Handbook Of Cancer Models With Applications

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Handbook of Cancer Models with Applications

W. Y. Tan
Handbook of Cancer Models with Applications Book PDF

Author : W. Y. Tan
Publisher : World Scientific
Page : 592 pages
File Size : 55,8 Mb
Release : 2008
Category : Political Science
ISBN : 9789812779489

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Handbook of Cancer Models with Applications by W. Y. Tan Pdf

Composed of contributions from an international team of leading researchers, this book pulls together the most recent research results in the field of cancer modeling to provide readers with the most advanced mathematical models of cancer and their applications.Topics included in the book cover oncogenetic trees, stochastic multistage models of carcinogenesis, effects of ionizing radiation on cell cycle and genomic instability, induction of DNA damage by ionizing radiation and its repair, epigenetic cancer models, bystander effects of radiation, multiple pathway models of human colon cancer, and stochastic models of metastasis. The book also provides some important applications of cancer models to the assessment of cancer risk associated with various hazardous environmental agents, to cancer screening by MRI, and to drug resistance in cancer chemotherapy. An updated statistical design and analysis of xenograft experiments as well as a statistical analysis of cancer occult clinical data are also provided.The book will serve as a useful source of reference for researchers in biomathematics, biostatistics and bioinformatics; for clinical investigators and medical doctors employing quantitative methods to develop procedures for cancer diagnosis, prevention, control and treatment; and for graduate students.

Handbook of Animal Models and its Uses in Cancer Research

Surajit Pathak,Antara Banerjee,Atil Bisgin
Handbook of Animal Models and its Uses in Cancer Research Book PDF

Author : Surajit Pathak,Antara Banerjee,Atil Bisgin
Publisher : Springer Nature
Page : 1158 pages
File Size : 44,8 Mb
Release : 2023-01-31
Category : Medical
ISBN : 9789811938245

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Handbook of Animal Models and its Uses in Cancer Research by Surajit Pathak,Antara Banerjee,Atil Bisgin Pdf

This reference book compiles together different animal models in cancer research. It provides knowledge and a better understanding of the advancement of the molecular and cellular mechanisms associated with the progression, formation, and clinical results of various types of cancer from the evidence collected from animal models utilized for cancer research. It discusses animal models for screening anti-cancer drugs and exploration of gene therapy. It presents different methods used to construct cancer animal models and the progress of each animal model in tumor research. The book also highlights the applications of genetic engineering, including CRISP/Cas9, in designing and developing animal models for cancer research. Further, it discusses strategies for modeling animals for investigating growth, metastasis, tumor-associated inflammation and microenvironment, cancer stem cells, tumor heterogeneity, and therapeutic resistance. This book is s a valuable resource for basic and translational cancer researchers, clinicians, and health care.

Stochastic Models With Applications To Genetics, Cancers, Aids And Other Biomedical Systems (Second Edition)

Wai-yuan Tan
Stochastic Models With Applications To Genetics Cancers Aids And Other Biomedical Systems Second Edition Book PDF

Author : Wai-yuan Tan
Publisher : World Scientific
Page : 524 pages
File Size : 54,8 Mb
Release : 2015-10-28
Category : Mathematics
ISBN : 9789814397216

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Stochastic Models With Applications To Genetics, Cancers, Aids And Other Biomedical Systems (Second Edition) by Wai-yuan Tan Pdf

This book presents a systematic treatment of Markov chains, diffusion processes and state space models, as well as alternative approaches to Markov chains through stochastic difference equations and stochastic differential equations. It illustrates how these processes and approaches are applied to many problems in genetics, carcinogenesis, AIDS epidemiology and other biomedical systems.One feature of the book is that it describes the basic MCMC (Markov chain and Monte Carlo) procedures and illustrates how to use the Gibbs sampling method and the multilevel Gibbs sampling method to solve many problems in genetics, carcinogenesis, AIDS and other biomedical systems.As another feature, the book develops many state space models for many genetic problems, carcinogenesis, AIDS epidemiology and HIV pathogenesis. It shows in detail how to use the multilevel Gibbs sampling method to estimate (or predict) simultaneously the state variables and the unknown parameters in cancer chemotherapy, carcinogenesis, AIDS epidemiology and HIV pathogenesis. As a matter of fact, this book is the first to develop several state space models for many genetic problems, carcinogenesis and other biomedical problems.To emphasize special applications to medical problems, in this new edition the book has added a new chapter to illustrate how to develop biologically-supported stochastic models and state space models of carcinogenesis in human beings. Specific examples include hidden Markov models and state space models for human colon cancer, human liver cancer and some human pediatric cancers such as retinoblastoma and hepatoblastoma. The book also gives examples to illustrate how to develop procedures to assess cancer risk of environmental agents through initiation-promotion protocols.

Stochastic Models of Tumor Latency and Their Biostatistical Applications

Andrej Yu Yakovlev,A. D. Tsodikov,B. Asselain
Stochastic Models of Tumor Latency and Their Biostatistical Applications Book PDF

Author : Andrej Yu Yakovlev,A. D. Tsodikov,B. Asselain
Publisher : World Scientific
Page : 287 pages
File Size : 49,6 Mb
Release : 1996
Category : Medical
ISBN : 9789810218317

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Stochastic Models of Tumor Latency and Their Biostatistical Applications by Andrej Yu Yakovlev,A. D. Tsodikov,B. Asselain Pdf

This research monograph discusses newly developed mathematical models and methods that provide biologically meaningful inferences from data on cancer latency produced by follow-up and discrete surveillance studies. Methods for designing optimal strategies of cancer surveillance are systematically presented for the first time in this book. It offers new approaches to the stochastic description of tumor latency, employs biologically-based models for making statistical inference from data on tumor recurrence and also discusses methods of statistical analysis of data resulting from discrete surveillance strategies. It also offers insight into the role of prognostic factors based on the interpretation of their effects in terms of parameters endowed with biological meaning, as well as methods for designing optimal schedules of cancer screening and surveillance. Last but not least, it discusses survival models allowing for cure rates and the choice of optimal treatment based on covariate information, and presents numerous examples of real data analysis.

Protocol Handbook for Cancer Biology

Gauri Misra,Jyotika Rajawat
Protocol Handbook for Cancer Biology Book PDF

Author : Gauri Misra,Jyotika Rajawat
Publisher : Academic Press
Page : 222 pages
File Size : 50,7 Mb
Release : 2021-02-12
Category : Science
ISBN : 9780323898171

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Protocol Handbook for Cancer Biology by Gauri Misra,Jyotika Rajawat Pdf

Protocol Handbook for Cancer Biology brings together a comprehensive collection of the methods used for cancer assessment, diagnostics, and therapeutics. Various protocols are discussed along with alternative strategies, including the advantages and limitations of techniques that have been used in labs globally. These protocols are presented by cancer biology experts based on their real-world experience. The protocols in this book will be a valuable resource for cancer researchers and graduate students, who can utilize the techniques described to conduct research more efficiently and successfully. Presents comprehensive protocols used for cancer assessment, diagnostics, and therapeutics all in one place Encompasses alternative strategies considering the requirements of the end user and taking into consideration diverse research settings Discusses limitations and advantages of each method in experimental design and execution, thus saving time during the research process

Information Resources in Toxicology

P.J. Bert Hakkinen,Asish Mohapatra,Steven G. G. Gilbert
Information Resources in Toxicology Book PDF

Author : P.J. Bert Hakkinen,Asish Mohapatra,Steven G. G. Gilbert
Publisher : Academic Press
Page : 1552 pages
File Size : 41,6 Mb
Release : 2009-08-19
Category : Science
ISBN : 0080920039

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Information Resources in Toxicology by P.J. Bert Hakkinen,Asish Mohapatra,Steven G. G. Gilbert Pdf

This latest version of Information Resources in Toxicology (IRT) continues a tradition established in 1982 with the publication of the first edition in presenting an extensive itemization, review, and commentary on the information infrastructure of the field. This book is a unique wide-ranging, international, annotated bibliography and compendium of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. Thoroughly updated, the current edition analyzes technological changes and is rife with online tools and links to Web sites. IRT-IV is highly structured, providing easy access to its information. Among the “hot topics covered are Disaster Preparedness and Management, Nanotechnology, Omics, the Precautionary Principle, Risk Assessment, and Biological, Chemical and Radioactive Terrorism and Warfare are among the designated. • International in scope, with contributions from over 30 countries • Numerous key references and relevant Web links • Concise narratives about toxicologic sub-disciplines • Valuable appendices such as the IUPAC Glossary of Terms in Toxicology • Authored by experts in their respective sub-disciplines within toxicology

Handbook of Probabilistic Models

Pijush Samui,Dieu Tien Bui,Subrata Chakraborty,Ravinesh C. Deo
Handbook of Probabilistic Models Book PDF

Author : Pijush Samui,Dieu Tien Bui,Subrata Chakraborty,Ravinesh C. Deo
Publisher : Butterworth-Heinemann
Page : 590 pages
File Size : 44,8 Mb
Release : 2019-10-05
Category : Computers
ISBN : 9780128165461

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Handbook of Probabilistic Models by Pijush Samui,Dieu Tien Bui,Subrata Chakraborty,Ravinesh C. Deo Pdf

Handbook of Probabilistic Models carefully examines the application of advanced probabilistic models in conventional engineering fields. In this comprehensive handbook, practitioners, researchers and scientists will find detailed explanations of technical concepts, applications of the proposed methods, and the respective scientific approaches needed to solve the problem. This book provides an interdisciplinary approach that creates advanced probabilistic models for engineering fields, ranging from conventional fields of mechanical engineering and civil engineering, to electronics, electrical, earth sciences, climate, agriculture, water resource, mathematical sciences and computer sciences. Specific topics covered include minimax probability machine regression, stochastic finite element method, relevance vector machine, logistic regression, Monte Carlo simulations, random matrix, Gaussian process regression, Kalman filter, stochastic optimization, maximum likelihood, Bayesian inference, Bayesian update, kriging, copula-statistical models, and more. Explains the application of advanced probabilistic models encompassing multidisciplinary research Applies probabilistic modeling to emerging areas in engineering Provides an interdisciplinary approach to probabilistic models and their applications, thus solving a wide range of practical problems

Handbook of Genetic Programming Applications

Amir H. Gandomi,Amir H. Alavi,Conor Ryan
Handbook of Genetic Programming Applications Book PDF

Author : Amir H. Gandomi,Amir H. Alavi,Conor Ryan
Publisher : Springer
Page : 593 pages
File Size : 43,7 Mb
Release : 2015-11-06
Category : Computers
ISBN : 9783319208831

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Handbook of Genetic Programming Applications by Amir H. Gandomi,Amir H. Alavi,Conor Ryan Pdf

This contributed volume, written by leading international researchers, reviews the latest developments of genetic programming (GP) and its key applications in solving current real world problems, such as energy conversion and management, financial analysis, engineering modeling and design, and software engineering, to name a few. Inspired by natural evolution, the use of GP has expanded significantly in the last decade in almost every area of science and engineering. Exploring applications in a variety of fields, the information in this volume can help optimize computer programs throughout the sciences. Taking a hands-on approach, this book provides an invaluable reference to practitioners, providing the necessary details required for a successful application of GP and its branches to challenging problems ranging from drought prediction to trading volatility. It also demonstrates the evolution of GP through major developments in GP studies and applications. It is suitable for advanced students who wish to use relevant book chapters as a basis to pursue further research in these areas, as well as experienced practitioners looking to apply GP to new areas. The book also offers valuable supplementary material for design courses and computation in engineering.

Towards a Mathematical Theory of Complex Biological Systems

C. Bianca,N. Bellomo
Towards a Mathematical Theory of Complex Biological Systems Book PDF

Author : C. Bianca,N. Bellomo
Publisher : World Scientific
Page : 227 pages
File Size : 54,5 Mb
Release : 2011
Category : Science
ISBN : 9789814340540

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Towards a Mathematical Theory of Complex Biological Systems by C. Bianca,N. Bellomo Pdf

This monograph has the ambitious aim of developing a mathematical theory of complex biological systems with special attention to the phenomena of ageing, degeneration and repair of biological tissues under individual self-repair actions that may have good potential in medical therapy.The approach to mathematically modeling biological systems needs to tackle the additional difficulties generated by the peculiarities of living matter. These include the lack of invariance principles, abilities to express strategies for individual fitness, heterogeneous behaviors, competition up to proliferative and/or destructive actions, mutations, learning ability, evolution and many others. Applied mathematicians in the field of living systems, especially biological systems, will appreciate the special class of integro-differential equations offered here for modeling at the molecular, cellular and tissue scales. A unique perspective is also presented with a number of case studies in biological modeling.

Towards a Mathematical Theory of Complex Biological Systems

C Bianca,N Bellomo
Towards a Mathematical Theory of Complex Biological Systems Book PDF

Author : C Bianca,N Bellomo
Publisher : World Scientific
Page : 228 pages
File Size : 50,5 Mb
Release : 2011-01-12
Category : Mathematics
ISBN : 9789814460972

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Towards a Mathematical Theory of Complex Biological Systems by C Bianca,N Bellomo Pdf

This monograph has the ambitious aim of developing a mathematical theory of complex biological systems with special attention to the phenomena of ageing, degeneration and repair of biological tissues under individual self-repair actions that may have good potential in medical therapy. The approach to mathematically modeling biological systems needs to tackle the additional difficulties generated by the peculiarities of living matter. These include the lack of invariance principles, abilities to express strategies for individual fitness, heterogeneous behaviors, competition up to proliferative and/or destructive actions, mutations, learning ability, evolution and many others. Applied mathematicians in the field of living systems, especially biological systems, will appreciate the special class of integro-differential equations offered here for modeling at the molecular, cellular and tissue scales. A unique perspective is also presented with a number of case studies in biological modeling. Contents:Looking for a Mathematical Theory of Biological SystemsOn the Complexity of Biological SystemsImmune System, Wound Healing Process, and System Biology:The Immune System: A Phenomenological OverviewWound Healing Process and Organ RepairFrom Levels of Biological Organization to System BiologyMathematical Tools:Mathematical Tools and StructuresMultiscale Modeling: Linking Molecular, Cellular, and Tissues ScalesApplications and Research Perspectives:A Model for the Malign Keloid Formation and Immune System CompetitionMacroscopic Models of Chemotaxis by KTAP Asymptotic MethodsLooking Ahead Readership: Researchers in mathematical modeling and biological systems. Keywords:Mathematical Theory;Biological Systems;SubsystemKey Features:Provides a new conceptual background to applied mathematicians involved in the challenging research field of living systems, and specifically biology systemsGives more accurate ODE, cellular-automata, and continuum models from the biological point of view

Handbook of Nanomaterials for Cancer Theranostics

Joao Conde
Handbook of Nanomaterials for Cancer Theranostics Book PDF

Author : Joao Conde
Publisher : Elsevier
Page : 606 pages
File Size : 53,6 Mb
Release : 2018-06-27
Category : Science
ISBN : 9780128133408

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Handbook of Nanomaterials for Cancer Theranostics by Joao Conde Pdf

Handbook of Nanomaterials for Cancer Theranostics focuses on recent developments in advanced theranostic nanomedicines from a chemical and biological perspective where the advantages of theranostics are achieved by combining multiple components. The authors explore the pros and cons of theranostic nanomaterials developed in cancer research in the last 15 years, with the different strategies compared and scrutinized. In addition, the book explores how nanomaterials may overcome the regulatory hurdles facing theranostic nanomedicines. This is an important research reference for postgraduates and researchers in nanomedicine and cancer research who want to learn more on how nanomaterials can help create more effective cancer treatments. Highlights the development of smart theranostic nanomaterials to tackle biomedical problems in cancer therapy and diagnostics Explores the regulatory hurdles facing theranostic nanomedicine Discusses how the use of nanomaterials can help create more effective cancer treatments

Handbook of Latent Variable and Related Models

Anonim
Handbook of Latent Variable and Related Models Book PDF

Author : Anonim
Publisher : Elsevier
Page : 458 pages
File Size : 52,5 Mb
Release : 2011-08-11
Category : Mathematics
ISBN : 9780080471266

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Handbook of Latent Variable and Related Models by Anonim Pdf

This Handbook covers latent variable models, which are a flexible class of models for modeling multivariate data to explore relationships among observed and latent variables. - Covers a wide class of important models - Models and statistical methods described provide tools for analyzing a wide spectrum of complicated data - Includes illustrative examples with real data sets from business, education, medicine, public health and sociology. - Demonstrates the use of a wide variety of statistical, computational, and mathematical techniques.

Gels Handbook: Fundamentals, Properties, Applications (In 3 Volumes)

Anonim
Gels Handbook Fundamentals Properties Applications In 3 Volumes Book PDF

Author : Anonim
Publisher : World Scientific
Page : 1172 pages
File Size : 45,9 Mb
Release : 2016-01-25
Category : Technology & Engineering
ISBN : 9789814656122

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Gels Handbook: Fundamentals, Properties, Applications (In 3 Volumes) by Anonim Pdf

Hydrogels are made from a three-dimensional network of cross linked hydrophilic polymers or colloidal particles that contain a large fraction of water. In recent years, hydrogels have attracted significant attention for a variety of applications in biology and medicine. This has resulted in significant advances in the design and engineering of hydrogels to meet the needs of these applications. This handbook explores significant development of hydrogels from characterization and applications. Volume 1 covers state-of-art knowledge and techniques of fundamental aspects of hydrogel physics and chemistry with an eye on bioengineering applications. Volume 2 explores the use of hydrogels in the interdisciplinary field of tissue engineering. Lastly volume 3 focuses on two important aspects of hydrogels, that is, drug delivery and biosensing. Contains 50 colour pages.

Multiscale Modeling in Biomechanics and Mechanobiology

Suvranu De,Wonmuk Hwang,Ellen Kuhl
Multiscale Modeling in Biomechanics and Mechanobiology Book PDF

Author : Suvranu De,Wonmuk Hwang,Ellen Kuhl
Publisher : Springer
Page : 287 pages
File Size : 42,6 Mb
Release : 2014-10-10
Category : Technology & Engineering
ISBN : 9781447165996

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Multiscale Modeling in Biomechanics and Mechanobiology by Suvranu De,Wonmuk Hwang,Ellen Kuhl Pdf

Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales – including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces – bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.

Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications

Krishnan Anand,Muthupandian Saravanan,Balakumar Chandrasekaran,Suvardhan Kanchi,Sarojini Jeeva Panchu,Quan-Sheng Chen
Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications Book PDF

Author : Krishnan Anand,Muthupandian Saravanan,Balakumar Chandrasekaran,Suvardhan Kanchi,Sarojini Jeeva Panchu,Quan-Sheng Chen
Publisher : Elsevier
Page : 610 pages
File Size : 43,7 Mb
Release : 2021-03-18
Category : Technology & Engineering
ISBN : 9780128219140

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Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications by Krishnan Anand,Muthupandian Saravanan,Balakumar Chandrasekaran,Suvardhan Kanchi,Sarojini Jeeva Panchu,Quan-Sheng Chen Pdf

Handbook of Nano-biomaterials for Therapeutics and Diagnostic Applications covers in-depth topics on nano-biomaterials and nano drug delivery systems (biosensors and bioimaging) involving polymer nanocomposites, metal nanocomposites, and other carbon family fibers and proteins. The book covers the current application of tiny machines or nanodevices and their use as early detection systems for life threatening diseases, giving detailed literature on the development of nanodevices, their use as diagnostic tools, and their present trend in the industry and market. In addition, their synthesis, potential applications and future of smart nanodevices in diagnosis of diseases and their use as smart clinical devices is covered. Users will find sections on recent advances in interdisciplinary research on the processing, morphology, structure and properties of nanostructured materials and their applications in drug delivery for various diseases such as cancer, tuberculosis, Alzheimer disease, ophthalmic diseases, and more. Offers a comprehensive coverage of the therapeutics and smart nanodevices as diagnostic tools and their potential clinical applications in biosensing and bioimaging Includes a glimpse into the nano-biomaterials that are essential components in nanomedicines Describes nanodevices in the early diagnosis of the diseases Explains the nano-drug delivery system for the treatment of various diseases, including cancer, tuberculosis, Alzheimer disease, and ophthalmic diseases Encompasses all information, starting from the design of nano-biomaterials to their applications in theranostics