Function Of The Kinesin Like Motor Protein Cho1 In Cytokinesis Of Mammalian Cells

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Kinesins and Cancer

Author : Frank Kozielski, FSB
Publisher : Springer
Page : 276 pages
File Size : 44,6 Mb
Release : 2015-03-02
Category : Medical
ISBN : 9789401797320

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Kinesins and Cancer by Frank Kozielski, FSB Pdf

This interdisciplinary volume collates research work on kinesins and cancer. Authors attempt to validate members of the kinesin superfamily as potential targets for drug development in cancer chemotherapy. The work begins by highlighting the importance of kinesins, summarising current knowledge and how they are shown to be crucial for mitosis. Chapters go on to explore how this family of proteins are emerging as a novel target for chemotherapeutic intervention and drug development. Readers will learn how kinesins travel along microtubules to fulfill their many roles in intracellular transport or cell division. Several compounds that inhibit two mitotic kinesins (called Eg5 and CENP-E) have entered Phase I and II clinical trials and are explored in these chapters. Additional mitotic kinesins are currently being validated as drug targets, raising the possibility that the repertoire of kinesin-based drug targets may expand in the future. The book is suitable as a reference standard for the field of kinesins and cancer. It will interest those in academia and pharmaceutical companies, and anyone with an interest in the medical relevance of these proteins, which cutting edge methodologies are now enabling us to understand in astonishing detail.

Dynamics of Cell Division

Author : Sharyn A. Endow,David M. Glover
Publisher : OUP Oxford
Page : 346 pages
File Size : 50,5 Mb
Release : 1998-10-01
Category : Science
ISBN : 9780191565779

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Dynamics of Cell Division by Sharyn A. Endow,David M. Glover Pdf

This volume focuses on the structural aspects of cell division - concentrating on both nuclear division (meiosis and mitosis) and cytoplasmic division (cytokinesis). Written as a companion volume to the earlier book in the series - Cell Cycle Control, this book provides an up-to-date account of developments in this exciting area of cell biology.

Dissertation Abstracts International

Author : Anonim
Publisher : Unknown
Page : 858 pages
File Size : 42,7 Mb
Release : 2004
Category : Dissertations, Academic
ISBN : UOM:39015057953351

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Dissertation Abstracts International by Anonim Pdf

Cytokinesis in Animal Cells

Author : R. Rappaport
Publisher : Cambridge University Press
Page : 401 pages
File Size : 41,8 Mb
Release : 1996-10-28
Category : Medical
ISBN : 9780521401739

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Cytokinesis in Animal Cells by R. Rappaport Pdf

This book traces the history of the major ideas and gives an account of our current knowledge of cytokinesis.

Molecular Biology of the Cell

Author : Anonim
Publisher : Unknown
Page : 584 pages
File Size : 42,8 Mb
Release : 2005
Category : Cells
ISBN : UOM:39015059029374

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Molecular Biology of the Cell by Anonim Pdf

Polyploidization and Cancer

Author : Randy Y.C. Poon
Publisher : Springer Science & Business Media
Page : 157 pages
File Size : 48,7 Mb
Release : 2011-01-11
Category : Medical
ISBN : 9781441961990

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Polyploidization and Cancer by Randy Y.C. Poon Pdf

Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.

Molecular Motors

Author : Manfred Schliwa
Publisher : John Wiley & Sons
Page : 604 pages
File Size : 48,8 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527605651

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Molecular Motors by Manfred Schliwa Pdf

The latest knowledge on molecular motors is vital for the understanding of a wide range of biological and medical topics: cell motility, organelle movement, virus transport, developmental asymmetry, myopathies, and sensory defects are all related to the function or malfunction of these minute molecular machines. Since there is a vast amount of information on motor mechanisms and potential biomedical and nanobiotechnological applications, this handbook fulfills the need for a collection of current research results on the functionality, regulation, and interactions of cytoskeletal, DNA, and rotary motors. Here, leading experts present a concise insight, ranging from atomic structure, biochemistry, and biophysics to cell biology, developmental biology and pathology. Basic principles and applications make this book a valuable reference tool for researchers, professionals, and clinicians alike - all set to become a "classic" in the years to come.

The Journal of Cell Biology

Author : Anonim
Publisher : Unknown
Page : 572 pages
File Size : 41,5 Mb
Release : 2008
Category : Cytology
ISBN : UOM:39015072617783

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The Journal of Cell Biology by Anonim Pdf

No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-

Journal of Cell Science

Author : Anonim
Publisher : Unknown
Page : 832 pages
File Size : 51,9 Mb
Release : 2004
Category : Cytology
ISBN : UOM:39015059066343

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Journal of Cell Science by Anonim Pdf

International Review of Cytology

Author : Kwang W. Jeon
Publisher : Elsevier
Page : 336 pages
File Size : 52,6 Mb
Release : 2004-12-07
Category : Science
ISBN : 9780080495682

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International Review of Cytology by Kwang W. Jeon Pdf

International Review of Cytology presents current advances and comprehensive reviews in cell biology – both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume address biosynthesis and alternate targeting of the lysosomal cysteine protesase cathepsin L; microtubule-associated proteins and their essential roles during mitosis; molecular and functional analysis of the dictyostelium centrosome; polytene chromosomes; and insect basic leucine zipper proteins and their role in cyclic AMP dependent regulation of gene expression.

Cytoskeleton and Human Disease

Author : Maria Kavallaris
Publisher : Springer Science & Business Media
Page : 463 pages
File Size : 49,5 Mb
Release : 2012-04-23
Category : Science
ISBN : 9781617797880

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Cytoskeleton and Human Disease by Maria Kavallaris Pdf

The cytoskeleton is comprised of a variety of specialized proteins, and is a dynamic structure that is involved in the majority of key cellular events. There is increasing interest in the role of the cytoskeleton in human disease. This volume brings together human disease states where cytoskeletal disruptions are driving disease. Our emerging understanding of the molecular and cellular events that drive cytoskeletal mediated diseases including cancer, heart disease, myopathies and skin disorders, are also helping shape targeted therapeutic approaches to treating these diseases.

Colloquium on Molecular Kinesis in Cellular Function and Plasticity

Author : Henri Tiedge,Floyd E. Bloom
Publisher : National Academies Press
Page : 120 pages
File Size : 41,8 Mb
Release : 2002
Category : Biological transport, Active
ISBN : 0309742587

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Colloquium on Molecular Kinesis in Cellular Function and Plasticity by Henri Tiedge,Floyd E. Bloom Pdf

Concerning the Origin of Malignant Tumours

Author : Theodor Boveri
Publisher : Unknown
Page : 108 pages
File Size : 49,9 Mb
Release : 2008
Category : Medical
ISBN : STANFORD:36105131699378

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Concerning the Origin of Malignant Tumours by Theodor Boveri Pdf

An English translation of Boveri's famous monograph which was first published in Germany in 1914. Written almost a hundred years ago, Theodor Boveri's Zur Frage der Entstehung maligner Tumoren has had a momentous impact on cancer research. In it he argues that malignancy arises as a consequence of chromosomal abnormalities and that multiplication is an inherent property of cells. With astonishing prescience, Boveri predicts in this monograph the existence of tumor suppressor mechanisms and is perhaps the first to suggest that hereditary factors (genes) are linearly arranged along chromosomes. This new translation by Sir Henry Harris, Regius Professor of Medicine Emeritus at Oxford University and former Editor-in-Chief of Journal of Cell Science, includes extensive annotations in which he discusses the relevance of Boveri's views today. It is essential reading for all cancer researchers, as well as those interested in the history of cytogenetics and cell biology.