Green Chemistry Strategies For Drug Discovery

Author : Emily A. Peterson,Julie B. Manley
Publisher : Royal Society of Chemistry
Page : 338 pages
File Size : 44,7 Mb
Release : 2015-06-30
Category : Medical
ISBN : 9781849739610

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Green Chemistry Strategies for Drug Discovery by Emily A. Peterson,Julie B. Manley Pdf

The incorporation of Green Chemistry is a relatively new phenomenon in the drug discovery discipline, since the scale that chemists operate on in drug discovery is smaller than those of process and manufacturing chemistry. The necessary metrics are more difficult to obtain in drug discovery due to the diversity of reactions conducted. However, pharmaceutical companies are realizing that incorporation of green chemistry techniques at earlier stages of drug development can speed the development of a drug candidate. Edited by experts who have pioneered green chemistry efforts within their own institutions, this book provides a practical guide for both academic and industrial labs wanting to know where to start with introducing greener approaches for greatest return on investment. The Editors have taken a comprehensive approach to the topic covering the entire drug discovery process from molecule conception, through synthesis, formulation and toxicology with specific examples and case studies where green chemistry strategies have been implemented. Currently employed as well as emerging techniques for performing greener drug discovery chemistry are addressed as well as cutting-edge topics like biologics discovery. Moreover, important surrounding issues such as intellectual property are included. This book will serve as a practical guide for both academic and industrial chemists who work across the breadth of the drug discovery discipline. Ultimately, readers will learn how to incorporate green chemistry strategies into their everyday workflow without slowing down their science.

Author : Marianna Torok
Publisher : Elsevier
Page : 568 pages
File Size : 51,5 Mb
Release : 2022-08-26
Category : Medical
ISBN : 9780128232712

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Contemporary Chemical Approaches for Green and Sustainable Drugs by Marianna Torok Pdf

Contemporary Chemical Approaches for Green and Sustainable Drugs provides readers with the knowledge they need to integrate sustainable approaches into their work. Sections cover different aspects of green and sustainable drug development from design to disposal, including computer-aided drug design, green resourcing of drugs and drug candidates, an overview of the health concerns of pharmaceutical pollution, and a survey of potential chemical methods for its reduction. Drawing together the knowledge of a global team of experts, this book provides an inclusive overview of the chemical tools and approaches available for minimizing the negative environmental impact of current and newly developed drugs. This will be a useful guide for all academic and industrial researchers across green and sustainable chemistry, medicinal chemistry, environmental chemistry and pharmaceutical science. Provides an integrative overview of the environmental risks of drugs and drug by products to support chemists in pre-emptively addressing these issues Highlights the advantages of computer-aided drug design, green and sustainable sourcing, and novel methods for the production of safer, more effective drugs Presents individual chapters written by renowned experts with diverse backgrounds Reflects research in practice through selected case studies and extensive state-of-the-art reference sections to serve as a starting point in the design of any specialized environmentally-conscious medicinal chemistry project

Author : Paul F. Richardson
Publisher : Humana
Page : 595 pages
File Size : 52,5 Mb
Release : 2021-10-26
Category : Medical
ISBN : 1071615777

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Green Chemistry in Drug Discovery by Paul F. Richardson Pdf

This detailed book highlights several emerging areas in the implementation of green chemistry in medicinal chemistry drug discovery with a specific focus on their application to the expeditious discovery of new biologically active entities. Divided into three sections, the collection explores greener approaches to chemical transformations that are both prevalent and have been highlighted as challenging within the pharmaceutical industry, overall synthetic strategy, as well as the implementation and impact of a range of enabling technologies within medicinal chemistry. As a volume of the Methods in Pharmacology and Toxicology series, chapters provide the kind of key insight that can guide researchers toward greater success in the lab. Authoritative and practical, Green Chemistry in Drug Discovery: From Academia to Industry provides both a fundamental insight into the progress that has been made as well as some of the challenges that still exist for these techniques to be effectively implemented in the drug discovery process in a routine manner.

Author : Bimal Krishna Banik
Publisher : Elsevier
Page : 699 pages
File Size : 50,8 Mb
Release : 2024-05-31
Category : Science
ISBN : 9780443161674

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Green Approaches in Medicinal Chemistry for Sustainable Drug Design by Bimal Krishna Banik Pdf

Extensive experimentation and high failure rates are a well-recognized downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry 2e reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry, Second Edition encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work. This second volume of the second edition includes the development of nanoparticles and nanocomposites, as well as the application of ultrasound and microwave-induced methods; studies solventless synthesis; defines the role of steroids; studies reactions in aqueous solution; identifies enzyme-mediated reactions; investigates ionic liquids and deep eutectic solvents; explores natural products; investigates solid supports; realizes the effects of salts; focuses on combinatorial chemistry; develops one-pot methods; analyzes multi-component reactions; investigates dipole moment values; and examines computer-assisted methods. Highlights the need for adoption of sustainable and green chemistry pathways in drug development Reveals risk factors associated with the drug development process and the ways sustainable approaches can help address these Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability

Author : Louise Summerton,Helen F. Sneddon,Leonie C. Jones,James H. Clark
Publisher : Royal Society of Chemistry
Page : 272 pages
File Size : 52,8 Mb
Release : 2016
Category : Science
ISBN : 9781782624677

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Green and Sustainable Medicinal Chemistry by Louise Summerton,Helen F. Sneddon,Leonie C. Jones,James H. Clark Pdf

Author : Peter J. Dunn,Andrew Wells,Michael T. Williams
Publisher : John Wiley & Sons
Page : 388 pages
File Size : 53,8 Mb
Release : 2010-02-02
Category : Science
ISBN : 3527629696

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Green Chemistry in the Pharmaceutical Industry by Peter J. Dunn,Andrew Wells,Michael T. Williams Pdf

Edited by three of the world's leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in the environment. Furthermore, this ready reference contains several convincing case studies from industry, such as Taxol, Pregabalin and Crestor, illustrating how this multidisciplinary approach has yielded efficient and environmentally-friendly processes. Finally, a section on technology and tools highlights the advantages of green chemistry.

Author : Tahmeena Khan,Abdul Rahman Khan,Saman Raza,Iqbal Azad,Alfred J. Lawrence
Publisher : Bentham Science Publishers
Page : 270 pages
File Size : 46,9 Mb
Release : 2021-09-02
Category : Science
ISBN : 9789814998284

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Medicinal and Environmental Chemistry: Experimental Advances and Simulations (Part I) by Tahmeena Khan,Abdul Rahman Khan,Saman Raza,Iqbal Azad,Alfred J. Lawrence Pdf

Medicinal and Environmental Chemistry: Experimental Advances and Simulations is a collection of topics that highlight the use of pharmaceutical chemistry to assess the environment or make drug design and chemical testing more environment friendly. The ten chapters included in the first part of this book set cover diverse topics, blending the fields of environmental chemistry and medicinal chemistry and have been authored by experts, scientists and academicians from renowned institutions. The book introduces the reader to environmental contaminants and techniques for their quantification and removal. A medicinal perspective for effects and remediation of environmental hazards, and therapeutic strategies available to design new and safer drugs, is addressed with a focus on knowledge about experimental and simulation methods. To further elaborate the importance of environmentally safe chemical practice, the concept of green chemistry has also been covered. Specialized chapters have been included in the book about persistent organic pollutants, heavy metal and plastic pollutants, the effect of environmental xenoesterogens on human health and the potential of natural products to combat ecotoxicity. Key Features: 1. 10 topics which blend environmental chemistry and medicinal chemistry 2. Contributions from more than 30 experts 3. Includes introductory topics on environmental pollutants, investigative techniques in drug design and environmental risk assessment and green chemistry 4. Includes specialized topics on persistent pollutants, ecotoxicity remediation and xenoestrogens 5. Bibliographic references This reference is an essential source of information for readers and scholars involved in environmental chemistry, pollution management and pharmaceutical chemistry courses at graduate and undergraduate levels. Professionals and students involved in occupational medicine will also benefit from the wide range of topics covered.

Author : Wei Zhang,Berkeley W. Cue
Publisher : John Wiley & Sons
Page : 726 pages
File Size : 49,5 Mb
Release : 2018-03-19
Category : Science
ISBN : 9781119288169

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Green Techniques for Organic Synthesis and Medicinal Chemistry by Wei Zhang,Berkeley W. Cue Pdf

An updated overview of the rapidly developing field of green techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.

Author : Bimal Krishna Banik
Publisher : Elsevier
Page : 658 pages
File Size : 44,6 Mb
Release : 2024-06-07
Category : Science
ISBN : 9780443161650

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Green Approaches in Medicinal Chemistry for Sustainable Drug Design by Bimal Krishna Banik Pdf

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry, Second Edition reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry 2e encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work. This first volume of the second edition covers synthesis methods following green chemistry principles, contributing to sustainability by saving energy, using lesser toxic reagents/solvents/catalysts and environmentally benign sources including plants and agricultural materials. Highlights the need for the adoption of sustainable and green chemistry pathways in drug development Reveals risk factors associated with the drug development process and the ways sustainable approaches can help address these factors Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability

Author : Rodney A. Fernandes
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 53,9 Mb
Release : 2018-05-25
Category : Science
ISBN : 9781119295198

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Protecting-Group-Free Organic Synthesis by Rodney A. Fernandes Pdf

Presents a comprehensive account of established protecting-group-free synthetic routes to molecules of medium to high complexity This book supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an “ideal synthesis” and back the global need of practicing green chemistry. The only resource of its kind to focus entirely on protecting-group-free synthesis, it is edited by a leading practitioner in the field, and features enlightening contributions by top experts and researchers from across the globe. The introductory chapter includes a concise review of historical developments, and discusses the concepts, need for, and future prospects of protecting-group-free synthesis. Following this, the book presents information on protecting-group-free synthesis of complex natural products and analogues, heterocycles, drugs, and related pharmaceuticals. Later chapters discuss practicing protecting-group-free synthesis using carbohydrates and of glycosyl derivatives, glycol-polymers and glyco-conjugates. The book concludes with a chapter on latent functionality as a tactic toward formal protecting-group-free synthesis. A comprehensive account of established protecting-group-free (PGF) synthetic routes to molecules of medium to high complexity Benefits total synthesis, methodology development and drug synthesis researchers Supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an “ideal synthesis” and support the global need of practicing green chemistry Covers a topic that is gaining importance because it renders syntheses more economical Protecting-Group-Free Organic Synthesis: Improving Economy and Efficiency is an important book for academic researchers in synthetic organic chemistry, green chemistry, medicinal and pharmaceutical chemistry, biochemistry, and drug discovery.

Author : Stefan Koenig
Publisher : CRC Press
Page : 378 pages
File Size : 40,5 Mb
Release : 2013-09-11
Category : Medical
ISBN : 9789814364812

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Scalable Green Chemistry by Stefan Koenig Pdf

Packed with real-world examples, this book illustrates the 12 principles of green chemistry. These diverse case studies demonstrate to scientists and students that beyond the theory, the challenges of green chemistry in pharmaceutical discovery and development remain an ongoing endeavor. By informing and welcoming additional practitioners to this m

Author : Goutam Brahmachari
Publisher : Elsevier
Page : 646 pages
File Size : 52,5 Mb
Release : 2021-03-20
Category : Science
ISBN : 9780323851305

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Green Synthetic Approaches for Biologically Relevant Heterocycles by Goutam Brahmachari Pdf

Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. Provides fully updated coverage of the field of greener heterocycle synthesis Includes new chapters on varied multicomponent reactions, alongside both traditional and novel approaches Presents information in an accessible style with an emphasis on sustainability

Author : Werngard Czechtizky,Peter Hamley
Publisher : John Wiley & Sons
Page : 546 pages
File Size : 54,7 Mb
Release : 2015-11-02
Category : Science
ISBN : 9781118771600

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Small Molecule Medicinal Chemistry by Werngard Czechtizky,Peter Hamley Pdf

Stressing strategic and technological solutions to medicinal chemistry challenges, this book presents methods and practices for optimizing the chemical aspects of drug discovery. Chapters discuss benefits, challenges, case studies, and industry perspectives for improving drug discovery programs with respect to quality and costs. • Focuses on small molecules and their critical role in medicinal chemistry, reviewing chemical and economic advantages, challenges, and trends in the field from industry perspectives • Discusses novel approaches and key topics, like screening collection enhancement, risk sharing, HTS triage, new lead finding approaches, diversity-oriented synthesis, peptidomimetics, natural products, and high throughput medicinal chemistry approaches • Explains how to reduce design-make-test cycle times by integrating medicinal chemistry, physical chemistry, and ADME profiling techniques • Includes descriptive case studies, examples, and applications to illustrate new technologies and provide step-by-step explanations to enable them in a laboratory setting

Author : A. John Blacker,Mike T. Williams,Michael T. Williams,Royal Society of Chemistry (Great Britain)
Publisher : Royal Society of Chemistry
Page : 375 pages
File Size : 45,8 Mb
Release : 2011
Category : Medical
ISBN : 9781849731461

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Pharmaceutical Process Development by A. John Blacker,Mike T. Williams,Michael T. Williams,Royal Society of Chemistry (Great Britain) Pdf

'Pharmaceutical Process Development' is aimed at both graduates and postgraduates interested in a career in the pharmaceutical industry and informs them about the breadth of the work carried out in chemical research and development departments.

Author : Aide Sáenz-Galindo,Adali Oliva Castañeda Facio,Raul Rodriguez-Herrera
Publisher : CRC Press
Page : 292 pages
File Size : 45,9 Mb
Release : 2020-11-26
Category : Science
ISBN : 9781000220087

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Green Chemistry and Applications by Aide Sáenz-Galindo,Adali Oliva Castañeda Facio,Raul Rodriguez-Herrera Pdf

Green chemistry is a work tool that can be applied in different areas such as medicine, materials, polymers, food, organic chemistry, etc., since it was propounded in the early 2000s. It has become a viable alternative for care, remediation and protection of the environment and has been implemented worldwide. In this book the twelve principles of green chemistry are presented in a simple way, with examples of the applications of green chemistry in numerous areas showcasing it as an ideal alternative for environmental care. It also provides information on current research being implemented at the pilot plant and industrial level. The book demonstrates the importance of the use of renewable raw materials, the use of catalysis and the implementation of alternative energy sources such as the use of microwaves and ultrasound in different separation and chemical processes.