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Immunology of Gametes and Embryo Implantation by Udo R. Markert Pdf
This book provides an overview of the current knowledge of physiological and pathological immune reactions which favor or disturb fertility. The regulation of embryo implantation and trophoblast invasion through cytokines, growth factors and other pregnancy-related immunoregulatory molecules is described in detail. Autoimmunity and allergy are presented as possible causes of reproductive failure.
Immunology of Pregnancy 2013 by Gérard Chaouat,Olivier Sandra,Nathalie Lédée Pdf
Since a September, 1992, Nature article which read: “Can there be life without LIF?”, researchers now realize that the maternal immune system is both a foe (it can reject the conception) and a friend (immune cells and molecules are also necessary for successful pregnancy). Leukemia Inhibitory Factor (LIF) when absent, prevents embryo implantation in rodents. From fecundation to parturition, immunity acts as a Janus, required but potentially dangerous. However, the complexity and the diversity of immunity in pregnancy deters many from entering the field. This book will try to give a complete overview of immunity from gametes till parturition, in brief, but with complete chapters and subsections, each written by specialists in the field. The importance of the topic relies not only on “the riddle of the fetal allograft”, which is per se fascinating, but on its consequences, linked to the development of IVF and in general, Assisted Reproductive Technologies (ART) / Medicine. Since the discovery that there would not be (mammalian) life without LIF, it has become clear that Immune Molecules, and in general, transient post mating inflammatory reactions are required for successful implantation. Disruptions of this process can lead to implantation failure / sterility. In later stages of pregnancy immunological cells, mostly of the innate immune system, control formation of local spiral arteries. Finally, a state of tolerance establishes itself, whose “break’ leads to immune abortion and the vascular bed is further transformed and enlarged, till delivery, and here again “immunological cytokines” do play a major role and can eventually cause immune mediated abortion. Failure of, not just, the cytokine and cell recognition mediated dialogue, but also the pre and peri-implantation “preparation of the uterus”, as stated, leads to sterility, early pregnancy loss and recurrent abortions. There is also an increasingly stronger argument to implicate immunology in pre-eclampsia. Further still, immunology is also implicated in the control of local infection, mother to child transmission of pathogens (notably, but not limited to, HIV). Finally, pregnancy is the only known physiological phenomenon where the once named “suppressor T cells,” re-emerge as “regulatory T cells”, and play a cardinal role. This E-book provides a complete compendium of gynecological immunology, spanning from fecundation to delivery. Topics also include the role of various cell types (such as T regs ad NK cells) in implantation and uterine changes as well as the genetic regulation of immunological processes. As such it will be of interest not only to fundamental and reproductive immunologists, but more importantly, clinicians in obstetrics and gynecology.
Immunology and Animal Biotechnology by MarquAA(c)s Starks Pdf
Biotechnology as any technique that used living organisms to make or modify a product, to improve plants or animals or to develop microorganisms for specific uses. Biotechnology as any technique that used living organisms to make or modify a product, to improve plants or animals or to develop microorganisms for specific uses. Animal biotechnology in use today is based on the science of genetic engineering. Under the umbrella of genetic engineering exist other technologies, such as transgenics and cloning, that also are used in animal biotechnology. Immunology is the study of the immune system and is a very important branch of the medical and biological sciences. The immune system protects us from infection through various lines of defence. If the immune system is not functioning as it should, it can result in disease, such as autoimmunity, allergy and cancer. Immunity is a biological term that describes a state of having sufficient biological defences to avoid infection, disease, or other unwanted biological invasion. Immunity involves both specific and non-specific components. The non-specific components act either as barriers or as eliminators of wide range of pathogens irrespective of antigenic specificity. Other components of the immune system adapt themselves to each new disease encountered and are able to generate pathogen-specific immunity. This book sums up information about Animal Biotechnology and is a valuable tool for students as well as teachers. The aim of this book is to provide the readers materials on the subject in a lucid and readable form so as to enable the research scholars, scientists, zoologist and even the common men to understand the subject properly.
This book presents the discipline of immunology which studies a unique physiological phenomenon contradicting many of the generally established rules in the field: immunology of pregnancy. It provides a wide overview of the current research of this topic. Prominent and leading international groups contributed by reviewing the most significant findings in the field.
Textbook of Minimal Stimulation IVF by Alejandro Chavez-Badiola Pdf
This textbook discusses Assisted Reproductive Technology (ART) and alternative solutions that mimic natural phenomena. With contributions from leading international experts, the book describes risks and complications, such as ovarian hyperstimulation and multiple pregnancies, as well as the financial, psychological, ethical and legal issues involved. Separate chapters are dedicated to IVF in developing countries, the mini-IVF experience at the New Hope Fertility Center, and the Kato Ladies Clinic Experience.
Immunology of Animal Reproduction by Blake Wilson Pdf
The book is expected to include in the investigation of microbiology, immunology, and creature generation as a prologue to more broad examinations. An outline of immunology is given in the book to allude instantly any fundamental data required, for additionally comprehension of the subject managed in this book. The book is secured may give the basic part to the fundamental comprehension of the conceptive immunology in creatures. It is intended to supplement, yet not to contend with the few books accessible as to multiplication. Immunological Aspects of Reproduction in creatures contains abundance of data on the field of conceptive immunology and show exactly how complex this field is and what number of inquiries still stay to be replied. Inoculation of a few animal groups with either the hypothalamic hormone LH-RH, pituitary gonadotrophins, or ovarian steroids; and concentrates guided towards endeavors to improve creature generation by either dynamic or inactive vaccination of female ranch creatures against steroid hormones.
Gamete Immunology by Hiroaki Shibahara,Akiko Hasegawa Pdf
This book describes the biology, diagnosis, treatment and the latest research on anti-sperm antibody (ASA) and anti-zona pellucida antibody (AZPA) produced in some infertile patients. It summarizes ASA in both men and women, and presents new research to serve as a guideline for medical treatment, which currently varies considerably. It also discusses the recently identified target antigens of these antibodies, and the latest immunocontraceptive development projects. The book features chapters on AZPA explaining the biological structure and function of the zona pellucida, and describing the abnormality and the antibody. It also provides insights into their evolution, presenting the differences in taxonomy, mammalian physiological functions and the morphologically and immunologically unique human zona pellucida. Gamete Immunology is a valuable resource for researchers, and postdocs who are curious about new research on ASA and AZPA. It offers clinicians and embryologists who are interested in gamete immunology diverse perspectives as well as the basis for new ideas to treat the antibodies and develop contraceptive vaccinogens.
Atlas on the Human Testis: Normal Morphology and Pathology presents histological illustrative material from paraffin and semi-thin sections of the human testis which are routinely used in the assessment of testicular morphology, allowing an early detection of carcinoma in situ and more advanced pathological changes of the testicular parenchyma. The early detection of cancer in situ is based on the careful morphological investigation of the biopsy and immunohistochemistry (IHC). Therefore, this atlas contains detailed descriptions of IHC methods as well as modern molecular biological methods such as DNA microarrays and proteomics and advanced microscopy techniques related to the testicular biopsy. Adequate evaluation of the testicular biopsy leads to high cure rates of testicular neoplasms which can be used as a basis to successfully treat infertility in men. Atlas on the Human Testis: Normal Morphology and Pathology is a valuable reference tool which will appeal to andrologists, urologists, pathologists, clinical embryologists, as well as reproductive biology scientists.
Lymphocyte Immunization Therapy (LIT) in Reproductive Failures by Mohan Raut,Mugdha Raut Pdf
Recurrent Miscarriages (RM) & Implantation Failure (IF) have remained an enigma to clinicians and researchers. Even after ruling out all possible causative factors, 50-60% cases still remain “Unexplained’. A majority of these so called “Unexplained” cases are now found to have immunological basis.This book is going into the Immunological aspects of these clinical dilemmas, demystifying the role of Immunology and Immunotherapy in RM and IF. The authors have been working in the field of Reproductive Immunology and Immunotherapy for the last 25 years and they have come out with this book combining the international studies with their own experience. The purpose of writing this book is to provide a comprehensive treatise about Immunotherapy, so that it can become an acceptable modality of treatment in cases where it is needed and is effective.The book discusses the basics in Reproductive Immunology. The immunological changes occurring during pregnancy, the role of Cell mediated Immunity (T cells), Humoral Immunity including cytokines is explained. The normal immunological mechanisms protecting the embryo are highlighted and how these mechanisms are disturbed leading to RM and IF, is also explained.The first and the most discussed method of Immunotherapy is Lymphocyte Immunization Therapy (LIT). The book has given a complete overview of LIT, describing how it created euphoria when it was first introduced, how it gradually went into disrepute and how it is now making a comeback. As the authors have personal experience of LIT, the book gives a detailed and complete information about this active form of immunotherapy.The book has a special section on case studies where the authors have given some clinical case reports (including some of their own), who were treated for immunological factor in RM/IF and were treated with Immunotherapy. These cases can be a useful guide to the readers.The book will be useful not only for undergraduate and postgraduate students but also for clinicians in their practice and for researchers for review of developments in the field.
Immunology of Recurrent Pregnancy Loss and Implantation Failure by Joanna Kwak-Kim Pdf
Immunology of Recurrent Pregnancy Loss provides doctors and immunologists with the information they need to help couples who experience recurrent pregnancy losses. Sections cover unexplained infertility, repeated in vitro fertilization, embryo transfer failures, history of second or third trimester pregnancy losses of unknown cause, or pregnancy with a history of or active autoimmune and/or alloimmune disease. Reproductive failure (RF), including recurrent pregnancy losses (RPL) and repeated implantation failures (RIF) is rather a syndrome than a disease caused by multiple etiologies, such as anatomical, endocrine, genetic, infectious, immunological, thrombotic and unexplained etiologies, hence this book strives to present the latest information. In 27 chapters, divided in 5 sections, the book introduces the current update of reproductive immunology topics in RF and provides systematic diagnostic guidelines, systemic and immune etiologies and therapeutic approaches. Provides detailed immunological background for understanding the etiology and management of reproduction failure Evaluates various immunological factors involved in the pathogenesis and management of reproduction failure Gives insights into various immunological and therapeutic approaches for reproduction failure
Immunology and Medical Zoology by Lucca Crosby & Andrew Elliott Pdf
Immunology and medical zoology presents current advancements and also thorough surveys in immunology. Articles address the extensive variety of points that contain immunology, including atomic and cell enactment components, phylogeny and sub-atomic development, and clinical modalities. Immunology is the investigation of the body's security from outside macromolecules or attacking life forms and the reactions to them. These trespassers incorporate infections, microorganisms, protozoa or significantly bigger parasites. What's more, immune reactions are produced against our own proteins (and different atoms) in autoimmunity and against our own particular distorted cells in tumor insusceptibility. The principal line of protection against outside creatures are hindrance tissues, for example, the skin that stop the passage of living being into our bodies. A moment line of resistance is the particular or versatile immune framework which may take days to react to an essential attack (that is contamination by a life form that has not up to this point been seen). This new book unites new research from around the world managing this critical subject. Immunology, with its premise in microbiology, is a critical segment of the essential sciences educational modules and has solid relationship with fields, for example, sensitivity, immunochemistry, immunopharmacology and transplantation.
A Practical Guide to Selecting Gametes and Embryos by Markus Montag Pdf
Among the many recent advances in assisted reproduction therapies (ART), improved technologies for identifying viable oocytes, sperm, and embryos are of primary importance. Paradoxically, the latest advances presented at conferences and symposia are often slow to become part of the daily routine in IVF laboratories. Detailing established and develo
National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Policy and Global Affairs,Committee on Science, Engineering, and Public Policy
Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Policy and Global Affairs,Committee on Science, Engineering, and Public Policy Publisher : National Academies Press Page : 295 pages File Size : 52,9 Mb Release : 2002-06-17 Category : Science ISBN : 9780309076371
Scientific and Medical Aspects of Human Reproductive Cloning by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Policy and Global Affairs,Committee on Science, Engineering, and Public Policy Pdf
Human reproductive cloning is an assisted reproductive technology that would be carried out with the goal of creating a newborn genetically identical to another human being. It is currently the subject of much debate around the world, involving a variety of ethical, religious, societal, scientific, and medical issues. Scientific and Medical Aspects of Human Reproductive Cloning considers the scientific and medical sides of this issue, plus ethical issues that pertain to human-subjects research. Based on experience with reproductive cloning in animals, the report concludes that human reproductive cloning would be dangerous for the woman, fetus, and newborn, and is likely to fail. The study panel did not address the issue of whether human reproductive cloning, even if it were found to be medically safe, would beâ€"or would not beâ€"acceptable to individuals or society.
Frontiers in Gynecological Endocrinology by Andrea R. Genazzani,Mark Brincat Pdf
This volume represents an up-to-date overview on the major areas of gynecological endocrinology, providing the reader with a complete explanation of female endocrine regulation and metabolism and relevant disorders and treatment. It is published within the International Society of Gynecological Endocrinology (ISGE) Series and is based on the 2013 International School of Gynecological and Reproductive Endocrinology Summer Course. The book covers a very wide range of topics – from primary amenorrhea to menopause, from the impact of ovarian surgery on fertility to fertility cryopreservation, from metabolic syndrome and polycystic ovary to premature ovarian failure and from the clinical impact of selective progesterone receptor modulators to the use of progesterone in prevention of premature labor. It will be an important tool for obstetricians and gynecologists, endocrinologists and experts in women’s health as well as interested GPs.