Free Radical Damage And Its Control

Author : C.A. Rice-Evans,R.H. Burdon
Publisher : Elsevier
Page : 409 pages
File Size : 44,9 Mb
Release : 1994-02-09
Category : Science
ISBN : 9780080860886

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Free Radical Damage and its Control by C.A. Rice-Evans,R.H. Burdon Pdf

This book provides a comprehensive treatise on the chemical and biochemical consequences of damaging free radical reactions, the implications for the pathogenesis of disease and how this might be controlled endogenously and by radical scavenging drugs. Oxidative stress may be influenced by exogenous agents of oxidative stress, radiation, trauma, drug activation, oxygen excess, or by exogenous oxidative stress which is associated with many pathological states including chronic inflammatory disorders, cardiovascular disease, injury to the central nervous system, and connective tissue damage. This and many other such aspects are presented clearly and in depth. The development of antioxidant drugs depends on the understanding of the mechanisms underlying the generation of excessive free radicals in vivo, the factors controlling their release and the site of their action. This excellent volume presents an up-to-date account of the current state of knowledge in these areas.

Author : Catherine Rice-Evans
Publisher : Elsevier Science
Page : 408 pages
File Size : 45,5 Mb
Release : 1994-02-09
Category : Electronic
ISBN : 0444548238

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Free Radical Damage and Its Control by Catherine Rice-Evans Pdf

This book provides a comprehensive treatise on the chemical and biochemical consequences of damaging free radical reactions, the implications for the pathogenesis of disease and how this might be controlled endogenously and by radical scavenging drugs. Oxidative stress may be influenced by exogenous agents of oxidative stress, radiation, trauma, drug activation, oxygen excess, or by exogenous oxidative stress which is associated with many pathological states including chronic inflammatory disorders, cardiovascular disease, injury to the central nervous system, and connective tissue damage. This and many other such aspects are presented clearly and in depth. The development of antioxidant drugs depends on the understanding of the mechanisms underlying the generation of excessive free radicals in vivo, the factors controlling their release and the site of their action. This excellent volume presents an up-to-date account of the current state of knowledge in these areas.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 48,7 Mb
Release : 1994
Category : Active oxygen
ISBN : 0444803033

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Free Radical Damage and Its Control by Anonim Pdf

Author : Manfred Lamprecht
Publisher : CRC Press
Page : 304 pages
File Size : 43,7 Mb
Release : 2014-09-17
Category : Medical
ISBN : 9781466567573

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Antioxidants in Sport Nutrition by Manfred Lamprecht Pdf

The use of antioxidants in sports is controversial due to existing evidence that they both support and hinder athletic performance. Antioxidants in Sport Nutrition covers antioxidant use in the athlete ́s basic nutrition and discusses the controversies surrounding the usefulness of antioxidant supplementation. The book also stresses how antioxidants may affect immunity, health, and exercise performance. The book contains scientifically based chapters explaining the basic mechanisms of exercise-induced oxidative damage. Also covered are methodological approaches to assess the effectiveness of antioxidant treatment. Biomarkers are discussed as a method to estimate the bioefficacy of dietary/supplemental antioxidants in sports. This book is useful for sport nutrition scientists, physicians, exercise physiologists, product developers, sport practitioners, coaches, top athletes, and recreational athletes. In it, they will find objective information and practical guidance.

Author : Toshiki Asao,Md Asaduzzaman
Publisher : BoD – Books on Demand
Page : 220 pages
File Size : 54,8 Mb
Release : 2018-11-07
Category : Science
ISBN : 9781789843774

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Phytochemicals by Toshiki Asao,Md Asaduzzaman Pdf

Phytochemicals provides original research work and reviews on the sources of phytochemicals, and their roles in disease prevention, supplementation, and accumulation in fruits and vegetables. The roles of anthocyanin, flavonoids, carotenoids, and taxol are presented in separate chapters. Antioxidative and free radicle scavenging activity of phytochemicals is also discussed. The medicinal properties of Opuntia, soybean, sea buckthorn, and gooseberry are presented in a number of chapters. Supplementation of plant extract with phytochemical properties in broiler meals is discussed in one chapter. The final two chapters include the impact of agricultural practices and novel processing technologies on the accumulation of phytochemicals in fruits and vegetables. This book mainly focuses on medicinal plants and the disease-preventing properties of phytochemicals, which will be a useful resource to the reader.

Author : Natan Gadoth,Hans Hilmar Göbel
Publisher : Springer Science & Business Media
Page : 323 pages
File Size : 52,7 Mb
Release : 2010-11-19
Category : Medical
ISBN : 9781603275149

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Oxidative Stress and Free Radical Damage in Neurology by Natan Gadoth,Hans Hilmar Göbel Pdf

The role of free radicals and oxidative stress in neurological disorders has only recently been recognized, leaving clinical neurologists to seek in vain for information on the subject even in major textbooks. What published information there is may consist of brief reminders of the possible association of superoxidase dismutase with familial amyotrophic lateral sclerosis and nitrous oxide with migraine. With luck they may also find information on the purported role of free radicals in the pathogenesis of traumatic brain injury. Oxidative Stress and Free Radical Damage in Neurology sets the record straight, focusing on clinical and research issues regarding the interplay of free radicals and the human nervous system. Crucially, the chapters cover numerous antioxidants and their possible therapeutic role in neurological disorders. Key illnesses such as epilepsy, multiple sclerosis and Parkinson’s are analyzed, and chapters also examine more general issues such as the link between free radicals and inflammation of the central nervous system. Clinicians and laboratory researchers alike will find that this book augments their understanding not only of the widespread involvement of free radicals in the central nervous system but also of some uncertainties surrounding whether free radical damage in neurology plays a primary or secondary role.

Author : Roberto Rodríguez,R.Sanchez Tamés,D.J. Durzan
Publisher : Springer Science & Business Media
Page : 425 pages
File Size : 53,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468457605

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Plant Aging by Roberto Rodríguez,R.Sanchez Tamés,D.J. Durzan Pdf

For many, the terms aging, maturation and senescence are synonymous and used interchangeably, but they should not be. Whereas senescence represents an endogenously controlled degenerative programme leading to plant or organ death, genetiC aging encompasses a wide array of passive degenerative genetiC processes driven primarily by exogenous factors (Leopold, 1975). Aging is therefore considered a consequence of genetiC lesions that accumulate over time, but by themselves do not necessarily cause death. These lesions are probably made more severe by the increase in size and complexity in trees and their attendant physiology. Thus while the withering of flower petals following pollination can be considered senescence, the loss of viability of stored seeds more clearly represents aging (Norden, 1988). The very recent book "Senescence and Aging in Plants" does not discuss trees, the most dominant group of plants on the earth. Yet both angiospermic and gymnospermic trees also undergo the above phenomena but less is known about them. Do woody plants senesce or do they just age? What is phase change? Is this synonymous with maturation? While it is now becoming recognized that there is no programmed senescence in trees, senescence of their parts, even in gymnosperms (e. g. , needles of temperate conifers las t an average of 3. 5 years), is common; but aging is a readily acknowledged phenomenon. In theory, at least, in the absence of any programmed senescence trees should -live forever, but in practice they do not.

Author : Ismail Laher
Publisher : Springer
Page : 0 pages
File Size : 41,5 Mb
Release : 2014-06-16
Category : Medical
ISBN : 3642300170

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Systems Biology of Free Radicals and Antioxidants by Ismail Laher Pdf

The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.

Author : Barry Halliwell,John M. C. Gutteridge
Publisher : Oxford University Press
Page : 961 pages
File Size : 50,6 Mb
Release : 2015
Category : Science
ISBN : 9780198717478

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Free Radicals in Biology and Medicine by Barry Halliwell,John M. C. Gutteridge Pdf

Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.

Author : Dimitri Kozyrev,Vasily Slutsky
Publisher : Unknown
Page : 0 pages
File Size : 55,7 Mb
Release : 2010
Category : Free radicals
ISBN : 1608761010

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Handbook of Free Radicals by Dimitri Kozyrev,Vasily Slutsky Pdf

Free radicals are molecules, ions, or atoms with unpaired electrons in their outermost shell of electrons. Although it is a relatively recent discovery, the occurrence of free radicals in biological processes is now widely accepted. Free radicals are involved in the pathogenesis of many diseases, such as diabetes, cardiovascular and pulmonary diseases and also in inflammation. Free radicals are also involved in important physiological processes, such as ageing. Free radicals are constantly formed in the human body, but they can become toxic when generated in excess or in the presence of a deficiency in the naturally occurring antioxidant defences. In general, the body has adequate antioxidant defences to cope with the production of free radicals under physiological conditions. This book reviews the updated knowledge on free radicals and its possible mechanisms in neurological disorders and in some oxidative stress processes, such as in intractable epilepsy and febrile seizures. Some approaches useful to elucidate the effects of free radical exposure on the overall protein structure are also discussed. Additionally, the potential risk factors and major cellular events contributing to the generation of reactive oxygen species and retinal pigment epithelium (EPI)/photoreceptor cell damage, and their roles in the pathogenesis of AMD are examined. Furthermore, thyroid cells are a unique model to study free radical processes involving reactive oxygen and iodine species. The role of oxidative stress in impairment in the thyroid function is explored. Other chapters in this book explore free radicals and its role in the in vivo disease control of malaria, as well as the monitoring of free radical in ultrasonic field in vitro and in vivo, its role in laboratory medicine, the relationship between rabies and free radicals, the correlation between exercise and free radical production, and the role of free radicals in several homeostatic processes through methods that can be used to detect free radicals either directly or indirectly (also known as fingerprinting methods).

Author : Anonim
Publisher : BoD – Books on Demand
Page : 140 pages
File Size : 42,7 Mb
Release : 2020-08-26
Category : Science
ISBN : 9781838801250

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Glutathione System and Oxidative Stress in Health and Disease by Anonim Pdf

The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system.

Author : Chris Lecos
Publisher : Unknown
Page : 4 pages
File Size : 41,9 Mb
Release : 1985
Category : Diet
ISBN : IND:30000050599202

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Diet and the Elderly by Chris Lecos Pdf

Author : POLI
Publisher : Birkhäuser
Page : 540 pages
File Size : 48,7 Mb
Release : 2013-03-11
Category : Science
ISBN : 9783034891165

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Free Radicals: from Basic Science to Medicine by POLI Pdf

Free radical-mediated reactions have been well known in chemistry and physical chemistry for many years. Applying this knowledge to living organisms, biochemists have shown that reactive free radicals are formed at many intracellular sites during normal metabolism, and they have started to suggest possible roles in various pathological processes and conditions, for example in radiation damage, in the metabolism of xenobiotics, in carcinogenesis and in metabolic disorders. At present, a large and relevant mass of experimental evidence supports the view that reactive free radicals are involved in the pathogenesis of several diseases and syndromes. This literature has captured the attention and interest of people involved in the biomedical field. Exciting developments in radical research are probable in the near future, establishing a greater interaction between basic science research and medicine. While the task of defining the involvement of free radicals in human pathology is difficult, it is nonetheless extremely important that such interaction be fulfilled as soon as possible. These were the considerations motivating us during the organization of the VI Biennial Meeting of the International Society for Free Radical Research held in Torino, Italy, in June 1992, and also during the preparation of this book. Experts in the various aspects of free radical research were invited to participate in the Torino Meeting and to contribute chapters for this volume.

Author : Helmut Sies
Publisher : Academic Press
Page : 876 pages
File Size : 46,8 Mb
Release : 2019-11-07
Category : Science
ISBN : 9780128196960

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Oxidative Stress by Helmut Sies Pdf

Oxidative Stress: Eustress and Distress presents current knowledge on oxidative stress within the framework of redox biology and translational medicine. It describes eustress and distress in molecular terms and with novel imaging and chemogenetic approaches in four sections: A conceptual framework for studying oxidative stress. Processes and oxidative stress responses. Signaling in major enzyme systems (oxidative eustress), and damaging modification of biomolecules (oxidative distress). The exposome addresses lifelong exposure and impact on health, nutrient sensing, exercise and environmental pollution. Health and disease processes, including ischemia-reperfusion injury, developmental and psychological disorders, hepatic encephalopathy, skeletal muscle disorders, pulmonary disease, gut disease, organ fibrosis, and cancer. Oxidative Stress: Eustress and Distress is an informative resource useful for active researchers and students in biochemistry, molecular biology, medicinal chemistry, pharmaceutical science, nutrition, exercise physiology, analytical chemistry, cell biology, pharmacology, clinical medicine, and environmental science. Characterizes oxidative stress within the framework of redox biology, redox signaling, and medicine. Empowers researchers and students to quantify specific reactants noninvasively, identify redox biomarkers, and advance translational studies. Features contributions from international leaders in oxidative stress and redox biology research.

Author : David R. Riddle
Publisher : CRC Press
Page : 408 pages
File Size : 47,6 Mb
Release : 2007-04-19
Category : Medical
ISBN : 1420005529

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Brain Aging by David R. Riddle Pdf

Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur