Genetic Testing For Alzheimer Disease

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Genetic Testing for Alzheimer Disease

Stephen Garrard Post,Peter J. Whitehouse
Genetic Testing for Alzheimer Disease Book PDF

Author : Stephen Garrard Post,Peter J. Whitehouse
Publisher : Unknown
Page : 310 pages
File Size : 54,9 Mb
Release : 1998
Category : Family & Relationships
ISBN : UOM:39015036046707

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Genetic Testing for Alzheimer Disease by Stephen Garrard Post,Peter J. Whitehouse Pdf

The genetics of Alzheimer disease has been a point of intense concern and immense informational confusion for families in which a loved one is diagnosed with dementia. In recent years, however, scientists have begun to uncover the genetic bases for some forms of Alzheimer disease. Once a chromosomal defect is identified, it becomes possible to devise a test for its presence. The far-reaching implications of such tests are the focus of the present volume. In Genetic Testing for Alzheimer Disease, Stephen G. Post and Peter J. Whitehouse bring together experts from the fields of ethics, genetics, policy, neurology, philosophy, and anthropology to examine the ethical and social aspects of genetic testing for Alzheimer disease. The authors begin by focusing on current genetic findings and their clinical applicability. They then address ethical issues in genetic testing and genetic counseling for Alzheimer disease. They examine social issues such as confidentiality, discrimination, and fairness in health care. Finally, they discuss ways to educate professionals and laypeople regarding these issues. Contributors: Robert H. Binstock, Ph.D.?Thomas D. Bird, M.D. ? Robert Mullan Cook-Deegan, M.D.? Leonard Fleck, Ph.D. ? Atwood D. Gaines, Ph.D, M.P.H. ? Eric T. Juengst, Ph.D. ? Harry Karlinsky, M.D. ? Steven Miles, M.D. ? Thomas H. Murray, Ph.D. ? Stephen G. Post, Ph.D. ? Kimberly A. Quaid, Ph.D. ? Allen D. Roses, M.D. ? Greg A. Sachs, M.D. ? Peter H. St. George-Hyslop, M.D. ? Bonnie Steinbock, Ph.D. ? Arthur B. Zinn, M.D., Ph.D.

Apolipoprotein E Genotyping in Alzheimer's Disease

Norman R. Relkin,Zaven S. Khachaturian,Samuel Gandy
Apolipoprotein E Genotyping in Alzheimer s Disease Book PDF

Author : Norman R. Relkin,Zaven S. Khachaturian,Samuel Gandy
Publisher : Unknown
Page : 248 pages
File Size : 41,7 Mb
Release : 1996
Category : Medical
ISBN : UVA:X004080911

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Apolipoprotein E Genotyping in Alzheimer's Disease by Norman R. Relkin,Zaven S. Khachaturian,Samuel Gandy Pdf

This volume addresses what is currently known about the use of ApoE genotyping in diagnosing and predicting Alzheimer's disease. Because ApoE genetic testing has such far-reaching consequences, this volume will be of use not only to those in the medical and scientific community involved in the care of patients with Alzheimer's disease, but also to those concerned with the ethical, legal, epidemiological and public health policy issues as well. A summary will also be included of the results of working groups defining the issues, asking methodological questions, and discussing issues concerning genetic counselling and research-related questions.

Genetic Testing

Neil F. Sharpe,Ronald F. Carter
Genetic Testing Book PDF

Author : Neil F. Sharpe,Ronald F. Carter
Publisher : John Wiley & Sons
Page : 622 pages
File Size : 42,9 Mb
Release : 2006-01-20
Category : Science
ISBN : 9780471748885

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Genetic Testing by Neil F. Sharpe,Ronald F. Carter Pdf

A complete review of the issues with specific recommendations and guidelines. With over 1,000 tests commercially available, genetic testing is revolutionizing medicine. Health care professionals diagnosing and treating patients today must consider genetic factors, the risks and limitations of genetic testing, and the relevant law. Genetic Testing: Care, Consent, and Liability offers the only complete, practical treatment of the genetic, clinical, ethical, and legal issue surrounding genetic testing. The authors present protocols, policies, and models of care that are currently in use, and explain the legal framework for genetic testing and counseling that has developed in North America, particularly with regard to the law of medical malpractice. This essential book features an international roster of esteemed contributors including, Nancy P. Callanan, Bonnie S. LeRoy, Carole H. Browner, H. Mabel Preloran, Riyana Babul-Hirji, Cheryl Shuman, M.J. Esplen, Maren T. Scheuner, Dena S. Davis, JonBeckwith, Lisa Geller, Mark A. Hall, Andrew R. MacRae, David Chitayat, Roxanne Mykitiuk, Stephanie Turnham, Mireille Lacroix, Jinger G, Hoop, Edwin H, Cook, Jr., S. H. Dinwiddie, Elliot S. Gershon, C. Anthony Rupar, Lynn Holt, Bruce R. Korf, Anne Summers, S. Annie Adams, Daniel L. Van Dyke, Rhett P. Ketterling, Erik C. Thorland, Timothy Caulfield, Lorraine Sheremeta, Richard Gold, Jon F. Merz, David Castle, Peter J. Bridge, JS Parboosingh, Patricia T. Kelly, Julianne M. O'Daniel, Allyn McConkie-Rosell, Beatrice Godard, Bartha Maria Knoppers, David Weisbrot. The coverage also includes: * Genetic screening, including prenatal, neonatal, carrier, and susceptibility testing * Diagnosis, risk assessment, confidentiality, and clinical/legal issues related to follow-up * Interpreting test results and communicating them to patients * psychological considerations * Informed consent * Family history evaluations * Referral to medical geneticists and genetic counselors Genetic Testing Care, Consent, and Liability is a must-have resource for clinical geneticists, genetic counselors, specialists, family physicians, nurses, public health professionals, and medical students.

Methods of Behavior Analysis in Neuroscience

Jerry J. Buccafusco
Methods of Behavior Analysis in Neuroscience Book PDF

Author : Jerry J. Buccafusco
Publisher : CRC Press
Page : 341 pages
File Size : 51,5 Mb
Release : 2000-08-29
Category : Medical
ISBN : 9781420041811

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Methods of Behavior Analysis in Neuroscience by Jerry J. Buccafusco Pdf

Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Frontiers in Psychiatry

Yong-Ku Kim
Frontiers in Psychiatry Book PDF

Author : Yong-Ku Kim
Publisher : Springer Nature
Page : 641 pages
File Size : 44,7 Mb
Release : 2019-11-09
Category : Science
ISBN : 9789813297210

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Frontiers in Psychiatry by Yong-Ku Kim Pdf

This book reviews key recent advances and new frontiers within psychiatric research and clinical practice. These advances either represent or are enabling paradigm shifts in the discipline and are influencing how we observe, derive and test hypotheses, and intervene. Progress in information technology is allowing the collection of scattered, fragmented data and the discovery of hidden meanings from stored data, and the impacts on psychiatry are fully explored. Detailed attention is also paid to the applications of artificial intelligence, machine learning, and data science technology in psychiatry and to their role in the development of new hypotheses, which in turn promise to lead to new discoveries and treatments. Emerging research methods for precision medicine are discussed, as are a variety of novel theoretical frameworks for research, such as theoretical psychiatry, the developmental approach to the definition of psychopathology, and the theory of constructed emotion. The concluding section considers novel interventions and treatment avenues, including psychobiotics, the use of neuromodulation to augment cognitive control of emotion, and the role of the telomere-telomerase system in psychopharmacological interventions.

Genetic Variants in Alzheimer's Disease

Kevin Morgan,Minerva M. Carrasquillo
Genetic Variants in Alzheimer s Disease Book PDF

Author : Kevin Morgan,Minerva M. Carrasquillo
Publisher : Springer Science & Business Media
Page : 257 pages
File Size : 51,7 Mb
Release : 2013-06-22
Category : Medical
ISBN : 9781461473091

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Genetic Variants in Alzheimer's Disease by Kevin Morgan,Minerva M. Carrasquillo Pdf

Alzheimer’s Disease is the most common form of dementia. The disease is characterised by the loss of synapses and neurons in the cerebral cortex and certain subcortical regions. In the last three years, the genetics of Alzheimer’s Disease has made significant advances; in fact, one could argue more than in the previous two decades. This has resulted in the identification of nine new genes and perhaps more importantly the realization that new pathways could be involved in the pathogenesis of Alzheimer’s. These new pathways are now legitimate targets for therapeutic intervention, which can possibly lead to treatment or a possible cure. The aim of this book is to put all of the recent genetic data on these new genes into context. Different genetic variants will be discussed, as well as biomarkers and future possibilities. ​

Genetics as Social Practice

Barbara Prainsack,Silke Schicktanz,Gabriele Werner-Felmayer
Genetics as Social Practice Book PDF

Author : Barbara Prainsack,Silke Schicktanz,Gabriele Werner-Felmayer
Publisher : Routledge
Page : 240 pages
File Size : 47,9 Mb
Release : 2016-04-22
Category : Social Science
ISBN : 9781317129431

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Genetics as Social Practice by Barbara Prainsack,Silke Schicktanz,Gabriele Werner-Felmayer Pdf

Recent debate about the ethical and regulatory dimensions of developments in genetics has sidelined societal and cultural aspects, which arguably are indispensable for a nuanced understanding of the complexities of the topic. Regulatory and ethical debates benefit from taking seriously this ’third dimension’ of culture, which often determines the configurations and limits of the space within which scientific, ethical and legal debate can take place. To fill this gap, this volume brings together contributions exploring the mutual relationships between genetics, markets, societies and identities in genetics and genomics. It draws upon the recent transdisciplinary debate on how socio-cultural factors influence understandings of ’genetics2.0' and shows how individual and collective identities are challenged or reinforced by cultural meanings and practices of genetics. This book will become a standard reference for everyone seeking to make sense of the controversies and shifts in the field of genetics in the second decade of the twenty-first century.

Assessing Genetic Risks

Institute of Medicine,Committee on Assessing Genetic Risks
Assessing Genetic Risks Book PDF

Author : Institute of Medicine,Committee on Assessing Genetic Risks
Publisher : National Academies Press
Page : 353 pages
File Size : 52,7 Mb
Release : 1994-01-01
Category : Medical
ISBN : 9780309047982

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Assessing Genetic Risks by Institute of Medicine,Committee on Assessing Genetic Risks Pdf

Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.

The Moral Challenge of Alzheimer Disease

Stephen G. Post
The Moral Challenge of Alzheimer Disease Book PDF

Author : Stephen G. Post
Publisher : JHU Press
Page : 176 pages
File Size : 44,6 Mb
Release : 2002-11-04
Category : Medical
ISBN : 9780801870156

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The Moral Challenge of Alzheimer Disease by Stephen G. Post Pdf

Society today, writes Stephen Post, is "hypercognitive": it places inordinate emphasis on people's powers of rational thinking and memory. Thus, Alzheimer disease and other dementias, which over an extended period incrementally rob patients of exactly those functions, raise many dilemmas. How are we to view—and value—persons deprived of what some consider the most important human capacities? In the second edition of The Moral Challenge of Alzheimer Disease, Post updates his highly praised account of the major ethical issues relating to dementia care. With chapters organized to follow the progression from mild to severe and then terminal stages of dementia, Post discusses topics including the experience of dementia, family caregiving, genetic testing for Alzheimer disease, quality of life, and assisted suicide and euthanasia. New to this edition are sections dealing with end-of-life issues (especially artificial nutrition and hydration), the emerging cognitive-enhancing drugs, distributive justice, spirituality, and hospice, as well as a critique of rationalistic definitions of personhood. The last chapter is a new summary of practical solutions useful to family members and professionals.

Neurology in Clinical Practice

Walter George Bradley
Neurology in Clinical Practice Book PDF

Author : Walter George Bradley
Publisher : Unknown
Page : 1672 pages
File Size : 44,7 Mb
Release : 2004
Category : Medical
ISBN : 0750674695

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Neurology in Clinical Practice by Walter George Bradley Pdf

New edition, completely rewritten, with new chapters on endovascular surgery and mitochrondrial and ion channel disorders.

Apolipoprotein E and Alzheimer’s Disease

A.D. Roses,K.H. Weisgraber,Y. Christen
Apolipoprotein E and Alzheimer s Disease Book PDF

Author : A.D. Roses,K.H. Weisgraber,Y. Christen
Publisher : Springer Science & Business Media
Page : 208 pages
File Size : 42,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642801099

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Apolipoprotein E and Alzheimer’s Disease by A.D. Roses,K.H. Weisgraber,Y. Christen Pdf

There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.

Mayo Clinic on Alzheimer's Disease

Anonim
Mayo Clinic on Alzheimer s Disease Book PDF

Author : Anonim
Publisher : Unknown
Page : 210 pages
File Size : 47,9 Mb
Release : 2002
Category : Alzheimer's disease
ISBN : OCLC:1036707911

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Mayo Clinic on Alzheimer's Disease by Anonim Pdf

Annotation This 13-volume set from the Mayo Clinic gives detailed information on various health conditions, for example, high blood pressure, depression, and prostate health. Each book contains a wealth of information including charts and graphs.

Early Diagnosis of Alzheimer’s Disease

Leonard F. M. Scinto,Kirk R. Daffner
Early Diagnosis of Alzheimer s Disease Book PDF

Author : Leonard F. M. Scinto,Kirk R. Daffner
Publisher : Springer Science & Business Media
Page : 366 pages
File Size : 50,7 Mb
Release : 2000-02-09
Category : Medical
ISBN : 9781592590056

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Early Diagnosis of Alzheimer’s Disease by Leonard F. M. Scinto,Kirk R. Daffner Pdf

Drs. Leonard Scinto and Kirk Daffner provide a comprehensive survey of new diagnostic approaches to Alzheimer's disease. The authoritative contributors critically survey the most promising current research on early diagnostic markers for Alzheimer's disease, including the elucidation of changes in the brain revealed by structural and functional neuroimaging, as well as the characteristic patterns of cognitive decline that are documented by sensitive neuropsychological tests, various genetic markers, and biological assays. Early Diagnosis of Alzheimer's Disease illuminates the complex issues surrounding the search for early markers of this increasingly widespread disease. It will establish a new standard reference guide for all those working with Alzheimer's patients.

Alzheimer's Disease

Zaven S Khachaturian,Teresa S. Radebaugh
Alzheimer s Disease Book PDF

Author : Zaven S Khachaturian,Teresa S. Radebaugh
Publisher : CRC Press
Page : 579 pages
File Size : 44,6 Mb
Release : 2019-06-04
Category : Medical
ISBN : 9780429535970

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Alzheimer's Disease by Zaven S Khachaturian,Teresa S. Radebaugh Pdf

Published in 1996: Alzheimer's disease is characterized by memory disturbances and changes in personality and is associated with aging, although it can occur in people under 65. It is a progressive disease, painful to witness as the patient's health declines. Alzheimer's Disease: Cause(s), Diagnosis, and Care, with its complete and authoritative discussions, will help you understand all facets of this complex disease. This book addresses a broad spectrum of topics ranging from diagnosis, causes, treatment, epidemiology, genetics, risk factors, and care and management. Alzheimer's Disease: Cause(s), Diagnosis, and Care is intended for a diverse audience, including practitioners and students, family members, and everyone who is concerned about this disease.

Epidemiology of Alzheimer’s Disease: From Gene to Prevention

Richard Mayeux
Epidemiology of Alzheimer s Disease From Gene to Prevention Book PDF

Author : Richard Mayeux
Publisher : Springer Science & Business Media
Page : 140 pages
File Size : 43,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642600760

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Epidemiology of Alzheimer’s Disease: From Gene to Prevention by Richard Mayeux Pdf

This volume contains the proceedings of the 14th Colloque Médecine et Recherche of the Fondation Ipsen pour la Recherche Thérapeutique devoted to Alzheimer's Disease and dedicated to the epidemiological study of this dementia, a very important issue because the incidence and prevalence of Alzheimer's Disease rise exponentially with age. Epidemiological findings not only confirm dementia as a major challenge for the coming years but also contribute defining risk factors, predicting and may be preventing this disease.