Multiscale Modeling In Biomechanics And Mechanobiology

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Multiscale Modeling in Biomechanics and Mechanobiology

Suvranu De,Wonmuk Hwang,Ellen Kuhl

Author : Suvranu De,Wonmuk Hwang,Ellen Kuhl
Publisher : Springer
Page : 286 pages
File Size : 40,5 Mb
Release : 2014-10-10
Category : Technology & Engineering
ISBN : 9781447165996

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Multiscale Modeling in Biomechanics and Mechanobiology by Suvranu De,Wonmuk Hwang,Ellen Kuhl Pdf

Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales – including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces – bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.

Multiscale Computer Modeling in Biomechanics and Biomedical Engineering

Amit Gefen

Author : Amit Gefen
Publisher : Springer Science & Business Media
Page : 397 pages
File Size : 49,7 Mb
Release : 2014-07-08
Category : Technology & Engineering
ISBN : 9783642364822

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Multiscale Computer Modeling in Biomechanics and Biomedical Engineering by Amit Gefen Pdf

This book reviews the state-of-the-art in multiscale computer modeling, in terms of both accomplishments and challenges. The information in the book is particularly useful for biomedical engineers, medical physicists and researchers in systems biology, mathematical biology, micro-biomechanics and biomaterials who are interested in how to bridge between traditional biomedical engineering work at the organ and tissue scales, and the newer arenas of cellular and molecular bioengineering.

Multiscale Mechanobiology of Bone Remodeling and Adaptation

Peter Pivonka

Author : Peter Pivonka
Publisher : Springer
Page : 287 pages
File Size : 43,8 Mb
Release : 2017-06-20
Category : Science
ISBN : 9783319588452

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Multiscale Mechanobiology of Bone Remodeling and Adaptation by Peter Pivonka Pdf

The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.

Multiscale Soft Tissue Mechanics and Mechanobiology

Gerhard A. Holzapfel,Raymond W. Ogden

Author : Gerhard A. Holzapfel,Raymond W. Ogden
Publisher : Springer
Page : 0 pages
File Size : 55,8 Mb
Release : 2018-09-11
Category : Technology & Engineering
ISBN : 9402415122

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Multiscale Soft Tissue Mechanics and Mechanobiology by Gerhard A. Holzapfel,Raymond W. Ogden Pdf

This volume covers aspects of multiscale modeling of the mechanics and mechanobiology of soft biological tissues. The individual contributions focus on the constitutive modeling from the micro to the macro level in addition to computational modeling and simulation. It consists of peer-reviewed papers written by leading international authorities and will serve as a major state-of-the-art source of reference for the next few years. It includes both review articles and original articles. Previously published in the Journal of Elasticity, Volume 129, Issue 1-2, December 2017.

Multiscale Modelling in Biomedical Engineering

Dimitrios I. Fotiadis,Antonis I. Sakellarios,Vassiliki T. Potsika

Author : Dimitrios I. Fotiadis,Antonis I. Sakellarios,Vassiliki T. Potsika
Publisher : John Wiley & Sons
Page : 404 pages
File Size : 46,9 Mb
Release : 2023-05-05
Category : Science
ISBN : 9781119517351

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Multiscale Modelling in Biomedical Engineering by Dimitrios I. Fotiadis,Antonis I. Sakellarios,Vassiliki T. Potsika Pdf

Multiscale Modelling in Biomedical Engineering Discover how multiscale modeling can enhance patient treatment and outcomes In Multiscale Modelling in Biomedical Engineering, an accomplished team of biomedical professionals delivers a robust treatment of the foundation and background of a general computational methodology for multi-scale modeling. The authors demonstrate how this methodology can be applied to various fields of biomedicine, with a particular focus on orthopedics and cardiovascular medicine. The book begins with a description of the relationship between multiscale modeling and systems biology before moving on to proceed systematically upwards in hierarchical levels from the molecular to the cellular, tissue, and organ level. It then examines multiscale modeling applications in specific functional areas, like mechanotransduction, musculoskeletal, and cardiovascular systems. Multiscale Modelling in Biomedical Engineering offers readers experiments and exercises to illustrate and implement the concepts contained within. Readers will also benefit from the inclusion of: A thorough introduction to systems biology and multi-scale modeling, including a survey of various multi-scale methods and approaches and analyses of their application in systems biology Comprehensive explorations of biomedical imaging and nanoscale modeling at the molecular, cell, tissue, and organ levels Practical discussions of the mechanotransduction perspective, including recent progress and likely future challenges In-depth examinations of risk prediction in patients using big data analytics and data mining Perfect for undergraduate and graduate students of bioengineering, biomechanics, biomedical engineering, and medicine, Multiscale Modelling in Biomedical Engineering will also earn a place in the libraries of industry professional and researchers seeking a one-stop reference to the basic engineering principles of biological systems.

Multiscale Biomechanics

Soheil Mohammadi

Author : Soheil Mohammadi
Publisher : John Wiley & Sons
Page : 564 pages
File Size : 46,8 Mb
Release : 2023-06-09
Category : Technology & Engineering
ISBN : 9781119033721

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Multiscale Biomechanics by Soheil Mohammadi Pdf

MULTISCALE BIOMECHANICS Model biomechanical problems at multiple scales with this cutting-edge technology Multiscale modelling is the set of techniques used to solve physical problems which exist at multiple scales either in space or time. It has been shown to have significant applications in biomechanics, the study of biological systems and their structures, which exist at scales from the macroscopic to the microscopic and beyond, and which produce a myriad of overlapping problems. The next generation of biomechanical researchers therefore has need of the latest multiscale modelling techniques. Multiscale Biomechanics offers a comprehensive introduction to these techniques and their biomechanical applications. It includes both the theory of multiscale biomechanical modelling and its practice, incorporating some of the latest research and surveying a wide range of multiscale methods. The result is a thorough yet accessible resource for researchers looking to gain an edge in their biomechanical modelling. Multiscale Biomechanics readers will find: Practical biomechanical applications for a variety of multiscale methods Detailed discussion of soft and hard tissues, and more An introduction to analysis of advanced topics ranging from stenting, drug delivery systems, and artificial intelligence in biomechanics Multiscale Biomechanics is a useful reference for researchers and scientists in any of the life sciences with an interest in biomechanics, as well as for graduate students in mechanical, biomechanical, biomedical, civil, material, and aerospace engineering.

Multiscale Biomechanical Modeling of the Brain

Mark F. Horstemeyer,Raj K. Prabhu

Author : Mark F. Horstemeyer,Raj K. Prabhu
Publisher : Academic Press
Page : 278 pages
File Size : 52,8 Mb
Release : 2021-10-27
Category : Technology & Engineering
ISBN : 9780128181454

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Multiscale Biomechanical Modeling of the Brain by Mark F. Horstemeyer,Raj K. Prabhu Pdf

Multiscale Biomechanical Modeling of the Brain discusses the constitutive modeling of the brain at various length scales (nanoscale, microscale, mesoscale, macroscale and structural scale). In each scale, the book describes the state-of-the- experimental and computational tools used to quantify critical deformational information at each length scale. Then, at the structural scale, several user-based constitutive material models are presented, along with real-world boundary value problems. Lastly, design and optimization concepts are presented for use in occupant-centric design frameworks. This book is useful for both academia and industry applications that cover basic science aspects or applied research in head and brain protection.The multiscale approach to this topic is unique, and not found in other books. It includes meticulously selected materials that aim to connect the mechanistic analysis of the brain tissue at size scales ranging from subcellular to organ levels. Presents concepts in a theoretical and thermodynamic framework for each length scale Teaches readers not only how to use an existing multiscale model for each brain but also how to develop a new multiscale model Takes an integrated experimental-computational approach and gives structured multiscale coverage of the problems

Biomechanics: Trends in Modeling and Simulation

Gerhard A. Holzapfel,Ray W. Ogden

Author : Gerhard A. Holzapfel,Ray W. Ogden
Publisher : Springer
Page : 316 pages
File Size : 54,5 Mb
Release : 2016-09-14
Category : Technology & Engineering
ISBN : 9783319414751

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Biomechanics: Trends in Modeling and Simulation by Gerhard A. Holzapfel,Ray W. Ogden Pdf

The book presents a state-of-the-art overview of biomechanical and mechanobiological modeling and simulation of soft biological tissues. Seven well-known scientists working in that particular field discuss topics such as biomolecules, networks and cells as well as failure, multi-scale, agent-based, bio-chemo-mechanical and finite element models appropriate for computational analysis. Applications include arteries, the heart, vascular stents and valve implants as well as adipose, brain, collagenous and engineered tissues. The mechanics of the whole cell and sub-cellular components as well as the extracellular matrix structure and mechanotransduction are described. In particular, the formation and remodeling of stress fibers, cytoskeletal contractility, cell adhesion and the mechanical regulation of fibroblast migration in healing myocardial infarcts are discussed. The essential ingredients of continuum mechanics are provided. Constitutive models of fiber-reinforced materials with an emphasis on arterial walls and the myocardium are discussed and the important influence of residual stresses on material response emphasized. The mechanics and function of the heart, the brain and adipose tissues are discussed as well. Particular attention is focused on microstructural and multi-scale modeling, finite element implementation and simulation of cells and tissues.

Computer Models in Biomechanics

Gerhard Holzapfel,Ellen Kuhl

Author : Gerhard Holzapfel,Ellen Kuhl
Publisher : Springer Science & Business Media
Page : 406 pages
File Size : 41,9 Mb
Release : 2012-10-17
Category : Technology & Engineering
ISBN : 9789400754638

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Computer Models in Biomechanics by Gerhard Holzapfel,Ellen Kuhl Pdf

This book contains a collection of papers that were presented at the IUTAM Symposium on “Computer Models in Biomechanics: From Nano to Macro” held at Stanford University, California, USA, from August 29 to September 2, 2011. It contains state-of-the-art papers on: - Protein and Cell Mechanics: coarse-grained model for unfolded proteins, collagen-proteoglycan structural interactions in the cornea, simulations of cell behavior on substrates - Muscle Mechanics: modeling approaches for Ca2+–regulated smooth muscle contraction, smooth muscle modeling using continuum thermodynamical frameworks, cross-bridge model describing the mechanoenergetics of actomyosin interaction, multiscale skeletal muscle modeling - Cardiovascular Mechanics: multiscale modeling of arterial adaptations by incorporating molecular mechanisms, cardiovascular tissue damage, dissection properties of aortic aneurysms, intracranial aneurysms, electromechanics of the heart, hemodynamic alterations associated with arterial remodeling following aortic coarctation, patient-specific surgery planning for the Fontan procedure - Multiphasic Models: solutes in hydrated biological tissues, reformulation of mixture theory-based poroelasticity for interstitial tissue growth, tumor therapies of brain tissue, remodeling of microcirculation in liver lobes, reactions, mass transport and mechanics of tumor growth, water transport modeling in the brain, crack modeling of swelling porous media - Morphogenesis, Biological Tissues and Organs: mechanisms of brain morphogenesis, micromechanical modeling of anterior cruciate ligaments, mechanical characterization of the human liver, in vivo validation of predictive models for bone remodeling and mechanobiology, bridging scales in respiratory mechanics

Multiscale Modeling of the Skeletal System

Marco Viceconti

Author : Marco Viceconti
Publisher : Cambridge University Press
Page : 223 pages
File Size : 42,6 Mb
Release : 2012
Category : Mathematics
ISBN : 9780521769501

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Multiscale Modeling of the Skeletal System by Marco Viceconti Pdf

Systematically working from the whole body down to cellular levels, this book presents a multiscale, integrative approach to skeletal research.

Multiscale Simulations and Mechanics of Biological Materials

Shaofan Li,Dong Qian

Author : Shaofan Li,Dong Qian
Publisher : John Wiley & Sons
Page : 509 pages
File Size : 47,8 Mb
Release : 2013-03-19
Category : Technology & Engineering
ISBN : 9781118402948

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Multiscale Simulations and Mechanics of Biological Materials by Shaofan Li,Dong Qian Pdf

Multiscale Simulations and Mechanics of Biological Materials A compilation of recent developments in multiscale simulation and computational biomaterials written by leading specialists in the field Presenting the latest developments in multiscale mechanics and multiscale simulations, and offering a unique viewpoint on multiscale modelling of biological materials, this book outlines the latest developments in computational biological materials from atomistic and molecular scale simulation on DNA, proteins, and nano-particles, to meoscale soft matter modelling of cells, and to macroscale soft tissue and blood vessel, and bone simulations. Traditionally, computational biomaterials researchers come from biological chemistry and biomedical engineering, so this is probably the first edited book to present work from these talented computational mechanics researchers. The book has been written to honor Professor Wing Liu of Northwestern University, USA, who has made pioneering contributions in multiscale simulation and computational biomaterial in specific simulation of drag delivery at atomistic and molecular scale and computational cardiovascular fluid mechanics via immersed finite element method. Key features: Offers a unique interdisciplinary approach to multiscale biomaterial modelling aimed at both accessible introductory and advanced levels Presents a breadth of computational approaches for modelling biological materials across multiple length scales (molecular to whole-tissue scale), including solid and fluid based approaches A companion website for supplementary materials plus links to contributors’ websites (www.wiley.com/go/li/multiscale)

Multi-scale Extracellular Matrix Mechanics and Mechanobiology

Yanhang Zhang

Author : Yanhang Zhang
Publisher : Unknown
Page : 392 pages
File Size : 49,5 Mb
Release : 2020
Category : Biomedical engineering
ISBN : 303020183X

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Multi-scale Extracellular Matrix Mechanics and Mechanobiology by Yanhang Zhang Pdf

This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms.

Cell Mechanics

Arnaud Chauvière,Luigi Preziosi,Claude Verdier

Author : Arnaud Chauvière,Luigi Preziosi,Claude Verdier
Publisher : CRC Press
Page : 482 pages
File Size : 48,6 Mb
Release : 2010-01-27
Category : Mathematics
ISBN : 1420094556

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Cell Mechanics by Arnaud Chauvière,Luigi Preziosi,Claude Verdier Pdf

Ubiquitous and fundamental in cell mechanics, multiscale problems can arise in the growth of tumors, embryogenesis, tissue engineering, and more. Cell Mechanics: From Single Scale-Based Models to Multiscale Modeling brings together new insight and research on mechanical, mathematical, physical, and biological approaches for simulating the behavior of cells, specifically tumor cells. In the first part of the text, the book discusses the powerful tool of microrheology for investigating cell mechanical properties, multiphysics and multiscale approaches for studying intracellular mechanisms in cell motility, and the role of subcellular effects involving certain genes for inducing cell motility in cancer. Focusing on models based on physical, mathematical, and computational approaches, the second section develops tools for describing the complex interplay of cell adhesion molecules and the dynamic evolution of the cell cytoskeleton. The third part explores cell interactions with the environment, particularly the role of external mechanical forces and their effects on cell behavior. The final part presents innovative models of multicellular systems for developmental biology, cancer, and embryogenesis. This book collects novel methods to apply to cells and tissues through a multiscale approach. It presents numerous existing tools while stimulating the discovery of new approaches that can lead to more effective and accurate predictions of pathologies.

Computational Modeling in Biomechanics

Suvranu De,Farshid Guilak,Mohammad Mofrad

Author : Suvranu De,Farshid Guilak,Mohammad Mofrad
Publisher : Springer Science & Business Media
Page : 581 pages
File Size : 46,9 Mb
Release : 2010-03-10
Category : Technology & Engineering
ISBN : 9789048135752

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Computational Modeling in Biomechanics by Suvranu De,Farshid Guilak,Mohammad Mofrad Pdf

Availability of advanced computational technology has fundamentally altered the investigative paradigm in the field of biomechanics. Armed with sophisticated computational tools, researchers are seeking answers to fundamental questions by exploring complex biomechanical phenomena at the molecular, cellular, tissue and organ levels. The computational armamentarium includes such diverse tools as the ab initio quantum mechanical and molecular dynamics methods at the atomistic scales and the finite element, boundary element, meshfree as well as immersed boundary and lattice-Boltzmann methods at the continuum scales. Multiscale methods that link various scales are also being developed. While most applications require forward analysis, e.g., finding deformations and stresses as a result of loading, others involve determination of constitutive parameters based on tissue imaging and inverse analysis. This book provides a glimpse of the diverse and important roles that modern computational technology is playing in various areas of biomechanics including biofluids and mass transfer, cardiovascular mechanics, musculoskeletal mechanics, soft tissue mechanics, and biomolecular mechanics.

Modeling Biomaterials

Josef Málek,Endre Süli

Author : Josef Málek,Endre Süli
Publisher : Springer Nature
Page : 281 pages
File Size : 53,5 Mb
Release : 2022-01-21
Category : Mathematics
ISBN : 9783030880842

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Modeling Biomaterials by Josef Málek,Endre Süli Pdf

The investigation of the role of mechanical and mechano-chemical interactions in cellular processes and tissue development is a rapidly growing research field in the life sciences and in biomedical engineering. Quantitative understanding of this important area in the study of biological systems requires the development of adequate mathematical models for the simulation of the evolution of these systems in space and time. Since expertise in various fields is necessary, this calls for a multidisciplinary approach. This edited volume connects basic physical, biological, and physiological concepts to methods for the mathematical modeling of various materials by pursuing a multiscale approach, from subcellular to organ and system level. Written by active researchers, each chapter provides a detailed introduction to a given field, illustrates various approaches to creating models, and explores recent advances and future research perspectives. Topics covered include molecular dynamics simulations of lipid membranes, phenomenological continuum mechanics of tissue growth, and translational cardiovascular modeling. Modeling Biomaterials will be a valuable resource for both non-specialists and experienced researchers from various domains of science, such as applied mathematics, biophysics, computational physiology, and medicine.

Multiscale Modeling In Biomechanics And Mechanobiology

Multiscale Modeling in Biomechanics and Mechanobiology by Suvranu De,Wonmuk Hwang,Ellen Kuhl Pdf

Multiscale Computer Modeling in Biomechanics and Biomedical Engineering by Amit Gefen Pdf

Multiscale Mechanobiology of Bone Remodeling and Adaptation by Peter Pivonka Pdf

Multiscale Soft Tissue Mechanics and Mechanobiology by Gerhard A. Holzapfel,Raymond W. Ogden Pdf

Multiscale Modelling in Biomedical Engineering by Dimitrios I. Fotiadis,Antonis I. Sakellarios,Vassiliki T. Potsika Pdf

Multiscale Biomechanics by Soheil Mohammadi Pdf

Multiscale Biomechanical Modeling of the Brain by Mark F. Horstemeyer,Raj K. Prabhu Pdf

Biomechanics: Trends in Modeling and Simulation by Gerhard A. Holzapfel,Ray W. Ogden Pdf

Computer Models in Biomechanics by Gerhard Holzapfel,Ellen Kuhl Pdf

Multiscale Modeling of the Skeletal System by Marco Viceconti Pdf

Multiscale Simulations and Mechanics of Biological Materials by Shaofan Li,Dong Qian Pdf

Multi-scale Extracellular Matrix Mechanics and Mechanobiology by Yanhang Zhang Pdf

Cell Mechanics by Arnaud Chauvière,Luigi Preziosi,Claude Verdier Pdf

Computational Modeling in Biomechanics by Suvranu De,Farshid Guilak,Mohammad Mofrad Pdf

Modeling Biomaterials by Josef Málek,Endre Süli Pdf

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