Umbilical Cord Blood Banking For Clinical Application And Regenerative Medicine

Author : Ana Colette Maurício
Publisher : BoD – Books on Demand
Page : 260 pages
File Size : 51,7 Mb
Release : 2017-01-11
Category : Science
ISBN : 9789535128656

Get Book

Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine by Ana Colette Maurício Pdf

Umbilical cord blood (UCB) and, more recently, umbilical cord tissue (UCT) have been stored cryopreserved in private and public cord blood and tissue banks worldwide, since the umbilical cord blood was used for the first time in a child with Fanconi anemia with his HLA-identical sibling, following strict guidelines that imply high-quality standards and total rastreability of these units. The hematopoietic stem cells (HSCs) are clinically used in hematopoietic treatments for blood disorders and hemato-oncological diseases. Also, the mesenchymal stem cells (MSCs) isolated from the UCT and UCB, nowadays, can be used as coadjuvants of hematopoietic transplants. In the near future, these stem cells will have a crucial role in regenerative medicine. For this reason, these cells have been tested in several clinical trials and compassive treatments in children and adults, concerning a wide range of pathologies and diseases, for instance, for the treatment of cerebral paralysis. Considering the worldwide availability of UCB and UCT units and the absence of ethical concerns will probably become the best sources for cell-based therapies for hematological and nonhematological pathologies. The UCB will also have a crucial role in neonatology-predictive analysis in the near future.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 45,8 Mb
Release : 19??
Category : Electronic
ISBN : 9535128663

Get Book

Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine by Anonim Pdf

Author : Suzanne Kadereit,Gerald Udolph
Publisher : World Scientific Publishing Company
Page : 372 pages
File Size : 40,7 Mb
Release : 2010-12-23
Category : Science
ISBN : 9789813107311

Get Book

Umbilical Cord Blood by Suzanne Kadereit,Gerald Udolph Pdf

Umbilical cord blood, previously discarded, has emerged as a new source of stem cells for hematologic reconstitution, bone marrow failures and other hematologic deficiencies. It has become increasingly clear that umbilical cord tissue contains unique stem cells of great potential for regenerative medicine. Importantly, umbilical cord blood is abundant, can be banked and transported with ease, and thus has an indisputable potential for future regenerative therapies. Driven by a massive interest for regenerative medicine and ethically acceptable stem cell sources, the scientific literature on umbilical cord stem cells has exploded. This book provides a consolidated overview of basic, translational as well as clinical research in academic institutions and industry, on hematopoietic and mesenchymal stem cells contained within umbilical cord tissue, as well as other more recently discovered stem and precursor cells of not yet fully elucidated potential. Although not discussed here, umbilical cord cells have been successfully reprogrammed into pluripotent stem cells (iPS), opening the door for a vast array of applications with this abundant human material likely catapulting cord-derived stem cells to the forefront of cell-based regenerative medicine. Suitable as a primer and reference book for medical fellows and researchers, this book can also be used by students (undergraduate and graduate) as a starting point into the vast literature on stem cells and their potential.

Author : Karen Ballen
Publisher : Springer
Page : 290 pages
File Size : 51,5 Mb
Release : 2014-08-12
Category : Science
ISBN : 9783319064444

Get Book

Umbilical Cord Blood Banking and Transplantation by Karen Ballen Pdf

This comprehensive volume discusses the current scope of umbilical cord blood transplantation (UCBT), including recent controversies and future developments for improving clinical outcomes. Its twenty chapters introduce new applications in regenerative medicine and discuss the latest scientific, regulatory, clinical and investigational aspects of cord blood banking. Physicians from around the world provide a global collaboration which explores strategies for umbilical cord blood expansion, homing, unit selection, and combining of graft sources to improve patient outcomes. Umbilical Cord Blood Banking and Transplantation also reviews advances in pediatric UCBT for hematologic and non-hematologic disorders as well as immune recovery, which is critical to preventing infection. Finally, it compares UCBT with other graft sources in an attempt to understand the optimal graft source for the individual patient. UCBT is an important option for many patients who need a transplant but do not have a family donor or a matched unrelated donor. The collective and timely knowledge presented here is essential reading for any regenerative medicine investigator, cord blood banker, transplant laboratory scientist or clinical physician interested in improving and expanding the applications of umbilical cord blood.

Author : Catherine Stavropoulos-Giokas,Dominique Charron,Cristina Navarrete
Publisher : Elsevier
Page : 399 pages
File Size : 42,7 Mb
Release : 2014-12-03
Category : Medical
ISBN : 9780124078369

Get Book

Cord Blood Stem Cells Medicine by Catherine Stavropoulos-Giokas,Dominique Charron,Cristina Navarrete Pdf

Cord Blood Stem Cells and Regenerative Medicine discusses the current applications for cord blood stem cells and techniques for banking cord blood. Cord blood, blood from the umbilical cord and placenta of an infant, represents an alternate source of stem cells that can be used to treat a myriad of disorders. Cord blood stem cells are being used more frequently and studied more seriously, as evidenced by the explosion of scientific literature on the topic. Currently, clinical and pre-clinical trials are being done in the field, treating conditions as severe as heart failure. Coupled with regenerative medicine, cord blood stem cells potentially carry the future of research and medicine in treating tissue damage, genetic disorders, and degenerative diseases. Read about new applications for cord blood stem cells and new techniques for banking cord blood — the future of regenerative medicine therapy. Comprehensive coverage of the medical application of cord blood stem cells Practical guide for usage of allogeneic and autologous cord blood in regenerative medicine Covers new applications of cord blood stem cells, particularly transplantation and HIV Introduces new technologies for cord blood stem cells and regenerative medicine

Author : Dusko Ilic
Publisher : Springer
Page : 175 pages
File Size : 44,9 Mb
Release : 2014-05-05
Category : Science
ISBN : 9781493905850

Get Book

Stem Cell Banking by Dusko Ilic Pdf

This book exemplifies experience across the globe in banking of cord blood, mesenchymal, embryonic and induced pluripotent stem cells for clinical use from the United States, Canada, the European Union, Switzerland and Japan to Iran, India and Serbia. The concerns are similar regardless of stem cell type or origin. Implementing core values and common standards depend often on specific circumstances of political and economic setting, which makes flexibility as important as systematic planning. Banking of stem cells is not just building a repository and storing samples. The planning, design, construction and maintenance involve multiple skilled professionals. Stem cell banks are points where technology and medicine converge with ethics, laws and regulations. If properly designed and organized, their utilization will have a broad impact not only on the scientific community and medical professionals but also on the general public.

Author : Lisandra Vanostrand
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 40,7 Mb
Release : 2013
Category : Blood banks
ISBN : 1626180725

Get Book

Cord Blood by Lisandra Vanostrand Pdf

In this book, the authors discuss cord blood banks and banking, the ethical issues involved and the risks and benefits. Topics include the virological risks and benefits of cord blood banking; mesenchymal stem cells and their role in regenerative medicine applications; osteogenic potential of human umbilical cord-derived mesenchymal stromal cells; public versus private cord blood banking; CCR5 deficient cord blood as a means of treatment for HIV-1 infection; and the therapeutic use of umbilical cord blood.

Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Establishing a National Cord Blood Stem Cell Bank Program
Publisher : National Academies Press
Page : 335 pages
File Size : 42,8 Mb
Release : 2005-11-26
Category : Medical
ISBN : 9780309095860

Get Book

Cord Blood by Institute of Medicine,Board on Health Sciences Policy,Committee on Establishing a National Cord Blood Stem Cell Bank Program Pdf

With the potential for self-renewal and differentiation, the possibilities for stem cells are enormous. One specific type of stem cell, the hematopoietic progenitor cell (HPC), which is derived from umbilical cord blood (as well as adult bone marrow and mobilized peripheral blood), holds particular promise. To make the most of these HPCs, the Institute of Medicine was asked to consider the optimal structure for a national cord blood program and to address pertinent issues related to maximizing the potential of stem cell technology. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program examines: The role of cord blood in stem cell transplantation The current status of blood banks already in existence The optimal structure for the cord blood program The current use and utility of cord blood for stem cell transplants The best way to advance the use of cord blood units and make them available for research Expert advice from leaders in the fields of economics, public health, medicine, and biostatistics combine to make this very timely and topical book useful to a number of stakeholders.

Author : Niranjan Bhattacharya,Phillip Stubblefield
Publisher : Springer Science & Business Media
Page : 455 pages
File Size : 52,5 Mb
Release : 2010-12-25
Category : Medical
ISBN : 9781848827189

Get Book

Regenerative Medicine Using Pregnancy-Specific Biological Substances by Niranjan Bhattacharya,Phillip Stubblefield Pdf

The proposed book is a holistic review of the clinical use of placental substances, amniotic fluid, the umbilical cord and its contents. It is intended to be a unique presentation of the current advances as well as also discussing the future applications of these substances. Attention is yet to be focused on the widespread clinical use of pregnancy-related biological substances. The aim for this book is to inform clinicians of the use of such materials and increase awareness of their therapeutic benefits. As such, this reference resource will be of great value to hematologists, rheumatologists, cardiologists, transplant technologists and all involved in regenerative medicine.

Author : Institute of Medicine (U.S.). Committee on Establishing a National Cord Blood Stem Cell Bank Program,Emily Ann Meyer,Kathi E. Hanna,Kristine M. Gebbie
Publisher : National Academy Press
Page : 314 pages
File Size : 41,7 Mb
Release : 2005-01-01
Category : Blood banks
ISBN : 0309096448

Get Book

Cord Blood by Institute of Medicine (U.S.). Committee on Establishing a National Cord Blood Stem Cell Bank Program,Emily Ann Meyer,Kathi E. Hanna,Kristine M. Gebbie Pdf

With the potential for self-renewal and differentiation, the possibilities for stem cells are enormous. One specific type of stem cell, the hematopoietic progenitor cell (HPC), which is derived from umbilical cord blood (as well as adult bone marrow and mobilized peripheral blood), holds particular promise. To make the most of these HPCs, the Institute of Medicine was asked to consider the optimal structure for a national cord blood program and to address pertinent issues related to maximizing the potential of stem cell technology. This book examines: The role of cord blood in stem cell transplantation; The current status of blood banks already in existence; The optimal structure for the cord blood program; The current use and utility of cord blood for stem cell transplants; The best way to advance the use of cord blood units and make them available for research.

Author : Phuc Van Pham
Publisher : Springer
Page : 225 pages
File Size : 40,5 Mb
Release : 2016-10-18
Category : Science
ISBN : 9783319400730

Get Book

Stem Cell Processing by Phuc Van Pham Pdf

This invaluable resource delineates procedures for development and use of stem cells in the laboratory and explores the potential for clinical applications. The text discusses mesenchymal stem cell isolation, isolation of adipose derived stem cells, new trends of induced pluripotent stem cells in disease treatment, cord blood banking, future directions of the discussed therapies and much more. The chapters are contributed by preeminent scientists in the field and present a comprehensive picture of stem cell processes, from development in the laboratory to effects and side-effects of clinical application. Stem Cell Processing and the other books in the Stem Cells in Clinical Applications series, edited by Dr. Phuc Van Pham, is essential reading for scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Author : Anthony Atala,Kyle J. Cetrulo,Rouzbeh R. Taghizadeh,Curtis L Cetrulo,Sean Murphy
Publisher : Academic Press
Page : 418 pages
File Size : 46,9 Mb
Release : 2018-06-14
Category : Science
ISBN : 9780128120637

Get Book

Perinatal Stem Cells by Anthony Atala,Kyle J. Cetrulo,Rouzbeh R. Taghizadeh,Curtis L Cetrulo,Sean Murphy Pdf

Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry. Explores current clinical and pre-clinical application of stem cells derived from perinatal sources Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells

Author : Kyle Cetrulo,Curtis L. Cetrulo, Jr.,Rouzbeh R. Taghizadeh
Publisher : John Wiley & Sons
Page : 438 pages
File Size : 46,9 Mb
Release : 2013-02-04
Category : Science
ISBN : 9781118497944

Get Book

Perinatal Stem Cells by Kyle Cetrulo,Curtis L. Cetrulo, Jr.,Rouzbeh R. Taghizadeh Pdf

Perinatal Stem Cells, 2nd Edition builds on the first edition to provide an updated tutorial on perinatal stem cells, including stem cells harvested from the amniotic fluid, placenta, maternal blood supply, umbilical cord and Wharton's Jelly. As in the first edition, coverage includes the underlying biology of each of the sources of pregnancy related stem cells, cell culture, and potential therapeutic uses, as well as insights on the impact of these stem cells from obstetricians and gynecologists, cardiologists, hematologists, tissue engineers, and cord blood bankers. Normally discarded as medical waste, perinatal stem cells offer a powerful therapeutic tool box alternative to the controversial embryonic stem cells. Since publication of the first edition, a burgeoning commerical industry has developed around various sources of perinatal cells, and the second edition now includes an overview of this growing industry. With contributions from some of the top academic stem cell laboratories in the United States as well as new chapters from international stem cell scientists, Perinatal Stem Cells presents an update on the cutting-edge research in the field while maintaining its signature clinical focus.

Author : Niranjan Bhattacharya,Phillip Stubblefield
Publisher : Springer Science & Business Media
Page : 385 pages
File Size : 46,6 Mb
Release : 2009-04-21
Category : Medical
ISBN : 9781848001671

Get Book

Frontiers of Cord Blood Science by Niranjan Bhattacharya,Phillip Stubblefield Pdf

Cord blood is a significant source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. Cord blood is also an alternative to embryos as a source of tissue for regenerative medicine. Cells from cord blood have been shown to transdifferentiate into nonhematopoietic cells, including those of the brain, heart, liver, pancreas, bone, and cartilage, in tissue culture and in animal systems. Recently it has been demonstrated that both cardiac and glial cell differentiation of cord blood donor cells occurred in recipients of unrelated donor cord blood transplantation as part of a treatment regime for Krabbe disease and Sanfilippo syndrome. These observations raise the possibility that cord blood may serve as a source of cells to facilitate tissue repair and regeneration in the future. CD34 stem cell-rich umbilical cord whole blood transfusion has the potential to have an immediate benefit of better tissue oxygenation with an additional delayed benefit of possible engraftment of umbilical cord stem cells.

Author : Zhong Chao Han,Tsuneo A. Takahashi,Zhibo Han,Zongjin Li
Publisher : Springer
Page : 173 pages
File Size : 45,7 Mb
Release : 2019-03-06
Category : Health & Fitness
ISBN : 9789811327032

Get Book

Perinatal Stem Cells by Zhong Chao Han,Tsuneo A. Takahashi,Zhibo Han,Zongjin Li Pdf

This book provides a comprehensive introduction to various types of perinatal stem cells. Given their unique regenerative abilities, stem cells offer a promising avenue in the treatment of degenerative diseases or injury. Currently, the limitations of postnatal cell sources and expanding efficiency may limit autologous stem cell therapies. Although embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can be cultured indefinitely ex vivo, and can differentiate into three germ layers, ethical issues, the teratoma formation of ESCs and oncogenic risk of iPSCs are major obstacles to their clinical application. More recently, perinatal stem cells have been isolated from the umbilical cord, Wharton’s Jelly, placenta, amniotic membrane and amniotic fluid, which are normally discarded as medical waste. This book, after describing perinatal stem cells in detail, introduces readers to the various types of perinatal stem cells, addressing their characterization, banking, quality control and stability. Importantly, it also reviews the clinical applications of perinatal stem cells to therapy of diseases. Accordingly, it offers a valuable resource for clinicians, researchers and graduate students alike.