Genome Transcriptome And Proteome Analysis

Author : Alain Bernot
Publisher : John Wiley and Sons
Page : 249 pages
File Size : 45,8 Mb
Release : 2007-12-10
Category : Science
ISBN : 9780470299562

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Genome Transcriptome and Proteome Analysis by Alain Bernot Pdf

Genome Transcriptome and Proteome Analysis is a concise introduction to the subject, successfully bringing together these three key areas of research. Starting with a revision of molecular genetics the book offers clear explanations of the tools and techniques widely used in genome, transcriptome and proteome analysis. Subsequent chapters offer a broad overview of linkage maps, physical maps and genome sequencing, with a final discussion on the identification of genes responsible for disease. An invaluable introduction to the basic concepts of the subject, this text offers the student an excellent overview of current research methods and applications and is a good starting point for those new to the area. A clear, concise introduction to the subject of modern genomic analysis A technology-oriented approach including the latest developments in the field Invaluable to those students taking courses in Bioinformatics, Human Genetics, Biochemistry and Molecular Biology

Author : David W Speicher
Publisher : Elsevier
Page : 394 pages
File Size : 40,8 Mb
Release : 2004-05-18
Category : Science
ISBN : 9780080515304

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Proteome Analysis by David W Speicher Pdf

This book explores the current status of proteomics, an exciting new discipline, which is less than 10 years old. This new field has rapidly grown into a major commercial and research enterprise with great prospects for dramatically advancing our knowledge of basic biological and disease processes. The contributors to this book are an international panel of proteomics experts, who review and discuss the current status of specific technologies and approaches. Proteomics represents an exciting new way to pursue biological and biomedical science at an unprecedented pace. Proteomics takes a broad, comprehensive, systematic approach to understanding biology that is generally unbiased and not dependent upon existing knowledge. The major components of proteomics from basic discovery using a range of alternative analytical methods to discovery validation and use for clinical applications are discussed. State-of-the-art protein profiling methods include high resolution two-dimensional gels, two-dimensional differential in-gel electrophoresis, LC-MS and LC-MS/MS using accurate mass tags, and protein identifications of proteins from gels using mass spectrometry methods are discussed in depth. Other chapters describe comprehensive characterization of proteomes using electrophoretic prefractionation and analyses of sub-proteomes based on specific posttranslational modifications including the phospho-proteome, the glyco-proteome, and nitrated proteins. These conventional proteome analysis chapters are complemented by discussion of emerging technologies and approaches such as affinity based biosensor proteomics as well as the use of protein microarrays, microfluidics and nanotechnology. Strategies for improving throughput by automation are also discussed. Additional chapters address the application of current proteome techniques to clinical problems and the availability of protein expression library resources for proteome studies. · Authored by international experts in the field · Covers a wide range of topics including 2-D gels, global proteomics using accurate mass tags, global proteomics using electrophoretic prefractionation, microfluidics, and nanotechnology · Includes state-of-the-art protein profiling methods, and emerging technologies

Author : Stephen R. Pennington,Michael J. Dunn
Publisher : Garland Science
Page : 352 pages
File Size : 48,5 Mb
Release : 2001
Category : Amino acid sequence
ISBN : 1859962963

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Proteomics by Stephen R. Pennington,Michael J. Dunn Pdf

Proteomics is an emerging research area, and the book reviews genome projects in relation to the need for complementary proteomics programmes.

Author : Guenter Kahl
Publisher : John Wiley & Sons
Page : 2742 pages
File Size : 51,8 Mb
Release : 2015-05-21
Category : Science
ISBN : 9783527678648

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The Dictionary of Genomics, Transcriptomics and Proteomics by Guenter Kahl Pdf

Now in its fifth edition and for the first time available as an electronic product with all entries cross-linked. This very successful long-seller has once again been thoroughly updated and greatly expanded. It now contains over 13,000 entries, and comprehensively covering genomics, transcriptomics, and proteomics. Each entry contains an extensive explanation, including a comprehensive listing of synonyms and acronyms, and all formulas have been redrawn to create a uniform style, while most of the figures are custom designed for this dictionary. The ultimate reference for all terms in the -omics fields.

Author : Michael J. Dunn
Publisher : John Wiley & Sons
Page : 552 pages
File Size : 48,7 Mb
Release : 2008-11-21
Category : Science
ISBN : 9783527613496

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From Genome to Proteome by Michael J. Dunn Pdf

As research on the human, animal, plant and microbial genomes matures towards descriptive fullness, the need for understanding the proteome has clearly emerged as the next major endeavor of life sciences. Proteomics - the quantitative analysis of all proteins working in a cell at a specific time and at specific conditions - provides deep insight into the highly organized network of expression, modification and degradation of proteins. Compiled in this book are reviews and research articles which describe the recent advances and perspectives of this new field of research. The articles are grouped into the following sections: - Sample Preparation and Solubilization - Developments in Electrophoresis - Detection and Quantitation - Mass Spectrometry - Proteome Data Analysis and Management - Prokayotes and Yeast - Biological Fluids - Eukaryotic Cells and Tissue - Oncology - Plants Proteomics is a new key for the functional analysis of living systems and of equal importance for basic as well as application oriented research.

Author : Leena Rawal,Sher Ali
Publisher : Springer
Page : 168 pages
File Size : 41,5 Mb
Release : 2017-06-08
Category : Medical
ISBN : 9789811042980

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Genome Analysis and Human Health by Leena Rawal,Sher Ali Pdf

This book highlights selected current data and its relevance in the human health care system, offering a fundamental primer on genetics and human health. With the advent of new high-throughput technologies (for the whole genome including exome sequencing), the conventional focus on genetics and individual genes is now shifting toward the analysis of complex genes, gene-gene interactions and the association between genes and environment, including epigenetics. The rapidly changing scientific research landscape, with the ever-growing influx of data on one hand and emergence of newer and more complicated diseases on the other, has created a dilemma for researchers and caregivers, who are still hopeful that advances in genetics and genomics will provide avenues for the understanding, prevention and possible cure of human diseases. The book focuses on the interactions between genes and proteins at both the transcriptome and proteome levels, which in turn affect the human genome and health. Additionally, it covers the domain that must be explored in order to understand the gene-gene and protein-protein interactions that contribute to human health. The book offers a valuable guide for all students and researchers working in the area of molecular genetics and genomics.

Author : Christopher A. Cullis
Publisher : John Wiley & Sons
Page : 230 pages
File Size : 48,9 Mb
Release : 2004-01-20
Category : Science
ISBN : 9780471488583

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Plant Genomics and Proteomics by Christopher A. Cullis Pdf

Plant research has stood at the forefront of the genomics revolution. One of the first genome projects, the sequencing of the commonly used model organism Arabidopsis, has already yielded important results for the study of a broad array of crops such as corn and soybeans. With crop and food bioengineering only in its infancy, the need to understand the fundamental genetic mechanisms of plants will only become more pressing. A comprehensive guide to this fascinating area of genomics, Plant Genomics and Proteomics presents an integrated, broadly accessible treatment of the complex relationship between the genome, transcriptome, and proteome of plants. This clearly written text introduces the reader to the range of molecular techniques applicable to investigating the unique facets of plant growth, development, and response to the environment. Coverage includes: Functional and structural genomics addressed within the context of current techniques and challenges to come How to utilize DNA and protein sequence data Practical considerations for choosing and employing the most commonly available computer applications A review of applications for biotechnology, including genetic modification and defense against pathogens Bioinformatics tools and Web resources Numerous examples from the latest research throughout Assuming no specialized knowledge of plant biology on the part of its reader, Plant Genomics and Proteomics provides an invaluable resource for students and researchers in biotechnology, plant biology, genomics, and bioinformatics.

Author : Rakeeb Ahmad Mir,Sheikh Mansoor Shafi,Sajad Majeed Zargar
Publisher : Elsevier
Page : 276 pages
File Size : 46,6 Mb
Release : 2023-01-25
Category : Science
ISBN : 9780323993784

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Principles of Genomics and Proteomics by Rakeeb Ahmad Mir,Sheikh Mansoor Shafi,Sajad Majeed Zargar Pdf

Principles of Genomics and Proteomics is the perfect reference for graduate students and researchers in these areas to understand its principles and execute precise and reproducible experiments. Following an introductory chapter, the book dives into proper research, including genome mapping. Experiments covered in the book span from Sangers Sequencing, Shotgun sequencing, SAGE analysis, DNA footprinting, Gel retardation, ChIP, and protein resolution methods, including PAGE, 2D gel electrophoresis and isoelectric focusing. Biophysical techniques are also described in detail, including ultraviolet and visible light spectroscopy, fluorescence spectroscopy, NMR and X-ray diffraction. A final proteome analysis is dedicated to functional analysis. Other chapters cover applications of omics technologies broadly. This book is the perfect reference for genetics labs around the world. Graduate students will benefit from the structured and detailed coverage of methods and established researchers will benefit from the book for staff training in research and may find it particularly helpful in enhancing reproducibility of experiments. Provides a comprehensive accounting of the technical aspects of genomic and proteomic analysis and applications in living organisms Includes detailed and standardized coverage of basic research methods in areas covered Presents advanced applications of genomics and proteomics that are highlighted with major significance in medical and agricultural fields

Author : Jeffrey Augen
Publisher : Addison-Wesley Professional
Page : 412 pages
File Size : 52,9 Mb
Release : 2005
Category : Computers
ISBN : STANFORD:36105114316099

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Bioinformatics in the Post-genomic Era by Jeffrey Augen Pdf

A comprehensive treatment of the role of bioinformatics in the emerging world of molecular medicine, for anyone involved in this new field

Author : Marc R. Wilkins,Keith L. Williams,Ron D. Appel,Denis F. Hochstrasser
Publisher : Springer Science & Business Media
Page : 256 pages
File Size : 52,7 Mb
Release : 2013-03-14
Category : Science
ISBN : 9783662034934

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Proteome Research: New Frontiers in Functional Genomics by Marc R. Wilkins,Keith L. Williams,Ron D. Appel,Denis F. Hochstrasser Pdf

Recent advances in two-dimensional electrophoresis, protein microanalysis and bioinformatics have made the large-scale, systematic analysis of proteins and their post-translational modifications from any tissue or organism possible. This approach has acquired the name "Proteome Research", and can be considered as the core of functional genomics. The results of proteome analysis show which genes are expressed, how the protein products are modified, and how they interact, making proteome research of fundamental importance for the biologist, clinician, and pharmaceutical industry.

Author : Jeffrey Augen
Publisher : Unknown
Page : 400 pages
File Size : 52,7 Mb
Release : 2004
Category : Bioinformatics
ISBN : 0012971332

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Bioinformatics in the Post-genomic Era by Jeffrey Augen Pdf

Author : Miroslav Blumenberg
Publisher : BoD – Books on Demand
Page : 110 pages
File Size : 51,6 Mb
Release : 2019-11-20
Category : Medical
ISBN : 9781789843279

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Transcriptome Analysis by Miroslav Blumenberg Pdf

Transcriptome analysis is the study of the transcriptome, of the complete set of RNA transcripts that are produced under specific circumstances, using high-throughput methods. Transcription profiling, which follows total changes in the behavior of a cell, is used throughout diverse areas of biomedical research, including diagnosis of disease, biomarker discovery, risk assessment of new drugs or environmental chemicals, etc. Transcriptome analysis is most commonly used to compare specific pairs of samples, for example, tumor tissue versus its healthy counterpart. In this volume, Dr. Pyo Hong discusses the role of long RNA sequences in transcriptome analysis, Dr. Shinichi describes the next-generation single-cell sequencing technology developed by his team, Dr. Prasanta presents transcriptome analysis applied to rice under various environmental factors, Dr. Xiangyuan addresses the reproductive systems of flowering plants and Dr. Sadovsky compares codon usage in conifers.

Author : P. Jolles,Hans Jörnvall
Publisher : Birkhäuser
Page : 240 pages
File Size : 49,5 Mb
Release : 2013-03-11
Category : Science
ISBN : 9783034884587

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Proteomics in Functional Genomics by P. Jolles,Hans Jörnvall Pdf

A wealth of information has accumulated over the last few years on the human genome. The new insights have completely changed the focus of protein analysis. It is no longer time-consuming analysis of unknown products, but rather selective identifications of individual forms, modifications and processings, and overall analysis of global protein outputs from cells and tissues in health and disease. This book gears to the rising need of sensitive, accurate, and fast separation and identification techniques in proteomics. It discusses current methodologies of modern protein analysis, from isolation and sample preparation, over analysis and identification, to final characterization. Several evaluations concentrate on the now productive approaches of two-dimensional gel electrophoresis and mass spectrometry, but alternative methods and further perspectives are also outlined. The book includes an overlook over current databases to connect protein analysis data with all available information,...

Author : Darius M. Dziuda
Publisher : Wiley-Interscience
Page : 328 pages
File Size : 42,9 Mb
Release : 2010-07-16
Category : Computers
ISBN : 9780470593400

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Data Mining for Genomics and Proteomics by Darius M. Dziuda Pdf

Data Mining for Genomics and Proteomics uses pragmatic examples and a complete case study to demonstrate step-by-step how biomedical studies can be used to maximize the chance of extracting new and useful biomedical knowledge from data. It is an excellent resource for students and professionals involved with gene or protein expression data in a variety of settings.

Author : Richard Twyman
Publisher : Garland Science
Page : 266 pages
File Size : 55,5 Mb
Release : 2004-05-01
Category : Science
ISBN : 9780203507391

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Principles of Proteomics by Richard Twyman Pdf

Principles of Proteomics is designed specifically to explain the different stages of proteomic analysis, their complexities and their jargon to students and researchers in a non-technical overview of the field. The author describes the broad range of problems which proteomics can address, including structural proteomics, interaction proteomics, protein modification analysis and functional proteomics. Methodologies are described in user-friendly language, from the more traditional two-dimensional gel electrophoresis to the new developments in protein chip technologies. These are well presented in the context of overall strategies which can be adopted to address the different aspects of large-scale protein analysis.