Structure And Action Of Molecular Chaperones

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Structure and Action of Molecular Chaperones

Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard
Structure and Action of Molecular Chaperones Book PDF

Author : Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard
Publisher : World Scientific
Page : 128 pages
File Size : 48,7 Mb
Release : 2016-08-08
Category : Science
ISBN : 9789814749343

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Structure and Action of Molecular Chaperones by Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard Pdf

This unique volume reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones, which provide essential kinetic assistance to processes of protein folding and unfolding in the cell. Ranging from multisubunit ring-shaped chaperonin and Hsp100 machines that use their central cavities to bind and compartmentalize action on proteins, to machines that use other topologies of recognition — binding cellular proteins in an archway or at the surface of a "clamp" or at the surface of a globular assembly — the structures show us the ways and means the cell has devised to assist its major effectors, proteins, to reach and maintain their unique active forms, as well as, when required, to disrupt protein structure in order to remodel or degrade. Each type of chaperone is beautifully illustrated by X-ray and EM structure determinations at near- atomic level resolution and described by a leader in the study of the respective family. The beauty of what Mother Nature has devised to accomplish essential assisting actions for proteins in vivo is fully appreciable.

Structure and Action of Molecular Chaperones

Lila M. Gierasch,Arthur Horwich,Christine Slingsby,Sue Wickner,David Agard
Structure and Action of Molecular Chaperones Book PDF

Author : Lila M. Gierasch,Arthur Horwich,Christine Slingsby,Sue Wickner,David Agard
Publisher : World Scientific Publishing Company
Page : 319 pages
File Size : 51,7 Mb
Release : 2016
Category : Molecular chaperones
ISBN : 981474932X

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Structure and Action of Molecular Chaperones by Lila M. Gierasch,Arthur Horwich,Christine Slingsby,Sue Wickner,David Agard Pdf

This unique volume reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones, which provide essential kinetic assistance to processes of protein folding and unfolding in the cell. Ranging from multisubunit ring-shaped chaperonin and Hsp100 machines that use their central cavities to bind and compartmentalize action on proteins, to machines that use other topologies of recognition -- binding cellular proteins in an archway or at the surface of a "clamp" or at the surface of a globular assembly -- the structures show us the ways and means the cell has devised to assist its major effectors, proteins, to reach and maintain their unique active forms, as well as, when required, to disrupt protein structure in order to remodel or degrade. Each type of chaperone is beautifully illustrated by X-ray and EM structure determinations at near- atomic level resolution and described by a leader in the study of the respective family. The beauty of what Mother Nature has devised to accomplish essential assisting actions for proteins in vivo is fully appreciable.

Molecular Chaperones

Sophie Jackson
Molecular Chaperones Book PDF

Author : Sophie Jackson
Publisher : Springer
Page : 274 pages
File Size : 45,8 Mb
Release : 2012-12-15
Category : Science
ISBN : 9783642345524

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Molecular Chaperones by Sophie Jackson Pdf

Assisting Oxidative Protein Folding: How Do Protein Disulphide-Isomerases Couple Conformational and Chemical Processes in Protein Folding?, by A. Katrine Wallis and Robert B. Freedman Peptide Bond cis/trans Isomerases: A Biocatalysis Perspective of Conformational Dynamics in Proteins, by Cordelia Schiene-Fischer, Tobias Aumüller and Gunter Fischer Small Heat-Shock Proteins: Paramedics of the Cell, by Gillian R. Hilton, Hadi Lioe, Florian Stengel, Andrew J. Baldwin und Justin L. P. Benesch Allostery in the Hsp70 Chaperone Proteins, by Erik R. P. Zuiderweg, Eric B. Bertelsen, Aikaterini Rousaki, Matthias P. Mayer, Jason E. Gestwicki and Atta Ahmad Hsp90: Structure and Function, by Sophie E. Jackson Extracellular Chaperones, by Rebecca A. Dabbs, Amy R. Wyatt, Justin J. Yerbury, Heath Ecroyd and Mark R. Wilson

Role of Molecular Chaperones in Structural Folding, Biological Functions, and Drug Interactions of Client Proteins

Mario D. Galigniana
Role of Molecular Chaperones in Structural Folding Biological Functions and Drug Interactions of Client Proteins Book PDF

Author : Mario D. Galigniana
Publisher : Bentham Science Publishers
Page : 279 pages
File Size : 45,7 Mb
Release : 2018-04-26
Category : Science
ISBN : 9781681086156

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Role of Molecular Chaperones in Structural Folding, Biological Functions, and Drug Interactions of Client Proteins by Mario D. Galigniana Pdf

The book provides an updated panorama of the functional relevance of molecular chaperones in the proper folding of client factors, protein-protein interactions, the regulation of key biological functions, the development of ligand-based structural complexes and the consequent pharmacological or biotechnological applications of these processes. The involvement of molecular chaperones in several processes ranging from regulation of transcription factors and protein-protein interactions in bacteria to proteostasis, signaling pathways and cancer are also addressed. The book is an essential consulting tool for researchers, working professionals in academia or industry, and students of all levels who wish to obtain the most relevant and updated information currently available about protein folding and chaperones.

The Molecular Chaperones Interaction Networks in Protein Folding and Degradation

Walid A. Houry
The Molecular Chaperones Interaction Networks in Protein Folding and Degradation Book PDF

Author : Walid A. Houry
Publisher : Springer
Page : 485 pages
File Size : 44,8 Mb
Release : 2014-09-01
Category : Science
ISBN : 9781493911301

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The Molecular Chaperones Interaction Networks in Protein Folding and Degradation by Walid A. Houry Pdf

Molecular chaperones are a fundamental group of proteins that have been identified only relatively recently. They are key components of a protein quality machinery in the cell which insures that the folding process of any newly-synthesized polypeptide chain results in the formation of a properly folded protein and that the folded protein is maintained in an active conformation throughout its functional lifetime. Molecular chaperones have been shown to play essential roles in cell viability under both normal and stress conditions. Chaperones can also assist in the unfolding and degradation of misfolded proteins and in disaggregating preformed protein aggregates. Chaperones are also involved in other cellular functions including protein translocation across membranes, vesicle fusion events, and protein secretion. In recent years, tremendous advances have been made in our understanding of the biology, biochemistry, and biophysics of function of molecular chaperones. In addition, recent technical developments in the fields of proteomics and genomics allowed us to obtain a global view of chaperone interaction networks. Finally, there is now a growing interest in the role of molecular chaperones in diseases. This book will provide a comprehensive analysis of the structure and function of the diverse systems of molecular chaperones and their role in cell stress responses and in diseases from a global network perspective. ​

Molecular Chaperones in the Life Cycle of Proteins

Anthony Fink
Molecular Chaperones in the Life Cycle of Proteins Book PDF

Author : Anthony Fink
Publisher : CRC Press
Page : 648 pages
File Size : 54,9 Mb
Release : 1997-09-26
Category : Medical
ISBN : 0824701003

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Molecular Chaperones in the Life Cycle of Proteins by Anthony Fink Pdf

Considers the integral role of molecular chaperones at different stages of a protein's life cycle. The text focuses on the biophysical, structural and functional properties of molecular chaperones, providing a biophysical view of chaperone problems useful in in vivo and in vitro studies, and augmenting current understanding of molecular chaperones as facilitators of de novo protein synthesis and recombinant protein folding.

Guidebook to Molecular Chaperones and Protein-Folding Catalysts

Mary-Jane Gething
Guidebook to Molecular Chaperones and Protein Folding Catalysts Book PDF

Author : Mary-Jane Gething
Publisher : OUP Oxford
Page : 586 pages
File Size : 51,7 Mb
Release : 1997-11-27
Category : Medical
ISBN : 9780191547270

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Guidebook to Molecular Chaperones and Protein-Folding Catalysts by Mary-Jane Gething Pdf

The precise shape of a protein is a crucial factor in its function. How do proteins become folded into the right conformation? Molecular chaperones and protein folding catalysts bind to developing polypeptides in the cytoplasm and ensure correct folding and transport. This Guidebook catalogues the latest information on nearly 200 of these molecules, including the important class of heat shock proteins; each entry is written by leading researchers in the field.

Molecular Chaperones and Cell Signalling

Brian Henderson,A. Graham Pockley
Molecular Chaperones and Cell Signalling Book PDF

Author : Brian Henderson,A. Graham Pockley
Publisher : Cambridge University Press
Page : 366 pages
File Size : 42,9 Mb
Release : 2005-07-18
Category : Science
ISBN : 9781139444019

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Molecular Chaperones and Cell Signalling by Brian Henderson,A. Graham Pockley Pdf

This book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?

Regulation of Heat Shock Protein Responses

Alexzander A A Asea,Punit Kaur
Regulation of Heat Shock Protein Responses Book PDF

Author : Alexzander A A Asea,Punit Kaur
Publisher : Springer
Page : 472 pages
File Size : 41,9 Mb
Release : 2018-05-01
Category : Medical
ISBN : 9783319747156

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Regulation of Heat Shock Protein Responses by Alexzander A A Asea,Punit Kaur Pdf

This books provides the most up-to-date reviews on current advances in our understanding of the regulation of heat shock protein responses. Key basic scientists and clinical research laboratories from major universities, academic medical centers and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into four sections, including, Section I - HSP and Stress Responses; Section II - Chaperone Functions of HSP; Section III - HSP in Human Diseases; Section IV - Prognosis & Diagnosis of HSP. The book is a must read for researchers involved in biomedical research, drug discovery and design to improve human health.

Handbook of Molecular Chaperones

Piero Durante,Leandro Colucci
Handbook of Molecular Chaperones Book PDF

Author : Piero Durante,Leandro Colucci
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 42,6 Mb
Release : 2010
Category : Molecular chaperones
ISBN : 1608763668

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Handbook of Molecular Chaperones by Piero Durante,Leandro Colucci Pdf

Molecular chaperones are a ubiquitous class of proteins that play important roles in protein folding and in the protection of cells from several stresses associated with the disruption of three native dimensional structures of proteins. The most important of these proteins are the so-called heat shock proteins (HSPs), also known as stress proteins. This book examines some of the biological aspects of this intriguing family of proteins that are important for consideration of the "proteiomics of HSPs". This book also reviews current research on protein folding in the endoplasmic reticulum (ER) and the functions of ER-resident molecular chaperones in protein folding in the ER. The biochemical, structural and functional information on Redox Enzyme Maturation Proteins (REMPs) are also reviewed in detail. Furthermore, recent progress in molecular biology has provided new insights into the molecular basis of diseases and molecular targets for diagnosis and therapy of human diseases. The role of molecular biology research in molecular imaging is examined, as well as the applications of molecular imaging in diagnostics, gene therapy and drug development. Other chapters in this book explore the role of protists as promising objects for the study of adaptive mechanisms at the biochemical and the molecular level, the different trends in the evolution of molecular adaptations to adverse environmental conditions, and a review of the molecular mechanisms of bicyclol in the protection against liver damage.

Molecular Chaperones in the Cell

Peter A. Lund
Molecular Chaperones in the Cell Book PDF

Author : Peter A. Lund
Publisher : Oxford University Press, USA
Page : 308 pages
File Size : 49,8 Mb
Release : 2001
Category : Science
ISBN : 0199638675

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Molecular Chaperones in the Cell by Peter A. Lund Pdf

In this text, leading experts synthesise our body of knowledge , and the reader gains not only a fuller understanding of the roles of chaperones in the context of cellular processes, but also an insight into the nature of these proteins.

HSF1 and Molecular Chaperones in Biology and Cancer

Marc Laurence Mendillo,David Pincus,Ruth Scherz-Shouval
HSF1 and Molecular Chaperones in Biology and Cancer Book PDF

Author : Marc Laurence Mendillo,David Pincus,Ruth Scherz-Shouval
Publisher : Springer Nature
Page : 185 pages
File Size : 43,9 Mb
Release : 2020-04-15
Category : Medical
ISBN : 9783030402044

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HSF1 and Molecular Chaperones in Biology and Cancer by Marc Laurence Mendillo,David Pincus,Ruth Scherz-Shouval Pdf

Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Molecular Chaperones

R.J. Ellis,R.A. Laskey,G.H. Lorimer
Molecular Chaperones Book PDF

Author : R.J. Ellis,R.A. Laskey,G.H. Lorimer
Publisher : Springer Science & Business Media
Page : 121 pages
File Size : 54,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401121088

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Molecular Chaperones by R.J. Ellis,R.A. Laskey,G.H. Lorimer Pdf

Currently one of the hottest topics in biochemistry, the concept of molecular chaperones has challenged the paradigm of protein self-assembly. Key figures in many disciplines review all aspects of molecular chaperones in this volume, which arises from a Royal Society discussion meeting. Overview chapters discuss the significance of chaperones in biochemistry, molecular genetics and cell biology. Each chapter is well referenced providing access to the literature.

Fundamentals of Protein Structure and Function

Engelbert Buxbaum
Fundamentals of Protein Structure and Function Book PDF

Author : Engelbert Buxbaum
Publisher : Springer
Page : 521 pages
File Size : 42,9 Mb
Release : 2015-11-27
Category : Science
ISBN : 9783319199207

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Fundamentals of Protein Structure and Function by Engelbert Buxbaum Pdf

This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of the purification and determination of proteins, as well as their characterisation for size and shape, structure and molecular interactions. The book emphasises the link between protein structure, physiological function and medical significance. This book can be used for graduate and advanced undergraduate classes covering protein structure and function and as an introductory text for researchers in protein biochemistry, molecular and cell biology, chemistry, biophysics, biomedicine and related courses. About the author: Dr. Buxbaum is a biochemist with interest in enzymology and protein science. He has been working on the biochemistry of membrane transport proteins for nearly thirty years and has taught courses in biochemistry and biomedicine at several universities.

The Networking of Chaperones by Co-Chaperones

Adrienne L. Edkins,Gregory L. Blatch
The Networking of Chaperones by Co Chaperones Book PDF

Author : Adrienne L. Edkins,Gregory L. Blatch
Publisher : Springer Nature
Page : 436 pages
File Size : 50,7 Mb
Release : 2022-12-15
Category : Science
ISBN : 9783031147401

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The Networking of Chaperones by Co-Chaperones by Adrienne L. Edkins,Gregory L. Blatch Pdf

Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is the dynamic integration of the processes of protein folding, degradation and translocation to ensure that cellular function is finely tuned in space and time. This third edition of the book The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by co-chaperones, a diverse cohort of non-client proteins. Since the second edition was released, not only has knowledge deepened on how co-chaperones act as nodes to network and functionalise chaperones, but an understanding of their broader biological function has started to emerge. The third edition provides new and updated chapters highlighting recent developments and emerging themes on co-chaperones, such as their extracellular functions, their role in human disease and their status as putative drug targets. The book is a useful resource for both newcomers and established researchers in the field of cell stress and chaperones, as well as those interested in cross-cutting disciplines such as cellular networks and systems biology.