Green Chemistry In Drug Discovery

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Contemporary Chemical Approaches for Green and Sustainable Drugs

Marianna Torok
Contemporary Chemical Approaches for Green and Sustainable Drugs Book PDF

Author : Marianna Torok
Publisher : Elsevier
Page : 568 pages
File Size : 52,6 Mb
Release : 2022-08-26
Category : Medical
ISBN : 9780128232712

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Contemporary Chemical Approaches for Green and Sustainable Drugs by Marianna Torok Pdf

Contemporary Chemical Approaches for Green and Sustainable Drugs provides readers with the knowledge they need to integrate sustainable approaches into their work. Sections cover different aspects of green and sustainable drug development from design to disposal, including computer-aided drug design, green resourcing of drugs and drug candidates, an overview of the health concerns of pharmaceutical pollution, and a survey of potential chemical methods for its reduction. Drawing together the knowledge of a global team of experts, this book provides an inclusive overview of the chemical tools and approaches available for minimizing the negative environmental impact of current and newly developed drugs. This will be a useful guide for all academic and industrial researchers across green and sustainable chemistry, medicinal chemistry, environmental chemistry and pharmaceutical science. Provides an integrative overview of the environmental risks of drugs and drug by products to support chemists in pre-emptively addressing these issues Highlights the advantages of computer-aided drug design, green and sustainable sourcing, and novel methods for the production of safer, more effective drugs Presents individual chapters written by renowned experts with diverse backgrounds Reflects research in practice through selected case studies and extensive state-of-the-art reference sections to serve as a starting point in the design of any specialized environmentally-conscious medicinal chemistry project

Green Chemistry Strategies for Drug Discovery

Emily A. Peterson,Julie B. Manley
Green Chemistry Strategies for Drug Discovery Book PDF

Author : Emily A. Peterson,Julie B. Manley
Publisher : Royal Society of Chemistry
Page : 338 pages
File Size : 53,8 Mb
Release : 2015-06-30
Category : Medical
ISBN : 9781849739610

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Green Chemistry Strategies for Drug Discovery by Emily A. Peterson,Julie B. Manley Pdf

The incorporation of Green Chemistry is a relatively new phenomenon in the drug discovery discipline, since the scale that chemists operate on in drug discovery is smaller than those of process and manufacturing chemistry. The necessary metrics are more difficult to obtain in drug discovery due to the diversity of reactions conducted. However, pharmaceutical companies are realizing that incorporation of green chemistry techniques at earlier stages of drug development can speed the development of a drug candidate. Edited by experts who have pioneered green chemistry efforts within their own institutions, this book provides a practical guide for both academic and industrial labs wanting to know where to start with introducing greener approaches for greatest return on investment. The Editors have taken a comprehensive approach to the topic covering the entire drug discovery process from molecule conception, through synthesis, formulation and toxicology with specific examples and case studies where green chemistry strategies have been implemented. Currently employed as well as emerging techniques for performing greener drug discovery chemistry are addressed as well as cutting-edge topics like biologics discovery. Moreover, important surrounding issues such as intellectual property are included. This book will serve as a practical guide for both academic and industrial chemists who work across the breadth of the drug discovery discipline. Ultimately, readers will learn how to incorporate green chemistry strategies into their everyday workflow without slowing down their science.

Green Chemistry in Drug Discovery

Paul F. Richardson
Green Chemistry in Drug Discovery Book PDF

Author : Paul F. Richardson
Publisher : Humana
Page : 595 pages
File Size : 49,7 Mb
Release : 2021-10-26
Category : Medical
ISBN : 1071615777

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Green Chemistry in Drug Discovery by Paul F. Richardson Pdf

This detailed book highlights several emerging areas in the implementation of green chemistry in medicinal chemistry drug discovery with a specific focus on their application to the expeditious discovery of new biologically active entities. Divided into three sections, the collection explores greener approaches to chemical transformations that are both prevalent and have been highlighted as challenging within the pharmaceutical industry, overall synthetic strategy, as well as the implementation and impact of a range of enabling technologies within medicinal chemistry. As a volume of the Methods in Pharmacology and Toxicology series, chapters provide the kind of key insight that can guide researchers toward greater success in the lab. Authoritative and practical, Green Chemistry in Drug Discovery: From Academia to Industry provides both a fundamental insight into the progress that has been made as well as some of the challenges that still exist for these techniques to be effectively implemented in the drug discovery process in a routine manner.

Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Bimal Krishna Banik
Green Approaches in Medicinal Chemistry for Sustainable Drug Design Book PDF

Author : Bimal Krishna Banik
Publisher : Elsevier
Page : 1046 pages
File Size : 55,8 Mb
Release : 2020-03-27
Category : Medical
ISBN : 9780128175934

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Green Approaches in Medicinal Chemistry for Sustainable Drug Design by Bimal Krishna Banik Pdf

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6. Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability Reflects on techniques for a broad range of compounds and materials Highlights sustainable and green chemistry pathways for molecular synthesis

Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Bimal K. Banik
Green Approaches in Medicinal Chemistry for Sustainable Drug Design Book PDF

Author : Bimal K. Banik
Publisher : Elsevier
Page : 1044 pages
File Size : 41,6 Mb
Release : 2020-04-09
Category : Medical
ISBN : 9780128175927

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Green Approaches in Medicinal Chemistry for Sustainable Drug Design by Bimal K. Banik Pdf

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6. Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability Reflects on techniques for a broad range of compounds and materials Highlights sustainable and green chemistry pathways for molecular synthesis

Green Chemistry in the Pharmaceutical Industry

Peter J. Dunn,Andrew Wells,Michael T. Williams
Green Chemistry in the Pharmaceutical Industry Book PDF

Author : Peter J. Dunn,Andrew Wells,Michael T. Williams
Publisher : John Wiley & Sons
Page : 388 pages
File Size : 43,6 Mb
Release : 2010-02-02
Category : Science
ISBN : 3527629696

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Green Chemistry in the Pharmaceutical Industry by Peter J. Dunn,Andrew Wells,Michael T. Williams Pdf

Edited by three of the world's leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in the environment. Furthermore, this ready reference contains several convincing case studies from industry, such as Taxol, Pregabalin and Crestor, illustrating how this multidisciplinary approach has yielded efficient and environmentally-friendly processes. Finally, a section on technology and tools highlights the advantages of green chemistry.

Scalable Green Chemistry

Stefan Koenig
Scalable Green Chemistry Book PDF

Author : Stefan Koenig
Publisher : CRC Press
Page : 350 pages
File Size : 48,6 Mb
Release : 2013-09-11
Category : Medical
ISBN : 9789814364812

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Scalable Green Chemistry by Stefan Koenig Pdf

Packed with real-world examples, this book illustrates the 12 principles of green chemistry. These diverse case studies demonstrate to scientists and students that beyond the theory, the challenges of green chemistry in pharmaceutical discovery and development remain an ongoing endeavor. By informing and welcoming additional practitioners to this mission, the negative environmental impact of pharmaceutical products will continue to be minimized. Green chemistry is the methodology by which chemical production in this industry can become more efficient, adding environmental stewardship to the noble mission of treating human disease.

Green and Sustainable Medicinal Chemistry

Louise Summerton,Helen F Sneddon,Leonie C Jones,James H Clark
Green and Sustainable Medicinal Chemistry Book PDF

Author : Louise Summerton,Helen F Sneddon,Leonie C Jones,James H Clark
Publisher : Royal Society of Chemistry
Page : 272 pages
File Size : 49,6 Mb
Release : 2016-03-08
Category : Science
ISBN : 9781782625940

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Green and Sustainable Medicinal Chemistry by Louise Summerton,Helen F Sneddon,Leonie C Jones,James H Clark Pdf

Pharmaceutical manufacturing was one of the first industries to recognize the importance of green chemistry, with pioneering work including green chemistry metrics and alternative solvents and reagents. Today, other topical factors also have to be taken into consideration, such as rapidly depleting resources, high energy costs and new legislation. This book addresses current challenges in modern green chemical technologies and sustainability thinking. It encompasses a broad range of topics covered by the CHEM21 project – Europe’s largest public-private partnership project which aims to develop a toolbox of sustainable technologies for green chemical intermediate manufacture. Divided into two sections, the book first gives an overview of the key green chemistry tools, guidance and considerations aimed at developing greener processes, before moving on to look at cutting-edge synthetic methodologies. Featuring innovative research, this book is an invaluable reference for chemists across academia and industry wanting to further their knowledge and understanding of this important topic.

Medicinal and Environmental Chemistry: Experimental Advances and Simulations (Part I)

Tahmeena Khan,Abdul Rahman Khan,Saman Raza,Iqbal Azad,Alfred J. Lawrence
Medicinal and Environmental Chemistry Experimental Advances and Simulations Part I Book PDF

Author : Tahmeena Khan,Abdul Rahman Khan,Saman Raza,Iqbal Azad,Alfred J. Lawrence
Publisher : Bentham Science Publishers
Page : 270 pages
File Size : 54,5 Mb
Release : 2021-09-02
Category : Science
ISBN : 9789814998284

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Medicinal and Environmental Chemistry: Experimental Advances and Simulations (Part I) by Tahmeena Khan,Abdul Rahman Khan,Saman Raza,Iqbal Azad,Alfred J. Lawrence Pdf

Medicinal and Environmental Chemistry: Experimental Advances and Simulations is a collection of topics that highlight the use of pharmaceutical chemistry to assess the environment or make drug design and chemical testing more environment friendly. The ten chapters included in the first part of this book set cover diverse topics, blending the fields of environmental chemistry and medicinal chemistry and have been authored by experts, scientists and academicians from renowned institutions. The book introduces the reader to environmental contaminants and techniques for their quantification and removal. A medicinal perspective for effects and remediation of environmental hazards, and therapeutic strategies available to design new and safer drugs, is addressed with a focus on knowledge about experimental and simulation methods. To further elaborate the importance of environmentally safe chemical practice, the concept of green chemistry has also been covered. Specialized chapters have been included in the book about persistent organic pollutants, heavy metal and plastic pollutants, the effect of environmental xenoesterogens on human health and the potential of natural products to combat ecotoxicity. Key Features: 1. 10 topics which blend environmental chemistry and medicinal chemistry 2. Contributions from more than 30 experts 3. Includes introductory topics on environmental pollutants, investigative techniques in drug design and environmental risk assessment and green chemistry 4. Includes specialized topics on persistent pollutants, ecotoxicity remediation and xenoestrogens 5. Bibliographic references This reference is an essential source of information for readers and scholars involved in environmental chemistry, pollution management and pharmaceutical chemistry courses at graduate and undergraduate levels. Professionals and students involved in occupational medicine will also benefit from the wide range of topics covered.

Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Bimal Krishna Banik
Green Approaches in Medicinal Chemistry for Sustainable Drug Design Book PDF

Author : Bimal Krishna Banik
Publisher : Elsevier
Page : 656 pages
File Size : 53,6 Mb
Release : 2024-06-07
Category : Medical
ISBN : 9780443161643

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Green Approaches in Medicinal Chemistry for Sustainable Drug Design by Bimal Krishna Banik Pdf

Green Approaches in Medicinal Chemistry for Sustainable Drug Design: Methods, Second Edition reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context on the growth of green chemistry in relation to drug discovery, the book identifies a range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure, and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global experts, the book encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists, and more. This volume covers synthesis methods following green chemistry principles, contributing to sustainability by saving energy, using lesser toxic reagents/solvents/catalysts and environmentally benign sources, including plants and agricultural materials.

Modern Green Chemistry and Heterocyclic Compounds

Ravindra S. Shinde,A. K. Haghi
Modern Green Chemistry and Heterocyclic Compounds Book PDF

Author : Ravindra S. Shinde,A. K. Haghi
Publisher : CRC Press
Page : 302 pages
File Size : 51,7 Mb
Release : 2020-03-31
Category : Medical
ISBN : 9781000029178

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Modern Green Chemistry and Heterocyclic Compounds by Ravindra S. Shinde,A. K. Haghi Pdf

This book covers the general properties of heterocyclic compounds and methods for their preparation to use in applications of green chemistry. Heterocyclic compounds are an important class of molecules in organic chemistry due to their presence in natural products and their use in pharmaceuticals and new materials. They also play a vital role in the metabolism of living cells. Heterocyclic compounds have a wide range of applications in agrochemicals, pharmaceuticals, veterinary products, etc. This research-oriented volume is ideal for readers who want to fully realize the almost limitless potential of heterocyclic compounds and to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features several case studies and step-by-step descriptions of synthetic methods and practical techniques. It also serves as a guide for chemists, offering them new insights and new paths to explore for effective drug discovery.

Green Toxicology

Alexandra Maertens
Green Toxicology Book PDF

Author : Alexandra Maertens
Publisher : Royal Society of Chemistry
Page : 307 pages
File Size : 55,7 Mb
Release : 2022-02-01
Category : Science
ISBN : 9781839164408

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Green Toxicology by Alexandra Maertens Pdf

Green toxicology is an integral part of green chemistry. One of the key goals of green chemistry is to design less toxic chemicals. Therefore, an understanding of toxicology and hazard assessment is important for any chemist working in green chemistry, but toxicology is rarely part of most chemists' education. As a consequence, chemists lack the toxicological lens necessary to view chemicals in order to design safer substitutions. This book seeks to fill that gap and demonstrate how a basic understanding of toxicology, as well as the tools of in silico and in vitro toxicology, can be an integral part of green chemistry. R&D chemists, product stewards, and toxicologists who work in the field of sustainability, can all benefit from integrating green toxicology principles into their work. Topics include in silico tools for hazard assessment, toxicity testing, and lifecycle considerations, this book aims to act as a bridge between green toxicologists and green chemists.

Green Techniques for Organic Synthesis and Medicinal Chemistry

Wei Zhang,Berkeley W. Cue
Green Techniques for Organic Synthesis and Medicinal Chemistry Book PDF

Author : Wei Zhang,Berkeley W. Cue
Publisher : John Wiley & Sons
Page : 726 pages
File Size : 48,7 Mb
Release : 2018-03-19
Category : Science
ISBN : 9781119288169

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Green Techniques for Organic Synthesis and Medicinal Chemistry by Wei Zhang,Berkeley W. Cue Pdf

An updated overview of the rapidly developing field of green techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.

Sustainable Synthesis of Pharmaceuticals

Mariette M. Pereira,Mario J. F. Calvete
Sustainable Synthesis of Pharmaceuticals Book PDF

Author : Mariette M. Pereira,Mario J. F. Calvete
Publisher : Royal Society of Chemistry
Page : 286 pages
File Size : 49,7 Mb
Release : 2018-03-26
Category : Business & Economics
ISBN : 9781788010658

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Sustainable Synthesis of Pharmaceuticals by Mariette M. Pereira,Mario J. F. Calvete Pdf

There is a growing interest in the development of sustainable processes for the synthesis of pharmaceuticals and this book bridges the divide between industrial examples and the fundamental chemistry. It explains the basic principles of using transition metal catalysis with several green approaches for the synthesis of pharmaceuticals. The topic is an important one for green chemistry and the chapters in this book on hydroformylation, green oxidation and olefin metathesis will also be of interest to both medicinal and organic chemists. Written by leading experts in the field, it provides a valuable and easy tool for scientists and industrialists who require information regarding this topic.

Flow Chemistry in Drug Discovery

Jesus Alcazar,Antonio de la Hoz,Angel Díaz-Ortiz
Flow Chemistry in Drug Discovery Book PDF

Author : Jesus Alcazar,Antonio de la Hoz,Angel Díaz-Ortiz
Publisher : Springer Nature
Page : 501 pages
File Size : 48,8 Mb
Release : 2021-12-08
Category : Science
ISBN : 9783030855925

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Flow Chemistry in Drug Discovery by Jesus Alcazar,Antonio de la Hoz,Angel Díaz-Ortiz Pdf

This book reviews the challenges and opportunities posed by flow chemistry in drug discovery, and offers a handy reference tool for medicinal chemists interested in the synthesis of biologically active compounds. Prepared by expert contributors, the respective chapters cover not only fundamental methodologies and reactions, such as the application of catalysis, especially biocatalysis and organocatalysis; and non-conventional activation techniques, from photochemistry to electrochemistry; but also the development of new process windows, processes and reactions in drug synthesis. Particular attention is given to automatization and library synthesis, which are of great importance in the pharmaceutical industry. Readers will also find coverage on selected topics of general interest, such as how flow chemistry is contributing to drug discovery R&D in developing countries, and the green character of this enabling technology, for example in the production of raw materials for the pharmaceutical industry from waste. Given its scope, the book appeals to medicinal chemistry researchers working in academia and industry alike, as well as professionals involved in scale-up and drug development.