Apolipoprotein E Genotyping In Alzheimer S Disease

Author : Norman R. Relkin,Zaven S. Khachaturian,Samuel Gandy
Publisher : Unknown
Page : 248 pages
File Size : 55,9 Mb
Release : 1996
Category : Medical
ISBN : UVA:X004080911

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Apolipoprotein E Genotyping in Alzheimer's Disease by Norman R. Relkin,Zaven S. Khachaturian,Samuel Gandy Pdf

This volume addresses what is currently known about the use of ApoE genotyping in diagnosing and predicting Alzheimer's disease. Because ApoE genetic testing has such far-reaching consequences, this volume will be of use not only to those in the medical and scientific community involved in the care of patients with Alzheimer's disease, but also to those concerned with the ethical, legal, epidemiological and public health policy issues as well. A summary will also be included of the results of working groups defining the issues, asking methodological questions, and discussing issues concerning genetic counselling and research-related questions.

Author : A.D. Roses,K.H. Weisgraber,Y. Christen
Publisher : Springer Science & Business Media
Page : 208 pages
File Size : 40,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642801099

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Apolipoprotein E and Alzheimer’s Disease by A.D. Roses,K.H. Weisgraber,Y. Christen Pdf

There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.

Author : Stephen Garrard Post,Peter J. Whitehouse
Publisher : Unknown
Page : 310 pages
File Size : 42,9 Mb
Release : 1998
Category : Family & Relationships
ISBN : UOM:39015036046707

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Genetic Testing for Alzheimer Disease by Stephen Garrard Post,Peter J. Whitehouse Pdf

The genetics of Alzheimer disease has been a point of intense concern and immense informational confusion for families in which a loved one is diagnosed with dementia. In recent years, however, scientists have begun to uncover the genetic bases for some forms of Alzheimer disease. Once a chromosomal defect is identified, it becomes possible to devise a test for its presence. The far-reaching implications of such tests are the focus of the present volume. In Genetic Testing for Alzheimer Disease, Stephen G. Post and Peter J. Whitehouse bring together experts from the fields of ethics, genetics, policy, neurology, philosophy, and anthropology to examine the ethical and social aspects of genetic testing for Alzheimer disease. The authors begin by focusing on current genetic findings and their clinical applicability. They then address ethical issues in genetic testing and genetic counseling for Alzheimer disease. They examine social issues such as confidentiality, discrimination, and fairness in health care. Finally, they discuss ways to educate professionals and laypeople regarding these issues. Contributors: Robert H. Binstock, Ph.D.?Thomas D. Bird, M.D. ? Robert Mullan Cook-Deegan, M.D.? Leonard Fleck, Ph.D. ? Atwood D. Gaines, Ph.D, M.P.H. ? Eric T. Juengst, Ph.D. ? Harry Karlinsky, M.D. ? Steven Miles, M.D. ? Thomas H. Murray, Ph.D. ? Stephen G. Post, Ph.D. ? Kimberly A. Quaid, Ph.D. ? Allen D. Roses, M.D. ? Greg A. Sachs, M.D. ? Peter H. St. George-Hyslop, M.D. ? Bonnie Steinbock, Ph.D. ? Arthur B. Zinn, M.D., Ph.D.

Author : United States. Congress. Senate. Committee on Labor and Human Resources. Subcommittee on Aging
Publisher : Unknown
Page : 80 pages
File Size : 45,8 Mb
Release : 1997
Category : Medical
ISBN : PSU:000031688536

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Meeting the Challenges of Alzheimer's Disease by United States. Congress. Senate. Committee on Labor and Human Resources. Subcommittee on Aging Pdf

Author : Masatoshi Takeda,Toshihisa Tanaka,Ramón Cacabelos
Publisher : Karger Medical and Scientific Publishers
Page : 320 pages
File Size : 53,8 Mb
Release : 2004
Category : Medical
ISBN : UOM:39015059104540

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Molecular Neurobiology of Alzheimer Disease and Related Disorders by Masatoshi Takeda,Toshihisa Tanaka,Ramón Cacabelos Pdf

Contains selected papers presented at the International Symposium on Molecular Neurobiology of Alzheimer Disease and Related Disorders held in Osaka, Japan, in October 2002.

Author : Daniela Galimberti,Elio Scarpani
Publisher : Nova Science Publishers
Page : 324 pages
File Size : 54,7 Mb
Release : 2008
Category : Medical
ISBN : IND:30000122535812

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Biomarkers for Early Diagnosis of Alzheimer's Disease by Daniela Galimberti,Elio Scarpani Pdf

Alzheimer's disease (AD) is characterized by the deposition into the brain of amyloid peptide, which originates a cascade of inflammatory events leading eventually to neuronal death. These pathological events likely occur several years before the clinical manifestation of the disease, implying that potential therapeutical interventions are currently started too late to give beneficial results. Recently, growing attention has been paid to the Mild Cognitive Impairment (MCI), considered the prodromal phase of AD, as 80% of subjects with MCI have been shown to develop AD within 5 years. Several studies aimed to identify biological markers to differentiate between normal aging and incipient AD have been carried out, including cerebrospinal fluid (CSF) analysis and neuroimaging. In particular, the evaluation of CSF Amyloid beta (1-42) levels, together with tau and phospotau, are of help for recognizing early AD. Besides, a number of additional molecules are altered in CSF. Other early modifications have been observed in peripheral cells, such as fibroblasts and leukocytes, as well as in serum from patients. Biomarkers for AD represent important tools supporting the clinical diagnosis and the choice of potential therapeutic options. Moreover, they would be of great help for the selection of cohorts of homogeneous patients for clinical trials with new disease-modifying compounds. This book is aimed to give an update about MCI as prodromal Alzheimer's disease (AD), to discuss the main known pathological mechanisms at the basis of AD and to describe the possible biomarkers to be used for an early diagnosis of the disease.

Author : Anonim
Publisher : Unknown
Page : 210 pages
File Size : 42,8 Mb
Release : 2002
Category : Alzheimer's disease
ISBN : OCLC:1036707911

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Mayo Clinic on Alzheimer's Disease by Anonim Pdf

Annotation This 13-volume set from the Mayo Clinic gives detailed information on various health conditions, for example, high blood pressure, depression, and prostate health. Each book contains a wealth of information including charts and graphs.

Author : Sonya Benjamina E. Dumanis
Publisher : Unknown
Page : 0 pages
File Size : 42,9 Mb
Release : 2013
Category : Electronic
ISBN : OCLC:1404960014

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Using APOE genotypes to identify new biomarkers for Alzheimer's disease risk by Sonya Benjamina E. Dumanis Pdf

Author : Kevin Morgan,Minerva M. Carrasquillo
Publisher : Springer Science & Business Media
Page : 257 pages
File Size : 45,8 Mb
Release : 2013-06-22
Category : Medical
ISBN : 9781461473091

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Genetic Variants in Alzheimer's Disease by Kevin Morgan,Minerva M. Carrasquillo Pdf

Alzheimer’s Disease is the most common form of dementia. The disease is characterised by the loss of synapses and neurons in the cerebral cortex and certain subcortical regions. In the last three years, the genetics of Alzheimer’s Disease has made significant advances; in fact, one could argue more than in the previous two decades. This has resulted in the identification of nine new genes and perhaps more importantly the realization that new pathways could be involved in the pathogenesis of Alzheimer’s. These new pathways are now legitimate targets for therapeutic intervention, which can possibly lead to treatment or a possible cure. The aim of this book is to put all of the recent genetic data on these new genes into context. Different genetic variants will be discussed, as well as biomarkers and future possibilities. ​

Author : Institute of Medicine,Board on Global Health,Committee on Preventing the Global Epidemic of Cardiovascular Disease: Meeting the Challenges in Developing Countries
Publisher : National Academies Press
Page : 483 pages
File Size : 47,8 Mb
Release : 2010-06-29
Category : Medical
ISBN : 9780309157612

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Promoting Cardiovascular Health in the Developing World by Institute of Medicine,Board on Global Health,Committee on Preventing the Global Epidemic of Cardiovascular Disease: Meeting the Challenges in Developing Countries Pdf

Cardiovascular disease (CVD), once thought to be confined primarily to industrialized nations, has emerged as a major health threat in developing countries. Cardiovascular disease now accounts for nearly 30 percent of deaths in low and middle income countries each year, and is accompanied by significant economic repercussions. Yet most governments, global health institutions, and development agencies have largely overlooked CVD as they have invested in health in developing countries. Recognizing the gap between the compelling evidence of the global CVD burden and the investment needed to prevent and control CVD, the National Heart, Lung, and Blood Institute (NHLBI) turned to the IOM for advice on how to catalyze change. In this report, the IOM recommends that the NHLBI, development agencies, nongovernmental organizations, and governments work toward two essential goals: creating environments that promote heart healthy lifestyle choices and help reduce the risk of chronic diseases, and building public health infrastructure and health systems with the capacity to implement programs that will effectively detect and reduce risk and manage CVD. To meet these goals, the IOM recommends several steps, including improving cooperation and collaboration; implementing effective and feasible strategies; and informing efforts through research and health surveillance. Without better efforts to promote cardiovascular health, global health as a whole will be undermined.

Author : Richard Mayeux
Publisher : Springer Science & Business Media
Page : 140 pages
File Size : 47,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642600760

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Epidemiology of Alzheimer’s Disease: From Gene to Prevention by Richard Mayeux Pdf

This volume contains the proceedings of the 14th Colloque Médecine et Recherche of the Fondation Ipsen pour la Recherche Thérapeutique devoted to Alzheimer's Disease and dedicated to the epidemiological study of this dementia, a very important issue because the incidence and prevalence of Alzheimer's Disease rise exponentially with age. Epidemiological findings not only confirm dementia as a major challenge for the coming years but also contribute defining risk factors, predicting and may be preventing this disease.

Author : World Health Organization
Publisher : Unknown
Page : 102 pages
File Size : 45,8 Mb
Release : 2012
Category : Medical
ISBN : 9241564458

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Dementia by World Health Organization Pdf

The report “Dementia: a public health priority” has been jointly developed by WHO and Alzheimer's Disease International. The purpose of this report is to raise awareness of dementia as a public health priority, to articulate a public health approach and to advocate for action at international and national levels.

Author : M.M. Verbeek,Harry V. Vinters,R.M. de Waal
Publisher : Springer Science & Business Media
Page : 400 pages
File Size : 45,9 Mb
Release : 2000-07-31
Category : Medical
ISBN : 0792363663

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Cerebral Amyloid Angiopathy in Alzheimer’s Disease and Related Disorders by M.M. Verbeek,Harry V. Vinters,R.M. de Waal Pdf

Cerebral amyloid angiopathy (CAA) is a distinctive abnormality of small cerebral blood vessels, one that has intrigued neuroscientists for decades. The time seems right for a book which examines the phenomenon of CAA using a multifaceted approach: What does it produce clinically? How might CAA be imaged? What are the crucial biochemical/cellular events within cerebral vessel walls that lead to CAA? How can in vitro or transgenic experimental systems be used to understand the etiology of, or even potential treatments for, CAA? The editors have assembled key figures in the field of CAA research to examine these (and other) questions in a series of focused chapters that address specific issues of importance in understanding CAA and its clinical manifestations. Comprehending the biology and pathogenesis of this fascinating vascular lesion may even provide clues to less common forms of cerebral microvascular disease that have been recognized for decades (hypertensive microangiopathy) or more recently (CADASIL).

Author : Ezio Giacobini,D.L. Smith,J.M. Barton,Robert E. Becker
Publisher : Springer Science & Business Media
Page : 673 pages
File Size : 48,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461581499

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Alzheimer Disease by Ezio Giacobini,D.L. Smith,J.M. Barton,Robert E. Becker Pdf

Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis.

Author : Wilma Wasco,Rudolph Tanzi
Publisher : Springer Science & Business Media
Page : 313 pages
File Size : 45,9 Mb
Release : 1996-11-01
Category : Medical
ISBN : 9781592594719

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Molecular Mechanisms of Dementia by Wilma Wasco,Rudolph Tanzi Pdf

The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal of Molecular Mechanisms of Dementia is to address the various mechanisms and multi faceted approaches currently being employed to more clearly delineate the etiological and pathogenic events responsible for the onset of dementia. Perhaps the greatest boon to obtaining a clearer understanding of the causes of AD has come from genetic and molecular biological studies carried out over the past decade. At the genetic level, it has become increasingly clear that AD is a heteroge neous disorder that can be broadly classified into two categories. "Late onset" (>60 yr) cases, which account for the vast majority of AD, genetically involve "susceptibility" genes representing risk factors for the disease (e. g. , inheritance of the 84 allele of the Apolipoprotein E gene). In many cases, the susceptibility gene can act as a "modifier" that modulates the pathogenic cascade occurring subsequent to a separate etiological event "initiating" or "causing" the disorder.