Handbook Of Animal Models And Its Uses In Cancer Research

Author : Surajit Pathak,Antara Banerjee,Atil Bisgin
Publisher : Springer Nature
Page : 1158 pages
File Size : 51,7 Mb
Release : 2023-01-31
Category : Medical
ISBN : 9789811938245

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Handbook of Animal Models and its Uses in Cancer Research by Surajit Pathak,Antara Banerjee,Atil Bisgin Pdf

This reference book compiles together different animal models in cancer research. It provides knowledge and a better understanding of the advancement of the molecular and cellular mechanisms associated with the progression, formation, and clinical results of various types of cancer from the evidence collected from animal models utilized for cancer research. It discusses animal models for screening anti-cancer drugs and exploration of gene therapy. It presents different methods used to construct cancer animal models and the progress of each animal model in tumor research. The book also highlights the applications of genetic engineering, including CRISP/Cas9, in designing and developing animal models for cancer research. Further, it discusses strategies for modeling animals for investigating growth, metastasis, tumor-associated inflammation and microenvironment, cancer stem cells, tumor heterogeneity, and therapeutic resistance. This book is s a valuable resource for basic and translational cancer researchers, clinicians, and health care.

Author : Asfar Azmi,Ramzi M. Mohammad
Publisher : Academic Press
Page : 470 pages
File Size : 40,8 Mb
Release : 2019-04-16
Category : Business & Economics
ISBN : 9780128147054

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Animal Models in Cancer Drug Discovery by Asfar Azmi,Ramzi M. Mohammad Pdf

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Author : Beverly A. Teicher
Publisher : Springer Science & Business Media
Page : 994 pages
File Size : 55,9 Mb
Release : 2001-11-07
Category : Medical
ISBN : 9781592591008

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Tumor Models in Cancer Research by Beverly A. Teicher Pdf

Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in animal tumor model research. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Author : Jann Hau,Per Svendsen,Steven J. Schapiro
Publisher : CRC Press
Page : 228 pages
File Size : 44,9 Mb
Release : 1994-06-02
Category : Medical
ISBN : 0849343909

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Handbook of Laboratory Animal Science by Jann Hau,Per Svendsen,Steven J. Schapiro Pdf

This two-volume set presents a comprehensive description of laboratory animal genetics, diseases, health monitoring, nutrition, and the environmental impact on animal testing. It considers the ethics of animal experimentation through a complete review of European and North American legislation on the topic. It discusses alternatives to animal experiments, including the use of isolated organs, cell cultures, and computer simulations. The book also examines general methods, including experimental design and statistical evaluation, non-surgical and surgical techniques, anesthesia, and post-mortem examinations. Reviews of animal models for studying diseases of different organ systems, infectious diseases, cancer, and toxicology are featured as well.

Author : Jann Hau,Steven J. Schapiro,Gerald L. Van Hoosier Jr.
Publisher : CRC Press
Page : 280 pages
File Size : 54,8 Mb
Release : 2002-12-26
Category : Medical
ISBN : 9781420040920

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Handbook of Laboratory Animal Science by Jann Hau,Steven J. Schapiro,Gerald L. Van Hoosier Jr. Pdf

The conservative nature of animal evolution makes animal models the ideal tool for learning about human biology. The Handbook of Laboratory Animal Science, Second Edition: Animal Models, Volume II addresses the development and application of models in different areas of biomedical research and details the criteria used to choose animal species and

Author : Marianne I. Martic-Kehl,Pius August Schubiger
Publisher : John Wiley & Sons
Page : 272 pages
File Size : 41,8 Mb
Release : 2016-05-18
Category : Medical
ISBN : 9783527695911

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Animal Models for Human Cancer by Marianne I. Martic-Kehl,Pius August Schubiger Pdf

Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural cancer models in mice and dogs to humanized animals. An evaluation of previously unpublished long-term data from the Swiss canine and feline cancer registry is also included. The final part of the book reviews the lessons learned over the last decade on how to interpret data from animal studies for improving human therapy and gives recommendations for future drug development.

Author : Eric C. Holland
Publisher : John Wiley & Sons
Page : 504 pages
File Size : 43,9 Mb
Release : 2004-08-27
Category : Science
ISBN : 9780471444602

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Mouse Models of Human Cancer by Eric C. Holland Pdf

Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments. Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text: Presents real experimental data Describes organ site-specific mouse models Clearly identifies suitable models for further drug testing Critically analyzes current methodologies and their limitations Features numerous recognizable expert contributors Lists key Web sites, reagents, and companies From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions. Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.

Author : Harikrishnan Vijayakumar Sreelatha
Publisher : Springer Nature
Page : 645 pages
File Size : 51,8 Mb
Release : 2024-06-23
Category : Electronic
ISBN : 9789819700486

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Animal Models in Research by Harikrishnan Vijayakumar Sreelatha Pdf

Author : Beverly A. Teicher
Publisher : Humana Press
Page : 690 pages
File Size : 42,6 Mb
Release : 2013-04-03
Category : Medical
ISBN : 1475768826

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Tumor Models in Cancer Research by Beverly A. Teicher Pdf

Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in animal tumor model research. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Author : Cory Abate-Shen,Katerina Politi,Lewis A. Chodosh,Kenneth P. Olive
Publisher : Unknown
Page : 0 pages
File Size : 46,5 Mb
Release : 2014
Category : SCIENCE
ISBN : 1621820041

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Mouse Models of Cancer by Cory Abate-Shen,Katerina Politi,Lewis A. Chodosh,Kenneth P. Olive Pdf

The laboratory mouse is an important model for addressing questions in cancer biology. In recent years, the questions have become more refined, and mouse models are increasingly being used to develop and test cancer therapeutics. Thus, the need for more sophisticated and clinically relevant mouse models has grown, as has the need for innovative tools to analyze and validate them. This laboratory manual provides cutting-edge methods for generating and characterizing mouse models that accurately recapitulate many features of human cancer. The contributors describe strategies for producing genetic models, including transgenic germline models, gene knockouts and knock-ins, and conditional and inducible systems, as well as models derived using transposon-based insertional mutagenesis, RNA interference, viral-mediated gene delivery, and chemical carcinogens. Tissue recombination, organ reconstitution, and transplantation methods to develop chimeric, allograft, and xenograft models are covered. Approaches to characterize tumor development, progression, and metastasis in these models using state-of-the-art imaging and histopathological, surgical, and other techniques are also included. Other chapters cover the use of mouse models to test and optimize drugs in pre-, co-, and postclinical trials. An appendix specifically addresses the use of mouse cancer models in translational studies and the integration of mouse and human clinical investigations. This manual is therefore an indispensable laboratory resource for all researchers, from the graduate level upward, who study cancer and its treatment.

Author : Robert A. Greenwald,Herbert S. Diamond
Publisher : CRC-Press
Page : 256 pages
File Size : 40,8 Mb
Release : 1988-09-30
Category : Science
ISBN : 0849329884

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Handbook of Animal Models Rheumatic Disease by Robert A. Greenwald,Herbert S. Diamond Pdf

Detailed methods of the most widely used and best established animal models and related approaches to the study of rheumatic diseases and their treatment are presented in this major reference book. The detailed description of each model allows the reader to select the model most appropriate for his research and to reproduce the model without resorting to additional references. In addition, other methods for induction of the model, sources for procurement of suitable animals and validation of the model are highlighted. Methods for eliciting non-spontaneous phenomena, follow-up examinations and data collection are also described. Specific techniques such as joint-injection, obtaining synovial tissue, methods of assessment and similar non-specific information are emphasized. This easy-to-read resource text is essential for scientists, graduate students, research assistants, physicians and other invbestigators who use animal models for the study of rheumatic diseases.

Author : Vladimir Korinek
Publisher : Mdpi AG
Page : 274 pages
File Size : 49,6 Mb
Release : 2021-08-27
Category : Medical
ISBN : 3036512764

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Animal Modeling in Cancer by Vladimir Korinek Pdf

Dear Readers, Understanding the pathological mechanisms involved in human diseases and their possible treatment has been historically based on comparative analysis of diverse animal species that share a similar genetic, physiological and behavioural composition. The ancient Greeks were the first to use animals as models for anatomy and physiology, and this was consequently adopted by other cultures and led to important discoveries. In recent years, there have been many efforts to understand and fight cancer through new revolutionary personalized treatments and wider screenings that help diagnose and treat cancer. A fundamental part of this effort is to develop suitable cancer animal models that simulate the different disease variants and their progression. Ranging from tumor-derived xenografts to genetically engineered models, a wide variety of systems are applied for this purpose, and many technological breakthroughs are changing the way cancer is studied and analyzed. In this Special Issue, we collected a set of research articles and reviews that focus on the generation of cancer animal models that are used for understanding the disease and contribute to designing and testing new drugs for cancer prevention or treatment. Vladimir Korinek Collection Editor.

Author : Wolfgang Arnold,Petra Köpf-Maier,Burkhard Micheel
Publisher : S. Karger AG (Switzerland)
Page : 252 pages
File Size : 54,5 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015037798371

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Immunodeficient Animals by Wolfgang Arnold,Petra Köpf-Maier,Burkhard Micheel Pdf

The classic immunodeficient mutants nude, scid and rnu have an important function in experimental cancer research: they allow unique methods of investigation and provide data of clinical relevance. This volume presents the state of the art of research work based on the use of these immunodeficient animal models. One section is dedicated to the biological aspects and immunological properties of immunodeficient mutants. Another part includes articles on xenogenous transplantation of human tumors, focusing on the establishment of transplantable lines, growth characteristics and tumor markers. Special attention is given to new approaches in the fields of chemotherapy, radiation therapy and immunotherapy. Various contributors consider in vitro methods as alternative models. In addition to current data, this publication contains useful technical and methodological information and is therefore valuable not only for specialists but also for scientists entering the field of experimental cancer research.

Author : Surajit Pathak,Antara Banerjee
Publisher : Elsevier
Page : 703 pages
File Size : 40,9 Mb
Release : 2023-11-14
Category : Science
ISBN : 9780443132117

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Cancer Stem Cells and Signaling Pathways by Surajit Pathak,Antara Banerjee Pdf

Cancer Stem Cells and Signaling Pathways explores the mechanism of cancer stem cell signaling pathways in cancer advancement, serving as an ideal reference guide for investigators with valuable answers to problems associated with anti-cancer treatments and an understanding of the crosstalk among the signaling pathways in CSC regulation. Despite recent advances in tumor therapy and a greater understanding of their biology, tumors continue to be a prevalent and fatal worldwide. According to a novel paradigm in tumor biology, a small percentage of the cells within a tumor known as cancer stem cells (CSCs) are predicted as a crucial population for tumor progression. Presents cancer stem characteristics and their signaling pathways Highlights the use of animal models for cancer research, the use of genetically modified stem cells to deliver antitumor agents, and the significance of stem cell signaling in drug discovery Covers basic and translational research appropriate for scientists and clinicians exploring alternative treatments for various cancers

Author : Merle A. Sande
Publisher : Unknown
Page : 1136 pages
File Size : 49,6 Mb
Release : 1999
Category : Medical
ISBN : 0127753907

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Handbook of Animal Models of Infection by Merle A. Sande Pdf

Handbook of Animal Models of Infection is a complete revision of a three-volume text that was published in 1986. It incorporates the major advances in the field during the past decade, in particular those concerning molecular biological procedures and new models that have been developed. It focuses on both methods and techniques, which makes it an essential and comprehensive reference as well as a benchtop manual. The Handbook will help investigators save time and effort in formulating an approach to test a new potential therapeutic agent or combination of agents for in vivo efficacy and to position the therapy for specific infections where it may have therapeutic promise. The book is divided into five sections; the first covering the general methodologies, followed by sections describing experimental bacterial, mycotic, parasitic, and viral infections. Key Features * Discusses ethical and safety aspects in an introductory background section * Covers principles of animal care and current techniques appropriate for the use of animal models of infection * Details a wide range of animals including rodents, rabbits, cats, and primates * Provides hands-on descriptions of how to set up the model * Discusses the major advantages and limitations of each model * Ensures full coverage of bacterial, fungal, viral, and parasitic infections