Heat Shock Protein Inhibitors

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Heat Shock Protein Inhibitors

Shelli R. McAlpine,Adrienne Lesley Edkins
Heat Shock Protein Inhibitors Book PDF

Author : Shelli R. McAlpine,Adrienne Lesley Edkins
Publisher : Springer
Page : 238 pages
File Size : 40,6 Mb
Release : 2016-05-23
Category : Science
ISBN : 9783319326078

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Heat Shock Protein Inhibitors by Shelli R. McAlpine,Adrienne Lesley Edkins Pdf

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Heat Shock Proteins in Cancer

Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca
Heat Shock Proteins in Cancer Book PDF

Author : Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca
Publisher : Springer Science & Business Media
Page : 400 pages
File Size : 41,7 Mb
Release : 2007-09-09
Category : Medical
ISBN : 9781402064012

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Heat Shock Proteins in Cancer by Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca Pdf

Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.

Heat Shock Protein 90 in Human Diseases and Disorders

Alexzander A. A. Asea,Punit Kaur
Heat Shock Protein 90 in Human Diseases and Disorders Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer Nature
Page : 607 pages
File Size : 44,7 Mb
Release : 2019-11-04
Category : Science
ISBN : 9783030231583

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Heat Shock Protein 90 in Human Diseases and Disorders by Alexzander A. A. Asea,Punit Kaur Pdf

The book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes and HSP90 in Natural Products Development and Section IV; give the most up to date reviews on Clinical Aspects of HSP90. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Natural Products, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Heat Shock Protein-Based Therapies

Alexzander A.A. Asea,Naif N. Almasoud,Sunil Krishnan,Punit Kaur
Heat Shock Protein Based Therapies Book PDF

Author : Alexzander A.A. Asea,Naif N. Almasoud,Sunil Krishnan,Punit Kaur
Publisher : Springer
Page : 385 pages
File Size : 40,5 Mb
Release : 2015-07-22
Category : Medical
ISBN : 9783319172118

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Heat Shock Protein-Based Therapies by Alexzander A.A. Asea,Naif N. Almasoud,Sunil Krishnan,Punit Kaur Pdf

The book Heat Shock Protein-Based Therapies provides the most up-to-date review on new heat shock protein-based mechanisms used in the therapy and treatment of various human disorders and diseases, including cancer, muscular atrophy, neurodegenerative disorders (Alzheimer's Disease, Multiple Sclerosis) and infectious diseases (HIV, periodontal disease). Written by leaders in the field of heat shock protein research, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which mechanisms dependent on heat shock proteins are targeted. The chapters also provide answers as to HSP biological significance to the host. This book is a must read for graduate and postgraduates in the field of Drug Development, Biotechnology, Pharmaceutical Industry, Phytomedicine, Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Oncology, Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.

Hsp90 in Cancer: Beyond the Usual Suspects

Anonim
Hsp90 in Cancer Beyond the Usual Suspects Book PDF

Author : Anonim
Publisher : Academic Press
Page : 288 pages
File Size : 47,7 Mb
Release : 2016-02-23
Category : Science
ISBN : 9780128024836

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Hsp90 in Cancer: Beyond the Usual Suspects by Anonim Pdf

Hsp90 in Cancer: Beyond the Usual Suspects, the latest volume in the Advances in Cancer Research series, focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins and discusses some of the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression. Focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins Highlights the rapidly evolving understanding of the fundamental roles of Hsp90 in cancer biology Discusses the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression

Stress Proteins

David S. Latchman
Stress Proteins Book PDF

Author : David S. Latchman
Publisher : Springer Science & Business Media
Page : 436 pages
File Size : 53,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642582592

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Stress Proteins by David S. Latchman Pdf

This work is concerned with a group of proteins which were originally consid ered to be an esoteric phenomenon but which have now been shown to play critical roles both in normal and stressed cells as well as being involved in a variety of human diseases. It is the purpose of this work to give a comprehen sive view of these proteins and their various aspects. After an introductory chapter providing an overview of these proteins, the work is divided into four main sections each of which deals with one important aspect of these proteins. Thus, the first section contains a series of chapters which describe individual stress proteins and their roles in particular biological phenomena. Evidently, the induction of these proteins by elevated tempera ture or other stresses is their defining feature and the second section of this book therefore considers the regulation of stress protein gene expression both by stressful stimuli such as elevated temperature or ischaemia and by non stressful stimuli such as cytokines.

HSF1 and Molecular Chaperones in Biology and Cancer

Marc Laurence Mendillo,David Pincus,Ruth Scherz-Shouval
HSF1 and Molecular Chaperones in Biology and Cancer Book PDF

Author : Marc Laurence Mendillo,David Pincus,Ruth Scherz-Shouval
Publisher : Springer Nature
Page : 185 pages
File Size : 42,5 Mb
Release : 2020-04-15
Category : Medical
ISBN : 9783030402044

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HSF1 and Molecular Chaperones in Biology and Cancer by Marc Laurence Mendillo,David Pincus,Ruth Scherz-Shouval Pdf

Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Heat Shock Proteins in the Immune System

Robert J. Binder,Pramod K. Srivastava
Heat Shock Proteins in the Immune System Book PDF

Author : Robert J. Binder,Pramod K. Srivastava
Publisher : Springer
Page : 185 pages
File Size : 44,5 Mb
Release : 2018-04-09
Category : Medical
ISBN : 9783319690421

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Heat Shock Proteins in the Immune System by Robert J. Binder,Pramod K. Srivastava Pdf

Experts from around the world review the current field of the immunobiology of heat shock proteins, and provide a comprehensive account of how these molecules are spearheading efforts in the understanding of various pathways of the immune system. This one-stop resource contains numerous images to both help illustrate the research on heat shock proteins, and better clarify the field for the non-expert. Heat shock proteins (HSPs) were discovered in 1962 and were quickly recognized for their role in protecting cells from stress. Twenty years later, the immunogenicity of a select few HSPs was described, and for the past 30 years, these findings have been applied to numerous branches of immunology, including tumor immunology and immunosurveillance, immunotherapy, etiology of autoimmunity, immunotherapy of infectious diseases, and expression of innate receptors. While HSPs can be used to manipulate immune responses by exogenous administration, they appear to be involved in initiation of de novo immune responses to cancer and likely in the maintenance of immune homeostasis.

Heat Shock Proteins in Signaling Pathways

Alexzander A. A. Asea,Punit Kaur
Heat Shock Proteins in Signaling Pathways Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer
Page : 482 pages
File Size : 44,7 Mb
Release : 2019-07-09
Category : Science
ISBN : 9783030039523

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Heat Shock Proteins in Signaling Pathways by Alexzander A. A. Asea,Punit Kaur Pdf

Signaling pathways is a comprehensive mechanism by which all cellular organisms communicate internally and externally with their microenvironment. This is a highly complex and exact process. Errors in signaling pathways and in the processing of cellular information are known to be responsible for the majority of diseases including cancer, inflammatory and neurological disorders. Knowledge gained from the better understanding of signaling pathways will help in elucidating disease processes and will assist in development and design of novel targeted treatment therapies to combat human diseases and disorders. Heat shock proteins (HSP) are uniquely involved in a number of critical signaling pathways. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Heat Shock Proteins in Human Diseases

Alexzander A. A. Asea,Punit Kaur
Heat Shock Proteins in Human Diseases Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer Nature
Page : 297 pages
File Size : 42,8 Mb
Release : 2021-03-23
Category : Science
ISBN : 9783030622893

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Heat Shock Proteins in Human Diseases by Alexzander A. A. Asea,Punit Kaur Pdf

The book Heat Shock Proteins in Cancer Therapeutics provides the most comprehensive review on contemporary knowledge on the role of HSP in various types of cancer therapeutics. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in cancer therapeutics. The heat shock response pathway is a highly conserved cellular process. Heat shock factors are a master transcriptional regulator responsible for expression of several important heat shock proteins, which can effectively protect critical client proteins from misfolding and degradation, thus maintaining intracellular integrity under stressed conditions. Recent studies have demonstrated the direct connections between heat shock response players and tumor cell survival, validating heat shock response players as novel molecular targets in anticancer treatment. Although many hurdles in clinical application still need to be effectively addressed, such as undesirable drug toxicity and off target effects; narrow therapeutic window; poor PK/PD profiles, etc. Recent reports on synergistic drug combination, advanced prodrug design, smart nanoparticle packaging, and RNA aptamer selection offer promising solutions to overcome these challenges. Future advancements in this fast-growing area can potentially lead to the next generation of cancer therapeutics. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks

Peter Csermely,László Vígh
Molecular Aspects of the Stress Response Chaperones Membranes and Networks Book PDF

Author : Peter Csermely,László Vígh
Publisher : Springer Science & Business Media
Page : 218 pages
File Size : 49,9 Mb
Release : 2007-08-09
Category : Science
ISBN : 9780387399751

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Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks by Peter Csermely,László Vígh Pdf

This book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. Authored by an exciting mixture of top experts and young rising stars, it provides a comprehensive summary of the field and identifies future trends.

Encyclopedia of Cancer

Manfred Schwab
Encyclopedia of Cancer Book PDF

Author : Manfred Schwab
Publisher : Springer Science & Business Media
Page : 3307 pages
File Size : 40,6 Mb
Release : 2008-09-23
Category : Medical
ISBN : 9783540368472

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Encyclopedia of Cancer by Manfred Schwab Pdf

This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

Histone Deacetylase Inhibitors as Cancer Therapeutics

Steven Grant
Histone Deacetylase Inhibitors as Cancer Therapeutics Book PDF

Author : Steven Grant
Publisher : Academic Press
Page : 290 pages
File Size : 50,8 Mb
Release : 2012-11
Category : Business & Economics
ISBN : 9780123943873

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Histone Deacetylase Inhibitors as Cancer Therapeutics by Steven Grant Pdf

Provides information on the exciting and fast-moving field of cancer research.

Immune Surveillance

Richard T. Smith
Immune Surveillance Book PDF

Author : Richard T. Smith
Publisher : Elsevier
Page : 552 pages
File Size : 52,6 Mb
Release : 2012-12-02
Category : Nature
ISBN : 9780323146265

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Immune Surveillance by Richard T. Smith Pdf

Immune Surveillance deals with the issues regarding tumor immunology and surveillance, in which the central theme is all about the life span of the mammalian host that is depleted by the environment with mutagenic agents and solutions. The book is divided into six chapters. It includes discussions on the organization and modulation of cell membrane receptors, as well as the origin and expression of membrane antigens. It also covers the topics on the triggering mechanisms for and effector mechanisms activated by the cellular recognition. These topics analyze and evaluate alternatives for the recognition and destruction mechanisms in the knowledge of cell cooperation and requirements for immune recognition. A chapter provides discourse on a solution for the paradox of thriving tumors based on the demonstrable in vitro host immunity. Another discusses the generation of antibody diversity and the theory of self-tolerance. The last chapter explains the evaluation of the evidence for immune surveillance. This reference will be invaluable to those who specialize in immunology.

Heat Shock Protein 60 in Human Diseases and Disorders

Alexzander A. A. Asea,Punit Kaur
Heat Shock Protein 60 in Human Diseases and Disorders Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer Nature
Page : 363 pages
File Size : 46,7 Mb
Release : 2019-10-31
Category : Science
ISBN : 9783030231545

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Heat Shock Protein 60 in Human Diseases and Disorders by Alexzander A. A. Asea,Punit Kaur Pdf

The book Heat Shock Protein 60 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP60 in human diseases and disorders. Using an integrative approach, the contributors provide a synopsis of novel mechanisms and signal transduction pathways. To enhance the ease of reading and comprehension the book has further been subdivided into various section including; Section I: Biomolecular Aspects of HSP60; Section II: HSP60 and Cancer; Section III: HSP60 and Inflammatory Diseases and Disorders; Section IV: HSP60 and Cardiovascular Diseases and Disorders; Section V: HSP60 and Neurological and Neurosciences; Section VI: Biomolecular Aspects of HSP60; Section VII: HSP60 and Skeletal Muscle Diseases and Disorders; and Section VIII: HSP60 in Human Health. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Neurology & Neuroscience, Oncology, Cardiovascular Disease, Skeletal Muscle Diseases and Disorders, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.