For Blood And Money Billionaires Biotech And The Quest For A Blockbuster Drug

Author : Nathan Vardi
Publisher : W. W. Norton & Company
Page : 254 pages
File Size : 41,7 Mb
Release : 2023-01-10
Category : Business & Economics
ISBN : 9780393540963

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For Blood and Money: Billionaires, Biotech, and the Quest for a Blockbuster Drug by Nathan Vardi Pdf

A gripping business narrative and scientific thriller about what it takes to bring a wonder drug to market—and save countless lives. For Blood and Money tells the little-known story of how an upstart biotechnology company created a one-in-a-million cancer drug, and how members of the core team—denied their share of the profits—went and did it again. In this epic saga of money and science, veteran financial journalist Nathan Vardi explains how the invention of two of the biggest cancer drugs in history became (for their backers) two of the greatest Wall Street bets of all time. In the multibillion-dollar business of biotech, where pharmaceutical companies, the government, hedge funds, and venture capitalists have spent billions on funding, experimentation, and treatments, a single molecule can stop cancer in its tracks—and make the people who find that rare molecule astonishingly rich. For Blood and Money follows a small team at a biotech start-up in California, who have found one of these rare molecules. Their compound, known as a BTK inhibitor, seems to work on a vicious type of leukemia. When patients start rising from their hospice beds, the team knows they’re onto something big. What follows is a story of genius, pathos, and drama, in which vivid characters navigate a world of corporate intrigue and ambiguous morality. Vardi’s narrative immerses readers in the recent explosion of biotech start-ups. He describes the scientists, doctors, and investors who are risking everything to develop new, life-saving treatments, and introduces suffering patients for whom the stakes are life-or-death. A gripping nonfiction read, For Blood and Money illustrates why it’s so hard to bring new drugs to market, explains why they are so expensive, and examines how profit-driven venture capitalists are shaping the future of medicine.

Author : Donald L. Drakeman,Lisa N. Drakeman,Nektarios Oraiopoulos
Publisher : Oxford University Press
Page : 241 pages
File Size : 54,7 Mb
Release : 2022
Category : Biotechnology industries
ISBN : 9780195084009

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From Breakthrough to Blockbuster by Donald L. Drakeman,Lisa N. Drakeman,Nektarios Oraiopoulos Pdf

"Beginning in the 1970s, several scientific breakthroughs promised to transform the creation of new medicines. As investors sought to capitalize on these Nobel Prize-winning discoveries, the biotech industry grew to thousands of small companies around the world. Each sought to emulate what the major pharmaceutical companies had been doing for a century or more, but without the advantages of scale, scope, experience, and massive resources. How could a large collection of small companies, most with fewer than 50 employees, compete in one of the world's most breathtakingly expensive and highly regulated industries? This book shows how biotech companies have met the challenge by creating nearly 40% more of the most important treatments for unmet medical needs. Moreover, they have done so with much lower overall costs. The book focuses on both the companies themselves and the broader biotech ecosystem that supports them. Its portrait of the crucial roles played by academic research, venture capital, contract research organizations, the capital markets, and pharmaceutical companies shows how a supportive environment enabled the entrepreneurial biotech industry to create novel medicines with unprecedented efficiency. In doing so, it also offers insights for any industry seeking to innovate in uncertain and ambiguous conditions. Looking to the future, it concludes that biomedical research will continue to be most effective in the hands of a large group of small companies as long as national healthcare policies allow the rest of the ecosystem to continue to thrive"--

Author : Donald R. Kirsch,Ogi Ogas
Publisher : Simon and Schuster
Page : 328 pages
File Size : 41,5 Mb
Release : 2016-12-13
Category : Science
ISBN : 9781628727197

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The Drug Hunters by Donald R. Kirsch,Ogi Ogas Pdf

The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter. The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery. The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.

Author : Barry Werth
Publisher : Simon and Schuster
Page : 480 pages
File Size : 44,5 Mb
Release : 2013-08-20
Category : Business & Economics
ISBN : 9781439126813

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The Billion-Dollar Molecule by Barry Werth Pdf

Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research. Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing—atom by atom—both a new life-saving immunosuppressant drug, and a drug to combat the virus that causes AIDS. You will be hooked from start to finish, as you go from the labs, where obsessive, fiercely competitive scientists struggle for a breakthrough, to Wall Street, where the wheeling and dealing takes on a life of its own, as Boger courts investors and finally decides to take Vertex public. Here is a fascinating no-holds-barred account of the business of science, which includes an updated epilogue about the most recent developments in the quest for a drug to cure AIDS.

Author : Katherine Eban
Publisher : HarperCollins
Page : 512 pages
File Size : 44,6 Mb
Release : 2020-06-23
Category : Medical
ISBN : 9780063054103

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Bottle of Lies by Katherine Eban Pdf

A NEW YORK TIMES BESTSELLER New York Times 100 Notable Books of 2019 New York Public Library Best Books of 2019 Kirkus Reviews Best Health and Science Books of 2019 Science Friday Best Books of 2019 New postscript by the author From an award-winning journalist, an explosive narrative investigation of the generic drug boom that reveals fraud and life-threatening dangers on a global scale—The Jungle for pharmaceuticals Many have hailed the widespread use of generic drugs as one of the most important public-health developments of the twenty-first century. Today, almost 90 percent of our pharmaceutical market is comprised of generics, the majority of which are manufactured overseas. We have been reassured by our doctors, our pharmacists and our regulators that generic drugs are identical to their brand-name counterparts, just less expensive. But is this really true? Katherine Eban’s Bottle of Lies exposes the deceit behind generic-drug manufacturing—and the attendant risks for global health. Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects. The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings? A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles.

Author : Barry Werth
Publisher : Simon and Schuster
Page : 448 pages
File Size : 43,7 Mb
Release : 2014-02-04
Category : Business & Economics
ISBN : 9781451655667

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The Antidote by Barry Werth Pdf

In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Journalist Barry Werth described the company's tumultuous early days during the AIDS crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he returns to tell the story of Vertex's bold endurance and eventual success. The pharmaceutical business is America's toughest and one of its most profitable. It's riskier and more rigorous at just about every stage than any other business, from the towering biological uncertainties inherent in its mission to treat disease; to the 30-to-1 failure rate in bringing out a successful medicine; to the multibillion-dollar cost of ramping up a successful product; to operating in the world's most regulated industry, matched only by nuclear power. Werth captures the full scope of Vertex's 25-year drive to deliver breakthrough medicines.--From publisher description.

Author : Gary P. Pisano
Publisher : Harvard Business Press
Page : 278 pages
File Size : 45,7 Mb
Release : 2006
Category : Business & Economics
ISBN : 1591398401

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Science Business by Gary P. Pisano Pdf

Why has the biotechnology industry failed to perform up to expectations? This book attempts to answer this question by providing a critique of the industry. It reveals the causes of biotech's problems and offers an analysis on how the industry works. It also provides prescriptions for companies, seeking ways to improve the industry's performance.

Author : Thomas Hager
Publisher : Abrams
Page : 342 pages
File Size : 40,6 Mb
Release : 2019-03-05
Category : Medical
ISBN : 9781683355311

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Ten Drugs by Thomas Hager Pdf

“The stories are skillfully told and entirely entertaining . . . An expert, mostly feel-good book about modern medicine” from the award-winning author (Kirkus Reviews, starred review). Behind every landmark drug is a story. It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine. Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book. “[An] absorbing new book.” —The New York Times Book Review “[A] well-written and engaging chronicle.” —The Wall Street Journal “Lucidly informative and compulsively readable.” —Publishers Weekly “Entertaining [and] insightful.” —Booklist “Well-written, well-researched and fascinating to read Ten Drugs provides an insightful look at how drugs have shaped modern medical practices. Towards the end of the book Hager writes that he ‘came away surprised by some of the things he had learned.’ I had the very same reaction.” —Penny Le Couteur, coauthor of Napoleon’s Buttons: How 17 Molecules Changed History

Author : Gordon M. Binder,Philip Bashe
Publisher : Harvard Business Review Press
Page : 326 pages
File Size : 41,7 Mb
Release : 2008
Category : Biography & Autobiography
ISBN : UOM:39015079165190

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Science Lessons by Gordon M. Binder,Philip Bashe Pdf

Under Gordon Binder's leadership, Amgen became the world's largest and most successful biotech company in the world. This text describes what it really takes to manage risk, financing, creative employees, and intellectual property on the international stage.

Author : Morton A. Meyers
Publisher : Skyhorse Publishing Inc.
Page : 115 pages
File Size : 50,8 Mb
Release : 2011-09
Category : History
ISBN : 9781611451627

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Happy Accidents by Morton A. Meyers Pdf

A fascinating and highly accessible look at the surprising role serendipity has played in some of the most important medical discoveries in the twentieth century.

Author : Henning Sjöström,Robert Nilsson
Publisher : Unknown
Page : 294 pages
File Size : 52,9 Mb
Release : 1972
Category : Business & Economics
ISBN : UOM:39015000303316

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Thalidomide and the Power of the Drug Companies by Henning Sjöström,Robert Nilsson Pdf

Author : Lara V. Marks
Publisher : Yale University Press
Page : 345 pages
File Size : 45,5 Mb
Release : 2015-06-28
Category : Medical
ISBN : 9780300213522

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The Lock and Key of Medicine by Lara V. Marks Pdf

This book is the first to tell the extraordinary yet unheralded history of monoclonal antibodies. Often referred to as Mabs, they are unfamiliar to most nonscientists, yet these microscopic protein molecules are everywhere, quietly shaping our lives and healthcare. Discovered in the mid-1970s in the laboratory where Watson and Crick had earlier unveiled the structure of DNA, Mabs have radically changed understandings of the pathways of disease. They have enabled faster, cheaper, and more accurate clinical diagnostic testing on a vast scale. And they have played a fundamental role in pharmaceutical innovation, leading to such developments as recombinant interferon and insulin, and personalized drug therapies such as Herceptin. Today Mabs constitute six of the world’s top ten blockbuster drugs and make up a third of new introduced treatments. Lara V. Marks recounts the risks and opposition that a daring handful of individuals faced while discovering and developing Mabs, and she addresses the related scientific, medical, technological, business, and social challenges that arose. She offers a saga of entrepreneurs whose persistence and creativity ultimately changed the healthcare landscape and brought untold relief to millions of patients. Even so, as Marks shows, controversies over Mabs remain, and she examines current debates over the costs and effectiveness of these innovative drugs.

Author : Bijal P. Trivedi
Publisher : BenBella Books
Page : 744 pages
File Size : 50,7 Mb
Release : 2020-09-08
Category : Medical
ISBN : 9781948836623

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Breath from Salt by Bijal P. Trivedi Pdf

Recommended by Bill Gates and included in GatesNotes "Elaborating on the science as well as the business behind the fight against cystic fibrosis, Trivedi captures the emotions of the families, doctors, and scientists involved in the clinical trials and their 'weeping with joy' as new drugs are approved, and shows how cystic fibrosis, once a 'death sentence,' became, for many, a manageable condition. This is a rewarding and challenging work." —Publishers Weekly Cystic fibrosis was once a mysterious disease that killed infants and children. Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia. In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday. The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease. From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it. Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.

Author : Gerald Posner
Publisher : Simon and Schuster
Page : 816 pages
File Size : 43,8 Mb
Release : 2021-04-13
Category : Business & Economics
ISBN : 9781501152030

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Pharma by Gerald Posner Pdf

"Exorbitant prices for lifesaving drugs, safety recalls affecting tens of millions of Americans, and soaring rates of addiction and overdose on prescription opioids have caused many to lose faith in pharmaceutical companies. Now, Americans are demanding national reckoning with a monolithic industry. In Pharma, award-winning journalist and New York Times best-selling author Gerald Posner uncovers the real story of the Sacklers, the family that became one of America's wealthiest from the success of OxyContin, their blockbuster narcotic painkiller at the centure of the opioid crisis. The unexpected twists and turns of the Sakler family saga are told against the startling chronicle of a powerful industry that sits at the intersection of public health and profits. Pharma reveals how and why American drug companies have put earnings ahead of patients"--

Author : Jim Weber
Publisher : HarperCollins Leadership
Page : 241 pages
File Size : 45,8 Mb
Release : 2022-04-26
Category : Business & Economics
ISBN : 9781400231706

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Running with Purpose by Jim Weber Pdf

Discover how Brooks Running Company CEO Jim Weber transformed a failing business into a billion-dollar brand in the ultracompetitive global running market. Running with Purpose is a leadership memoir with insights, inspirational stories, and tangible takeaways for current and aspiring leaders, entrepreneurs, and the 150+ million runners worldwide and those in the broader running community who continually invest in themselves. This leadership memoir starts with Jim Weber's seventh-grade dream to run a successful company that delivered something people passionately valued. Fast forward to 2001, Jim became the CEO of Brooks and, as the struggling brand's fourth CEO in two years, he faced strong headwinds. A lifelong competitor, Jim devised a one-page strategy that he believed would not only save the company but would also lay the foundation for Brooks to become a leading brand in the athletic, fitness, and outdoor categories. To succeed, he had to get his team to first believe it was possible and then employ the conviction, fortitude, and constancy of purpose to outperform larger brands. Brooks' success was validated when Warren Buffett made it a standalone Berkshire Hathaway subsidiary in 2012. In the pages of Running with Purpose, you will find: Brooks’ bold strategy and unique brand positioning that fueled its move from the back of the pack to lead. The key to building a purpose-driven brand that is oriented around customer obsession, building trust, competing with heart, and having fun along the way. The six clear leadership lessons Jim has learned along his path and applies at Brooks to develop staff into authentic leaders. How Berkshire Hathaway's support and influence provided a tailwind for Brooks' business and brand to surge. An inside look at the ups and downs of Jim's personal journey, which led to his conviction that life is too short not to enjoy what you do and the people by your side.