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Author : Jeffrey Augen
Publisher : Addison-Wesley Professional
Page : 412 pages
File Size : 50,6 Mb
Release : 2005
Category : Computers
ISBN : STANFORD:36105114316099
A comprehensive treatment of the role of bioinformatics in the emerging world of molecular medicine, for anyone involved in this new field
Author : Ivan Y. Torshin
Publisher : Nova Publishers
Page : 282 pages
File Size : 52,7 Mb
Release : 2006
Category : Medical
ISBN : 1600210481
Biomedicine is one of the most important fields for the prospective applications of the information from human genome studies. However, there are many 'white spots' in the present-day understanding of the biomedical implications of this information. Given that at least half of the proteins in the established sequence of the human genome have no annotation whatsoever and that the sequence similarity searches are not likely to produce any, definite research strategies to analyse the functions of these unknown proteins as well as other enigmatic aspects of the human genome are being elaborated. The elaboration of the logistics of these research strategies, of the relevant computational methodologies as well as the general management of the informational complexity of the biological systems belong to the main tasks for the post-genomic bioinformatics. This volume concentrates on the role of the biophysical studies and biophysical concepts that can assist the endeavour.
Author : Frédéric Dardel,François Képès
Publisher : John Wiley & Sons
Page : 252 pages
File Size : 46,8 Mb
Release : 2007-01-11
Category : Science
ISBN : 0470020024
This book is an excellent introductory text describing the use of bioinformatics to analyze genomic and post-genomic data. It has been translated from the original popular French edition, which was based on a course taught at the well-respected École Polytechnique in Palaiseau. This edition has been fully revised and updated by the authors. After a brief introduction to gene structure and sequence determination, it describes the techniques used to identify genes, their protein-coding sequences and regulatory regions. The book discusses the methodology of comparative genomics, using information from different organisms to deduce information about unknown sequences. There is a comprehensive chapter on structure prediction, covering both RNA and protein. Finally, the book describes the complex networks of RNA and protein that exist within the cell and their interactions, ending with a discussion of the simulation approaches that can be used to model these networks. Praise from the reviews: “In context of the new developments the genomic era has brought, Bioinformatics: Genomics and Post-Genomics becomes a fundamental and indispensable resource for undergraduate and early graduate students...insightfully authored...will immensely help students...in establishing important foundations while shaping their careers.” NEWSLETTER, BRITISH SOCIETY OF CELL BIOLOGY
Author : Igor Jurisica,Dennis A. Wigle,Bill Wong
Publisher : Springer Science & Business Media
Page : 193 pages
File Size : 53,9 Mb
Release : 2007-05-04
Category : Medical
ISBN : 9780387693217
Cancer Informatics in Post-Genomic Era provides both the necessary methodology and practical information tools for analyzing data in the field of medical information science. This, of course, requires analytic tools. Those tools are garnered by developing and assessing methods and systems for the acquisition, processing, and interpretation of patient data, aided by scientific discovery. Key challenges in this field include integrating research and clinical care, sharing data, and establishing partnerships within and across sectors of patient diagnosis and treatment.
Author : Ranil S. Dassanayake,Y. I. N. Silva Gunawardene
Publisher : Alpha Science International, Limited
Page : 0 pages
File Size : 52,9 Mb
Release : 2011
Category : Science
ISBN : 1842656600
Describes the high throughput sophisticated computational tools and experimental techniques used in post genomic analyses to harness the genomic information to make novel biological discoveries. Beginning with a chapter on bioinformatics that introduces readers to Word Wide Web based servers and software programs that are widely used for mining genomic information it moves on to a miniaturized high throughput technique, DNA microarrays, tailored for studying genome-scale genotyping and gene-expression profiling. An overview of another high throughput proteomic technique; two-dimensional polyacrylamide gel electrophoresis used in proteome separation and mass spectrometry and protein sequencing related techniques used for characterization and identification of proteins is followed by a description of yet another miniaturized high throughput proteomic technique, Protein Microarrays, developed to overcome the limitations associated with DNA microarray and to provide direct information about protein quantity, interactions, functions etc. Knowledge-based theoretical three-dimensional protein structure modeling approach; homology modeling as a realistic method to minimize the ever widening gap between known protein coding sequences and known protein structures and fully automated protein modeling software and servers implemented in protein structure modeling in the post genomic era are also discussed.
Author : Ziwei Huang
Publisher : John Wiley & Sons
Page : 560 pages
File Size : 53,8 Mb
Release : 2007-06-11
Category : Science
ISBN : 9780470131855
Post Genomics Drug Discovery and Research explores and discusses some of the most important topics in post-genomics life and biopharmaceutical sciences. It provides an introduction to the field, outlining examples of many techniques currently used, as well as those still under development, which are important for the research of biopharmaceutical discovery in the post-genomics era. Integrates several developing and cutting-edge technologies and methods like bioinformatics, experimental therapeutics, and molecular recognition Includes discussion on topics such as: computer-aided ligand design; peptide and protein chemistry and synthesis; synthesis of active natural products; and the use of emerging technologies like proteomics, nanotechnology, or bioengineering.
Author : Ibrokhim Y. Abdurakhmonov
Publisher : BoD – Books on Demand
Page : 190 pages
File Size : 55,8 Mb
Release : 2018-06-20
Category : Medical
ISBN : 9781789232684
Bioinformatics has evolved significantly in the era of post genomics and big data. Huge advancements were made toward storing, handling, mining, comparing, extracting, clustering and analysis as well as visualization of big macromolecular data using novel computational approaches, machine and deep learning methods, and web-based server tools. There are extensively ongoing world-wide efforts to build the resources for regional hosting, organized and structured access and improving the pre-existing bioinformatics tools to efficiently and meaningfully analyze day-to-day increasing big data. This book intends to provide the reader with updates and progress on genomic data analysis, data modeling and network-based system tools.
Author : Ziwei Huang
Publisher : Wiley-Interscience
Page : 0 pages
File Size : 45,8 Mb
Release : 2006-11-02
Category : Science
ISBN : 0470131861
Post Genomics Drug Discovery and Research explores and discusses some of the most important topics in post-genomics life and biopharmaceutical sciences. It provides an introduction to the field, outlining examples of many techniques currently used, as well as those still under development, which are important for the research of biopharmaceutical discovery in the post-genomics era. Integrates several developing and cutting-edge technologies and methods like bioinformatics, experimental therapeutics, and molecular recognition Includes discussion on topics such as: computer-aided ligand design; peptide and protein chemistry and synthesis; synthesis of active natural products; and the use of emerging technologies like proteomics, nanotechnology, or bioengineering.
Author : Jorge L. Contreras,A. Jamie Cuticchia
Publisher : American Bar Association
Page : 0 pages
File Size : 47,7 Mb
Release : 2013
Category : Bioinformatics
ISBN : 1627220100
"Databases containing the accumulated genomic data of the research community are growing exponentially. This book contains cutting-edge insights from scholars, bioethicists and legal practitioners who work at the ever-changing intersection of law and bioinformatics"--Page 4 of cover.
Author : Gary Hardiman,Richard Lin
Publisher : Unknown
Page : 0 pages
File Size : 43,7 Mb
Release : 2005-08
Category : Science
ISBN : 096640274X
An introduction to gene cloning, this analysis examines the current state of biotechnology. Exploring cutting-edge research methods for the analysis of gene expression, this book discusses the bioinformatics-based approach to uncovering novel genes from the finished human genome sequencing project also reviews how model organisms can be a platform for investigating biology and enabling therapeutic target discovery, and provides case studies for how genomics technologies are applied in specific areas of drug development.
Author : Sarah S. Richardson,Hallam Stevens
Publisher : Duke University Press
Page : 304 pages
File Size : 51,7 Mb
Release : 2015-04-15
Category : Science
ISBN : 9780822375449
Ten years after the Human Genome Project’s completion the life sciences stand in a moment of uncertainty, transition, and contestation. The postgenomic era has seen rapid shifts in research methodology, funding, scientific labor, and disciplinary structures. Postgenomics is transforming our understanding of disease and health, our environment, and the categories of race, class, and gender. At the same time, the gene retains its centrality and power in biological and popular discourse. The contributors to Postgenomics analyze these ruptures and continuities and place them in historical, social, and political context. Postgenomics, they argue, forces a rethinking of the genome itself, and opens new territory for conversations between the social sciences, humanities, and life sciences. Contributors. Russ Altman, Rachel A. Ankeny, Catherine Bliss, John Dupré, Michael Fortun, Evelyn Fox Keller, Sabina Leonelli, Adrian Mackenzie, Margot Moinester, Aaron Panofsky, Sarah S. Richardson, Sara Shostak, Hallam Stevens
Author : Ivan Y. Torshin
Publisher : Nova Publishers
Page : 320 pages
File Size : 51,5 Mb
Release : 2007
Category : Bioinformatics
ISBN : 1600217524
Several years have passed since the sequencing of the human genome and what might be called "the post-genomic era" has begun. Of course, there are many different genomes and the term "post-genomic" does not necessarily imply the human genome. However, it is the data encoded in the human genome that hold the promise to be of practical importance in a wide range of biomedical applications. The sequencing and preliminary annotations of the human genome provided an incredible amount of the raw, largely unprocessed information. Coupled with the millions of publications on human physiology already available in public databases, it is clear that certain informational strategies should be adopted for the retrieval, analysis and representation of these data. Among biological sciences, bioinformatics is a specific branch that deals with managing complexities in the biological information. However, the bioinformatics is in no way restricted to the compilation of large databases or elaboration of sophisticated software. The methods of bioinformatics can greatly assist the generation of productive hypotheses that allow subsequent experimental testing followed by confirmation or disapproval. The main idea behind the present volume is not worrying about the steadily growing amounts of biomedical information or about the relative quality of it. This volume, as well as the entire book series, is based on the purpose-oriented attitude: how to make a good use of this information in particular research projects.
Author : Pradeep Sharma,Dinesh Yadav,R.K. Gaur
Publisher : Academic Press
Page : 707 pages
File Size : 42,9 Mb
Release : 2022-04-28
Category : Technology & Engineering
ISBN : 9780323885997
Bioinformatics in Agriculture: Next Generation Sequencing Era is a comprehensive volume presenting an integrated research and development approach to the practical application of genomics to improve agricultural crops. Exploring both the theoretical and applied aspects of computational biology, and focusing on the innovation processes, the book highlights the increased productivity of a translational approach. Presented in four sections and including insights from experts from around the world, the book includes: Section I: Bioinformatics and Next Generation Sequencing Technologies; Section II: Omics Application; Section III: Data mining and Markers Discovery; Section IV: Artificial Intelligence and Agribots. Bioinformatics in Agriculture: Next Generation Sequencing Era explores deep sequencing, NGS, genomic, transcriptome analysis and multiplexing, highlighting practices forreducing time, cost, and effort for the analysis of gene as they are pooled, and sequenced. Readers will gain real-world information on computational biology, genomics, applied data mining, machine learning, and artificial intelligence. This book serves as a complete package for advanced undergraduate students, researchers, and scientists with an interest in bioinformatics. Discusses integral aspects of molecular biology and pivotal tool sfor molecular breeding Enables breeders to design cost-effective and efficient breeding strategies Provides examples ofinnovative genome-wide marker (SSR, SNP) discovery Explores both the theoretical and practical aspects of computational biology with focus on innovation processes Covers recent trends of bioinformatics and different tools and techniques
Author : José Marín-García
Publisher : Academic Press
Page : 935 pages
File Size : 50,7 Mb
Release : 2014-05-09
Category : Medical
ISBN : 9780124046429
In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome, comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs
Author : Ibrokhim Y. Abdurakhmonov
Publisher : Unknown
Page : 177 pages
File Size : 45,6 Mb
Release : 2018
Category : Electronic
ISBN : 1789232694
