Handbook Of Mouse Mutations With Skin And Hair Abnormalities

Author : John P. Sundberg
Publisher : CRC Press
Page : 582 pages
File Size : 48,9 Mb
Release : 2020-08-26
Category : Medical
ISBN : 9781000142327

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Handbook of Mouse Mutations with Skin and Hair Abnormalities by John P. Sundberg Pdf

Handbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects. The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system.

Author : Anonim
Publisher : Elsevier
Page : 829 pages
File Size : 42,7 Mb
Release : 2006-12-15
Category : Science
ISBN : 9780080469072

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The Mouse in Biomedical Research by Anonim Pdf

Normative Biology, Husbandry, and Models, the third volume in the four volume set, The Mouse in Biomedical Research, encompasses 23 chapters whose contents provide a broad overview on the laboratory mouse’s normative biology, husbandry, and its use as a model in biomedical research. This consists of chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. Other chapters cover management, as well as nutrition, gnotobiotics and disease surveillance. There are also individual chapters describing the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases. Chapters on imaging techniques and the use of the mouse in assays of biological products are also included.

Author : Hans Hedrich
Publisher : Academic Press
Page : 868 pages
File Size : 55,5 Mb
Release : 2012-06-14
Category : Science
ISBN : 9780123820099

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The Laboratory Mouse by Hans Hedrich Pdf

The Laboratory Mouse, Second Edition is a comprehensive book written by international experts. With inclusions of the newly revised European standards on laboratory animals, this will be the most current, global authority on the care of mice in laboratory research. This well-illustrated edition offers new and updated chapters including immunology, viruses and parasites, behavior, enrichment and care standards of laboratory mice across the life sciences, medical and veterinary fields. Features four-color illustrations with complete instruction on mouse surgery, anatomy, behavior and care of the mouse in laboratory research Offers additional chapters on new mouse strains, phenotyping of strains, bacteria and parasites, and immunology Includes the newly revised EU standards on care, as well as, comparisons to standards and regulations in the US and other countries

Author : John P. Sundberg
Publisher : CRC Press
Page : 201 pages
File Size : 51,9 Mb
Release : 1999-07-23
Category : Medical
ISBN : 9781420049480

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Systematic Approach to Evaluation of Mouse Mutations by John P. Sundberg Pdf

Experts from The Jackson Laboratory and around the world provide practical advice on everything from how to establish a colony to where to go for specific mutations. The book includes information on medical photography, grafting procedures, and how to map the genes and evaluate the special biological characteristics of mice. It also discusses how to maintain a colony of mice that breed with difficulty, how to approach mapping spontaneous mutations, how to set up systems to evaluate a specific antibody, how to perform simple measurements that yield a large amount of information, and how to access mouse informatics on the Web.

Author : Eric C. Holland
Publisher : John Wiley & Sons
Page : 504 pages
File Size : 54,7 Mb
Release : 2004-08-27
Category : Science
ISBN : 9780471444602

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Mouse Models of Human Cancer by Eric C. Holland Pdf

Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments. Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text: Presents real experimental data Describes organ site-specific mouse models Clearly identifies suitable models for further drug testing Critically analyzes current methodologies and their limitations Features numerous recognizable expert contributors Lists key Web sites, reagents, and companies From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions. Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.

Author : John P. Sundberg,Peter Vogel,Jerrold M. Ward
Publisher : John Wiley & Sons
Page : 564 pages
File Size : 55,8 Mb
Release : 2022-01-26
Category : Medical
ISBN : 9781119624578

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Pathology of Genetically Engineered and Other Mutant Mice by John P. Sundberg,Peter Vogel,Jerrold M. Ward Pdf

An updated and comprehensive reference to pathology in every organ system in genetically modified mice The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice. The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice. Readers will also benefit from: A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice An exploration of concepts related to validating animal models, including the Cinderella Effect Practical discussions of basic necropsy methods and grading lesions for computational analyses Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.

Author : Anonim
Publisher : Unknown
Page : 138 pages
File Size : 50,5 Mb
Release : 1992
Category : Pathology, Comparative
ISBN : UIUC:30112018159415

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Comparative Pathology Bulletin by Anonim Pdf

Author : Brian J. Nickoloff,Frank O. Nestle
Publisher : Karger Medical and Scientific Publishers
Page : 391 pages
File Size : 48,9 Mb
Release : 2008-01-01
Category : Medical
ISBN : 9783805583916

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Dermatologic Immunity by Brian J. Nickoloff,Frank O. Nestle Pdf

Nickeloff (skin cancer research, Cardinal Bernardin Cancer Center, Chicago) and Nestle (cutaneous medicine and immunotherapy, King's College, London School of Medicine at Guy's, UK) assemble 19 review articles on autoimmune disease processes that affect the skin, covering both humoral and cellular immunity. The etiology, cellular and molecular mechanisms, therapeutic strategies, and pathophysiology of diseases such as psoriasis, dermatitis, cutaneous lupus erythematosus, vitiligo, and scleroderma are discussed by individuals in dermatology, genetics, immunology, and pathology who are based around the world. The book is aimed at clinical researchers, students, allergists, immunologists, dermatologists, and internists.

Author : Piper M. Treuting,Suzanne M. Dintzis,Kathleen S. Montine
Publisher : Academic Press
Page : 570 pages
File Size : 41,5 Mb
Release : 2017-08-29
Category : Science
ISBN : 9780128029190

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Comparative Anatomy and Histology by Piper M. Treuting,Suzanne M. Dintzis,Kathleen S. Montine Pdf

The second edition of Comparative Anatomy and Histology is aimed at the new rodent investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse and rat anatomy and histology using direct comparison to the human. The side by side comparison of mouse, rat, and human tissues highlight the unique biology of the rodents, which has great impact on the validation of rodent models of human disease. Offers the only comprehensive source for comparing mouse, rat, and human anatomy and histology through over 1500 full-color images, in one reference work Enables human and veterinary pathologists to examine tissue samples with greater accuracy and confidence Teaches biomedical researchers to examine the histologic changes in their model rodents Experts from both human and veterinary fields take readers through each organ system in a side-by-side comparative approach to anatomy and histology - human Netter anatomy images along with Netter-style rodent images

Author : Ulrich Mohr
Publisher : International Life Sciences Institute/I L S I Press
Page : 532 pages
File Size : 42,6 Mb
Release : 1996
Category : Medical
ISBN : WISC:89063172977

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Pathobiology of the Aging Mouse: Nervous system, special senses (eye and ear), digestive system, integumentary system and mammary gland, and musculoskeletal system by Ulrich Mohr Pdf

Author : J. Eduardo Calonje,Thomas Brenn,Alexander J Lazar,Steven D Billings
Publisher : Elsevier Health Sciences
Page : 2128 pages
File Size : 49,7 Mb
Release : 2018-10-29
Category : Medical
ISBN : 9780702075520

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McKee's Pathology of the Skin, 2 Volume Set E-Book by J. Eduardo Calonje,Thomas Brenn,Alexander J Lazar,Steven D Billings Pdf

Comprehensive and lavishly illustrated, McKee’s Pathology of the Skin, 5th Edition, is your reference of choice for up-to-date, authoritative information on dermatopathology. You’ll find clinical guidance from internationally renowned experts along with details on etiology, pathogenesis, histopathology, and differential diagnosis – making this unique reference unparalleled in its wealth of clinical and histopathological material. The 5th Edition of this classic text is a must-have resource for practicing dermatopathologists and general pathologists who sign out skin biopsies. Covers pathological aspects of skin diseases in addition to providing superb descriptions and illustrations of their clinical manifestations – the only available reference with this unique combination of features. Integrates dermatopathology, clinical correlations, and clinical photographs throughout, and features bulleted lists of clinical features and differential diagnosis tables for easy reference. Contains more than 5,000 superb histopathologic and clinical illustrations that demonstrate the range of histologic manifestations. Brings you fully up to date with key molecular aspects of disease, the capabilities and limitations of molecular diagnostics, and targeted/personalized medicine. Features up-to-date information on biologics, drug eruptions, and other developments in therapeutics. Helps you stay current with the latest diagnostic tumor markers and other new developments in immunohistochemistry. Includes a completely revised chapter on cutaneous lymphoma that reflects recent WHO-EORTC classification changes, as well as new coverage of sentinel lymph node biopsy for melanoma. Shares the knowledge of the main editor Dr. J. Eduardo Calonje, along with co-editors Thomas Brenn, and Alexander Lazar, and new co-editor Steven D. Billings who offers expertise on both dermatopathology and soft tissue tumors.

Author : Victor R. Preedy
Publisher : Springer
Page : 493 pages
File Size : 53,6 Mb
Release : 2012-05-23
Category : Science
ISBN : 9789086867288

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Handbook of hair in health and disease by Victor R. Preedy Pdf

Hair is a major component of the body's tissue system that contributes to the individual's make up and confers a large degree of personal identity. Apart from its visible façade, hair also has a functional role. It has an unique structure and complex molecular development. The very nature of hair makes it a suitable marker for the prognosis of disease. Hair can also be used to screen for toxins and changes in the diet. However, there are currently no suitable publications available that describe hair in a rational scientific context. This handbook provides an academic approach to hair in health and disease. Divided into five sections the Handbook of Hair in Health and Disease provides an insight into hair growth and loss, molecular and cellular biology of hair, dietary toxicity and pathological history, diseases and treatments of hair, as well as shampoos and conditioners. Unique features of each chapter in this volume include relevant and useful 'Key facts' which highlight interesting or important findings of the specific subjects and 'Summary points' that will give a clear overview of the subjects treated in each chapter. The Handbook of Hair in Health and Disease will be essential to a variety of users, such as trichologists, doctors and nurses and all those interested or working within the area of hair health. This includes nutritionists and dieticians, scientific beauticians, health workers and practitioners, college and university lecturers and undergraduate and graduate students.

Author : Valerie A. Randall
Publisher : Elsevier Science & Technology
Page : 532 pages
File Size : 55,6 Mb
Release : 1996
Category : Health & Fitness
ISBN : UOM:39015038117597

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Hair Research for the Next Millenium by Valerie A. Randall Pdf

This volume covers aspects of hair research and provides an understanding for research in the future which will lead to the development of better treatments for hair disorders.

Author : Jamie Davies
Publisher : Springer Science & Business Media
Page : 255 pages
File Size : 44,8 Mb
Release : 2007-03-20
Category : Science
ISBN : 9780387308739

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Branching Morphogenesis by Jamie Davies Pdf

Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.

Author : Lawrence F. Eichenfield,Ilona J. Frieden,Nancy B. Esterly
Publisher : Saunders
Page : 592 pages
File Size : 44,7 Mb
Release : 2008
Category : Family & Relationships
ISBN : UOM:39015076180002

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Neonatal Dermatology by Lawrence F. Eichenfield,Ilona J. Frieden,Nancy B. Esterly Pdf

Addresses various dermatologic entities and includes data on fetal skin development, barrier function, percutaneous absorption, skin of the premature infant, toxicology, and iatrogenic and traumatic injuries. Abundant high-quality color illustrations.