Genomes

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Genome

Author : Matt Ridley
Publisher : Harper Collins
Page : 370 pages
File Size : 49,5 Mb
Release : 2013-03-26
Category : Science
ISBN : 9780062253460

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Genome by Matt Ridley Pdf

“Ridley leaps from chromosome to chromosome in a handy summation of our ever increasing understanding of the roles that genes play in disease, behavior, sexual differences, and even intelligence. . . . . He addresses not only the ethical quandaries faced by contemporary scientists but the reductionist danger in equating inheritability with inevitability.” — The New Yorker The genome's been mapped. But what does it mean? Matt Ridley’s Genome is the book that explains it all: what it is, how it works, and what it portends for the future Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life. Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.

Mapping and Sequencing the Human Genome

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome
Publisher : National Academies Press
Page : 128 pages
File Size : 43,5 Mb
Release : 1988-01-01
Category : Science
ISBN : 9780309038409

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Mapping and Sequencing the Human Genome by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome Pdf

There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Genomes and What to Make of Them

Author : Barry Barnes,John Dupré
Publisher : University of Chicago Press
Page : 282 pages
File Size : 40,8 Mb
Release : 2009-05-15
Category : Science
ISBN : 9780226172965

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Genomes and What to Make of Them by Barry Barnes,John Dupré Pdf

The announcement in 2003 that the Human Genome Project had completed its map of the entire human genome was heralded as a stunning scientific breakthrough: our first full picture of the basic building blocks of human life. Since then, boasts about the benefits—and warnings of the dangers—of genomics have remained front-page news, with everyone agreeing that genomics has the potential to radically alter life as we know it. For the nonscientist, the claims and counterclaims are dizzying—what does it really mean to understand the genome? Barry Barnes and John Dupré offer an answer to that question and much more in Genomes and What to Make of Them, a clear and lively account of the genomic revolution and its promise. The book opens with a brief history of the science of genetics and genomics, from Mendel to Watson and Crick and all the way up to Craig Venter; from there the authors delve into the use of genomics in determining evolutionary paths—and what it can tell us, for example, about how far we really have come from our ape ancestors. Barnes and Dupré then consider both the power and risks of genetics, from the economic potential of plant genomes to overblown claims that certain human genes can be directly tied to such traits as intelligence or homosexuality. Ultimately, the authors argue, we are now living with a new knowledge as powerful in its way as nuclear physics, and the stark choices that face us—between biological warfare and gene therapy, a new eugenics or a new agricultural revolution—will demand the full engagement of both scientists and citizens. Written in straightforward language but without denying the complexity of the issues, Genomes and What to Make of Them is both an up-to-date primer and a blueprint for the future.

Ecological Genomics

Author : Christian R. Landry,Nadia Aubin-Horth
Publisher : Springer Science & Business Media
Page : 358 pages
File Size : 54,8 Mb
Release : 2013-11-25
Category : Science
ISBN : 9789400773479

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Ecological Genomics by Christian R. Landry,Nadia Aubin-Horth Pdf

Researchers in the field of ecological genomics aim to determine how a genome or a population of genomes interacts with its environment across ecological and evolutionary timescales. Ecological genomics is trans-disciplinary by nature. Ecologists have turned to genomics to be able to elucidate the mechanistic bases of the biodiversity their research tries to understand. Genomicists have turned to ecology in order to better explain the functional cellular and molecular variation they observed in their model organisms. We provide an advanced-level book that covers this recent research and proposes future development for this field. A synthesis of the field of ecological genomics emerges from this volume. Ecological Genomics covers a wide array of organisms (microbes, plants and animals) in order to be able to identify central concepts that motivate and derive from recent investigations in different branches of the tree of life. Ecological Genomics covers 3 fields of research that have most benefited from the recent technological and conceptual developments in the field of ecological genomics: the study of life-history evolution and its impact of genome architectures; the study of the genomic bases of phenotypic plasticity and the study of the genomic bases of adaptation and speciation.

Genomes

Author : Terence A. Brown
Publisher : Unknown
Page : 608 pages
File Size : 41,9 Mb
Release : 2002
Category : Medical
ISBN : UOM:39015055208949

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Genomes by Terence A. Brown Pdf

Genomes 2 covers modern molecular genetics from the genomics perspective, incorporating major advances made in the past three years, including the sequencing of the human genome, characterization of genome expression and replication processes, and transcriptomics and proteomics. The text is richly illustrated with clear, easy-to-follow, full-color diagrams, which are downloadable from the book's website.

Genes And Genomes

Author : Maxine Singer,Paul Berg
Publisher : University Science Books
Page : 964 pages
File Size : 51,6 Mb
Release : 1991
Category : Medical
ISBN : 0935702172

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Genes And Genomes by Maxine Singer,Paul Berg Pdf

The celebrated authors present an in-depth overview of the molecular structures and mechanisms that underlie the utilization of genetic information by complex organisms. They emphasize the experimental aspects of molecular genetics, offering a complete introduction to both principles and methods. "Excellent, suitably detailed and superbly written." Philip Leder, Harvard Medical School

The Grape Genome

Author : Dario Cantu,M. Andrew Walker
Publisher : Springer Nature
Page : 367 pages
File Size : 54,9 Mb
Release : 2019-11-13
Category : Science
ISBN : 9783030186012

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The Grape Genome by Dario Cantu,M. Andrew Walker Pdf

This book describes the current state of international grape genomics, with a focus on the latest findings, tools and strategies employed in genome sequencing and analysis, and genetic mapping of important agronomic traits. It also discusses how these are having a direct impact on outcomes for grape breeders and the international grape research community. While V. vinifera is a model species, it is not always appreciated that its cultivation usually requires the use of other Vitis species as rootstocks. The book discusses genetic diversity within the Vitis genus, the available genetic resources for breeding, and the available genomic resources for other Vitis species. Grapes (Vitis vinifera spp. vinifera) have been a source of food and wine since their domestication from their wild progenitor (Vitis vinifera ssp. sylvestris) around 8,000 years ago, and they are now the world’s most valuable horticultural crop. In addition to being economically important, V. vinifera is also a model organism for the study of perennial fruit crops for two reasons: Firstly, its ability to be transformed and micropropagated via somatic embryogenesis, and secondly its relatively small genome size of 500 Mb. The economic importance of grapes made V. vinifera an obvious early candidate for genomic sequencing, and accordingly, two draft genomes were reported in 2007. Remarkably, these were the first genomes of any fruiting crop to be sequenced and only the fourth for flowering plants. Although riddled with gaps and potentially omitting large regions of repetitive sequences, the two genomes have provided valuable insights into grape genomes. Cited in over 2,000 articles, the genome has served as a reference in more than 3,000 genome-wide transcriptional analyses. Further, recent advances in DNA sequencing and bioinformatics are enabling the assembly of reference-grade genome references for more grape genotypes revealing the exceptional extent of structural variation in the species.

Evolution of the Human Genome II

Author : Naruya Saitou
Publisher : Springer Nature
Page : 260 pages
File Size : 48,5 Mb
Release : 2021-05-27
Category : Science
ISBN : 9784431569046

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Evolution of the Human Genome II by Naruya Saitou Pdf

This two-volume set provides a general overview of the evolution of the human genome; The first volume overviews the human genome with descriptions of important gene groups. This second volume provides up-to-date, concise yet ample knowledge on the genome evolution of modern humans. It comprises twelve chapters divided into two parts discussing “Non-neutral Evolution on Human Genes” (Part I) and “Evolution of Modern Human Populations” (Part II.) The most significant feature of this book is the continent-wise discussion of modern human dispersal using human genomic data in Part II. Recent results such as introgression of paleogenomes to modern humans, new methods such as computer simulation of global human dispersals, and new information on genes for humanness will be of particular interest to the readers. Since the euchromatin regions of the human genome was sequenced in 2003, a huge number of research papers were published on modern human evolution for a variety of populations. It is now time to summarize these achievements. This book stands out as the most comprehensive book on the modern human evolution, focusing on genomic points of view with a broad scope. Primary target audiences are researchers and graduate students in evolutionary biology.

The Barley Genome

Author : Nils Stein,Gary J. Muehlbauer
Publisher : Springer
Page : 394 pages
File Size : 45,7 Mb
Release : 2018-08-18
Category : Science
ISBN : 9783319925288

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The Barley Genome by Nils Stein,Gary J. Muehlbauer Pdf

This book presents an overview of the state-of-the-art in barley genome analysis, covering all aspects of sequencing the genome and translating this important information into new knowledge in basic and applied crop plant biology and new tools for research and crop improvement. Unlimited access to a high-quality reference sequence is removing one of the major constraints in basic and applied research. This book summarizes the advanced knowledge of the composition of the barley genome, its genes and the much larger non-coding part of the genome, and how this information facilitates studying the specific characteristics of barley. One of the oldest domesticated crops, barley is the small grain cereal species that is best adapted to the highest altitudes and latitudes, and it exhibits the greatest tolerance to most abiotic stresses. With comprehensive access to the genome sequence, barley’s importance as a genetic model in comparative studies on crop species like wheat, rye, oats and even rice is likely to increase.

From Genes to Genomes

Author : Jeremy W. Dale,Malcolm von Schantz
Publisher : Wiley
Page : 372 pages
File Size : 53,6 Mb
Release : 2002-10-08
Category : Science
ISBN : 0471497827

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From Genes to Genomes by Jeremy W. Dale,Malcolm von Schantz Pdf

Rapid advances in our understanding of genetics have required that new books contain topics such as the concept and theory of gene cloning, transgenics, genomics, and various other coverage of traditional and contemporary subjects. Although there is an abundance of textbooks that cover introductory genetics and advanced courses in genetics, there is a noticeable gap at the intermediate (second year) level. In the past gene structure, function and expression were taught at final year /postgraduate level, but the rapid advances in our understanding of genetics has encouraged courses to change considerably. Over recent years these topics have filtered down the curriculum and are currently taught as core topics at second year, with a corresponding change in textbook requirements. Where once second year students were restricted to learning about the concept and theory of gene cloning, now they routinely clone genes for themselves as part of their practical assignments. Genes to Genomics will fill the gap, cover much of the same ground as previous titles, but go further on contemporary topics like transgenics, sequence comparison and analysis of variation. * A concise, up to date textbook that provides a balanced coverage of traditional and contemporary topics taught within intermediate courses in molecular genetics * Jeremy Dale has a proven track record as the successful author of Molecular Genetics of Bacteria * Genes to Genomics will include a series of feature box-outs that will examine some of the topical issues related to the scientific concepts and examples explored within the text * A range of questions and exercises including worked examples and web-based practicals * An accompanying web site will allow the authors to keep their audience up to date in the areas that are prone to date most rapidly between successive editions of the textbook. It will also include the illustrations and images from the textbook, in addition to worked examples, answers to questions within the book, and links to related websites of key interest.

Human Genes and Genomes

Author : Leon E. Rosenberg,Diane Drobnis Rosenberg
Publisher : Academic Press
Page : 446 pages
File Size : 48,5 Mb
Release : 2012-05-21
Category : Science
ISBN : 9780123852137

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Human Genes and Genomes by Leon E. Rosenberg,Diane Drobnis Rosenberg Pdf

In the nearly 60 years since Watson and Crick proposed the double helical structure of DNA, the molecule of heredity, waves of discoveries have made genetics the most thrilling field in the sciences. The study of genes and genomics today explores all aspects of the life with relevance in the lab, in the doctor’s office, in the courtroom and even in social relationships. In this helpful guidebook, one of the most respected and accomplished human geneticists of our time communicates the importance of genes and genomics studies in all aspects of life. With the use of core concepts and the integration of extensive references, this book provides students and professionals alike with the most in-depth view of the current state of the science and its relevance across disciplines. Bridges the gap between basic human genetic understanding and one of the most promising avenues for advances in the diagnosis, prevention and treatment of human disease. Includes the latest information on diagnostic testing, population screening, predicting disease susceptibility, pharmacogenomics and more Explores ethical, legal, regulatory and economic aspects of genomics in medicine. Integrates historical (classical) genetics approach with the latest discoveries in structural and functional genomics

Curiosity Guides: The Human Genome

Author : John Quackenbush
Publisher : Charlesbridge
Page : 189 pages
File Size : 55,6 Mb
Release : 2011-02-01
Category : Science
ISBN : 9781607343561

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Curiosity Guides: The Human Genome by John Quackenbush Pdf

The DNA sequence that comprises the human genome--the genetic blueprint found in each of our cells--is undoubtedly the greatest code ever to be broken. Completed at the dawn of a new millennium, the feat electrified both the scientific community and the general public with its tantalizing promise of new and better treatments for countless diseases, including Alzheimer's, cancer, diabetes, and Parkinson's. Yet what is arguably the most important discovery of our time has also opened a Pandora's box of questions about who we are as humans and how the unique information stored in our genomes can and might be used, making it all the more important for everyone to understand the new science of genomics. In the CURIOSITY GUIDE TO THE HUMAN GENOME, Dr. John Quackenbush, a renowned scientist and professor, conducts a fascinating tour of the history and science behind the Human Genome Project and the technologies that are revolutionizing the practice of medicine today. With a clear and engaging narrative style, he demystifies the fundamental principles of genetics and molecular biology, including the astounding ways in which genes function, alone or together with other genes and the environment, to either sustain life or trigger disease. In addition, Dr. Quackenbush goes beyond medicine to examine how DNA-sequencing technology is changing how we think of ourselves as a species by providing new insights about our earliest ancestors and reconfirming our inextricable link to all life on earth. Finally, he explores the legal and ethical questions surrounding such controversial topics as stem cell research, prenatal testing, forensics, and cloning, making this volume of the Curiosity Guides series an indispensable resource for navigating our brave new genomic world.

The Chickpea Genome

Author : Rajeev K. Varshney,Mahendar Thudi,Fred Muehlbauer
Publisher : Springer
Page : 142 pages
File Size : 50,8 Mb
Release : 2018-01-02
Category : Science
ISBN : 9783319661179

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The Chickpea Genome by Rajeev K. Varshney,Mahendar Thudi,Fred Muehlbauer Pdf

This book sheds new light on the chickpea genome sequencing and resequencing of chickpea germplasm lines and provides insights into classical genetics, cytogenetics, and trait mapping. It also offers an overview of the latest advances in genome sequencing and analysis. The growing human population, rapid climate changes and limited amounts of arable land are creating substantial challenges in connection with the availability and affordability of nutritious food for smallholder farmers in developing countries. In this context, climate smart crops are essential to alleviating the hunger of the millions of poor and undernourished people living in developing countries. In addition to cereals, grain legumes are an integral part of the human diet and provide sustainable income for smallholder farmers in the arid and semi-arid regions of the world. Among grain legumes, the chickpea (Cicer arietinum) is the second most important in terms of production and productivity. Besides being a rich source of proteins, it can fix atmospheric nitrogen through symbiosis with rhizobia and increase the input of combined nitrogen. Several abiotic stresses like drought, heat, salinity, together with biotic stresses like Fusarium wilt, Ascochyta blight, and Botrytis grey mould have led to production losses, as the chickpeas is typically grown in the harsh climates of our planet’s semi-arid regions.

The $1,000 Genome

Author : Kevin Davies
Publisher : Simon and Schuster
Page : 352 pages
File Size : 50,7 Mb
Release : 2015-08-18
Category : Medical
ISBN : 9781416569619

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The $1,000 Genome by Kevin Davies Pdf

In 2000, President Bill Clinton signaled the completion of the Human Genome Project at a cost in excess of $2 billion. A decade later, the price for any of us to order our own personal genome sequence--a comprehensive map of the 3 billion letters in our DNA--is rapidly and inevitably dropping to just $1,000. Dozens of men and women--scientists, entrepreneurs, celebrities, and patients--have already been sequenced, pioneers in a bold new era of personalized genomic medicine. The $1,000 genome has long been considered the tipping point that would open the floodgates to this revolution. Do you have gene variants associated with Alzheimer's or diabetes, heart disease or cancer? Which drugs should you consider taking for various diseases, and at what dosage? In the years to come, doctors will likely be able to tackle all of these questions--and many more--by using a computer in their offices to call up your unique genome sequence, which will become as much a part of your medical record as your blood pressure.

Genomes 3

Author : Terence A. Brown
Publisher : Garland Science
Page : 736 pages
File Size : 45,9 Mb
Release : 2007
Category : Science
ISBN : 9780815341383

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Genomes 3 by Terence A. Brown Pdf

The VitalBook e-book version of Genomes 3 is only available in the US and Canada at the present time. To purchase or rent please visit http://store.vitalsource.com/show/9780815341383 Covering molecular genetics from the basics through to genome expression and molecular phylogenetics, Genomes 3is the latest edition of this pioneering textbook. Updated to incorporate the recent major advances, Genomes 3 is an invaluable companion for any undergraduate throughout their studies in molecular genetics. Genomes 3 builds on the achievements of the previous two editions by putting genomes, rather than genes, at the centre of molecular genetics teaching. Recognizing that molecular biology research was being driven more by genome sequencing and functional analysis than by research into genes, this approach has gathered momentum in recent years.