Fundamentals Of Epigenetics

Author : Gurbachan S. Miglani
Publisher : I K International Pvt Ltd
Page : 1048 pages
File Size : 48,5 Mb
Release : 2023-05-23
Category : Fiction
ISBN : 9789390620975

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Fundamentals of Epigenetics by Gurbachan S. Miglani Pdf

Fundamentals of Epigenetics provides concise yet complete information on the many aspects of the basic and most recent concepts in epigenetics, a branch of life science that deals with the mechanisms such as DNA modifications, histone modifications, RNA modifications, small and long non-coding RNAs, chromatin remodeling, which are involved in epigenetic control of gene expression without involving variations in DNA sequences. These regulatory mechanisms lead to phenotypic variations. These epigenetic mechanisms can be exploited for crop improvement and cure of human diseases. This book is primarily designed for undergraduate and graduate level students studying epigenetics in conventional, agricultural and medicinal universities. Teachers and researchers in any discipline of life sciences, agricultural sciences, medicine, and biotechnology, molecular epigenetics and biotechnology will also find it useful as a reference book.

Author : Jerry L. Workman,Susan M. Abmayr
Publisher : Springer Science & Business Media
Page : 594 pages
File Size : 41,5 Mb
Release : 2013-12-04
Category : Medical
ISBN : 9781461486244

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Fundamentals of Chromatin by Jerry L. Workman,Susan M. Abmayr Pdf

​​​​​​​​​​​​​While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamentals of chromatin. ​Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. Its primary function is to package DNA to fit into the cell, to strengthen the DNA to prevent damage, to allow mitosis and meiosis, and to control the expression of genes and DNA replication. The audience for this book is mainly newly established scientists ​and graduate students. Rather than going into the more specific areas of recent research on chromatin the chapters in this book give a strong, updated groundwork about the topic. Some the fundamentals that this book will cover include the structure of chromatin and biochemistry and the enzyme complexes that manage it.

Author : June Corder
Publisher : Unknown
Page : 51 pages
File Size : 52,7 Mb
Release : 2021-08-21
Category : Electronic
ISBN : 9798461522858

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Epigenetics for Beginners by June Corder Pdf

Your genes play an important role in your health, but so do your behaviors and environment, such as what you eat and how physically active you are. Epigenetics is the study of how your behaviors and environment can cause changes that affect the way your genes work. Unlike genetic changes, epigenetic changes are reversible and do not change your DNA sequence, but they can change how your body reads a DNA sequence. Gene expression refers to how often or when proteins are created from the instructions within your genes. While genetic changes can alter which protein is made, epigenetic changes affect gene expression to turn genes "on" and "off." Since your environment and behaviors, such as diet and exercise, can result in epigenetic changes, it is easy to see the connection between your genes and your behaviors and environment. Researchers studying the microscopic roundworm Caenorhabditis elegans recently discovered a set of mutations that extended the worms' normal 2-3 week lifespan by up to 30%. This was exciting, not least because discoveries in animals such as roundworms can sometimes help us understand processes like ageing in humans. This was not the end of the story though, as the researchers found that the descendants of the long-lived roundworms could also live longer than normal, even if they only inherited the non-mutated version of the genes from their parents. This doesn't seem to make sense at first; surely characteristics such as hair colour, height and even how long we or a microscopic worm could potentially live are carried in the DNA sequence of the genes that we inherit from our parents. So how can we solve the conundrum of how the roundworms inherited the long lived characteristic, without inheriting the DNA sequence that initially caused it? The answer is epigenetics. GET YOUR COPY TODAY BY SCROLLING UP AND CLICKING BUY NOW TO GET YOUR COPY TODAY

Author : Raúl Alvarez-Venegas,Clelia De la Peña,Juan Armando Casas-Mollano
Publisher : Springer
Page : 152 pages
File Size : 53,7 Mb
Release : 2014-07-22
Category : Science
ISBN : 9783319079714

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Epigenetics in Plants of Agronomic Importance: Fundamentals and Applications by Raúl Alvarez-Venegas,Clelia De la Peña,Juan Armando Casas-Mollano Pdf

Over the past decades, chromatin remodelling has emerged as an important regulator of gene expression and plant defense. This book provides a detailed understanding of the epigenetic mechanisms involved in plants of agronomic importance. The information presented here is significant because it is expected to provide the knowledge needed to develop in the future treatments to manipulate and selectively activate/inhibit proteins and metabolic pathways to counter pathogens, to treat important diseases and to increase crop productivity. New approaches of this kind and the development of new technologies will certainly increase our knowledge of currently known post-translational modifications and facilitate the understanding of their roles in, for example, host-pathogen interactions and crop productivity. Furthermore, we provide important insight on how the plant epigenome changes in response to developmental or environmental stimuli, how chromatin modifications are established and maintained, to which degree they are used throughout the genome, and how chromatin modifications influence each another.

Author : Augustus Drew
Publisher : Foster Academics
Page : 0 pages
File Size : 43,8 Mb
Release : 2023-09-19
Category : Medical
ISBN : 164646608X

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Essentials of Epigenetics by Augustus Drew Pdf

Epigenetics refers to a field of study concerned with the changes in DNA that do not involve modifications to the underlying sequence. It entails genetic control by factors other than a person's DNA sequence. Epigenetic modifications can activate or deactivate genes and determine which proteins are transcribed. The modifications have various effects on gene expression. The types of epigenetic changes include non-coding RNA, DNA methylation and histone modification. Epigenetic patterns may be affected by a number of lifestyle factors including tobacco smoking, food, exposure to environmental toxins, working on night shifts, obesity, alcohol consumption, psychological stress and physical activity. Epigenetics is a developing area of scientific study that demonstrates how environmental influences such as children's experiences affect the expression of their genes. This book unravels the recent studies in the field of epigenetics. It presents researches and studies performed by experts across the globe. The readers would gain knowledge that would broaden their perspective in this area of study.

Author : Mason Hartley
Publisher : Bookademy
Page : 29 pages
File Size : 53,8 Mb
Release : 2024-06-27
Category : Science
ISBN : 8210379456XXX

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The Science of Epigenetics by Mason Hartley Pdf

"The Science of Epigenetics - A Comprehensive Overview" provides a comprehensive exploration of the fascinating field of epigenetics. From the fundamentals of epigenetic mechanisms to their role in development, disease, and aging, this book delves into the intricate connections between our genes and the environment. With a focus on the latest research and applications, this book offers a valuable resource for understanding the profound impact of epigenetics on human health and the potential for precision medicine interventions.

Author : Raúl Alvarez-Venegas,Clelia De-la-Peña,Juan Armando Casas-Mollano
Publisher : Springer
Page : 415 pages
File Size : 45,6 Mb
Release : 2019-04-26
Category : Science
ISBN : 9783030147600

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Epigenetics in Plants of Agronomic Importance: Fundamentals and Applications by Raúl Alvarez-Venegas,Clelia De-la-Peña,Juan Armando Casas-Mollano Pdf

Over the past few decades, chromatin modulation has emerged as an important regulator of gene expression. This second edition provides detailed information on the epigenetic mechanisms in plants, illustrating the value of this research in plants of agronomic importance. It examines recent advances regarding plants’ epigenetic regulation in response to abiotic and biotic types of stress; the epigenetic basis of plant immunity; evolution and functions of plant histones; epigenetic variation and plant breeding; and epigenome editing and crop improvement. The content is intended to promote the development of future biotechnologies to manipulate and selectively activate/inhibit proteins and metabolic pathways to counter pathogens, to treat important diseases, and to increase crop productivity. The development of new fields, like epigenome editing and RNA epigenetics, will certainly improve our understanding of currently known epigenetic modifications and their roles in e.g. host-pathogen interactions, crop productivity, and in response to environmental stimuli. This volume contains twelve new/revised chapters, written by an international team of experts on plant epigenetics, and addresses the needs of researchers and professionals in the fields of agronomics, crop breeding, epigenetics, plant biochemistry, plant developmental biology, and related disciplines.

Author : Judy S. Crabtree
Publisher : Academic Press
Page : 114 pages
File Size : 42,6 Mb
Release : 2019-11-15
Category : Medical
ISBN : 9780128204023

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Clinical Precision Medicine by Judy S. Crabtree Pdf

Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care. Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine. Includes applied discussions of chromosomes and chromosomal abnormalities, molecular genetics, epigenetic regulation, heredity, clinical genetics, pharmacogenomics and immunogenomics Features chapter contributions from leaders in the field Consolidates fundamental concepts and current practices of precision medicine in one convenient resource

Author : Shuai Li,John Hopper
Publisher : Academic Press
Page : 376 pages
File Size : 54,9 Mb
Release : 2021-08-19
Category : Medical
ISBN : 9780128209523

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Twin and Family Studies of Epigenetics by Shuai Li,John Hopper Pdf

Twin and Family Studies of Epigenetics, Volume 27, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more. Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects. Offers a practical, interdisciplinary approach across epigenetics, epidemiology and various disease specialties Applies epigenetic twin and family studies to determine the relationship between epigenetics and mental illness, cancers, cardiovascular disease, diabetes, obesity and high blood pressure, among other diseases and disorders Features chapter contributions from a wide range of international researchers in the field

Author : Debasish Kar,Sagartirtha Sarkar
Publisher : Springer Nature
Page : 1149 pages
File Size : 50,7 Mb
Release : 2022-10-06
Category : Science
ISBN : 9789811670411

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Genetics Fundamentals Notes by Debasish Kar,Sagartirtha Sarkar Pdf

This up-to-date and comprehensive textbook is essential reading material for advanced undergraduate and graduate students with a course module in genetics and developmental biology. The book provides clear, concise, and rigorous foundational concepts of genetics. It opens with an introductory chapter that provides an overview of genetics. The book includes separate and detailed sections on classical genetics, molecular genetics, and population genetics. It covers basic and foundational principles such as Mendelian genetics, chromosomal theory, transcription, translation, mutation, and gene regulation. It further includes chapters on advanced topics such as molecular genetic techniques, genomics, and applied molecular genetics. The concluding section includes chapters on population genetics, developmental genetics, and evolutionary genetics. The chapters are written by authors with in-depth knowledge of the field. The book is replete with interesting examples, case studies, questions and suggested reading. It is useful to students and course instructors in the field of human genetics, developmental biology, life sciences, and biotechnology. It is also meant for researchers who wish to further their understanding about the fundamental concepts of genetics.

Author : Institute of Medicine,Food and Nutrition Board
Publisher : National Academies Press
Page : 170 pages
File Size : 50,6 Mb
Release : 2015-09-08
Category : Medical
ISBN : 9780309376983

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Examining a Developmental Approach to Childhood Obesity by Institute of Medicine,Food and Nutrition Board Pdf

Recent scientific evidence points to the origins of childhood obesity as an outcome of the dynamic interplay of genetic, behavioral, and environmental factors throughout early development, with a compelling body of evidence suggesting that both maternal and paternal nutritional and other exposures affect a child's risk of later obesity. The burgeoning field of epigenetics has led researchers to speculate that many of the observed associations between early developmental exposures and later risk of childhood obesity are mediated, at least in part, through epigenetic mechanisms. To explore the body of evolving science that examines the nexus of biology, environment, and developmental stage on risk of childhood obesity, the Institute of Medicine and the National Research Council convened a workshop in February 2015. The workshop focused on the prenatal period, infancy, and early childhood and addressed evidence from both animal and human studies. Workshop objectives were to (1) identify epigenetic-mediated relationships between exposure to risk factors during sensitive periods of development (gestation through age 3) and subsequent obesity-related outcomes; (2) explore the science around periods of plasticity and potential reversibility of obesity risk in the context of early childhood development; and (3) examine the translation of epigenetic science to guide early childhood obesity prevention and intervention to reduce obesity risk. This report summarizes the information presented and discussed at the workshop.

Author : Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz
Publisher : Springer Nature
Page : 215 pages
File Size : 41,9 Mb
Release : 2021-03-23
Category : Science
ISBN : 9783030686703

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Introduction to Epigenetics by Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz Pdf

This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease

Author : Raúl Alvarez-Venegas,Clelia De La Pena,Juan Armando Casas-Mollano
Publisher : Unknown
Page : 164 pages
File Size : 54,9 Mb
Release : 2014-08-31
Category : Electronic
ISBN : 3319079727

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Epigenetics in Plants of Agronomic Importance by Raúl Alvarez-Venegas,Clelia De La Pena,Juan Armando Casas-Mollano Pdf

Author : Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
Publisher : Unknown
Page : 716 pages
File Size : 51,9 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015047449171

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Epigenetic Mechanisms of Gene Regulation by Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs Pdf

Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.

Author : Mihai D. Niculescu,Paul Haggarty
Publisher : John Wiley & Sons
Page : 382 pages
File Size : 41,8 Mb
Release : 2011-06-28
Category : Medical
ISBN : 9780813816050

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Nutrition in Epigenetics by Mihai D. Niculescu,Paul Haggarty Pdf

The study of epigenetics, or how heritable changes in gene expression are regulated without modifying the coding DNA sequence, has become an increasingly important field of study in recent years. Rapid developments in our understanding of the way in which gene function is modulated by the environment has revolutionized the way we think about human development and health. Nutrition in Epigenetics reviews the latest research looking at the interaction between genes and nutrients and the role they play together in maintaining human health. Nutrition in Epigenetics is divided into two primary parts. The first part provides key principles such as epigenetic mechanisms, developmental epigenetics, and the role of epigenetics in disease. The second part looks specifically at the application of epigenetics to the field of human nutrition. Chapters review the role of specific nutrients in modulating epigenetic status and the effect on health and disease. Nutrition in Epigenetics is an indispensable resource for researchers, professionals and advanced students with an interest in human nutrition, epigenetics, and biomedical research.