Guidebook To Molecular Chaperones And Protein Folding Catalysts

Author : Mary-Jane Gething
Publisher : OUP Oxford
Page : 586 pages
File Size : 42,6 Mb
Release : 1997-11-27
Category : Medical
ISBN : 9780191547270

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Guidebook to Molecular Chaperones and Protein-Folding Catalysts by Mary-Jane Gething Pdf

The precise shape of a protein is a crucial factor in its function. How do proteins become folded into the right conformation? Molecular chaperones and protein folding catalysts bind to developing polypeptides in the cytoplasm and ensure correct folding and transport. This Guidebook catalogues the latest information on nearly 200 of these molecules, including the important class of heat shock proteins; each entry is written by leading researchers in the field.

Author : Bernd Bakau
Publisher : CRC Press
Page : 784 pages
File Size : 50,5 Mb
Release : 2003-09-02
Category : Science
ISBN : 9780203303757

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Molecular Chaperones and Folding Catalysts by Bernd Bakau Pdf

One of the most intriguing discoveries in molecular biology in the last decade is the existence of an evolutionary conserved and essential system, consisting of molecular chaperones and folding catalysts, which promotes the folding of the proteins in the cell. This text summarizes our current knowledge of the cellular roles, the regulation and the mechanism of action of this system. It has a broad scope, covering cell biological, genetic and biochemical aspects of protein folding in cells from bacteria to man. Particularly appropriate to researchers working in basic and applied aspects of molecular medicine, this volume should also prove useful as an up-to-date reference book and as a textbook for specialized university courses.

Author : Sophie Jackson
Publisher : Springer
Page : 274 pages
File Size : 51,9 Mb
Release : 2012-12-15
Category : Science
ISBN : 9783642345524

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Molecular Chaperones by Sophie Jackson Pdf

Assisting Oxidative Protein Folding: How Do Protein Disulphide-Isomerases Couple Conformational and Chemical Processes in Protein Folding?, by A. Katrine Wallis and Robert B. Freedman Peptide Bond cis/trans Isomerases: A Biocatalysis Perspective of Conformational Dynamics in Proteins, by Cordelia Schiene-Fischer, Tobias Aumüller and Gunter Fischer Small Heat-Shock Proteins: Paramedics of the Cell, by Gillian R. Hilton, Hadi Lioe, Florian Stengel, Andrew J. Baldwin und Justin L. P. Benesch Allostery in the Hsp70 Chaperone Proteins, by Erik R. P. Zuiderweg, Eric B. Bertelsen, Aikaterini Rousaki, Matthias P. Mayer, Jason E. Gestwicki and Atta Ahmad Hsp90: Structure and Function, by Sophie E. Jackson Extracellular Chaperones, by Rebecca A. Dabbs, Amy R. Wyatt, Justin J. Yerbury, Heath Ecroyd and Mark R. Wilson

Author : R.J. Ellis,R.A. Laskey,G.H. Lorimer
Publisher : Springer Science & Business Media
Page : 121 pages
File Size : 41,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401121088

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Molecular Chaperones by R.J. Ellis,R.A. Laskey,G.H. Lorimer Pdf

Currently one of the hottest topics in biochemistry, the concept of molecular chaperones has challenged the paradigm of protein self-assembly. Key figures in many disciplines review all aspects of molecular chaperones in this volume, which arises from a Royal Society discussion meeting. Overview chapters discuss the significance of chaperones in biochemistry, molecular genetics and cell biology. Each chapter is well referenced providing access to the literature.

Author : Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard
Publisher : World Scientific
Page : 128 pages
File Size : 50,9 Mb
Release : 2016-08-08
Category : Science
ISBN : 9789814749343

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Structure and Action of Molecular Chaperones by Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard Pdf

This unique volume reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones, which provide essential kinetic assistance to processes of protein folding and unfolding in the cell. Ranging from multisubunit ring-shaped chaperonin and Hsp100 machines that use their central cavities to bind and compartmentalize action on proteins, to machines that use other topologies of recognition — binding cellular proteins in an archway or at the surface of a "clamp" or at the surface of a globular assembly — the structures show us the ways and means the cell has devised to assist its major effectors, proteins, to reach and maintain their unique active forms, as well as, when required, to disrupt protein structure in order to remodel or degrade. Each type of chaperone is beautifully illustrated by X-ray and EM structure determinations at near- atomic level resolution and described by a leader in the study of the respective family. The beauty of what Mother Nature has devised to accomplish essential assisting actions for proteins in vivo is fully appreciable.

Author : Mario D. Galigniana
Publisher : Bentham Science Publishers
Page : 279 pages
File Size : 48,8 Mb
Release : 2018-04-26
Category : Science
ISBN : 9781681086156

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Role of Molecular Chaperones in Structural Folding, Biological Functions, and Drug Interactions of Client Proteins by Mario D. Galigniana Pdf

The book provides an updated panorama of the functional relevance of molecular chaperones in the proper folding of client factors, protein-protein interactions, the regulation of key biological functions, the development of ligand-based structural complexes and the consequent pharmacological or biotechnological applications of these processes. The involvement of molecular chaperones in several processes ranging from regulation of transcription factors and protein-protein interactions in bacteria to proteostasis, signaling pathways and cancer are also addressed. The book is an essential consulting tool for researchers, working professionals in academia or industry, and students of all levels who wish to obtain the most relevant and updated information currently available about protein folding and chaperones.

Author : Walid A. Houry
Publisher : Springer
Page : 485 pages
File Size : 48,6 Mb
Release : 2014-09-01
Category : Science
ISBN : 9781493911301

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The Molecular Chaperones Interaction Networks in Protein Folding and Degradation by Walid A. Houry Pdf

Molecular chaperones are a fundamental group of proteins that have been identified only relatively recently. They are key components of a protein quality machinery in the cell which insures that the folding process of any newly-synthesized polypeptide chain results in the formation of a properly folded protein and that the folded protein is maintained in an active conformation throughout its functional lifetime. Molecular chaperones have been shown to play essential roles in cell viability under both normal and stress conditions. Chaperones can also assist in the unfolding and degradation of misfolded proteins and in disaggregating preformed protein aggregates. Chaperones are also involved in other cellular functions including protein translocation across membranes, vesicle fusion events, and protein secretion. In recent years, tremendous advances have been made in our understanding of the biology, biochemistry, and biophysics of function of molecular chaperones. In addition, recent technical developments in the fields of proteomics and genomics allowed us to obtain a global view of chaperone interaction networks. Finally, there is now a growing interest in the role of molecular chaperones in diseases. This book will provide a comprehensive analysis of the structure and function of the diverse systems of molecular chaperones and their role in cell stress responses and in diseases from a global network perspective. ​

Author : Adrienne L. Edkins,Gregory L. Blatch
Publisher : Springer Nature
Page : 436 pages
File Size : 44,6 Mb
Release : 2022-12-15
Category : Science
ISBN : 9783031147401

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The Networking of Chaperones by Co-Chaperones by Adrienne L. Edkins,Gregory L. Blatch Pdf

Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is the dynamic integration of the processes of protein folding, degradation and translocation to ensure that cellular function is finely tuned in space and time. This third edition of the book The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by co-chaperones, a diverse cohort of non-client proteins. Since the second edition was released, not only has knowledge deepened on how co-chaperones act as nodes to network and functionalise chaperones, but an understanding of their broader biological function has started to emerge. The third edition provides new and updated chapters highlighting recent developments and emerging themes on co-chaperones, such as their extracellular functions, their role in human disease and their status as putative drug targets. The book is a useful resource for both newcomers and established researchers in the field of cell stress and chaperones, as well as those interested in cross-cutting disciplines such as cellular networks and systems biology.

Author : Lila M. Gierasch,Arthur Horwich,Christine Slingsby,Sue Wickner,David Agard
Publisher : World Scientific Publishing Company
Page : 319 pages
File Size : 44,5 Mb
Release : 2016
Category : Molecular chaperones
ISBN : 981474932X

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Structure and Action of Molecular Chaperones by Lila M. Gierasch,Arthur Horwich,Christine Slingsby,Sue Wickner,David Agard Pdf

This unique volume reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones, which provide essential kinetic assistance to processes of protein folding and unfolding in the cell. Ranging from multisubunit ring-shaped chaperonin and Hsp100 machines that use their central cavities to bind and compartmentalize action on proteins, to machines that use other topologies of recognition -- binding cellular proteins in an archway or at the surface of a "clamp" or at the surface of a globular assembly -- the structures show us the ways and means the cell has devised to assist its major effectors, proteins, to reach and maintain their unique active forms, as well as, when required, to disrupt protein structure in order to remodel or degrade. Each type of chaperone is beautifully illustrated by X-ray and EM structure determinations at near- atomic level resolution and described by a leader in the study of the respective family. The beauty of what Mother Nature has devised to accomplish essential assisting actions for proteins in vivo is fully appreciable.

Author : Gerald R. Fink
Publisher : Gulf Professional Publishing
Page : 786 pages
File Size : 50,8 Mb
Release : 2002
Category : Science
ISBN : 0121822540

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Guide to Yeast Genetics and Molecular and Cell Biology, Part C by Gerald R. Fink Pdf

This volume and its companion, Volume 350, are specifically designed to meet the needs of graduate students and postdoctoral students as well as researchers, by providing all the up-to-date methods necessary to study genes in yeast. Procedures are included that enable newcomers to set up a yeast laboratory and to master basic manipulations. Relevant background and reference information given for procedures can be used as a guide to developing protocols in a number of disciplines. Specific topics addressed in this book include cytology, biochemistry, cell fractionation, and cell biology.

Author : Anonim
Publisher : Elsevier
Page : 448 pages
File Size : 49,8 Mb
Release : 2001-01-24
Category : Science
ISBN : 0080527434

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Agriculture and Food Production by Anonim Pdf

Presenting a stimulating synthesis of rapidly growing research interests and publications by scholars in the field of applied mycology and biotechnology. The surge of research and development activity in applied mycology and fungal biotechnology relates to the need and utility of fungi in many contexts. These contexts are wide in scope, and include agriculture, animal and plant health, biotransformation of organic or inorganic matter, food safety, composition of nutrients and micronutrients, and human and animal infectious disease. Containing a balanced treatment of principles, biotechnological manipulations and applications of major groups of fungi in agriculture and food, this book will serve as a practical resource for mycologists, microbiologists, biotechnologists, bioengineers, scientists from agri-food industry, biochemists, botanists and agriculturists.

Author : Peter A. Lund
Publisher : Oxford University Press, USA
Page : 308 pages
File Size : 44,8 Mb
Release : 2001
Category : Science
ISBN : 0199638675

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Molecular Chaperones in the Cell by Peter A. Lund Pdf

In this text, leading experts synthesise our body of knowledge , and the reader gains not only a fuller understanding of the roles of chaperones in the context of cellular processes, but also an insight into the nature of these proteins.

Author : Piero Durante
Publisher : Unknown
Page : 567 pages
File Size : 48,9 Mb
Release : 2010
Category : Molecular chaperones
ISBN : 1612098940

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Handbook of Molecular Chaperones by Piero Durante Pdf

Author : Panayiotis Vlamos
Publisher : Springer
Page : 338 pages
File Size : 43,5 Mb
Release : 2017-10-01
Category : Science
ISBN : 9783319562469

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GeNeDis 2016 by Panayiotis Vlamos Pdf

The 2nd World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2016), focuses on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments and provides an international forum for the latest scientific discoveries, medical practices and care initiatives. Advanced information technologies are discussed concerning the various research, implementation and policy, as well as European and global issues in the funding of long-term care and medico-social policies regarding elderly people. This volume focuses on the sessions from the conference on computational biology and bioinformatics.

Author : Mohammad Pessarakli
Publisher : CRC Press
Page : 1282 pages
File Size : 42,6 Mb
Release : 1999-05-19
Category : Science
ISBN : 0824746724

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Handbook of Plant and Crop Stress, Second Edition by Mohammad Pessarakli Pdf

Detailing interrelated topics, this work addresses issues and concerns related to plant and crop stress. This edition includes information on pH stress, temperature stress, water-deficit conditions, carotenoids and stress, light stress, pollution stress, agrichemical stress, oxidative damage to proteins, UV-B induced stress and abiotic stress tolerance.