Functionalised Cardiovascular Stents

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Functionalised Cardiovascular Stents

Author : Gerard Wall,Halina Podbielska,Magdalena Wawrzynska
Publisher : Woodhead Publishing
Page : 368 pages
File Size : 46,7 Mb
Release : 2018-02-06
Category : Medical
ISBN : 9780081004982

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Functionalised Cardiovascular Stents by Gerard Wall,Halina Podbielska,Magdalena Wawrzynska Pdf

Cardiovascular disease is a major cause of mortality in the western world and about half of these deaths are caused by coronary artery disease. One of the most commonly used interventions to treat arterial blockages is to deploy an arterial stent to keep the vessel open. Traditionally, some cardiovascular stents have been associated with serious side-effects, such as thrombosis. This book describes the fundamentals of cardiovascular stents, technologies to functionalize their surfaces and the market status of these important implants. The chapters provide specific focus on the production and evolution of cardiovascular stents, providing essential knowledge for researchers on advances in the field and knowledge of how cardiovascular stents are currently being "functionalized" in order to improve their biocompatibility and minimize negative outcomes in vivo. Provides a specific focus on cardiovascular stents Includes a range of topics covering the fundamentals, surface modification and biofunctionalization Provides essential knowledge for researchers on advances in the field

Bioresorbable Scaffolds

Author : Yoshinobu Onuma,Patrick W.J.C. Serruys
Publisher : CRC Press
Page : 1076 pages
File Size : 40,7 Mb
Release : 2017-10-02
Category : Medical
ISBN : 9781498779784

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Bioresorbable Scaffolds by Yoshinobu Onuma,Patrick W.J.C. Serruys Pdf

This book focuses on the coronary bioresorbable scaffold, a new interventional treatment for coronary artery disease, differentiated from a permanent metallic stent. The book provides an overview of the technology including non-clinical studies and clinical evidences in order to help clinicians understand the appropriate application of the technology and the optimal techniques of implantation. It covers the basics of bioresorbable scaffolds; bench test results; preclinical studies; clinical evidences; and tips and tricks of implantation.

Oxidative Stress and Vascular Disease

Author : John F. Keaney Jr.
Publisher : Springer Science & Business Media
Page : 373 pages
File Size : 52,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461546498

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Oxidative Stress and Vascular Disease by John F. Keaney Jr. Pdf

One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.

Coatings for Biomedical Applications

Author : Mike Driver
Publisher : Elsevier
Page : 376 pages
File Size : 41,7 Mb
Release : 2012-02-22
Category : Science
ISBN : 9780857093677

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Coatings for Biomedical Applications by Mike Driver Pdf

The biomaterials sector is rapidly expanding and significant advances have been made in the technology of biomedical coatings and materials, which provide a means to improve the wear of joints, change the biological interaction between implant and host and combine the properties of various materials to improve device performance. Coatings for biomedical applications provides an extensive review of coating types and surface modifications for biomedical applications. The first part of the book explores a range of coating types and their biomedical applications. Chapters look at hydrophilic, mineral and pyrolytic carbon coatings in and ex vivo orthopaedic applications and finally at surface modification and preparation techniques. Part two presents case studies of orthopaedic and ophthalmic coatings, and biomedical applications including vascular stents, cardiopulomonary by-pass equipment and ventricular assist devices. With its clear structure and comprehensive review of research, Coatings for biomedical applications is a valuable resource to researchers, scientists and engineers in the biomedical industry. It will also benefit anyone studying or working within the biomedical sector, particularly those specialising in biomedical coatings. Provides an extensive review of coating types and surface modifications for biomedical applications Chapters look at hydrophilic coatings for biomedical applications in and ex vivo, mineral coatings for orthopaedic applications, pyrolytic carbon coating and other commonly-used biomedical coatings Presents case studies of orthopaedic and ophthalmic coatings, and biomedical applications including vascular stents, cardiopulomonary by-pass equipment and ventricular assist devices

Biomaterials and Devices for the Circulatory System

Author : Terence Gourlay,Richard A Black
Publisher : Woodhead Publishing
Page : 0 pages
File Size : 52,9 Mb
Release : 2016-08-19
Category : Medical
ISBN : 0081014686

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Biomaterials and Devices for the Circulatory System by Terence Gourlay,Richard A Black Pdf

Cardiovascular disease is one of the leading causes of death in the world today. Thanks to major advances in circulatory biomaterials and medical devices over the past few decades, many complications of this prevalent disease can be managed with great success for prolonged periods. Biomaterials and devices for the circulatory system reviews the latest developments in this important field and how they can be used to improve the success and safety in this industry. Part one discusses physiological responses to biomaterials with chapters on tissue response, blood interface and biocompatibility. Part two then reviews clinical applications including developments in valve technology, percutaneous valve replacement, bypass technologies and cardiovascular stents. Part three covers future developments in the field with topics such as nanomedicine, cardiac restoration therapy, biosensor technology in the treatment of cardiovascular disease and vascular tissue engineering. With its distinguished editors and international team of contributors Biomaterials and devices for the circulatory system is a vital reference for those concerned with bioengineering, medical devices and clinicians within this critical field.

Recent Advances in Mechanical Engineering

Author : Anil Kumar,Amit Pal,Surendra Singh Kachhwaha,Prashant Kumar Jain
Publisher : Springer Nature
Page : 1134 pages
File Size : 42,8 Mb
Release : 2021-05-25
Category : Science
ISBN : 9789811596780

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Recent Advances in Mechanical Engineering by Anil Kumar,Amit Pal,Surendra Singh Kachhwaha,Prashant Kumar Jain Pdf

This book presents the select proceedings of the second International Conference on Recent Advances in Mechanical Engineering (RAME 2020). The topics covered include aerodynamics and fluid mechanics, automation, automotive engineering, composites, ceramics and polymers processing, computational mechanics, failure and fracture mechanics, friction, tribology and surface engineering, heating and ventilation, air conditioning system, industrial engineering, IC engines, turbomachinery and alternative fuels, machinability and formability of materials, mechanisms and machines, metrology and computer-aided inspection, micro- and nano-mechanics, modelling, simulation and optimization, product design and development, rapid manufacturing technologies and prototyping, solid mechanics and structural mechanics, thermodynamics and heat transfer, traditional and non-traditional machining processes, vibration and acoustics. The book also discusses various energy-efficient renewable and non-renewable resources and technologies, strategies and technologies for sustainable development and energy & environmental interaction. The book is a valuable reference for beginners, researchers, and professionals interested in sustainable construction and allied fields.

Tissue-Engineered Vascular Grafts

Author : Beat H. Walpoth,Helga Bergmeister,Gary L. Bowlin,Deling Kong,Joris I. Rotmans,Peter Zilla
Publisher : Springer
Page : 0 pages
File Size : 40,6 Mb
Release : 2020-08-21
Category : Science
ISBN : 3030053350

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Tissue-Engineered Vascular Grafts by Beat H. Walpoth,Helga Bergmeister,Gary L. Bowlin,Deling Kong,Joris I. Rotmans,Peter Zilla Pdf

Cardiovascular diseases are still the leading cause of death in developed countries. Revascularization procedures such as coronary artery and peripheral bypass grafts, as well as access surgery represent a 2$ billion market yearly for the US alone. Despite intense research over many decades, no clinically suitable, shelf-ready, synthetic, vascular, small-caliber graft exists. There is therefore still a quest for such a clinical vascular prosthesis for surgical revascularization procedures and access surgery. Many approaches have been tried and are currently under investigation with promising results. These range from acellular and cell-based, stable or bio-degradable, synthetic scaffolds to biological or decellularized grafts, not forgetting self-assembly technologies for in vitro or in vivo VTE. All these approaches can be further enhanced by functionalization, e.g. with growth factors and drug elution. This updatable book aims to cover all the relevant aspects of Vascular Tissue Engineering (VTE) and novel alternatives to develop vascular grafts for clinical applications. The chapters in this book cover different aspects of manufacturing scaffolds with various polymers, mechanical characteristics, degradation rates, decellularization techniques, cell sheet assembly, 3-D printing and autologous mandril-based VTE. All the necessary in vitro tests such as biocompatibility and thrombogenicity are reviewed. Pre-clinical assessment of in vivo experimental models include patency, compliance, intimal hyperplasia, inflammatory reaction, cellular ingrowth and remodeling. Finally, early clinical trials will be periodically updated regarding results, regulatory aspects and post-marketing quality assessment. Furthermore, the reader should get an insight into various approaches, technologies and methods to better understand the complexity of blood surface and cell interactions in VTE. Translational research has yielded early human applications clearly showing the enormous need of research in the field to provide better solutions for our patients and this continuously updated book will hopefully become a reference in the field for life sciences.

Plasma Processes and Polymers

Author : Riccardo d'Agostino,Pietro Favia,Christian Oehr,Michael R. Wertheimer
Publisher : John Wiley & Sons
Page : 545 pages
File Size : 53,7 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527605576

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Plasma Processes and Polymers by Riccardo d'Agostino,Pietro Favia,Christian Oehr,Michael R. Wertheimer Pdf

This volume compiles essential contributions to the most innovative fields of Plasma Processes and Polymers. High-quality contributions cover the fields of plasma deposition, plasma treatment of polymers and other organic compounds, plasma processes under partial vacuum and at atmospheric pressure, biomedical, textile, automotive, and optical applications as well as surface treatment of bulk materials, clusters, particles and powders. This unique collection of refereed papers is based on the best contributions presented at the 16th International Symposium on Plasma Chemistry in Taormina, Italy (ISPC-16, June 2003). A high class reference of relevance to a large audience in plasma community as well as in the area of its industrial applications.

Chemistry of Biologically Potent Natural Products and Synthetic Compounds

Author : Shahid Ul-Islam,Javid Ahmad Banday
Publisher : John Wiley & Sons
Page : 434 pages
File Size : 46,8 Mb
Release : 2021-06-29
Category : Science
ISBN : 9781119640349

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Chemistry of Biologically Potent Natural Products and Synthetic Compounds by Shahid Ul-Islam,Javid Ahmad Banday Pdf

In view of their promising biological and pharmaceutical activities, natural product inspired and heterocyclic compounds have recently gained a reputation in the field of medicinal chemistry. Over the past decades, intensive research efforts have been ongoing to understand the synthesis, biochemistry and engineering involved in their preparation and action mechanisms. Several novel natural product derivatives, heterocyclic and other synthetic compounds, have been reported to have shown interesting biological activities including anticancer, antimicrobial, anti-inflammatory, anti-glycemic, anti-allergy and antiviral etc. Chemistry of Biologically Potent Natural Products and Synthetic Compounds provides up-to-date information on new developments and most recent medicinal applications of the natural products and derivatives, as well as the chemistry and synthesis of heterocyclic and other related compounds.

Shape Memory Polymers

Author : Jinlian Hu
Publisher : Smithers Rapra
Page : 326 pages
File Size : 41,5 Mb
Release : 2014-05-27
Category : Science
ISBN : 9781909030336

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Shape Memory Polymers by Jinlian Hu Pdf

Shape-memory polymers (SMP) are a unique branch of the smart materials family which are capable of changing shape on-demand upon exposure to external stimulus. The discovery of SMP made a significant breakthrough in the developments of novel smart materials for a variety of engineering applications, superseded the traditional materials, and also influenced the current methods of product designing. This book provides the latest advanced information of on-going research domains of SMP. This will certainly enlighten the reader to the achievements and tremendous potentials of SMP. The basic fundamentals of SMP, including shape-memory mechanisms and mechanics are described. This will aid reader to become more familiar with SMP and the basic concepts, thus guiding them in undergoing independent research in the SMP field. The book also provides the reader with associated challenges and existing application problems of SMP. This could assist the reader to focus more on these issues and further exploit their knowledge to look for innovative solutions. Future outlooks of SMP research are discussed as well. This book should prove to be extremely useful for academics, R&D managers, researcher scientists, engineers, and all others related to the SMP research.

Piezoelectric Nanomaterials for Biomedical Applications

Author : Gianni Ciofani,Arianna Menciassi
Publisher : Springer Science & Business Media
Page : 250 pages
File Size : 47,6 Mb
Release : 2012-03-31
Category : Technology & Engineering
ISBN : 9783642280443

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Piezoelectric Nanomaterials for Biomedical Applications by Gianni Ciofani,Arianna Menciassi Pdf

Nanoscale structures and materials have been explored in many biological applications because of their novel and impressive physical and chemical properties. Such properties allow remarkable opportunities to study and interact with complex biological processes. This book analyses the state of the art of piezoelectric nanomaterials and introduces their applications in the biomedical field. Despite their impressive potentials, piezoelectric materials have not yet received significant attention for bio-applications. This book shows that the exploitation of piezoelectric nanoparticles in nanomedicine is possible and realistic, and their impressive physical properties can be useful for several applications, ranging from sensors and transducers for the detection of biomolecules to “sensible” substrates for tissue engineering or cell stimulation.

Polymer Synthesis: Theory and Practice

Author : Dietrich Braun,Harald Cherdron,Matthias Rehahn,Helmut Ritter,Brigitte Voit
Publisher : Springer Science & Business Media
Page : 401 pages
File Size : 49,9 Mb
Release : 2006-10-14
Category : Science
ISBN : 9783540268901

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Polymer Synthesis: Theory and Practice by Dietrich Braun,Harald Cherdron,Matthias Rehahn,Helmut Ritter,Brigitte Voit Pdf

The first English edition of this book was pubUshed in 1971 with the late Prof. Dr. Werner Kern as coauthor. In 1997, for the preparation of the third edition, Prof. Dr. Helmut Ritter joined the team of authors and in 2001 Prof. Dr. Brigitte Voit and Prof. Dr. Matthias Rehahn complemented this team. The change in authors has not altered the basic concept of this 4th edition: again we were not aimed at compiling a comprehensive collection of recipes. In stead, we attempted to reach a broader description of the general methods and techniques for the synthesis, modification, and characterization of macromo- cules, supplemented by 105 selected and detailed experiments and by sufficient theoretical treatment so that no additional textbook be needed in order to under stand the experiments. In addition to the preparative aspects we have also tried to give the reader an impression of the relation of chemical structure and mor phology of polymers to their properties, as well as of areas of their application.

Biomaterials and Tissue Engineering in Urology

Author : J Denstedt,A Atala
Publisher : Elsevier
Page : 592 pages
File Size : 47,9 Mb
Release : 2009-04-29
Category : Technology & Engineering
ISBN : 9781845696375

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Biomaterials and Tissue Engineering in Urology by J Denstedt,A Atala Pdf

Urology is the branch of medicine dealing with disorders or diseases of the male genitor-urinary tract and the female urinary tract. This important book summarises the wealth of recent research on the use of biomaterials and tissue engineering to treat urological disorders. Part one reviews the fundamentals with chapters on such topics as biofilms and encrustation formation. Part two then discusses recent advances in biomaterials and design of urological devices such as metal ureteral stents, self-lubricating catheter materials and penile implants. Chapters in Part three address urological tissue engineering with coverage of themes such as artificial and natural biomaterials, nano-technology and placental stem cells for tissue engineering the regeneration of urological tissue and organs. With its eminent editors and international team of contributors, Biomaterials and tissue engineering in urology is an invaluable resource to researchers of urological biomaterials, devices and regenerative medicine in both industry and academia, as well as an important reference for medical practitioners. Provides a comprehensive review of biomaterials and tissue engineering in urology Explores the fundamentals of urology, focusing on biofilms and encrustation and formation Discusses recent advances in biomaterials and the design of urological devices, catheters and stents

Polyphosphazenes for Biomedical Applications

Author : K. A. Andrianov
Publisher : John Wiley & Sons
Page : 480 pages
File Size : 47,8 Mb
Release : 2009-07-28
Category : Science
ISBN : 9780470478875

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Polyphosphazenes for Biomedical Applications by K. A. Andrianov Pdf

Brings together, analyzes, and contextualizes the latest findings and practical applications Polyphosphazenes, an emerging class of polymers, include macromolecules, which have been proven to be biocompatible, biodegradable, and bioactive. Their unprecedented structural diversity and unique properties make them suitable as vaccine adjuvants, microencapsulating agents, biodegradable materials, scaffolds for tissue engineering, biocompatible coatings, and carriers for gene delivery. Polyphosphazenes for Biomedical Applications offers a thorough review of polyphosphazene research findings in the life sciences, chemistry, and chemical engineering. It emphasizes biomedical applications as well as recent advances in polyphosphazene development such as high-throughput discovery and the latest controlled methods of synthesis. The book brings together, analyzes, and contextualizes a wealth of knowledge that previously could only be found scattered throughout the scientific literature. Following two introductory chapters, the book reviews: Vaccine delivery and immunomodulation Biomaterials Drug delivery systems Biodetection Well-defined polyphosphazenes: synthetic aspects and novel molecular architectures All the chapters have been written by leading researchers in the field. Editor Alexander Andrianov, who has led the effort to commercialize polyphosphazenes for biomedical applications, has carefully reviewed and edited all chapters to ensure readability, accuracy, and thoroughness. Polyphosphazenes for Biomedical Applications is not only intended for researchers working in polyphosphazene chemistry, but also for all researchers seeking solutions to problems arising in the areas of biomaterials, drug delivery systems, and controlled release formulations.

Principles of Regenerative Biology

Author : Bruce M. Carlson
Publisher : Elsevier
Page : 400 pages
File Size : 50,9 Mb
Release : 2011-10-10
Category : Science
ISBN : 0080477968

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Principles of Regenerative Biology by Bruce M. Carlson Pdf

With the explosion of knowledge from molecular biology and the burgeoning interest in generating or regenerating tissues or organs through various bioengineering or stem cell approaches, many scientists and students have shown a renewed interest in the phenomenon of regeneration. Because relatively few have had the luxury of being able to approach the phenomenon of regeneration from a broad biological perspective, Dr. Carlson has produced a book that outlines the fundamental principles of regeneration biology. Subject matters focus principally on regeneration in vertebrate systems, but also invertebrate regeneration. In order to manipulate regenerative processes, it is important to understand the underlying principles of regeneration. Principles of Regnerative Biology is the key introductory reference for all developmental biologists, geneticists, and tissue and stem cell researchers. Creates a general understanding of one of the most fascinating and complex phenomena in biology Discusses the ability and diversity of regeneration in various organisms Explains the history and origins of cells in regenerating systems Includes information on stem cells and its important role in regeneration