Immunology Of Recurrent Pregnancy Loss And Implantation Failure

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Immunology of Recurrent Pregnancy Loss and Implantation Failure

Joanna Kwak-Kim
Immunology of Recurrent Pregnancy Loss and Implantation Failure Book PDF

Author : Joanna Kwak-Kim
Publisher : Academic Press
Page : 457 pages
File Size : 46,8 Mb
Release : 2022-07-03
Category : Medical
ISBN : 9780323908061

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Immunology of Recurrent Pregnancy Loss and Implantation Failure by Joanna Kwak-Kim Pdf

Immunology of Recurrent Pregnancy Loss provides doctors and immunologists with the information they need to help couples who experience recurrent pregnancy losses. Sections cover unexplained infertility, repeated in vitro fertilization, embryo transfer failures, history of second or third trimester pregnancy losses of unknown cause, or pregnancy with a history of or active autoimmune and/or alloimmune disease. Reproductive failure (RF), including recurrent pregnancy losses (RPL) and repeated implantation failures (RIF) is rather a syndrome than a disease caused by multiple etiologies, such as anatomical, endocrine, genetic, infectious, immunological, thrombotic and unexplained etiologies, hence this book strives to present the latest information. In 27 chapters, divided in 5 sections, the book introduces the current update of reproductive immunology topics in RF and provides systematic diagnostic guidelines, systemic and immune etiologies and therapeutic approaches. Provides detailed immunological background for understanding the etiology and management of reproduction failure Evaluates various immunological factors involved in the pathogenesis and management of reproduction failure Gives insights into various immunological and therapeutic approaches for reproduction failure

Immunology of Pregnancy 2013

Gérard Chaouat,Olivier Sandra,Nathalie Lédée
Immunology of Pregnancy 2013 Book PDF

Author : Gérard Chaouat,Olivier Sandra,Nathalie Lédée
Publisher : Bentham Science Publishers
Page : 982 pages
File Size : 48,7 Mb
Release : 2013-11-08
Category : Medical
ISBN : 9781608057337

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Immunology of Pregnancy 2013 by Gérard Chaouat,Olivier Sandra,Nathalie Lédée Pdf

Since a September, 1992, Nature article which read: “Can there be life without LIF?”, researchers now realize that the maternal immune system is both a foe (it can reject the conception) and a friend (immune cells and molecules are also necessary for successful pregnancy). Leukemia Inhibitory Factor (LIF) when absent, prevents embryo implantation in rodents. From fecundation to parturition, immunity acts as a Janus, required but potentially dangerous. However, the complexity and the diversity of immunity in pregnancy deters many from entering the field. This book will try to give a complete overview of immunity from gametes till parturition, in brief, but with complete chapters and subsections, each written by specialists in the field. The importance of the topic relies not only on “the riddle of the fetal allograft”, which is per se fascinating, but on its consequences, linked to the development of IVF and in general, Assisted Reproductive Technologies (ART) / Medicine. Since the discovery that there would not be (mammalian) life without LIF, it has become clear that Immune Molecules, and in general, transient post mating inflammatory reactions are required for successful implantation. Disruptions of this process can lead to implantation failure / sterility. In later stages of pregnancy immunological cells, mostly of the innate immune system, control formation of local spiral arteries. Finally, a state of tolerance establishes itself, whose “break’ leads to immune abortion and the vascular bed is further transformed and enlarged, till delivery, and here again “immunological cytokines” do play a major role and can eventually cause immune mediated abortion. Failure of, not just, the cytokine and cell recognition mediated dialogue, but also the pre and peri-implantation “preparation of the uterus”, as stated, leads to sterility, early pregnancy loss and recurrent abortions. There is also an increasingly stronger argument to implicate immunology in pre-eclampsia. Further still, immunology is also implicated in the control of local infection, mother to child transmission of pathogens (notably, but not limited to, HIV). Finally, pregnancy is the only known physiological phenomenon where the once named “suppressor T cells,” re-emerge as “regulatory T cells”, and play a cardinal role. This E-book provides a complete compendium of gynecological immunology, spanning from fecundation to delivery. Topics also include the role of various cell types (such as T regs ad NK cells) in implantation and uterine changes as well as the genetic regulation of immunological processes. As such it will be of interest not only to fundamental and reproductive immunologists, but more importantly, clinicians in obstetrics and gynecology.

Immune Involvement in Recurrent Pregnancy Loss

Gendie Lash,Raj Raghupathy
Immune Involvement in Recurrent Pregnancy Loss Book PDF

Author : Gendie Lash,Raj Raghupathy
Publisher : Frontiers Media SA
Page : 119 pages
File Size : 52,8 Mb
Release : 2023-11-27
Category : Medical
ISBN : 9782832539798

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Immune Involvement in Recurrent Pregnancy Loss by Gendie Lash,Raj Raghupathy Pdf

Recurrent pregnancy loss (RPL) is defined as two or more consecutive pregnancy losses before the 20th week of gestation, occuring in 1%–3% of reproductive women. Unexplained RPL (URPL) is a heterogeneous condition affecting approximately 50% of RPL cases, with one contributing factor thought to be a disruption in maternal immune tolerance. Various immune effectors and molecules in the immune-microenvironment establish specific maternal tolerance toward the semi-allogeneic fetus during pregnancy. Immune cells including innate lymphoid cells (ILCs), myeloid cells, T cells and B cells have been found to contribute to maintaining this maternal immunological tolerance during pregnancy. ILCs have been found to be the most abundant immune cells in the pregnant uterus, with many studies focusing on the relationship between RPL and either T cells or natural killer (NK) cells in peripheral blood and the endometrium/decidua. Despite progress in uncovering the roles of NK, and regulatory T cells and cytokines in pregnancy, the immune heterogeneity in patients with URPL remains elusive.

Immunology of Pregnancy

Udo R. Markert
Immunology of Pregnancy Book PDF

Author : Udo R. Markert
Publisher : Karger Medical and Scientific Publishers
Page : 201 pages
File Size : 54,5 Mb
Release : 2005-01-01
Category : Medical
ISBN : 9783805579704

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Immunology of Pregnancy by Udo R. Markert Pdf

This book presents the discipline of immunology which studies a unique physiological phenomenon contradicting many of the generally established rules in the field: immunology of pregnancy. It provides a wide overview of the current research of this topic. Prominent and leading international groups contributed by reviewing the most significant findings in the field.

Lymphocyte Immunization Therapy (LIT) in Reproductive Failures

Mohan Raut,Mugdha Raut
Lymphocyte Immunization Therapy LIT in Reproductive Failures Book PDF

Author : Mohan Raut,Mugdha Raut
Publisher : Springer Nature
Page : 150 pages
File Size : 51,5 Mb
Release : 2022-08-27
Category : Medical
ISBN : 9789811929601

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Lymphocyte Immunization Therapy (LIT) in Reproductive Failures by Mohan Raut,Mugdha Raut Pdf

Recurrent Miscarriages (RM) & Implantation Failure (IF) have remained an enigma to clinicians and researchers. Even after ruling out all possible causative factors, 50-60% cases still remain “Unexplained’. A majority of these so called “Unexplained” cases are now found to have immunological basis.This book is going into the Immunological aspects of these clinical dilemmas, demystifying the role of Immunology and Immunotherapy in RM and IF. The authors have been working in the field of Reproductive Immunology and Immunotherapy for the last 25 years and they have come out with this book combining the international studies with their own experience. The purpose of writing this book is to provide a comprehensive treatise about Immunotherapy, so that it can become an acceptable modality of treatment in cases where it is needed and is effective.The book discusses the basics in Reproductive Immunology. The immunological changes occurring during pregnancy, the role of Cell mediated Immunity (T cells), Humoral Immunity including cytokines is explained. The normal immunological mechanisms protecting the embryo are highlighted and how these mechanisms are disturbed leading to RM and IF, is also explained.The first and the most discussed method of Immunotherapy is Lymphocyte Immunization Therapy (LIT). The book has given a complete overview of LIT, describing how it created euphoria when it was first introduced, how it gradually went into disrepute and how it is now making a comeback. As the authors have personal experience of LIT, the book gives a detailed and complete information about this active form of immunotherapy.The book has a special section on case studies where the authors have given some clinical case reports (including some of their own), who were treated for immunological factor in RM/IF and were treated with Immunotherapy. These cases can be a useful guide to the readers.The book will be useful not only for undergraduate and postgraduate students but also for clinicians in their practice and for researchers for review of developments in the field.

Immunology of Pregnancy

Gil Mor
Immunology of Pregnancy Book PDF

Author : Gil Mor
Publisher : Springer Science & Business Media
Page : 338 pages
File Size : 43,5 Mb
Release : 2007-12-27
Category : Medical
ISBN : 9780387349442

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Immunology of Pregnancy by Gil Mor Pdf

This book covers in detail contemporary hypotheses and studies related to the immunology of implantation and provides a practical approach for the application of basic reproductive immunology research to pregnancy complications such as preeclampsia, pre-term labor and IUGR. Provides complete and up to date review of current knowledge of the role of the immune system during pregnancy and the interactions between the placenta and the maternal immune system.

Recurrent Miscarriage and Pre-eclampsia

Rhoda Wilson
Recurrent Miscarriage and Pre eclampsia Book PDF

Author : Rhoda Wilson
Publisher : World Scientific
Page : 112 pages
File Size : 54,5 Mb
Release : 2004
Category : Medical
ISBN : 9789812388506

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Recurrent Miscarriage and Pre-eclampsia by Rhoda Wilson Pdf

The author explores similarities in two complications that occur at different points in pregnancies - miscarriage, being a first trimester condition, and pre-eclampsia, being a third trimester condition - and the roles of antioxidants and the immune system in both conditions.

Treatment Strategy for Unexplained Infertility and Recurrent Miscarriage

Keiji Kuroda,Jan J. Brosens,Siobhan Quenby,Satoru Takeda
Treatment Strategy for Unexplained Infertility and Recurrent Miscarriage Book PDF

Author : Keiji Kuroda,Jan J. Brosens,Siobhan Quenby,Satoru Takeda
Publisher : Springer
Page : 125 pages
File Size : 53,9 Mb
Release : 2018-06-15
Category : Medical
ISBN : 9789811086908

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Treatment Strategy for Unexplained Infertility and Recurrent Miscarriage by Keiji Kuroda,Jan J. Brosens,Siobhan Quenby,Satoru Takeda Pdf

This book offers a highly informative guide to treating unexplained infertility and recurrent miscarriage (RM). In particular, it provides detailed treatment strategies for infertility or RM derived from uterine circumstance such as chronic endometritis and perturbation of endometrial decidualization, as well as maternal immunological rejection of an embryo as semi-allograft. Unexplained infertility refers to those types that cannot be detected by the general screening test. The causes are sometimes detected in the course of treatment with assisted reproductive technology including IVF. However, some unexplained infertility is intractable even after intracytoplasmic sperm injection or repeated implantation of morphologically suitable embryos. Patients with unexplained RM also have a high likelihood of undetectable risk factors of miscarriage. As a result, gynecologists often repeatedly provide these couples with general treatments for infertility and miscarriage or even discontinue treatment because they cannot detect the reason, which places serious financial, physical and mental burdens on the couples affected. This book offers gynecologists essential insights into the pathological condition of unexplained infertility and RM, equipping them to identify it, explain it to patients, and consider further examinations and more aggressive fertility treatments.

Immunology of Gametes and Embryo Implantation

Udo R. Markert
Immunology of Gametes and Embryo Implantation Book PDF

Author : Udo R. Markert
Publisher : Karger Medical and Scientific Publishers
Page : 219 pages
File Size : 55,5 Mb
Release : 2005-01-01
Category : Medical
ISBN : 9783805579513

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Immunology of Gametes and Embryo Implantation by Udo R. Markert Pdf

This book provides an overview of the current knowledge of physiological and pathological immune reactions which favor or disturb fertility. The regulation of embryo implantation and trophoblast invasion through cytokines, growth factors and other pregnancy-related immunoregulatory molecules is described in detail. Autoimmunity and allergy are presented as possible causes of reproductive failure.

The Maternal Fetal Interface

Anthony Carter,Vibeke Dantzer,Thomas Jansson
The Maternal Fetal Interface Book PDF

Author : Anthony Carter,Vibeke Dantzer,Thomas Jansson
Publisher : Boydell & Brewer
Page : 456 pages
File Size : 51,6 Mb
Release : 1998
Category : Maternal-fetal exchange
ISBN : 1580460437

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The Maternal Fetal Interface by Anthony Carter,Vibeke Dantzer,Thomas Jansson Pdf

The 29 papers contained in this volume look closely at various aspects of what is termed, "The Maternal-Fetal Interface," as it relates to the latest research in placental science. A substantial section of the book is devoted to the troublesome question of vertical transmission of infectious agents: namely, the HIV-1 virus. However, other sections of the volume examine related issues such as drug and toxin transfer across the term placenta and the diversity of placental types and how this can affect a placenta's effectiveness as a barrier. Anthony Carter is at the University of Odense, Denmark Vibeke Dantzer is at the University of Copenhagen, DenmarkThomas Jansson is at the University of Gothenburg, Sweden

Early Pregnancy Loss

Richard W. Beard,Frank Sharp
Early Pregnancy Loss Book PDF

Author : Richard W. Beard,Frank Sharp
Publisher : Springer Science & Business Media
Page : 427 pages
File Size : 55,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781447116585

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Early Pregnancy Loss by Richard W. Beard,Frank Sharp Pdf

The first few months of any pregnancy are of supreme importance to the success of that pregnancy. This statement is so obvious as to be almost a platitude, yet it must be said that no aspect of pregnancy has been more neglected in the human than the first three months. Little is known of the morphological changes that occur at that time and our knowledge of the mechanisms that control this vital stage of pregnancy is almost non-existent. The explanation for this neglect of what is an obvious area for study is the difficulty of obtaining normal material. It is rare to have material to study from a healthy first trimester pregnancy and the study by Hertig and Rock!l) of early conception found by chance in hysterectomy speci mens must be unique. The information that we do have about early pregnancy is mostly gained from animal studies or single miscarriages in humans. Chromosomal defects are common but are not an explanation for the majority of recurrent miscarriages. Obstetricians have hypothesised many causes for this condition and have deve loped numerous metQods for treating it, but the studies have been poorly con trolled so that our understanding of the cause(s) has not advanced. Treatment of women with a history of recurrent miscarriage by paternal leuco cyte infusion (immunotherapy) may be yet another form of treatment that is hailed as a new advance only to be rejected when subject to rigorous testing.

Reproductive Immunology

Satish Kumar Gupta
Reproductive Immunology Book PDF

Author : Satish Kumar Gupta
Publisher : Springer Science & Business Media
Page : 416 pages
File Size : 45,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401141970

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Reproductive Immunology by Satish Kumar Gupta Pdf

Reproductive Immunology is a compilation of research articles presented during the VII International Congress of Reproductive Immunology which was held in New Delhi, India on 27-30 October 1998. The articles pertain to the following six major themes: Molecular and Immunological Aspects of Sperm-Egg Interaction Embryonic-Endometrial Cross-Talk Immunobiology of Pregnancy Autoantibodies and Infertility Immunocontraception Mucosal Immunology and Reproductive Tract Infections . The first section deals with our current understanding of various steps involved in fertilization. The functional significance of sperm surface mannosidase and glutathione S-transferases to bind zona pellucida is described. The role of zona pellucida glycoproteins in the binding of sperm, induction of acrosome reactions and avoidance of polyspermy is discussed. In the second section, the role of various cytokines, growth factors and immunomodulatory agents in implantation of embryos is described. In the field of reproductive immunology, one of the major issues is to explore the successful gestation of the histoincompatible fetus in the uterus of an immunologically competent mother. The Proceedings presents the issues of paternal antigens at the feto-maternal interface and shows that Th2-type of immunity is involved in normal successful conception. The role of membrane-bound and soluble HLA-G in protecting the fetus from the lytic activities of maternal uterine and peripheral blood natural killer (NK) cells is also presented. Nature's experiments suggest that antibodies against sperm-specific antigens are responsible for infertility in some women. The possibility that an immunogenetic background contributes to production of sperm-immobilizing antibodies in infertile women is discussed in the section on autoantibodies and infertility. The Proceedings presents the issue of Th1-type cytokines in inducing recurrent spontaneous abortions of unexplained etiology. The roles of β2-glycoprotein 1 (β2-GP1)-dependent anticardiolipin antibody, lupus anticoagulant, antiphospholipids, anti-thyroid antibody and anti-nuclear antibody in miscarriages are also described. The rising global human population, particularly in the developing countries, has driven the need for new and safer methods of contraception. Fertility regulation by vaccines is thus an interesting proposition. The section on contraceptive vaccines discusses the latest advances in this area and describes the current status of vaccines based on βhCG, sperm antigens, zona pellucida glycoproteins, and riboflavin carrier proteins. The issues of mucosal immunity and strategies for enhancing local genital immune responses to combat HIV infection is discussed. The role of inflammatory and related cytokines in chorioamnionitis is described. The contents of this Proceedings describes various facets of reproductive immunology which will help us to design strategies to combat genital infections and miscarriages caused by immunological etiology. Descriptions of the molecular basis of gamete recognition, implantation and survival of the allogenic fetus will help in designing strategies for overcoming infertility and also new contraceptive approaches. The Proceedings will be useful to researchers and clinicians involved in basic or applied research in the disciplines of reproductive biology, reproductive immunology, and obstetrics and gynecology.

Infertility and Assisted Reproduction

Wei-Hua Wang
Infertility and Assisted Reproduction Book PDF

Author : Wei-Hua Wang
Publisher : BoD – Books on Demand
Page : 246 pages
File Size : 51,9 Mb
Release : 2021-11-17
Category : Medical
ISBN : 9781839628245

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Infertility and Assisted Reproduction by Wei-Hua Wang Pdf

Infertility affects approximately 15% of couples of reproductive age. High live birth rates rely on many advanced technologies in infertility treatment, including more accurate clinical diagnosis and patient management as well as state-of-the-art in vitro fertilization (IVF) technologies. This book discusses infertility and infertility treatments such as embryo implantation, non-invasive preimplantation genetic diagnosis (PGT), oocyte cryopreservation, cryopreservation of small numbers of sperm, and embryo culture technologies. It delivers new information and data valuable to clinicians, embryologists, and others in infertility treatment.

Reproductive Immunology

Gil Mor
Reproductive Immunology Book PDF

Author : Gil Mor
Publisher : Academic Press
Page : 462 pages
File Size : 42,6 Mb
Release : 2021-02-12
Category : Medical
ISBN : 9780128189306

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Reproductive Immunology by Gil Mor Pdf

Reproductive Immunology: Basic Concepts gives a holistic insight into the understanding of the complex interactions between the maternal immune system and the fetal/placental unit necessary for the success of pregnancy. This interaction is critical for the support of the human fetal semiallograft and the protection against infections. The book covers various topics such as B cells, macrophages, T cells, discussion on fetal signals and their impact on maternal reproductive cells such as endometrial cells, mast cells, and the role of fetal Hofbauer cells, the immune regulatory role of glucorticoids, and many other novel topics within the field of reproductive immunology. Edited and written by experts in the field, this book introduces the up-to-date knowledge of the role of the immune system during pregnancy and provides the necessary background to understand pregnancy complications associated with alterations in the functioning of the immune system. The book provides a complete discussion on the immunological aspects of pregnancy and serves as a great tool for research scientists, students, reproductive immunologists and OBGYNs. Shows the detailed evaluation of the knowledge related to each immune cell type in the pregnant and not pregnant uterus Evaluates each immune cell type and its function during specific reproductive events Provides the biological background for understanding the clinical aspects that will be discussed in subsequent volumes in the series

Recurrent Pregnancy Loss

Sumita Mehta,Bindiya Gupta
Recurrent Pregnancy Loss Book PDF

Author : Sumita Mehta,Bindiya Gupta
Publisher : Springer
Page : 431 pages
File Size : 52,8 Mb
Release : 2018-04-20
Category : Medical
ISBN : 9789811073380

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Recurrent Pregnancy Loss by Sumita Mehta,Bindiya Gupta Pdf

This book covers the entire topic of recurrent miscarriage extensively. Chapters cover demographics to recent and future management options. A special section on the role of controversial strategies has also been included. Lastly, the book features dedicated chapters on evidence-based approaches, which include step-by-step algorithms for the reader’s convenience.