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Gamete Immunology by Hiroaki Shibahara,Akiko Hasegawa Pdf
This book describes the biology, diagnosis, treatment and the latest research on anti-sperm antibody (ASA) and anti-zona pellucida antibody (AZPA) produced in some infertile patients. It summarizes ASA in both men and women, and presents new research to serve as a guideline for medical treatment, which currently varies considerably. It also discusses the recently identified target antigens of these antibodies, and the latest immunocontraceptive development projects. The book features chapters on AZPA explaining the biological structure and function of the zona pellucida, and describing the abnormality and the antibody. It also provides insights into their evolution, presenting the differences in taxonomy, mammalian physiological functions and the morphologically and immunologically unique human zona pellucida. Gamete Immunology is a valuable resource for researchers, and postdocs who are curious about new research on ASA and AZPA. It offers clinicians and embryologists who are interested in gamete immunology diverse perspectives as well as the basis for new ideas to treat the antibodies and develop contraceptive vaccinogens.
Immunology of Gametes and Embryo Implantation by Udo R. Markert Pdf
This book provides an overview of the current knowledge of physiological and pathological immune reactions which favor or disturb fertility. The regulation of embryo implantation and trophoblast invasion through cytokines, growth factors and other pregnancy-related immunoregulatory molecules is described in detail. Autoimmunity and allergy are presented as possible causes of reproductive failure.
Contraceptive Research and Development Program. International Workshop,Contraceptive Research and Development Program
Author : Contraceptive Research and Development Program. International Workshop,Contraceptive Research and Development Program Publisher : Unknown Page : 680 pages File Size : 50,8 Mb Release : 1990 Category : Contraception, Immunological ISBN : UOM:39015024800594
Gamete Interaction by Contraceptive Research and Development Program. International Workshop,Contraceptive Research and Development Program Pdf
Brings together contributions from experts involved with all aspects of reproductive research and discusses how an immune-type response to inhibit conception might be induced via an antigen vaccine. The coverage provides a thorough description of the sperm-egg surface domain interactions in fertilization, with specific emphasis on the influence of antibodies and gamete-specific antigens in preventing or enhancing conception. Individual chapters deal with a broad range of subjects pertaining to the fertilization reaction and each is followed by a short discussion clarifying or expanding upon the ideas presented.
Immunology of Human Reproduction by M. Kurpisz and N. Fernandez (Eds) Pdf
A comprehensive and cohesive account of reproductive immunology. Over 30 international experts review the key areas, including gamete immunobiology, the immunology of pregnancy and immunocontraception. The book deals primarily with immunological events
Reproductive Immunology is a compilation of research articles presented during the VII International Congress of Reproductive Immunology which was held in New Delhi, India on 27-30 October 1998. The articles pertain to the following six major themes: Molecular and Immunological Aspects of Sperm-Egg Interaction Embryonic-Endometrial Cross-Talk Immunobiology of Pregnancy Autoantibodies and Infertility Immunocontraception Mucosal Immunology and Reproductive Tract Infections . The first section deals with our current understanding of various steps involved in fertilization. The functional significance of sperm surface mannosidase and glutathione S-transferases to bind zona pellucida is described. The role of zona pellucida glycoproteins in the binding of sperm, induction of acrosome reactions and avoidance of polyspermy is discussed. In the second section, the role of various cytokines, growth factors and immunomodulatory agents in implantation of embryos is described. In the field of reproductive immunology, one of the major issues is to explore the successful gestation of the histoincompatible fetus in the uterus of an immunologically competent mother. The Proceedings presents the issues of paternal antigens at the feto-maternal interface and shows that Th2-type of immunity is involved in normal successful conception. The role of membrane-bound and soluble HLA-G in protecting the fetus from the lytic activities of maternal uterine and peripheral blood natural killer (NK) cells is also presented. Nature's experiments suggest that antibodies against sperm-specific antigens are responsible for infertility in some women. The possibility that an immunogenetic background contributes to production of sperm-immobilizing antibodies in infertile women is discussed in the section on autoantibodies and infertility. The Proceedings presents the issue of Th1-type cytokines in inducing recurrent spontaneous abortions of unexplained etiology. The roles of β2-glycoprotein 1 (β2-GP1)-dependent anticardiolipin antibody, lupus anticoagulant, antiphospholipids, anti-thyroid antibody and anti-nuclear antibody in miscarriages are also described. The rising global human population, particularly in the developing countries, has driven the need for new and safer methods of contraception. Fertility regulation by vaccines is thus an interesting proposition. The section on contraceptive vaccines discusses the latest advances in this area and describes the current status of vaccines based on βhCG, sperm antigens, zona pellucida glycoproteins, and riboflavin carrier proteins. The issues of mucosal immunity and strategies for enhancing local genital immune responses to combat HIV infection is discussed. The role of inflammatory and related cytokines in chorioamnionitis is described. The contents of this Proceedings describes various facets of reproductive immunology which will help us to design strategies to combat genital infections and miscarriages caused by immunological etiology. Descriptions of the molecular basis of gamete recognition, implantation and survival of the allogenic fetus will help in designing strategies for overcoming infertility and also new contraceptive approaches. The Proceedings will be useful to researchers and clinicians involved in basic or applied research in the disciplines of reproductive biology, reproductive immunology, and obstetrics and gynecology.
This book portrays substances of the versatile insusceptible reaction, particles of versatile safe acknowledgment, the lymphocytes, humoral resistance, the genetics components of invulnerable assorted variety, safe resilience, and disappointments of the safeguard capacities. Essentials of Immunology, presenting the microbial world and the techniques the body utilizes to guard itself. Each chapter then guides the reader through a different part of the immune system, and explains the role of each cell or molecule individually, and then as a whole. Applied Immunology, talks about what happens when things turn out badly, and the part the invulnerable framework plays close by the harming impacts of a sickness, including disease, immunodeficiency, hypersensitivities and transplantation and the valuable impacts of immunizations. Immunology gives the new biomedical researcher a knowledge into the capacity of the invulnerable framework, the bleeding edge of safeguard against neurotic malady, and the demonstrative strategies used to distinguish related breakdowns and scatters. By inspecting the key immunological standards and logical premise of research facility procedures with an attention on the biomedical researcher's part in the indicative lab, the reader is furnished with everything expected to get ready for a master capability in immunology.
Immunology and Medical Zoology by Lucca Crosby & Andrew Elliott Pdf
Immunology and medical zoology presents current advancements and also thorough surveys in immunology. Articles address the extensive variety of points that contain immunology, including atomic and cell enactment components, phylogeny and sub-atomic development, and clinical modalities. Immunology is the investigation of the body's security from outside macromolecules or attacking life forms and the reactions to them. These trespassers incorporate infections, microorganisms, protozoa or significantly bigger parasites. What's more, immune reactions are produced against our own proteins (and different atoms) in autoimmunity and against our own particular distorted cells in tumor insusceptibility. The principal line of protection against outside creatures are hindrance tissues, for example, the skin that stop the passage of living being into our bodies. A moment line of resistance is the particular or versatile immune framework which may take days to react to an essential attack (that is contamination by a life form that has not up to this point been seen). This new book unites new research from around the world managing this critical subject. Immunology, with its premise in microbiology, is a critical segment of the essential sciences educational modules and has solid relationship with fields, for example, sensitivity, immunochemistry, immunopharmacology and transplantation.
W. Arber,W. Henle,P. H. Hofschneider,J. H. Humphrey,J. Klein,P. Koldovský,H. Koprowski,O. Maaløe,F. Melchers,R. Rott,H. G. Schweiger,L. Syru?ek,P. K. Vogt
Author : W. Arber,W. Henle,P. H. Hofschneider,J. H. Humphrey,J. Klein,P. Koldovský,H. Koprowski,O. Maaløe,F. Melchers,R. Rott,H. G. Schweiger,L. Syru?ek,P. K. Vogt Publisher : Springer Science & Business Media Page : 175 pages File Size : 40,8 Mb Release : 2012-12-06 Category : Medical ISBN : 9783642669569
Current Topics in Microbiology and Immunology by W. Arber,W. Henle,P. H. Hofschneider,J. H. Humphrey,J. Klein,P. Koldovský,H. Koprowski,O. Maaløe,F. Melchers,R. Rott,H. G. Schweiger,L. Syru?ek,P. K. Vogt Pdf
Immunology of Pregnancy 2013 by Gérard Chaouat,Olivier Sandra,Nathalie Lédée Pdf
Since a September, 1992, Nature article which read: “Can there be life without LIF?”, researchers now realize that the maternal immune system is both a foe (it can reject the conception) and a friend (immune cells and molecules are also necessary for successful pregnancy). Leukemia Inhibitory Factor (LIF) when absent, prevents embryo implantation in rodents. From fecundation to parturition, immunity acts as a Janus, required but potentially dangerous. However, the complexity and the diversity of immunity in pregnancy deters many from entering the field. This book will try to give a complete overview of immunity from gametes till parturition, in brief, but with complete chapters and subsections, each written by specialists in the field. The importance of the topic relies not only on “the riddle of the fetal allograft”, which is per se fascinating, but on its consequences, linked to the development of IVF and in general, Assisted Reproductive Technologies (ART) / Medicine. Since the discovery that there would not be (mammalian) life without LIF, it has become clear that Immune Molecules, and in general, transient post mating inflammatory reactions are required for successful implantation. Disruptions of this process can lead to implantation failure / sterility. In later stages of pregnancy immunological cells, mostly of the innate immune system, control formation of local spiral arteries. Finally, a state of tolerance establishes itself, whose “break’ leads to immune abortion and the vascular bed is further transformed and enlarged, till delivery, and here again “immunological cytokines” do play a major role and can eventually cause immune mediated abortion. Failure of, not just, the cytokine and cell recognition mediated dialogue, but also the pre and peri-implantation “preparation of the uterus”, as stated, leads to sterility, early pregnancy loss and recurrent abortions. There is also an increasingly stronger argument to implicate immunology in pre-eclampsia. Further still, immunology is also implicated in the control of local infection, mother to child transmission of pathogens (notably, but not limited to, HIV). Finally, pregnancy is the only known physiological phenomenon where the once named “suppressor T cells,” re-emerge as “regulatory T cells”, and play a cardinal role. This E-book provides a complete compendium of gynecological immunology, spanning from fecundation to delivery. Topics also include the role of various cell types (such as T regs ad NK cells) in implantation and uterine changes as well as the genetic regulation of immunological processes. As such it will be of interest not only to fundamental and reproductive immunologists, but more importantly, clinicians in obstetrics and gynecology.
Kevin N. Couper,Julius C. Hafalla,Noah S. Butler,Ashraful Haque
Author : Kevin N. Couper,Julius C. Hafalla,Noah S. Butler,Ashraful Haque Publisher : Frontiers Media SA Page : 487 pages File Size : 54,8 Mb Release : 2019-10-10 Category : Electronic ISBN : 9782889630462
Immunity to Malaria and Vaccine Strategies by Kevin N. Couper,Julius C. Hafalla,Noah S. Butler,Ashraful Haque Pdf
Malaria, caused by infection with protozoan parasites belonging to the genus Plasmodium, is a highly prevalent and lethal infectious disease, responsible for 435,000 deaths in 2017. Optimism that malaria was gradually being controlled and eliminated has been tempered by recent evidence that malaria control measures are beginning to stall and that Plasmodium parasites are developing resistance to front-line anti-malarial drugs. An important milestone has been the recent development of a malaria vaccine (Mosquirix) for use in humans, the very first against a parasitic infection. Unfortunately, this vaccine has modest and short-lived efficacy, with vaccinated individuals possibly being at increased risk of severe malarial disease when protection wanes. Thus, to define new ways to combat malaria, there remains an urgent requirement to identify the immune mechanisms that promote resistance to malarial disease and to understand why these so often fail. The review and primary research articles in this Research Topic illustrate the breadth of research performed worldwide aimed to understand the biology of the Plasmodium parasite, the roles of the various cell types that act within the immune response against the parasite, and the parasitological and immunological basis of severe malarial disease. The articles in section 1 exemplify the different vaccination strategies being developed and tested by the research community in the fight against malaria. The articles in section 2 review important overarching aspects of malaria immunology and the use of models to study human malaria. The articles in section 3 describe the ways through which the Plasmodium parasite is initially recognised by the immune system during infection, how the parasite can directly impact this critical event to restrict anti-Plasmodial immunity, and resolve the roles of key innate cell populations, such as dendritic cells, in coordinating malarial immunity. The articles in sections 4-6 outline the roles T and B cell populations play during malaria, highlighting the activation, diversification and regulation of the crucial cell types during malaria, and discuss some of the reasons adaptive immunity to malaria is often considered so poor compared with other diseases. The articles in section 7 provide up to date information on the pathogenesis of cerebral malaria, bridging our understanding of the syndrome in humans with information learned from animal models. Overall, the articles in this research, many of which are published by leaders in the malaria field, emphasize the imagination and technical advances being employed by researchers against malaria. We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Immunology of Recurrent Pregnancy Loss and Implantation Failure by Joanna Kwak-Kim Pdf
Immunology of Recurrent Pregnancy Loss provides doctors and immunologists with the information they need to help couples who experience recurrent pregnancy losses. Sections cover unexplained infertility, repeated in vitro fertilization, embryo transfer failures, history of second or third trimester pregnancy losses of unknown cause, or pregnancy with a history of or active autoimmune and/or alloimmune disease. Reproductive failure (RF), including recurrent pregnancy losses (RPL) and repeated implantation failures (RIF) is rather a syndrome than a disease caused by multiple etiologies, such as anatomical, endocrine, genetic, infectious, immunological, thrombotic and unexplained etiologies, hence this book strives to present the latest information. In 27 chapters, divided in 5 sections, the book introduces the current update of reproductive immunology topics in RF and provides systematic diagnostic guidelines, systemic and immune etiologies and therapeutic approaches. Provides detailed immunological background for understanding the etiology and management of reproduction failure Evaluates various immunological factors involved in the pathogenesis and management of reproduction failure Gives insights into various immunological and therapeutic approaches for reproduction failure
John E. Fogarty International Center for Advanced Study in the Health Sciences
Author : John E. Fogarty International Center for Advanced Study in the Health Sciences Publisher : Unknown Page : 522 pages File Size : 53,8 Mb Release : 1979 Category : Medicine ISBN : STANFORD:36105111145871
National Institutes of Health Annual Report of International Activities by John E. Fogarty International Center for Advanced Study in the Health Sciences Pdf
