Gene Expression To Neurobiology And Behaviour

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Gene Expression to Neurobiology and Behaviour

Anonim
Gene Expression to Neurobiology and Behaviour Book PDF

Author : Anonim
Publisher : Elsevier
Page : 376 pages
File Size : 44,9 Mb
Release : 2011-04-21
Category : Science
ISBN : 9780444538857

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Gene Expression to Neurobiology and Behaviour by Anonim Pdf

How does the genome, interacting with the multi-faceted environment, translate into the development by which the human brain achieves its astonishing, adaptive array of cognitive and behavioral capacities? Why and how does this process sometimes lead to neurodevelopmental disorders with a major, lifelong personal and social impact? This volume of Progress in Brain Research links findings on the structural development of the human brain, the expression of genes in behavioral and cognitive phenotypes, environmental effects on brain development, and developmental processes in perception, action, attention, cognitive control, social cognition, and language, in an attempt to answer these questions. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Regulation of Gene Expression and Brain Function

Paul J. Harrison
Regulation of Gene Expression and Brain Function Book PDF

Author : Paul J. Harrison
Publisher : Springer Science & Business Media
Page : 71 pages
File Size : 43,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642784583

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Regulation of Gene Expression and Brain Function by Paul J. Harrison Pdf

Gene expression converts the information coded by our genes into proteins. These determine the structure and function of an organ such as the brain. Itis therefore an essential process, linking molecular genetics with neurochemistry and behavioral neuroscience. This volume presents a didactic approach to the understanding of the basic processes of gene expression and their involvement in certain brain diseases, such asAlzheimer's disease and schizophrenia. Generously illustrated, the contributions provide a valuable outline of this key aspect of molecular neurobiology and clinical neuroscience.

Behavioral and Neural Genetics of Zebrafish

Robert T. Gerlai
Behavioral and Neural Genetics of Zebrafish Book PDF

Author : Robert T. Gerlai
Publisher : Academic Press
Page : 616 pages
File Size : 49,8 Mb
Release : 2020-04-03
Category : Medical
ISBN : 9780128175293

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Behavioral and Neural Genetics of Zebrafish by Robert T. Gerlai Pdf

Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions. Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field Describes behavioral, genetic and neural methods and concepts for use in adult and larval zebrafish Features examples of zebrafish models of human central nervous system disorders Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics

Brain Transcriptome

Anonim
Brain Transcriptome Book PDF

Author : Anonim
Publisher : Academic Press
Page : 358 pages
File Size : 45,9 Mb
Release : 2014-08-27
Category : Science
ISBN : 9780128013199

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Brain Transcriptome by Anonim Pdf

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume, concentrates on the brain transcriptome. Brings together cutting-edge research on the brain transcriptome

Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research

Robert T. Gerlai
Molecular Genetic and Statistical Techniques for Behavioral and Neural Research Book PDF

Author : Robert T. Gerlai
Publisher : Academic Press
Page : 710 pages
File Size : 41,6 Mb
Release : 2018-04-24
Category : Mathematics
ISBN : 9780128041161

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Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research by Robert T. Gerlai Pdf

Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists. Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior Written and edited by leading international experts

Brain, Behavior and Epigenetics

Arturas Petronis,Jonathan Mill
Brain Behavior and Epigenetics Book PDF

Author : Arturas Petronis,Jonathan Mill
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 40,9 Mb
Release : 2011-05-19
Category : Medical
ISBN : 9783642174261

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Brain, Behavior and Epigenetics by Arturas Petronis,Jonathan Mill Pdf

Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease? If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment? Over the last couple of decades, epigenetics has undergone a significant metamorphosis from an abstract developmental theory to a very dynamic and rapidly developing branch of molecular biology. This volume represents a compilation of our current understanding about the key aspects of epigenetic processes in the brain and their role in behavior. The chapters in this book bring together some of the leading researchers in the field of behavioral epigenetics. They explore many of the epigenetic processes which operate or may be operating to mediate neurobiological functions in the brain and describe how perturbations to these systems may play a key role in mediating behavior and the origin of brain diseases.

Regulation of Gene Expression and Brain Function

Paul Buckley
Regulation of Gene Expression and Brain Function Book PDF

Author : Paul Buckley
Publisher : Springer
Page : 64 pages
File Size : 46,9 Mb
Release : 2011-12-30
Category : Science
ISBN : 3642784593

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Regulation of Gene Expression and Brain Function by Paul Buckley Pdf

Gene expression converts the information coded by our genes into proteins. These determine the structure and function of an organ such as the brain. Itis therefore an essential process, linking molecular genetics with neurochemistry and behavioral neuroscience. This volume presents a didactic approach to the understanding of the basic processes of gene expression and their involvement in certain brain diseases, such asAlzheimer's disease and schizophrenia. Generously illustrated, the contributions provide a valuable outline of this key aspect of molecular neurobiology and clinical neuroscience.

Handbook of Object Novelty Recognition

Anonim
Handbook of Object Novelty Recognition Book PDF

Author : Anonim
Publisher : Academic Press
Page : 600 pages
File Size : 42,9 Mb
Release : 2018-11-16
Category : Science
ISBN : 9780128120149

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Handbook of Object Novelty Recognition by Anonim Pdf

Handbook of Object Novelty Recognition, Volume 26, synthesizes the empirical and theoretical advances in the field of object recognition and memory that have occurred since the development of the spontaneous object recognition task. The book is divided into four sections, covering vision and perception of object features and attributions, definitions of concepts that are associated with object recognition, the influence of brain lesions and drugs on various memory functions and processes, and models of neuropsychiatric disorders based on spontaneous object recognition tasks. A final section covers genetic and developmental studies and gender and hormone studies. Details the brain structures and the neural circuits that underlie memory of objects, including vision and olfaction Provides a thorough description of the object novelty recognition task, variations on the basic task, and methods and techniques to help researchers avoid common pitfalls Assists researchers in understanding all aspects of object memory, conducting object novelty recognition tests, and producing reliable, reproducible results

Epigenetics, Brain and Behavior

Paolo Sassone Corsi,Yves Christen
Epigenetics Brain and Behavior Book PDF

Author : Paolo Sassone Corsi,Yves Christen
Publisher : Springer Science & Business Media
Page : 171 pages
File Size : 48,7 Mb
Release : 2012-08-28
Category : Medical
ISBN : 9783642279126

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Epigenetics, Brain and Behavior by Paolo Sassone Corsi,Yves Christen Pdf

What lies at the heart of neuronal plasticity? Accumulating evidence points to epigenetics. This word originally indicated potentially heritable modifications in gene expression that do not involve changes in DNA sequence. Today this definition is much less strict, and epigenetic control is thought to include DNA methylation, histone modifications, histone variants, microRNA metabolic pathways and non-histone proteins modifications. Thus, while neuronal plasticity is rightly thought to be intimately associated to genomic control, it is critical to appreciate that there is much more to the genome than DNA sequence. Recent years have seen spectacular advances in the field of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigenetic regulation to brain functions has been accumulating. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molecular mechanisms implicated in epigenetic control and how these may operate in concert. It will be critical to unravel how specificity is achieved. Importantly, specific modifications seem to mediate both developmental processes and adult brain functions, such as synaptic plasticity and memory. Many aspects of the research in neurosciences and endocrinology during the upcoming decade will be dominated by the deciphering of epigenetic control. This book constitutes a compendium of the most updated views in the field.

Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction

L. Kaczmarek,H.A. Robertson
Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction Book PDF

Author : L. Kaczmarek,H.A. Robertson
Publisher : Gulf Professional Publishing
Page : 390 pages
File Size : 55,8 Mb
Release : 2002-07-01
Category : Medical
ISBN : 0080534465

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Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction by L. Kaczmarek,H.A. Robertson Pdf

That molecular neurobiology has become a dominant part of neuroscience research can be credited to the discovery of inducible gene expression in the brain and spinal cord. This volume deals with genes, whose expression patterns in the vertebrate central nervous system were the first to be revealed and then the most extensively investigated over the last 15 years. Immediate early genes (IEG) and their protein products, especially those acting as regulators of transcription (inducible transcription factors, ITF) have proven to be very valuable tools in functional neuroanatomy and neurophysiology, as they are rapidly and transiently induced in specific neurons in response to various modes of stimulation. Thus, they have been used to map neuronal populations selectively responsive to a variety of conditions, such as sensory and learning experience, electrical stimulation of specific circuits, seizures, and neurodegeneration. This single volume, written by the most prominent authors in the field, brings together for the first time information about the most widely studied IEG/ITF in a whole variety of phenomena of neuronal activation. It starts with a critical appraisal of the technologies employed for the studies on gene, protein, and transcription factor activity in the nervous system. Several chapters present exhaustive examples of expression patterns of the ITF in "vocal" avian brain, mammalian brain sensory regions, areas involved in regulation of circadian rhythms, and the spinal cord. The next parts cover functional and regular aspects of individual IEG/ITF expression: c-fos in learning and memory, c-jun and others in neuropathology and neuronal stress responses, Elk-1, egr family, and CREB in neuronal plasticity and learning. This volume will be useful as a major reference on this topic. Furthermore, it attempts to unravel the seemingly overwhelming complexity of the phenomena of gene expression in the central nervous system.

Methods in Genomic Neuroscience

Hemin R. Chin,Steven O. Moldin
Methods in Genomic Neuroscience Book PDF

Author : Hemin R. Chin,Steven O. Moldin
Publisher : CRC Press
Page : 344 pages
File Size : 41,5 Mb
Release : 2001-09-26
Category : Science
ISBN : 9781420038477

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Methods in Genomic Neuroscience by Hemin R. Chin,Steven O. Moldin Pdf

The past few years have witnessed extraordinary advances in molecular genetic techniques and the accumulation of structural genomics information and resources in both human and model organisms. With the development of new technologies and the availability of resources like the sequence of eukaryotic genomes, problems of a previously unthinkable sco

Epigenetics and Behavior

F. Scott Hall,Maria T.G. Perona
Epigenetics and Behavior Book PDF

Author : F. Scott Hall,Maria T.G. Perona
Publisher : Academic Press
Page : 400 pages
File Size : 43,7 Mb
Release : 2017-10-01
Category : Medical
ISBN : 9780128016732

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Epigenetics and Behavior by F. Scott Hall,Maria T.G. Perona Pdf

Epigenetics and Behavior: Exploring Biological Determinants of Behavior discusses the evolutionary basis of neurodevelopmental regulation of gene expression by experience (epigenetics). While many areas of scientific inquiry have sought to understand what determines the variation in human attributes (phenotypes) that have consistent trait-like features, including anxiety or fearlessness, aggressive or non-aggressive behavior, social or antisocial behavior, charitable or miserly traits, and so forth, this book takes a comprehensive approach. Over the lifespan of a particular individual, these traits, although flexible, are often highly consistent. The “nature-nurture or “genes versus environment discussion is one of the longstanding arguments in all philosophical inquiry. And now, as we stand on the threshold of a complete understanding of the most fundamental question about human nature, all a result of combined empirical and theoretical advances in epigenetics which influence developmental psychobiology and evolutionary biology, the science is rapidly progressing. With the advent of epigenetics, we now have a mechanism (or mechanisms, really) to explain how this process works at a molecular level – that is, evolutionary selected mechanisms of gene-environment interactions are literally “written into our genetic code. This book draws together the knowledge and ideas from the different fields that collectively have answered the “nature-nurture discussion. Integrates the findings of developmental psychobiology with epigenetics in an evolutionary context Written to convey a new perspective on epigenetic effects on behavior, while maintaining fluid writing prose for the uninformed reader Assembles knowledge from a number of fields, including developmental psychobiology, genomics, epigenetics, and evolutionary biology to paint a precise picture of epigenetic influences on personality

The Neurobiology of Criminal Behavior

Dr Jonathan D Bolen,Professor Anthony Walsh
The Neurobiology of Criminal Behavior Book PDF

Author : Dr Jonathan D Bolen,Professor Anthony Walsh
Publisher : Ashgate Publishing, Ltd.
Page : 233 pages
File Size : 45,7 Mb
Release : 2013-02-28
Category : Social Science
ISBN : 9781409497950

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The Neurobiology of Criminal Behavior by Dr Jonathan D Bolen,Professor Anthony Walsh Pdf

The main feature of this work is that it explores criminal behavior from all aspects of Tinbergen's Four Questions. Rather than focusing on a single theoretical point of view, this book examines the neurobiology of crime from a biosocial perspective. It suggests that it is necessary to understand some genetics and neuroscience in order to appreciate and apply relevant concepts to criminological issues. Presenting up-to-date information on the circuitry of the brain, the authors explore and examine a variety of characteristics, traits and behavioral syndromes related to criminal behavior such as ADHD, intelligence, gender, the age-crime curve, schizophrenia, psychopathy, violence and substance abuse. This book brings together the sociological tradition with the latest knowledge the neurosciences have to offer and conveys biological information in an accessible and understanding way. It will be of interest to scholars in the field and to professional criminologists.

Genes, Brain Function, and Behavior

Douglas Wahlsten
Genes Brain Function and Behavior Book PDF

Author : Douglas Wahlsten
Publisher : Academic Press
Page : 300 pages
File Size : 42,8 Mb
Release : 2019-03-01
Category : Science
ISBN : 9780128128329

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Genes, Brain Function, and Behavior by Douglas Wahlsten Pdf

Genes, Brain Function, and Behavior offers a concise description of the nervous system that processes sensory input and initiates motor movements. It reviews how behaviors are defined and measured, and how experts decide when a behavior is perturbed and in need of treatment. Behavioral disorders that are clearly related to a defect in a specific gene are reviewed, and the challenges of understanding complex traits such as intelligence, autism and schizophrenia that involve numerous genes and environmental factors are explored. New methods of altering genes offer hope for treating or even preventing difficulties that arise in our genes. This book explains what genes are, what they do in the nervous system, and how this impacts both brain function and behavior. Presents essential background, facts, and terminology about genes, brain function, and behavior Builds clear explanations on this solid foundation while minimizing technical jargon Explores in depth several single-gene and chromosomal neurological disorders Derives lessons from these clear examples and highlights key lessons in boxes Examines the intricacies of complex traits that involve multiple genetic and environmental factors by applying lessons from simpler disorders Explains diagnosis and definition Includes a companion website with Powerpoint slides and images for each chapter for instructors and links to resources

Epigenetic Regulation in the Nervous System

J. David Sweatt,Michael J. Meaney,Eric J. Nestler,Schahram Akbarian
Epigenetic Regulation in the Nervous System Book PDF

Author : J. David Sweatt,Michael J. Meaney,Eric J. Nestler,Schahram Akbarian
Publisher : Academic Press
Page : 374 pages
File Size : 48,6 Mb
Release : 2012-12-31
Category : Science
ISBN : 9780123944054

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Epigenetic Regulation in the Nervous System by J. David Sweatt,Michael J. Meaney,Eric J. Nestler,Schahram Akbarian Pdf

Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. BMA Medical Book Awards 2014 - Highly Commended, Neurology, British Medical Association BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics