presents applied guidance on the preparation of original fluorinated compounds, potentially transferable from the lab scale to industrial applications Provides practical synthesis information for a wide audience interested in fluorine compounds in many branches of chemistry, materials science, and physics

Fluorine and Health

Alain Tressaud,Gunter Haufe
Fluorine and Health Book PDF

Author : Alain Tressaud,Gunter Haufe
Publisher : Elsevier
Page : 816 pages
File Size : 49,9 Mb
Release : 2008-06-06
Category : Medical
ISBN : 0080558119

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Fluorine and Health by Alain Tressaud,Gunter Haufe Pdf

Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms. Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized. - New approach of topics involving chemistry, biology and medicinal techniques - Transdisciplinar papers on fluoride products - Importance of fluoride products in health - Updated data on specific topics

Photonic and Electronic Properties of Fluoride Materials

Alain Tressaud,Kenneth R. Poeppelmeier
Photonic and Electronic Properties of Fluoride Materials Book PDF

Author : Alain Tressaud,Kenneth R. Poeppelmeier
Publisher : Elsevier
Page : 532 pages
File Size : 45,9 Mb
Release : 2016-03-15
Category : Science
ISBN : 9780128017951

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Photonic and Electronic Properties of Fluoride Materials by Alain Tressaud,Kenneth R. Poeppelmeier Pdf

Photonic and Electronic Properties of Fluoride Materials: Progress in Fluorine Science, the first volume in this new Elsevier series, provides an overview of the important optical, magnetic, and non-linear properties of fluoride materials. Beginning with a brief review of relevant synthesis methods from single crystals to nanopowders, this volume offers valuable insight for inorganic chemistry and materials science researchers. Edited and written by leaders in the field, this book explores the practical aspects of working with these materials, presenting a large number of examples from inorganic fluorides in which the type of bonding occurring between fluorine and transition metals (either d- or 4f-series) give rise to peculiar properties in many fundamental and applicative domains. This one-of-a-kind resource also includes several chapters covering functional organic fluorides used in nano-electronics, in particular in liquid crystal devices, in organic light-emitting diodes, or in organic dyes for sensitized solar cells. The book describes major advances and breakthroughs achieved by the use of fluoride materials in important domains such as superconductivity, luminescence, laser properties, multiferroism, transport properties, and more recently, in fluoro-perovskite for dye-sensitized solar cells and inorganic fluoride materials for NLO, and supports future development in these varied and key areas. The book is edited by Alain Tressaud, past chair and founder of the CNRS French Fluorine Network. Each book in the collection includes the work of highly-respected volume editors and contributors from both academia and industry to bring valuable and varied content to this active field. Provides unique coverage of the physical properties of fluoride materials for chemists and material scientists Begins with a brief review of relevant synthesis methods from single crystals to nanopowders Includes valuable information about functional organic fluorides used in nano-electronics, in particular in liquid crystal devices, in organic light-emitting diodes, or in organic dyes for sensitized solar cells

Electrochemical Biosensors

Serge Cosnier
Electrochemical Biosensors Book PDF

Author : Serge Cosnier
Publisher : CRC Press
Page : 412 pages
File Size : 43,8 Mb
Release : 2015-01-26
Category : Science
ISBN : 9789814411479

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Electrochemical Biosensors by Serge Cosnier Pdf

Since four decades, rapid detection and monitoring in clinical and food diagnostics and in environmental and biodefense have paved the way for the elaboration of electrochemical biosensors. Thanks to their adaptability, ease of use in relatively complex samples, and their portability, electrochemical biosensors now are one of the mainstays of analytical chemistry. In particular, electrochemistry has played a pivotal role in the development of transduction methods for biological processes and biosensors. In parallel, the explosion of activity in nanoscience and nanotechnology and their huge success have profoundly affected biosensor technology, opening new avenues of research for electrode materials and transduction. This book provides an overview of biosensors based on amperometry, conductimetry, potentiometry, square-wave voltammetry, impedance, and electrochemiluminescence and describes the use of ultramicroelectrodes for the real-time monitoring and understanding of exocytosis. Areas of particular interest are the use of silver and gold nanoparticles for signal amplification, photocurrent transduction, and aptamer design. Moreover, advanced insights in the innovative concept of self-powered biosensors derived from biofuel cells are also discussed.