Gene Therapy For Autoimmune And Inflammatory Diseases

Author : Yuti Chernajovsky,Paul D. Robbins
Publisher : Springer Science & Business Media
Page : 239 pages
File Size : 53,9 Mb
Release : 2011-01-28
Category : Medical
ISBN : 9783034601658

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Gene Therapy for Autoimmune and Inflammatory Diseases by Yuti Chernajovsky,Paul D. Robbins Pdf

In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not only from the quantitative point of view, but also for currently unknown and unexpected secondary effects of the vector or the transgene. Some of these approaches have already been tested in the clinic, but much more needs to be done to understand the human conditions treated and the n- ural history of their pathology. We are indebted to the secretarial assistance of Ms. Lin Wells (Bone and Joint Research Unit, London, UK) and the help of Hans Detlef Klüber for his help in getting this book published. We hope this book will be of interest to c- nicians and scientists and inspiring to students of the subject who will use their own ingenuity and knowledge to further forward this discipline into clinical use.

Author : Christopher H. Evans,Paul D. Robbins
Publisher : Birkhäuser
Page : 260 pages
File Size : 53,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783034884785

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Gene Therapy in Inflammatory Diseases by Christopher H. Evans,Paul D. Robbins Pdf

Gene therapy for inflammatory diseases is a new , burgeoning field of medicine. Edited by the undisputed pioneers of this area of research, this volume is the first devoted to its topic. It contains thirteen chapters, each written by leaders in their respective fields, that summarize the state of the art in developing novel, gene based treatments for inflammatory diseases. As well as providing an introduction to the basic concepts of gene therapy and the use of naked DNA approaches, the book describes the advances that have been made in applying them to arthritis, lupus, multiple sclerosis, diabetes, Sjogren`s syndrome and transplantation.One chapter is devoted to discussing the first human clinical trials that apply gene therapy to the treatment of an inflammatory disease. As well as providing novel therapeutic approaches, gene therapy facilitates the development of new and improved animal models of disease; a chapter describing these advances is also included. As an up-to-date, timely book written by th

Author : C. Garrison Fathman
Publisher : Karger Medical and Scientific Publishers
Page : 229 pages
File Size : 42,6 Mb
Release : 2000-01-01
Category : Medical
ISBN : 9783805569491

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Biologic and Gene Therapy of Autoimmune Disease by C. Garrison Fathman Pdf

The clinical management of autoimmune diseases has proven to be extremely difficult. Current therapies focus on trying to alleviate symptoms, but fail to correct the fundamental immune defects that lead to pathology. To achieve this goal, it is necessary to understand much of the biology of antigen presentation, lymphocyte activation and the effects of cytokines. The articles in this book provide an up-to-date review of current innovative therapies using both biologic and gene therapy for the treatment of selected autoimmune diseases. Therapeutical approaches discussed include oral tolerance, the use of anti-CD4 monoclonal antibodies, IL-10 and anti-TNFa antibodies, DNA vaccination, and gene therapy applied to organ-specific autoimmune disease. Although some of these techniques are still in their infancy, their potential efficacy has been demonstrated in several animal models of autoimmune disease, holding great promise for the future development of treatments. Written by recognized experts in the field, the chapters in this book illustrate the concept of technology transfer from bench to bedside and provide a valuable update for clinicians and scientists in clinical immunology.

Author : Gerald J. Prud'homme
Publisher : Springer Science & Business Media
Page : 148 pages
File Size : 45,6 Mb
Release : 2007-02-26
Category : Medical
ISBN : 9780387286709

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Gene Therapy of Autoimmune Disease by Gerald J. Prud'homme Pdf

Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.

Author : Gerald J. Prud'homme
Publisher : Springer
Page : 149 pages
File Size : 44,8 Mb
Release : 2005-07-13
Category : Medical
ISBN : 0306479915

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Gene Therapy of Autoimmune Disease by Gerald J. Prud'homme Pdf

Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.

Author : Christopher Howard Evans,Paul D. Robbins
Publisher : Unknown
Page : 260 pages
File Size : 44,8 Mb
Release : 2000
Category : Anti-inflammatoires
ISBN : 0817658556

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Gene Therapy in Inflammatory Diseases by Christopher Howard Evans,Paul D. Robbins Pdf

Author : Paola Mina-Osorio
Publisher : Springer
Page : 202 pages
File Size : 48,7 Mb
Release : 2017-01-21
Category : Medical
ISBN : 9783319422527

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Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases by Paola Mina-Osorio Pdf

As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is different in different patient subsets. Promising new technologies have been conceived that address the hypotheses that targeting multiple pathways simultaneously, selectively delivering therapeutics to areas of inflammation and/or resetting the immune system, could take efficacy to new levels. However, we have long waited for the arrival of some of these technologies to the bedside, or even far enough in the drug development process in spite of the initial enthusiasm. Some of the examples covered in this book include bispecific antibodies and genomic medicines, microparticles and targeted delivery of drugs to inflamed vasculature. Most published reviews and book chapters on novel therapies for inflammatory diseases describe positive attributes of molecules or technologies under investigation and the rationale for developing them into therapeutics. The originality and potential value of this book is not in the description of these targets or technologies from the point of view of their structure or mechanism of action exclusively, but rather, in making an effort to critically address the question of what is needed to move these technologies into the clinic. Has the technology not made it past the preclinical stage and why? Has it already been tested in humans and failed? What are the potential reasons behind those failures? What do experts in each field believe can be done better to increase the probabilities of success? In addition, the authors address the competitive landscape and summarize clinical studies that have failed in the respective area. They talk about the patient populations that would be required for the successful conduction of a clinical trial to test certain molecules, and they proactively share their views regarding both the potential and the drawbacks of targets or methodologies.

Author : Gerald J. Prud'homme
Publisher : Springer
Page : 0 pages
File Size : 54,5 Mb
Release : 2008-11-01
Category : Medical
ISBN : 0387500162

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Gene Therapy of Autoimmune Disease by Gerald J. Prud'homme Pdf

Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.

Author : Dagan (NA) Wells
Publisher : Unknown
Page : 128 pages
File Size : 52,6 Mb
Release : 2003-01-01
Category : Medical
ISBN : 1587062054

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Gene Therapy for Autoimmune Disease by Dagan (NA) Wells Pdf

Author : C. Pozzilli,P. Pozzilli,J.-F. Kapp
Publisher : Springer Science & Business Media
Page : 158 pages
File Size : 40,5 Mb
Release : 2001-05-15
Category : Medical
ISBN : 3540414797

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New Concepts in Pathology and Treatment of Autoimmune Disorders by C. Pozzilli,P. Pozzilli,J.-F. Kapp Pdf

Autoimmunity, characterized by autoreactive lymphocytes and autoantibodies, is the consequence of a failure to discriminate between self and non-self, and autoimmune diseases are an increasing threat to people living in the industrialized countries. Autoimmune disorders are treatable, but not curable, and patients can face disability at later stages of the disease. Thus, there is a medical and economic need for new concepts and treatments in autoimmune disorders. New concepts and treatments can only be achieved by an interdisciplinary approach bringing together expertise, technologies, and clinical experience. The workshop focused on multiple sclerosis, rheumatoid arthritis and type I diabetes, and discussed conventional drug therapies, gene therapy, cell and tissue transplantation therapies, and first treatments using blood stem cells for reprogramming the patients' immune system.

Author : Michael Sticherling,Enno Christophers
Publisher : Springer Science & Business Media
Page : 200 pages
File Size : 49,6 Mb
Release : 2003
Category : Medical
ISBN : 3211837728

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Treatment of Autoimmune Disorders by Michael Sticherling,Enno Christophers Pdf

Progress in basic and clinical immunology within the last two decades has provided profound insight into the immune system and its role in preventing endogenous and exogenous damage. In contrast, disbalances within this system can result in autoimmune disorders which may affect diverse organs and result in distinct clinical pictures. In many of these, however, the individual etiopathogenetic mechanisms are poorly understood and even more their clinical symptoms are hard to treat. The book offers insight into basic mechanisms of autoimmune disorders. It includes neurological, gastrointestinal, ophthalmological and skin diseases as well as current and future therapeutic options including immunomodulatory drugs and different vaccination strategies. By addressing diverse organ systems, both singular and shared features are elaborated. Thus an exchange of ideas is intended across research on single organ systems within a truly interdisciplinary setting.

Author : Ronald F van Vollenhoven
Publisher : World Scientific Publishing Company
Page : 396 pages
File Size : 50,9 Mb
Release : 2015-08-13
Category : Medical
ISBN : 9789814656344

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Clinical Therapy Research in the Inflammatory Diseases by Ronald F van Vollenhoven Pdf

This unique textbook provides information on the dramatic advances taking place in the field of inflammatory (autoimmune) diseases and their therapies. Experts in many different medical fields — allergology, dermatology, gastroenterology, pulmonology, rheumatology etc. — will describe the advances in our understanding of the most important inflammatory diseases linking basic science discoveries to the advances in therapeutics that have taken place over the past years and foreshadow even more dramatic changes which will occur in the years to come. This is a truly multi-specialty bench-to-bedside textbook that will enable readers to gain a wide-ranging but also solidly built understanding of the therapeutic areas of inflammatory diseases.

Author : Phuc Van Pham
Publisher : Springer
Page : 163 pages
File Size : 40,8 Mb
Release : 2019-08-13
Category : Science
ISBN : 9783030234218

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Stem Cell Transplantation for Autoimmune Diseases and Inflammation by Phuc Van Pham Pdf

This book introduces many new technologies and clinical applications of hematopoietic stem cells and mesenchymal stem cell transplantation for the treatment of autoimmune diseases and inflammatory diseases. Presented in two parts, Part 1 focuses on stem cell therapies for autoimmune disease treatment; Part 2 focuses on stem cell therapies and their application in the treatment of common inflammatory diseases, including chronic knee osteoarthritis, chronic obstructive pulmonary disease, liver cirrhosis, Crohn's Disease, Multiple Sclerosis, and more. This book is an essential source for all advanced students and researchers involved with these diseases, stem cells, or both. Stem Cell Transplantation for Autoimmune Diseases and Inflammation and the other books in the Stem Cells in Clinical Applications series are invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine, or tissue engineering as well as cancer or genetics research.

Author : Gerhard Gross,Thomas Häupl
Publisher : Walter de Gruyter
Page : 426 pages
File Size : 51,7 Mb
Release : 2013-10-29
Category : Medical
ISBN : 9783110298307

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Stem Cell-Dependent Therapies by Gerhard Gross,Thomas Häupl Pdf

Multipotent mesenchymal stem cells (MSCs) are a heterogeneous population of cells which reside in a variety of tissues. They differentiate into several mesodermal lineages, secrete a multitude of trophic factors and contribute to tissue homeostasis. MSCs are able to exert immunosuppressive activities by interfering with inflammatory cytokine production and with T- and B-cell proliferation. These immunomodulating properties make MSCs promising candidates for the treatment of chronic inflammatory and autoimmune disorders. There are, however, certain caveats involved including inappropriate migration of cells in the body, immune rejection, tumor formation, or graft versus host disease (GvHD). This book investigates the current state of the MSC-dependent therapy of chronic inflammatory disorders and autoimmune diseases. Among the covered topics are GvHD, chronic kidney, liver and lung disease, ischemic heart and inflammatory bowel disease, diabetes, osteoarthritis, various rheumatic and neurological disorders and, lastly, tumors and solid organ transplantations. This book also questions the immunoprivileged status of MSCs, discusses the therapeutic role of MSCs in experimental animal disease models and their translation to the corresponding human disorders, envisions a role for MSCs in tumor interventions and, lastly, describes a systems biology approach for stem cells and inflammation.

Author : Andras Perl
Publisher : Humana Press
Page : 504 pages
File Size : 41,8 Mb
Release : 2016-08-23
Category : Medical
ISBN : 149395637X

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Autoimmunity by Andras Perl Pdf

Continued refinement of wide-spread access to transgenic technology has allowed for new animal models have been developed that exhibit features of autoimmune disease have been developed that exhibit features of autoimmune disease. The second edition of Autoimmunity: Methods and Protocols researchers in the field detail many of the most up-to-date methods which are now commonly used to study autoimmunity. The first half the book focuses on methods and protocols used to assess immunological and biochemical pathways of diseases pathogenesis in human subjects. While the second half investigates treatment of inflammatory arthritis, experimental allergic encephalomyelitis (EAE), IDDM, scleroderma, and uveitis in animal models and assessment of genetic, immunological, and biochemical parameters underlying spontaneous or exogenous antigen-induced diseases. Written in the highly successful Methods in Molecular Biology(tm) series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Through and intuitive, Autoimmunity: Methods and Protocols, Second Edition seeks to aid scientists in the autoimmunity field to extract new meaning of old models and developing new ones.