New Concepts In Pathology And Treatment Of Autoimmune Disorders

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New Concepts in Pathology and Treatment of Autoimmune Disorders

C. Pozzilli,P. Pozzilli,J.-F. Kapp
New Concepts in Pathology and Treatment of Autoimmune Disorders Book PDF

Author : C. Pozzilli,P. Pozzilli,J.-F. Kapp
Publisher : Springer Science & Business Media
Page : 158 pages
File Size : 52,9 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9783662044506

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New Concepts in Pathology and Treatment of Autoimmune Disorders by C. Pozzilli,P. Pozzilli,J.-F. Kapp Pdf

Autoimmunity, characterized by autoreactive lymphocytes and autoantibodies, is the consequence of a failure to discriminate between self and non-self, and autoimmune diseases are an increasing threat to people living in the industrialized countries. Autoimmune disorders are treatable, but not curable, and patients can face disability at later stages of the disease. Thus, there is a medical and economic need for new concepts and treatments in autoimmune disorders. New concepts and treatments can only be achieved by an interdisciplinary approach bringing together expertise, technologies, and clinical experience. The workshop focused on multiple sclerosis, rheumatoid arthritis and type I diabetes, and discussed conventional drug therapies, gene therapy, cell and tissue transplantation therapies, and first treatments using blood stem cells for reprogramming the patients' immune system.

Autoimmunity

Andrzej Górski,Hubert Krotkiewski,Michal Zimecki
Autoimmunity Book PDF

Author : Andrzej Górski,Hubert Krotkiewski,Michal Zimecki
Publisher : Springer Science & Business Media
Page : 209 pages
File Size : 47,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401009812

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Autoimmunity by Andrzej Górski,Hubert Krotkiewski,Michal Zimecki Pdf

This book presents an excellent review of the mechanisms underlying the phenomena of autoimmunity. It provides not only an update of the field's state of the art, but also presents new concepts in the fundamentals and treatment of autoimmune disorders. The finest example of the new approach is understanding the nature of autoimmunity and the treatment of autoimmune diseases is the introductory article. The author opposes the current dogma that autoimmune disorders should be treated with immunosuppressors, and postulates rather the activation of the immune system, which may lead to redirecting the immune response to the protective, Th-2 type of immunity. A series of articles deals with several aspects of the subject, such as the generation, progression, and regulation of autoimmune phenomena. The roles of pathogens, apoptosis, cytokines, complement components, and regulatory T cells are described, as well as the association between the immune and neurohormonal systems in major autoimmune disorders. This is not a textbook, but it is highly recommended for clinicians and university workers, and as supplementary reading for lecturers and students.

The Molecular Pathology of Autoimmune Diseases

Argyrios N Theofilopoulos,Constantin A. Bona
The Molecular Pathology of Autoimmune Diseases Book PDF

Author : Argyrios N Theofilopoulos,Constantin A. Bona
Publisher : CRC Press
Page : 1518 pages
File Size : 46,7 Mb
Release : 2002-12-06
Category : Science
ISBN : 9057026457

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The Molecular Pathology of Autoimmune Diseases by Argyrios N Theofilopoulos,Constantin A. Bona Pdf

Remarkable advances have been made in the pathogenesis of autoimmunity, such as with bone marrow transplantation, which is becoming a powerful strategy in treating certain life-threatening diseases. The Molecular Pathology of Autoimmune Diseases is a concise and centralized resource for information on the topic, with a special focus on the molecular and genetic basis of these disorders. Dozens of international experts devote themselves to illuminating the reader in this volume, with discussions on the basic aspects of autoimmune processes to systemic and organ-specific diseases. This volume is an invaluable reference to students and professionals in immunology and related fields.

Emerging and Evolving Topics in Multiple Sclerosis Pathogenesis and Treatments

Anne C. La Flamme,Jacqueline Monique Orian
Emerging and Evolving Topics in Multiple Sclerosis Pathogenesis and Treatments Book PDF

Author : Anne C. La Flamme,Jacqueline Monique Orian
Publisher : Springer
Page : 235 pages
File Size : 43,8 Mb
Release : 2015-10-07
Category : Medical
ISBN : 9783319255439

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Emerging and Evolving Topics in Multiple Sclerosis Pathogenesis and Treatments by Anne C. La Flamme,Jacqueline Monique Orian Pdf

Over the past decade, we have made great advances in the field of multiple sclerosis (MS) research, and this book focuses on those advances in MS pathogenesis and treatment. While some of these advances have been through new approaches and ideas that have emerged in the last decade such as the newly identified protective role that amyloid proteins may play in MS or the use of helminths to treat autoimmune diseases, others have evolved from previous theories and ideas that have only now gained momentum and a deeper understanding such as the role of HLA or gender in MS susceptibility. This book covers these emerging and evolving topics and highlights the substantial advancements made in elucidation of the factors regulating susceptibility or disease progression, identification of new ways to monitor or predict MS pathology, and development of new strategies for treating MS.

Polymyositis and Dermatomyositis

Marinos C. Dalakas
Polymyositis and Dermatomyositis Book PDF

Author : Marinos C. Dalakas
Publisher : Butterworth-Heinemann
Page : 362 pages
File Size : 49,8 Mb
Release : 2013-10-22
Category : Health & Fitness
ISBN : 9781483163048

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Polymyositis and Dermatomyositis by Marinos C. Dalakas Pdf

Polymyositis and Dermatomyositis provides extensive information regarding Polymyositis and Dermatomyositis (PM/DM), which is described as a heterogeneous disease complex. This book is divided into four sections: Part I (Clinical Features) covers the classification of PM/DM, details of the clinical presentation, and the disease's association with the other connective tissue disorders and malignancies. Part II (Etiology and Mechanisms) covers advances in the immunopathology and viral etiology of PM/DM along with a frequently recognized entity: inclusion body myositis. Part III (Diagnosis and Treatment) covers the histologic, muscle enzyme histochemical, electron microscopic, and resin histology features of PM/DM along with those electromyographic features that could help make a more accurate diagnosis. Part IV (Overview) summarizes the issues that may not have been clear and highlights differing and unsettled views or present available data. This text is directed to clinicians in private practice or in academic institutions concerned with PM/DM patients, including neurologists, rheumatologists, pediatricians, dermatologists, physiatrists, and neuromuscular investigators. This book is intended as well for neuromuscular pathologists who interpret muscle biopsy specimens and electromyographers who perform EMG studies to help determine the clinical diagnosis. Researchers in immunology and immunopathology of neuromuscular diseases will find discussions in this book invaluable.

Animal Models of T Cell-Mediated Skin Diseases

T. Zollner,Harald Renz,Khusru Asadullah
Animal Models of T Cell Mediated Skin Diseases Book PDF

Author : T. Zollner,Harald Renz,Khusru Asadullah
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 55,9 Mb
Release : 2004-10-07
Category : Science
ISBN : 3540210679

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Animal Models of T Cell-Mediated Skin Diseases by T. Zollner,Harald Renz,Khusru Asadullah Pdf

Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.

Chemokine Roles in Immunoregulation and Disease

Philip M. Murphy,Richard Horuk
Chemokine Roles in Immunoregulation and Disease Book PDF

Author : Philip M. Murphy,Richard Horuk
Publisher : Springer Science & Business Media
Page : 186 pages
File Size : 42,5 Mb
Release : 2003-10-23
Category : Medical
ISBN : 3540402217

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Chemokine Roles in Immunoregulation and Disease by Philip M. Murphy,Richard Horuk Pdf

The Ernst Schering Workshop on Chemokine Roles in Immunoregulation and Disease, with contributions by leading experts in the field, succinctly summarizes cutting-edge research in immunology, protein chemistry, and disease. This book gives an up-to-date overview of important developments in immunology with a concise, state-of-the-art review of chemokines. It is a time-saving reference for both researchers and students, providing fast and easy access to the latest information in this important area of research.

The Autoimmune Diseases

Noel R. Rose,Ian R. Mackay
The Autoimmune Diseases Book PDF

Author : Noel R. Rose,Ian R. Mackay
Publisher : Academic Press
Page : 1134 pages
File Size : 40,8 Mb
Release : 2006
Category : Medical
ISBN : 9780125959612

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The Autoimmune Diseases by Noel R. Rose,Ian R. Mackay Pdf

Since publication of the Third Edition in 1998, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This Fourth Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels. New to This Edition: * Tissue-specific interventions to arrest or “cure” autoimmune disease * Bone marrow eradication and replacement * Both basic science and clinical medicine is covered * Boxed points to emphasize key features of each chapter

Autoimmune Disorders Handbook and Resource Guide

Grey House Publishing
Autoimmune Disorders Handbook and Resource Guide Book PDF

Author : Grey House Publishing
Publisher : Unknown
Page : 400 pages
File Size : 41,6 Mb
Release : 2021-02
Category : Reference
ISBN : 1637000359

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Autoimmune Disorders Handbook and Resource Guide by Grey House Publishing Pdf

"Autoimmune Diseases Handbook & Resource Guide combines valuable, easy-to-understand educational information for patients and their families, with national and state statistics and discussions about prevention, treatment and outcomes. It offers resources on 21 specific types of autoimmune disease, including Celiac, Diabetes Type 1, Endometriosis, Fibromyalgia, Lupus, Lyme disease, Rheumatoid arthritis, Scleroderma, and more, with notes on disease subtypes." --

Janeway's Immunobiology

Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Janeway s Immunobiology Book PDF

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 40,5 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Neurologic Involvement in Systemic Autoimmune Diseases

Doruk Erkan
Neurologic Involvement in Systemic Autoimmune Diseases Book PDF

Author : Doruk Erkan
Publisher : Elsevier Science Limited
Page : 279 pages
File Size : 49,7 Mb
Release : 2004
Category : Medical
ISBN : 0444516514

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Neurologic Involvement in Systemic Autoimmune Diseases by Doruk Erkan Pdf

Systemic autoimmune diseases can affect both the central and peripheral nervous systems in a myriad of ways and through a heterogeneous number of mechanisms leading to many different clinical manifestations. As a result, neurological complications of these disorders can result in significant morbidity and mortality. Advances in the diagnosis, laboratory investigations, and management of these conditions has placed an increasing burden on the practicing clinician to correctly assess and treat these patients. This volume of the Handbook of the Systemic Autoimmune Diseases will help the clinician and researcher better understand the current concepts of nervous system involvement from systemic autoimmune disorders, recognize current approaches to diagnosis and treatment, current controversies, and areas that need significant research efforts. It is believed that providing this approach in a single volume will facilitate its use as a frequent resource for all those caring for or investigating these patients and their diseases. Each chapter follows a consistent outline to provide the reader with important and useful information in an easy-to-navigate manner and is also liberally referenced to provide more primary source material for further consideration. The standardized approach to each chapter will allow the reader to be able to compare and contrast more efficiently the neurological complications of the autoimmune diseases discussed.

Emerging and Evolving Topics in Multiple Sclerosis Pathogenesis and Treatments

Anne C. La Flamme,Jacqueline Monique Orian
Emerging and Evolving Topics in Multiple Sclerosis Pathogenesis and Treatments Book PDF

Author : Anne C. La Flamme,Jacqueline Monique Orian
Publisher : Unknown
Page : 128 pages
File Size : 41,7 Mb
Release : 2015
Category : Electronic
ISBN : 3319255428

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Emerging and Evolving Topics in Multiple Sclerosis Pathogenesis and Treatments by Anne C. La Flamme,Jacqueline Monique Orian Pdf

Over the past decade, we have made great advances in the field of multiple sclerosis (MS) research, and this book focuses on those advances in MS pathogenesis and treatment. While some of these advances have been through new approaches and ideas that have emerged in the last decade such as the newly identified protective role that amyloid proteins may play in MS or the use of helminths to treat autoimmune diseases, others have evolved from previous theories and ideas that have only now gained momentum and a deeper understanding such as the role of HLA or gender in MS susceptibility. This book covers these emerging and evolving topics and highlights the substantial advancements made in elucidation of the factors regulating susceptibility or disease progression, identification of new ways to monitor or predict MS pathology, and development of new strategies for treating MS.

Blistering Diseases

Dédée F. Murrell
Blistering Diseases Book PDF

Author : Dédée F. Murrell
Publisher : Springer
Page : 0 pages
File Size : 48,9 Mb
Release : 2016-10-06
Category : Medical
ISBN : 3662507854

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Blistering Diseases by Dédée F. Murrell Pdf

This book is a comprehensive compendium of current knowledge on inherited and autoimmune blistering diseases that relates advances in our understanding of the pathogenetic mechanisms to management of the individual diseases. The aim is to provide a detailed reference for dermatologists who care for patients with these conditions and a useful “one-stop information shop” for specialists outside of dermatology. The book opens by describing the structure and biology of the epidermis and basement membrane zone and discussing the genes and proteins that are targets for mutations and autoantibodies. The role of the various diagnostic tests is explained, and clinical manifestations of the specific diseases are presented with the aid of many high-quality illustrations. The forms of treatment appropriate in specific conditions are then described in depth, with coverage of dressings, drugs, surgical procedures, gene therapy, and other novel approaches. Helpful algorithms are included both for testing and monitoring and for treatment.

Immune Rebalancing

Diana Boraschi,Giselle Penton-Rol
Immune Rebalancing Book PDF

Author : Diana Boraschi,Giselle Penton-Rol
Publisher : Academic Press
Page : 298 pages
File Size : 48,8 Mb
Release : 2016-01-25
Category : Medical
ISBN : 9780128033364

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Immune Rebalancing by Diana Boraschi,Giselle Penton-Rol Pdf

Immune Rebalancing: The Future of Immunosuppression summarizes the most promising perspectives of immunopharmacology, in particular in the area of immunosuppression by considering molecular pathways, personalized medicine, microbiome and nanomedicine. Modulation of immune responses for therapeutic purposes is a particularly relevant area, given the central role of anomalous immunity in diseases. These diseases vary from the most typically immune-related syndromes (autoimmune diseases, allergy and asthma, immunodeficiencies) to those in which altered immunity and inflammation define the pathological outcomes (chronic infections, tumours, chronic inflammatory and degenerative diseases, metabolic disorders, etc. Visits immunosuppression from a modern point of view of signalling mechanisms at the light of the current knowledge of signalling mechanisms and regulatory networks allows the reader to formulate new ideas and concepts on how to use immunosuppression the therapeutic purposes Encourages researchers to engage into exploring the field of pharmacological modulation of immune responses in depth, and with the new knowledge and tools available, designs more effective therapeutic strategies to autoimmune and inflammatory diseases, cancer, degenerative diseases and infections Examines the link between molecular pathways associated to immune-suppression and the new immunopharmacology approaches Provides information on the new strategies for drug development in this field Considers the role of microbes in the development of the mammalian immune system and immune responses, which will widen the reader’s strategy for addressing therapeutic immune modulations

Immune Regulation and Immunotherapy in Autoimmune Disease

Jingwu Zhang
Immune Regulation and Immunotherapy in Autoimmune Disease Book PDF

Author : Jingwu Zhang
Publisher : Springer
Page : 0 pages
File Size : 54,5 Mb
Release : 2010-10-29
Category : Medical
ISBN : 1441942092

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Immune Regulation and Immunotherapy in Autoimmune Disease by Jingwu Zhang Pdf

This volume reviews the most recent advances in the understanding of cellular and molecular mechanisms for immune responses and immune regulation. The books editor, Dr. Zhang, is well-known internationally, particularly in the field of multiple sclerosis and T-cell vaccination as a potential treatment of multiple sclerosis. He has much experience and expertise in both basic and clinical aspects of autoimmune disease.