Oxidative Stress And Free Radical Damage In Neurology

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Oxidative Stress and Free Radical Damage in Neurology

Natan Gadoth,Hans Hilmar Göbel
Oxidative Stress and Free Radical Damage in Neurology Book PDF

Author : Natan Gadoth,Hans Hilmar Göbel
Publisher : Springer Science & Business Media
Page : 323 pages
File Size : 50,8 Mb
Release : 2010-11-19
Category : Medical
ISBN : 9781603275149

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Oxidative Stress and Free Radical Damage in Neurology by Natan Gadoth,Hans Hilmar Göbel Pdf

The role of free radicals and oxidative stress in neurological disorders has only recently been recognized, leaving clinical neurologists to seek in vain for information on the subject even in major textbooks. What published information there is may consist of brief reminders of the possible association of superoxidase dismutase with familial amyotrophic lateral sclerosis and nitrous oxide with migraine. With luck they may also find information on the purported role of free radicals in the pathogenesis of traumatic brain injury. Oxidative Stress and Free Radical Damage in Neurology sets the record straight, focusing on clinical and research issues regarding the interplay of free radicals and the human nervous system. Crucially, the chapters cover numerous antioxidants and their possible therapeutic role in neurological disorders. Key illnesses such as epilepsy, multiple sclerosis and Parkinson’s are analyzed, and chapters also examine more general issues such as the link between free radicals and inflammation of the central nervous system. Clinicians and laboratory researchers alike will find that this book augments their understanding not only of the widespread involvement of free radicals in the central nervous system but also of some uncertainties surrounding whether free radical damage in neurology plays a primary or secondary role.

Oxidative Stress and Neurodegenerative Disorders

G. Ali Qureshi,S. Hasan Parvez
Oxidative Stress and Neurodegenerative Disorders Book PDF

Author : G. Ali Qureshi,S. Hasan Parvez
Publisher : Elsevier
Page : 794 pages
File Size : 46,6 Mb
Release : 2007-03-22
Category : Science
ISBN : 0080489494

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Oxidative Stress and Neurodegenerative Disorders by G. Ali Qureshi,S. Hasan Parvez Pdf

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders * Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

Oxidative Stress and Antioxidant Protection

Donald Armstrong,Robert D. Stratton
Oxidative Stress and Antioxidant Protection Book PDF

Author : Donald Armstrong,Robert D. Stratton
Publisher : John Wiley & Sons
Page : 610 pages
File Size : 51,6 Mb
Release : 2016-04-11
Category : Science
ISBN : 9781118832486

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Oxidative Stress and Antioxidant Protection by Donald Armstrong,Robert D. Stratton Pdf

Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.

Brain Aging

David R. Riddle
Brain Aging Book PDF

Author : David R. Riddle
Publisher : CRC Press
Page : 408 pages
File Size : 40,9 Mb
Release : 2007-04-19
Category : Medical
ISBN : 1420005529

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Brain Aging by David R. Riddle Pdf

Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur

Metals and Oxidative Damage in Neurological Disorders

James R. Connor
Metals and Oxidative Damage in Neurological Disorders Book PDF

Author : James R. Connor
Publisher : Springer Science & Business Media
Page : 383 pages
File Size : 42,9 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781489901972

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Metals and Oxidative Damage in Neurological Disorders by James R. Connor Pdf

The purpose of this book is to bring together scientists and clinicians interested in oxidative injury in the nervous system but whose approaches to investigation and treatment design vary widely. Indeed the goal of this book is to show that the investiga tive approaches and potential therapeutic interventions perhaps do not vary as widely as some may think. I think that the readers of this book will not read it from front to back, but will pick chapters of interest. Thus, the chapters are organized to contain information that is essential to understanding basic aspects of oxidative injury, and thus have some redundancy. However, within the context of each chapter the reader should hopefully find impetus and direction to go on to another chapter. The book is divided into three seetions. The first section contains reviews of metals and their role in generating oxidative injury. lron is considered in three of these chapters because of its relative abundance in the brain and its potency in inducing free radicals. The second section focuses on mechanisms by which the brain attempts to protect itself from oxidative injury. Some of these mechanisms have the potential to be protective in some situations and potentiaIly damaging in others. The third section contains the clinicaI diseases in which oxidative injury is known to contribute to the pathogenic process. This seetion ends with a chapter on antioxidant therapeutic strate gies in neurological disorders.

Free Radicals in the Brain

Lester Packer,Leonid Prilipko
Free Radicals in the Brain Book PDF

Author : Lester Packer,Leonid Prilipko
Publisher : Springer Science & Business Media
Page : 191 pages
File Size : 41,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642776090

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Free Radicals in the Brain by Lester Packer,Leonid Prilipko Pdf

Free radicals appear to play a mojor role in many neurological (and non neurological) dieseases. Both acute and degenerative disorders are thought to involve free radicals reactions in tissue injury (for a list see this book page 18). This issue is very important for basic science and for therapeuthic approach as well. In order to review and discuss the place of free radicals in psychiatry and neurology, a joint meeting was initiated by the World Health Organization and the Fondation Ipsen in Paris on June 17-18,1991. This book contains the papers presented during this meeting. Although the papers included in this volume have been produced in the framework of WHO/Fondation Ipsen review of knowledge about free radicals and brain disorders, they express the views of the individual authors rather than a consensus of the participants at the meeting. They do not necessarily represent the decision or stated policy of the World Health Organiszation or the Fondation Ipsen. The editors wish to express their appreciation to Mrs Mervaillie for the organization of the meeting and Mrs M.-L. Gage for her editorial assis tance. L. Packer, L. Prilipko, Y Christen Contents Free Radical Scavengers and Antioxidants in Prophylaxy and Treatment of Brain Diseases L. Packer ........................................... 1 Reactive Oxygen Species and the Central Nervous System B. Halliwell .... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 . . . . . . . . .

The Role of Oxidative Stress in Neuronal Death

Irene Ceballos-Picot
The Role of Oxidative Stress in Neuronal Death Book PDF

Author : Irene Ceballos-Picot
Publisher : Springer Science & Business Media
Page : 203 pages
File Size : 47,7 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9783662225165

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The Role of Oxidative Stress in Neuronal Death by Irene Ceballos-Picot Pdf

This book examines current knowledge and recent advances in the study of fundamental processes involved in neuronal death, particularly oxidative stress as a causal agent or risk factor. The author presents discussion of oxidative stress in neuronal apoptosis and its role in the neuropathogenesis of age-related neurodegenerative diseases exemplified by Alzheimer's disease, Parkinson's disease and Amyotrophic Lateral Sclerosis.

Oxidative Neural Injury

Sigrid C. Veasey
Oxidative Neural Injury Book PDF

Author : Sigrid C. Veasey
Publisher : Springer Science & Business Media
Page : 224 pages
File Size : 44,8 Mb
Release : 2009-05-28
Category : Medical
ISBN : 9781603273428

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Oxidative Neural Injury by Sigrid C. Veasey Pdf

Twenty-five years ago, Earl R. Stadtman, PhD discovered that specific enzymes regulating metabolism can be inactivated by oxidation [1]. He later showed that age-related oxidative modification contributes, at least in part, to age-related loss of function of the enzymes [2, 3]. Dr. Stadtman broke the ground for a new field of study to discover how oxidative stress contributes in significant ways to age-related cellular dysfunction and protein accumulation and that oxidation in the aging brain influences Alzheimer’s disease, ischemia-reperfusion injury, amyotrophic lateral sclerosis, and lifespan [4–6]. Today, his research and mentorship have positively influenced the work of hundreds of scientists in this field. We dedicate this book to Dr. Earl R. Stadtman (1912–2008), in celebration of his passion for science and his superior collaborative and mentorship skills. This book is comprised of three sections. The first describes the valuable roles reactive oxygen species (ROS) and reactive nitrogen species (RNS) play in cellular biology. The second section provides an overview of redox imbalance injury with effects on mitochondria, signaling, endoplasmic reticular function, and on aging in general. The third section takes these mechanisms to neurodegenerative disorders and provides a state-of-the-art look at the roles redox imbalances play in age-related susceptibility to disease and in the disease processes. In the first section we attempt to answer a question posed by Dr. Stadtman, ‘‘Why have cells selected reactive oxygen species to regulate cell signaling events’’ [7].

Free Radicals in Brain Pathophysiology

Giuseppe Poli
Free Radicals in Brain Pathophysiology Book PDF

Author : Giuseppe Poli
Publisher : CRC Press
Page : 592 pages
File Size : 50,8 Mb
Release : 2000-02-25
Category : Medical
ISBN : 0824703170

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Free Radicals in Brain Pathophysiology by Giuseppe Poli Pdf

This volume provides an authoritative, comprehensive view of the most current issues in brain pathophysiology and offers a critical evaluation of antioxidant-based therapeutic approaches to neurodegeneration, providing an up-to-date account of the role of antioxidants in the prevention and moderation of clinical symptoms. Examines free radicals in spinal cord damage, subarachnoid hemorrhage, reperfusion damage, and cytotoxicity! With over 2400 references, tables, drawings, photographs, and micrographs, Free Radicals in Brain Pathophysiology focuses on important biological signaling molecules such as superoxide anion and nitric oxide evaluates the action of low levels of oxygen- and nitrogen-centered radicals on cell membranes and receptors to modulate signal transduction pathways and gene expression links high mitochondrial density in neural tissue to brain disease considers how prions and -amyloid proteins influence the level of free radicals within cells assesses the abnormalities of superoxide dismutase in the familial form of amyotrophic lateral sclerosis highlights the occurrence of oxidative stress and the impact of oxidative injury in brain physiology and neurodegeneration and more! With contributions from nearly 70 internationally recognized researchers, physiologists, and clinicians who describe their latest findings and provide new insights into the factors underlying neurological disorders, Free Radicals in Brain Pathophysiology is an unsurpassed reference for nutritionists and dietitians, clinical neurologists, pathologists, cell biologists and biochemists, cardiologists, oncologists, dermatologists, and graduate and medical school students in these disciplines.

Free Radicals, Oxidative Stress, and Antioxidants

Tomris Özben
Free Radicals Oxidative Stress and Antioxidants Book PDF

Author : Tomris Özben
Publisher : Springer Science & Business Media
Page : 390 pages
File Size : 50,7 Mb
Release : 2013-06-29
Category : Science
ISBN : 9781475729078

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Free Radicals, Oxidative Stress, and Antioxidants by Tomris Özben Pdf

There has been an explosion of research related to free radicals and antioxidants in recent years, and hundreds of laboratories worldwide are actively involved in many as pects of free radicals, oxidative stress, and antioxidants. The literature on these topics in creases exponentially every year. Over the last few years, we have been fortunate to witness a widespread recognition of the important role of free radicals in a wide variety of pathological conditions including diseases such as atherosclerosis, cardiovascular and neurological diseases, ischemia, emphysema, diabetes, radiation injury, cancer, etc. In ad dition, many laboratories are studying the role of free radicals in the inexorable process of aging. Increased evidence involves free radicals with the etiology of various diseases, thereby suggesting the use of antioxidants as a viable therapeutic approach for the treat ment of free radical mediated pathologies. Despite these impressive developments, many important aspects of free radical and antioxidant research are open for investigation. It is important to understand the overall mechanisms involved in free radical mediated physiological and pathological conditions. This knowledge will undoubtedly lead to the development of new therapeutic approaches to prevent or control free radical related diseases. This book contains the proceedings of the NATO Advanced Study Institute (ASI) on "Free Radicals, Oxidative Stress, and Antioxidants: Pathological and Physiological Sig nificance," which was held in Antalya, Turkey from May 24-June 4, 1997.

Free Radicals in Human Health and Disease

Vibha Rani,Umesh Chand Singh Yadav
Free Radicals in Human Health and Disease Book PDF

Author : Vibha Rani,Umesh Chand Singh Yadav
Publisher : Springer
Page : 430 pages
File Size : 51,5 Mb
Release : 2014-11-14
Category : Science
ISBN : 9788132220350

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Free Radicals in Human Health and Disease by Vibha Rani,Umesh Chand Singh Yadav Pdf

The role of oxidative stress in human disease has become an area of intense interest. Free radicals, a normal product of metabolism, exist in all aerobic cells in balance with biochemical antioxidants. Environmental stress increases the levels of free radicals drastically, thereby disturbing the equilibrium between free radical production and the antioxidant capability causing oxidative stress. Over the years, ROS has been implicated in the pathologies of various diseases like cancer, neurological disorder, cardiovascular diseases rheumatoid arthritis, diabetes etc. This book provides an in depth critical state-of-art reviews from established investigators on free radicals, ROS associated pathogenesis of human diseases, biomarkers of oxidative damage, antioxidants, phytonutrients and other related health concerns of modern society. The present book is aimed at graduate students, researchers in academia, industry and clinicians with the interest in redox biology. Special attention has been devoted to the topic of ROS signalling, oxidative stress induced human pathologies & antioxidative therapies. The book consists of four parts in specified topics based on the current literatures for the better understanding of the readers with respect to their subject-wise interests. The first section of the book provides an overview about the ROS production and their measuring tools and techniques followed by the mechanisms involved in the oxidative stress in the second section. The third section describes the involvement of oxidative stress in different human diseases and the last section focuses on the different strategies to ameliorate oxidative stress induced stress.

Nutrition and Traumatic Brain Injury

Institute of Medicine,Food and Nutrition Board,Committee on Nutrition, Trauma, and the Brain
Nutrition and Traumatic Brain Injury Book PDF

Author : Institute of Medicine,Food and Nutrition Board,Committee on Nutrition, Trauma, and the Brain
Publisher : National Academies Press
Page : 444 pages
File Size : 46,9 Mb
Release : 2011-07-01
Category : Medical
ISBN : 9780309210089

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Nutrition and Traumatic Brain Injury by Institute of Medicine,Food and Nutrition Board,Committee on Nutrition, Trauma, and the Brain Pdf

Traumatic brain injury (TBI) accounts for up to one-third of combat-related injuries in Iraq and Afghanistan, according to some estimates. TBI is also a major problem among civilians, especially those who engage in certain sports. At the request of the Department of Defense, the IOM examined the potential role of nutrition in the treatment of and resilience against TBI.

Oxidative Stress and Dietary Antioxidants in Neurological Diseases

Colin R Martin,Victor R Preedy
Oxidative Stress and Dietary Antioxidants in Neurological Diseases Book PDF

Author : Colin R Martin,Victor R Preedy
Publisher : Academic Press
Page : 438 pages
File Size : 44,8 Mb
Release : 2020-06-12
Category : Medical
ISBN : 9780128177815

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Oxidative Stress and Dietary Antioxidants in Neurological Diseases by Colin R Martin,Victor R Preedy Pdf

Oxidative Stress and Dietary Antioxidants in Neurological Diseases provides an overview of oxidative stress in neurological diseases and associated conditions, including behavioral aspects and the potentially therapeutic usage of natural antioxidants in the diet. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book examines basic processes of oxidative stress—from molecular biology to whole organs—relative to cellular defense systems, and across a range of neurological diseases. Sections discuss antioxidants in foods, including plants and components of the diet, examining the underlying mechanisms associated with therapeutic potential and clinical applications. Although some of this material is exploratory or preclinical, it can provide the framework for further in-depth analysis or studies via well-designed clinical trials or the analysis of pathways, mechanisms, and components in order to devise new therapeutic strategies. Very often oxidative stress is a feature of neurological disease and associated conditions which either centers on or around molecular and cellular processes. Oxidative stress can also arise due to nutritional imbalance during a spectrum of timeframes before the onset of disease or during its development. Offers an overview of oxidative stress from molecular biology to whole organs Discusses the potentially therapeutic usage of natural antioxidants in the patient diet Provides the framework for further in-depth analysis or studies of potential treatments

Brain vs Retina - Differences and Commonalities: The Role of Oxidative Stress in Neurodegenerative Diseases

Jose Hurst,Sven Schnichels,Ritushree Kukreti,Sandra Kuehn,Abel Santamaria
Brain vs Retina Differences and Commonalities The Role of Oxidative Stress in Neurodegenerative Diseases Book PDF

Author : Jose Hurst,Sven Schnichels,Ritushree Kukreti,Sandra Kuehn,Abel Santamaria
Publisher : Frontiers Media SA
Page : 109 pages
File Size : 55,8 Mb
Release : 2023-06-15
Category : Science
ISBN : 9782832520253

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Brain vs Retina - Differences and Commonalities: The Role of Oxidative Stress in Neurodegenerative Diseases by Jose Hurst,Sven Schnichels,Ritushree Kukreti,Sandra Kuehn,Abel Santamaria Pdf

Oxidative stress, free radicals, antioxidants - when it comes to our health, this topic is taking up more and more attention. But what is oxidative stress, how does it arise and what effects does it have on the most sensitive area of our body: the neuronal tissue or the retina. Many neurological diseases affecting the brain or the retina are associated with elevated levels of reactive oxygen species (ROS). High levels of ROS can cause damage to proteins, nucleic acids, lipids, membranes, and organelles such as mitochondria, and can be caused not only by external stimuli but also by aging. Most theories on the aging scenario assume that cumulative oxidative stress leads to mitochondrial changes, mitochondrial dysfunction, and oxidative damage. Therefore, it is not surprising that excess ROS is among others associated with the development of a variety of age-related neuronal diseases, including Alzheimer's and Parkinson's disease, as well as retinal diseases diabetic retinopathy, glaucoma, and age-related macular (AMD) degeneration. The aim of this Research Topic is to answer open questions, to combine already gained knowledge, to close the gaps between ophthalmology and neurology when it comes to oxidative stress in order to understand the underlying pathways and derive innovative therapies. It searches for the updates and new findings in both fields that answer the central question: are the same cell types affected by oxidative stress in the same way in the brain and retina? Experimental studies or patient studies that provide new insights are welcome, as well as studies that investigate antioxidant therapies.

Oxidative Stress and Aging

R.C. Cutler,L. Packer,J. Bertram,A. Mori
Oxidative Stress and Aging Book PDF

Author : R.C. Cutler,L. Packer,J. Bertram,A. Mori
Publisher : Birkhäuser
Page : 393 pages
File Size : 43,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783034873376

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Oxidative Stress and Aging by R.C. Cutler,L. Packer,J. Bertram,A. Mori Pdf

Oxidative stress and aging Over the past several years there has been an extraordinarily rapid growth in our knowledge of free radical chemistry and its possible involvement in both normal essential biology and age related disease and dysfunction. Much of this growth in the traditionally separate sciences of chemistry and molecular gerontology occurred independently, with little interaction or communi cation between the scientists working in these two fields. In view of the growing maturity of the two fields and the potential importance of advancing our knowledge in the area of oxidative stress and aging, we perceived a critical need to organize an international conference the "First Inter national Conference on Oxidative Stress and Aging" in Hawaii in 1994 to bring together the world's leading scientists in the fields of reactive oxygen species and molecular gerontology. The objective of this conference was to provide a unique opportunity for scholars working in these two related and rapidly growing fields to participate in the exchange, integration, and synthesis of new concepts and ideas, to engage in constructive criticism and to initiate new collaborative research projects. The conference focused on the molecular and cellular aspects of aging as related to oxidative stress. It was one of the largest and most comprehensive international conferences held in molecular gerontology. At this conference a call was made for submission of papers to be used in the publication of a book covering the major contributions of the meeting.