Gene Expression And Regulation In Mammalian Cells Transcription Toward The Establishment Of Novel Therapeutics

Author : Fumiaki Uchiumi
Publisher : BoD – Books on Demand
Page : 374 pages
File Size : 40,9 Mb
Release : 2018-02-28
Category : Medical
ISBN : 9789535138679

Get Book

Gene Expression and Regulation in Mammalian Cells by Fumiaki Uchiumi Pdf

Sixty years after the "central dogma," great achievements have been developed in molecular biology. We have also learned the important functions of noncoding RNAs and epigenetic regulations. More importantly, whole genome sequencing and transcriptome analyses enabled us to diagnose specific diseases. This book is not only intended for students and researchers working in laboratory but also physicians and pharmacists. This volume consists of 14 chapters, divided into 4 parts. Each chapter is written by experts investigating biological stresses, epigenetic regulation, and functions of transcription factors in human diseases. All articles presented in this volume by excellent investigators provide new insights into the studies in transcriptional control in mammalian cells and will inspire us to develop or establish novel therapeutics against human diseases.

Author : Fumiaki Uchiumi
Publisher : Unknown
Page : 372 pages
File Size : 47,8 Mb
Release : 2018
Category : Genetics
ISBN : 953514099X

Get Book

Gene Expression and Regulation in Mammalian Cells - Transcription Toward the Establishment of Novel Therapeutics by Fumiaki Uchiumi Pdf

Sixty years after the ""central dogma,"" great achievements have been developed in molecular biology. We have also learned the important functions of noncoding RNAs and epigenetic regulations. More importantly, whole genome sequencing and transcriptome analyses enabled us to diagnose specific diseases. This book is not only intended for students and researchers working in laboratory but also physicians and pharmacists. This volume consists of 14 chapters, divided into 4 parts. Each chapter is written by experts investigating biological stresses, epigenetic regulation, and functions of transcription factors in human diseases. All articles presented in this volume by excellent investigators provide new insights into the studies in transcriptional control in mammalian cells and will inspire us to develop or establish novel therapeutics against human diseases.

Author : Fumiaki Uchiumi
Publisher : BoD – Books on Demand
Page : 336 pages
File Size : 53,7 Mb
Release : 2018-02-21
Category : Medical
ISBN : 9789535138556

Get Book

Gene Expression and Regulation in Mammalian Cells by Fumiaki Uchiumi Pdf

"Central dogma" was presented by Dr. Francis Crick 60 years ago. The information of nucleotide sequences on DNAs is transcribed into RNAs by RNA polymerases. We learned the mechanisms of how transcription determines function of proteins and behaviour of cells and even how it brings appearances of organisms. This book is intended for scientists and medical researchers especially who are interested in the relationships between transcription and human diseases. This volume consists of an introductory chapter and 14 chapters, divided into 4 parts. Each chapter is written by experts in the basic scientific field. A collection of articles presented by active and laboratory-based investigators provides recent advances and progresses in the field of transcriptional regulation in mammalian cells.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 49,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

Get Book

Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Ghedira Kais
Publisher : BoD – Books on Demand
Page : 136 pages
File Size : 40,8 Mb
Release : 2018-10-10
Category : Medical
ISBN : 9781789237917

Get Book

Transcriptional and Post-transcriptional Regulation by Ghedira Kais Pdf

This book focuses on the transcriptional and post-transcriptional gene regulations and presents a detailed portrait of many novel aspects related to highlighting the importance of key TFs in some vital biological processes, the role of certain TFs to control some infectious diseases, the role of non-coding RNAs in controlling mRNA expression, the involvement of these non-coding RNAs in diseases, and the interplay between TFs and microRNAs as key players for gene expression regulation giving a complete picture of how genes are regulated at the cellular level. The editor embarked upon this writing project entitled "Transcriptional and Post-transcriptional Regulation" to make pertinent contributions accessible to the scientific community. Hopefully, a large audience will enjoy reading and benefit from the chapters of this book.

Author : Suming Huang,Michael D Litt,C. Ann Blakey
Publisher : Academic Press
Page : 482 pages
File Size : 54,9 Mb
Release : 2015-10-19
Category : Science
ISBN : 9780128004715

Get Book

Epigenetic Gene Expression and Regulation by Suming Huang,Michael D Litt,C. Ann Blakey Pdf

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science

Author : Fumiaki Uchiumi
Publisher : Unknown
Page : 334 pages
File Size : 54,7 Mb
Release : 2018
Category : Genetics
ISBN : 9535140957

Get Book

Gene Expression and Regulation in Mammalian Cells - Transcription From General Aspects by Fumiaki Uchiumi Pdf

""Central dogma"" was presented by Dr. Francis Crick 60 years ago. The information of nucleotide sequences on DNAs is transcribed into RNAs by RNA polymerases. We learned the mechanisms of how transcription determines function of proteins and behaviour of cells and even how it brings appearances of organisms. This book is intended for scientists and medical researchers especially who are interested in the relationships between transcription and human diseases. This volume consists of an introductory chapter and 14 chapters, divided into 4 parts. Each chapter is written by experts in the basic scientific field. A collection of articles presented by active and laboratory-based investigators provides recent advances and progresses in the field of transcriptional regulation in mammalian cells.

Author : Sam Thiagalingam
Publisher : Cambridge University Press
Page : 597 pages
File Size : 51,7 Mb
Release : 2015-04-09
Category : Mathematics
ISBN : 9780521493390

Get Book

Systems Biology of Cancer by Sam Thiagalingam Pdf

An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Author : Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Publisher : Springer
Page : 330 pages
File Size : 50,6 Mb
Release : 2015-10-13
Category : Science
ISBN : 9784431556510

Get Book

Innovative Medicine by Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto Pdf

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Author : Daan J. A. Crommelin,Robert D. Sindelar
Publisher : CRC Press
Page : 456 pages
File Size : 50,5 Mb
Release : 2002-11-14
Category : Medical
ISBN : 0415285011

Get Book

Pharmaceutical Biotechnology by Daan J. A. Crommelin,Robert D. Sindelar Pdf

The field of pharmaceutical biotechnology is evolving rapidly. A whole new arsenal of protein pharmaceuticals is being produced by recombinant techniques for cancer, viral infections, cardiovascular and hereditary disorders, and other diseases. In addition, scientists are confronted with new technologies such as polymerase chain reactions, combinatorial chemistry and gene therapy. This introductory textbook provides extensive coverage of both the basic science and the applications of biotechnology-produced pharmaceuticals, with special emphasis on their clinical use. Pharmaceutical Biotechnology serves as a complete one-stop source for undergraduate pharmacists, and it is valuable for researchers and professionals in the pharmaceutical industry as well.

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 570 pages
File Size : 49,6 Mb
Release : 2011-12-30
Category : Science
ISBN : 9780309219396

Get Book

The Science and Applications of Synthetic and Systems Biology by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.

Author : Ganji Purnachandra Nagaraju,Sujatha Peela
Publisher : Springer Nature
Page : 259 pages
File Size : 42,9 Mb
Release : 2020-10-01
Category : Medical
ISBN : 9789811554711

Get Book

Novel therapeutic approaches for gastrointestinal malignancies by Ganji Purnachandra Nagaraju,Sujatha Peela Pdf

This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents. Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies.

Author : Michael F. Carey,Stephen T. Smale
Publisher : CSHL Press
Page : 684 pages
File Size : 41,8 Mb
Release : 2000
Category : Medical
ISBN : 0879696354

Get Book

Transcriptional Regulation in Eukaryotes by Michael F. Carey,Stephen T. Smale Pdf

In the genome era, the analysis of gene expression has become a critical requirement in many laboratories. But there has been no comprehensive source of strategic, conceptual, and technical information to guide this often complex task. Transcriptional Regulation in Eukaryotes answers that need. Written by two experienced investigators, Michael Carey and Stephen Smale at the UCLA School of Medicine, and based in part on the Gene Expression course taught at Cold Spring Harbor Laboratory, this book directly addresses all the concerns of a laboratory studying the regulation of a newly isolated gene and the biochemistry of a new transcription factor. This important and unique book is essential reading for anyone pursuing the analysis of gene expression in model systems or disease states.

Author : Otto Warburg
Publisher : EnCognitive.com
Page : 359 pages
File Size : 47,5 Mb
Release : 2015-09-15
Category : Health & Fitness
ISBN : 9781927091159

Get Book

The Metabolism of Tumours by Otto Warburg Pdf

This is the original text of Nobel Prize Laureate Dr. Otto Warburg's classic, "The Metabolism of Tumours." In this book Dr. Warburg, MD, PhD, and distinguished scientists demonstrate, through empirical evidence that: “Cancer, above all other diseases, has countless secondary causes. But, even for cancer, there is only one prime cause. Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by fermentation of sugar.” All the experiments, in their original text, are included in this book.

Author : Lucy W. Barrett,Sue Fletcher,Steve D. Wilton
Publisher : Springer Science & Business Media
Page : 63 pages
File Size : 53,5 Mb
Release : 2013-06-26
Category : Science
ISBN : 9783034806794

Get Book

Untranslated Gene Regions and Other Non-coding Elements by Lucy W. Barrett,Sue Fletcher,Steve D. Wilton Pdf

There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.​