Frontiers Of Cord Blood Science

Author : Niranjan Bhattacharya,Phillip Stubblefield
Publisher : Springer Science & Business Media
Page : 385 pages
File Size : 44,7 Mb
Release : 2009-04-21
Category : Medical
ISBN : 9781848001671

Get Book

Frontiers of Cord Blood Science by Niranjan Bhattacharya,Phillip Stubblefield Pdf

Cord blood is a significant source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. Cord blood is also an alternative to embryos as a source of tissue for regenerative medicine. Cells from cord blood have been shown to transdifferentiate into nonhematopoietic cells, including those of the brain, heart, liver, pancreas, bone, and cartilage, in tissue culture and in animal systems. Recently it has been demonstrated that both cardiac and glial cell differentiation of cord blood donor cells occurred in recipients of unrelated donor cord blood transplantation as part of a treatment regime for Krabbe disease and Sanfilippo syndrome. These observations raise the possibility that cord blood may serve as a source of cells to facilitate tissue repair and regeneration in the future. CD34 stem cell-rich umbilical cord whole blood transfusion has the potential to have an immediate benefit of better tissue oxygenation with an additional delayed benefit of possible engraftment of umbilical cord stem cells.

Author : Niranjan Bhattacharya,Phillip Stubblefield
Publisher : Springer
Page : 400 pages
File Size : 46,5 Mb
Release : 2010-12-14
Category : Medical
ISBN : 1848824521

Get Book

Frontiers of Cord Blood Science by Niranjan Bhattacharya,Phillip Stubblefield Pdf

Cord blood is a significant source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. Cord blood is also an alternative to embryos as a source of tissue for regenerative medicine. Cells from cord blood have been shown to transdifferentiate into nonhematopoietic cells, including those of the brain, heart, liver, pancreas, bone, and cartilage, in tissue culture and in animal systems. Recently it has been demonstrated that both cardiac and glial cell differentiation of cord blood donor cells occurred in recipients of unrelated donor cord blood transplantation as part of a treatment regime for Krabbe disease and Sanfilippo syndrome. These observations raise the possibility that cord blood may serve as a source of cells to facilitate tissue repair and regeneration in the future. CD34 stem cell-rich umbilical cord whole blood transfusion has the potential to have an immediate benefit of better tissue oxygenation with an additional delayed benefit of possible engraftment of umbilical cord stem cells.

Author : Suzanne Kadereit,Gerald Udolph
Publisher : World Scientific Publishing Company
Page : 372 pages
File Size : 53,6 Mb
Release : 2010-12-23
Category : Science
ISBN : 9789813107311

Get Book

Umbilical Cord Blood by Suzanne Kadereit,Gerald Udolph Pdf

Umbilical cord blood, previously discarded, has emerged as a new source of stem cells for hematologic reconstitution, bone marrow failures and other hematologic deficiencies. It has become increasingly clear that umbilical cord tissue contains unique stem cells of great potential for regenerative medicine. Importantly, umbilical cord blood is abundant, can be banked and transported with ease, and thus has an indisputable potential for future regenerative therapies. Driven by a massive interest for regenerative medicine and ethically acceptable stem cell sources, the scientific literature on umbilical cord stem cells has exploded. This book provides a consolidated overview of basic, translational as well as clinical research in academic institutions and industry, on hematopoietic and mesenchymal stem cells contained within umbilical cord tissue, as well as other more recently discovered stem and precursor cells of not yet fully elucidated potential. Although not discussed here, umbilical cord cells have been successfully reprogrammed into pluripotent stem cells (iPS), opening the door for a vast array of applications with this abundant human material likely catapulting cord-derived stem cells to the forefront of cell-based regenerative medicine. Suitable as a primer and reference book for medical fellows and researchers, this book can also be used by students (undergraduate and graduate) as a starting point into the vast literature on stem cells and their potential.

Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Establishing a National Cord Blood Stem Cell Bank Program
Publisher : National Academies Press
Page : 334 pages
File Size : 51,7 Mb
Release : 2005-10-26
Category : Medical
ISBN : 9780309165174

Get Book

Cord Blood by Institute of Medicine,Board on Health Sciences Policy,Committee on Establishing a National Cord Blood Stem Cell Bank Program Pdf

With the potential for self-renewal and differentiation, the possibilities for stem cells are enormous. One specific type of stem cell, the hematopoietic progenitor cell (HPC), which is derived from umbilical cord blood (as well as adult bone marrow and mobilized peripheral blood), holds particular promise. To make the most of these HPCs, the Institute of Medicine was asked to consider the optimal structure for a national cord blood program and to address pertinent issues related to maximizing the potential of stem cell technology. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program examines: The role of cord blood in stem cell transplantation The current status of blood banks already in existence The optimal structure for the cord blood program The current use and utility of cord blood for stem cell transplants The best way to advance the use of cord blood units and make them available for research Expert advice from leaders in the fields of economics, public health, medicine, and biostatistics combine to make this very timely and topical book useful to a number of stakeholders.

Author : Catherine Stavropoulos-Giokas,Dominique Charron,Cristina Navarrete
Publisher : Elsevier
Page : 399 pages
File Size : 50,9 Mb
Release : 2014-12-03
Category : Medical
ISBN : 9780124078369

Get Book

Cord Blood Stem Cells Medicine by Catherine Stavropoulos-Giokas,Dominique Charron,Cristina Navarrete Pdf

Cord Blood Stem Cells and Regenerative Medicine discusses the current applications for cord blood stem cells and techniques for banking cord blood. Cord blood, blood from the umbilical cord and placenta of an infant, represents an alternate source of stem cells that can be used to treat a myriad of disorders. Cord blood stem cells are being used more frequently and studied more seriously, as evidenced by the explosion of scientific literature on the topic. Currently, clinical and pre-clinical trials are being done in the field, treating conditions as severe as heart failure. Coupled with regenerative medicine, cord blood stem cells potentially carry the future of research and medicine in treating tissue damage, genetic disorders, and degenerative diseases. Read about new applications for cord blood stem cells and new techniques for banking cord blood — the future of regenerative medicine therapy. Comprehensive coverage of the medical application of cord blood stem cells Practical guide for usage of allogeneic and autologous cord blood in regenerative medicine Covers new applications of cord blood stem cells, particularly transplantation and HIV Introduces new technologies for cord blood stem cells and regenerative medicine

Author : European Group on Ethics in Science and New Technologies to the European Commission
Publisher : Unknown
Page : 192 pages
File Size : 41,5 Mb
Release : 2004
Category : Banques de sang de cordon ombilical
ISBN : PURD:32754069649204

Get Book

Opinion on the Ethical Aspects of Umbilical Cord Blood Banking by European Group on Ethics in Science and New Technologies to the European Commission Pdf

Author : Karen Ballen
Publisher : Springer
Page : 290 pages
File Size : 45,5 Mb
Release : 2014-08-12
Category : Science
ISBN : 9783319064444

Get Book

Umbilical Cord Blood Banking and Transplantation by Karen Ballen Pdf

This comprehensive volume discusses the current scope of umbilical cord blood transplantation (UCBT), including recent controversies and future developments for improving clinical outcomes. Its twenty chapters introduce new applications in regenerative medicine and discuss the latest scientific, regulatory, clinical and investigational aspects of cord blood banking. Physicians from around the world provide a global collaboration which explores strategies for umbilical cord blood expansion, homing, unit selection, and combining of graft sources to improve patient outcomes. Umbilical Cord Blood Banking and Transplantation also reviews advances in pediatric UCBT for hematologic and non-hematologic disorders as well as immune recovery, which is critical to preventing infection. Finally, it compares UCBT with other graft sources in an attempt to understand the optimal graft source for the individual patient. UCBT is an important option for many patients who need a transplant but do not have a family donor or a matched unrelated donor. The collective and timely knowledge presented here is essential reading for any regenerative medicine investigator, cord blood banker, transplant laboratory scientist or clinical physician interested in improving and expanding the applications of umbilical cord blood.

Author : Ana Colette Maurício
Publisher : BoD – Books on Demand
Page : 260 pages
File Size : 42,7 Mb
Release : 2017-01-11
Category : Science
ISBN : 9789535128656

Get Book

Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine by Ana Colette Maurício Pdf

Umbilical cord blood (UCB) and, more recently, umbilical cord tissue (UCT) have been stored cryopreserved in private and public cord blood and tissue banks worldwide, since the umbilical cord blood was used for the first time in a child with Fanconi anemia with his HLA-identical sibling, following strict guidelines that imply high-quality standards and total rastreability of these units. The hematopoietic stem cells (HSCs) are clinically used in hematopoietic treatments for blood disorders and hemato-oncological diseases. Also, the mesenchymal stem cells (MSCs) isolated from the UCT and UCB, nowadays, can be used as coadjuvants of hematopoietic transplants. In the near future, these stem cells will have a crucial role in regenerative medicine. For this reason, these cells have been tested in several clinical trials and compassive treatments in children and adults, concerning a wide range of pathologies and diseases, for instance, for the treatment of cerebral paralysis. Considering the worldwide availability of UCB and UCT units and the absence of ethical concerns will probably become the best sources for cell-based therapies for hematological and nonhematological pathologies. The UCB will also have a crucial role in neonatology-predictive analysis in the near future.

Author : Institute of Medicine (U.S.). Committee on Establishing a National Cord Blood Stem Cell Bank Program,Emily Ann Meyer,Kathi E. Hanna,Kristine M. Gebbie
Publisher : National Academy Press
Page : 314 pages
File Size : 43,9 Mb
Release : 2005-01-01
Category : Blood banks
ISBN : 0309096448

Get Book

Cord Blood by Institute of Medicine (U.S.). Committee on Establishing a National Cord Blood Stem Cell Bank Program,Emily Ann Meyer,Kathi E. Hanna,Kristine M. Gebbie Pdf

With the potential for self-renewal and differentiation, the possibilities for stem cells are enormous. One specific type of stem cell, the hematopoietic progenitor cell (HPC), which is derived from umbilical cord blood (as well as adult bone marrow and mobilized peripheral blood), holds particular promise. To make the most of these HPCs, the Institute of Medicine was asked to consider the optimal structure for a national cord blood program and to address pertinent issues related to maximizing the potential of stem cell technology. This book examines: The role of cord blood in stem cell transplantation; The current status of blood banks already in existence; The optimal structure for the cord blood program; The current use and utility of cord blood for stem cell transplants; The best way to advance the use of cord blood units and make them available for research.

Author : Atta-ur-Rahman,Shazia Anjum
Publisher : Bentham Science Publishers
Page : 302 pages
File Size : 44,7 Mb
Release : 2016-04-11
Category : Science
ISBN : 9781681081830

Get Book

Frontiers in Stem Cell and Regenerative Medicine Research by Atta-ur-Rahman,Shazia Anjum Pdf

Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as tumors, Alzheimer’s disease and related neurodegenerative diseases may well be addressed employing stem cell therapies and tissue regeneration. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine. The second volume of this series features reviews on several key topics in this field including cardiac regeneration strategies, induced pluripotent stem cell therapeutics, stem cell therapy for peripheral nerve and cutaneous injuries, dental tissue regeneration, the potential of stem cell differentiation into ovarian cells and much more.

Author : Hal E. Broxmeyer
Publisher : American Association of Blood Banks (AABB)
Page : 0 pages
File Size : 55,9 Mb
Release : 2011
Category : Fetal blood
ISBN : 1563953188

Get Book

Cord Blood by Hal E. Broxmeyer Pdf

Author : Nancy E. Snow
Publisher : Unknown
Page : 234 pages
File Size : 50,9 Mb
Release : 2003
Category : Medical
ISBN : UOM:39015061449669

Get Book

Stem Cell Research by Nancy E. Snow Pdf

This volume brings together essays by an internationally distinguished and diverse group of scholars. Contributors thoughtfully explore the ethical, public policy, and scientific implications of embryonic and adult stem cell research. Part one of the book offers a variety of scientific and public policy perspectives, including essays on stem cell plasticity and using umbilical cord blood as an alternative source of pluripotent stem cells. Part two vigorously examines the ethics of stem cell research and considers issues of social justice, morality, and public policy. Scientific alternatives, a natural law perspective regarding federal funding, and a discussion of the possible moral complicity of Catholic researchers are among the distinctive contributions made to the stem cell research debate by this collection. The objective and balanced discussions contained in this volume serve as an accessible introduction to the bioethical questions, issues, and problems surrounding stem cell research.

Author : Zhong Chao Han,Tsuneo A. Takahashi,Zhibo Han,Zongjin Li
Publisher : Springer
Page : 0 pages
File Size : 48,7 Mb
Release : 2019-03-25
Category : Health & Fitness
ISBN : 9811327025

Get Book

Perinatal Stem Cells by Zhong Chao Han,Tsuneo A. Takahashi,Zhibo Han,Zongjin Li Pdf

This book provides a comprehensive introduction to various types of perinatal stem cells. Given their unique regenerative abilities, stem cells offer a promising avenue in the treatment of degenerative diseases or injury. Currently, the limitations of postnatal cell sources and expanding efficiency may limit autologous stem cell therapies. Although embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can be cultured indefinitely ex vivo, and can differentiate into three germ layers, ethical issues, the teratoma formation of ESCs and oncogenic risk of iPSCs are major obstacles to their clinical application. More recently, perinatal stem cells have been isolated from the umbilical cord, Wharton’s Jelly, placenta, amniotic membrane and amniotic fluid, which are normally discarded as medical waste. This book, after describing perinatal stem cells in detail, introduces readers to the various types of perinatal stem cells, addressing their characterization, banking, quality control and stability. Importantly, it also reviews the clinical applications of perinatal stem cells to therapy of diseases. Accordingly, it offers a valuable resource for clinicians, researchers and graduate students alike.

Author : Kuldip S. Sidhu
Publisher : Bentham Science Publishers
Page : 250 pages
File Size : 46,9 Mb
Release : 2012
Category : Science
ISBN : 9781608052899

Get Book

Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials Bench-to-Bedside by Kuldip S. Sidhu Pdf

"Pluripotent stem cells have garnered tremendous interest in recent years, which is primarily driven by the hope of finding a cure for several debilitating human diseases. Cell transplantation (regeneratve medicine) offers considerable therapeutic potentia"

Author : Eric E. Bouhassira
Publisher : SAGE Publications
Page : 1517 pages
File Size : 41,9 Mb
Release : 2015-06-15
Category : Medical
ISBN : 9781483347677

Get Book

The SAGE Encyclopedia of Stem Cell Research by Eric E. Bouhassira Pdf

The SAGE Encyclopedia of Stem Cell Research, Second Edition is filled with new procedures and exciting medical breakthroughs, including executive orders from the Obama administration reversing barriers to research imposed under the Bush administration, court rulings impacting NIH funding of research based on human embryonic stem cells, edicts by the Papacy and other religious leaders, and the first success in cloning human stem cells. Stem cell biology is clearly fueling excitement and potential in traditional areas of developmental biology and in the field of regenerative medicine, where they are believed to hold much promise in addressing any number of intractable medical conditions. This updated second edition encyclopedia will expand on information that was given in the first edition and present more than 270 new and updated articles that explore major topics in ways accessible to nonscientists, thus bringing readers up-to-date with where stem cell biology stands today, including new and evolving ethical, religious, legal, social, and political perspectives. This second edition reference work will serve as a universal resource for all public and academic libraries. It is an excellent foundation for anyone who is interested in the subject area of stem cell biology. Key Features: Reader’s Guide, Further Readings, Cross References, Chronology, Resource Guide, Index A Glossary will elucidate stem cell terminology for the nonscientist Statistics and selected reprints of major journal articles that pertain to milestones achieved in stem cell research Documents from Congressional Hearings on stem cells and cloning Reports to the President’s Council on Bioethics, and more