Hedgehog Signaling Activation In Human Cancer And Its Clinical Implications

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Hedgehog signaling activation in human cancer and its clinical implications

Jingwu Xie
Hedgehog signaling activation in human cancer and its clinical implications Book PDF

Author : Jingwu Xie
Publisher : Springer Science & Business Media
Page : 223 pages
File Size : 40,9 Mb
Release : 2011-04-30
Category : Medical
ISBN : 9781441984357

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Hedgehog signaling activation in human cancer and its clinical implications by Jingwu Xie Pdf

Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that activation of this pathway occurs in a variety of human cancer, including basal cell carcinomas (BCCs), medulloblastomas, leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. This book provides insightful views suitable for graduate students, medical students, undergraduate students, basic and clinical scientists, cancer patients as well as the general public.

Hedgehog Signaling

Gerald Litwack
Hedgehog Signaling Book PDF

Author : Gerald Litwack
Publisher : Academic Press
Page : 571 pages
File Size : 50,5 Mb
Release : 2012-03-12
Category : Health & Fitness
ISBN : 9780123946225

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Hedgehog Signaling by Gerald Litwack Pdf

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on hedgehog signaling. Contributions from leading authorities Informs and updates on all the latest developments in the field

Innovative Medicine

Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Innovative Medicine Book PDF

Author : Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Publisher : Springer
Page : 330 pages
File Size : 40,6 Mb
Release : 2015-10-13
Category : Science
ISBN : 9784431556510

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Innovative Medicine by Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto Pdf

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Natural Products in Medicinal Chemistry

Stephen Hanessian
Natural Products in Medicinal Chemistry Book PDF

Author : Stephen Hanessian
Publisher : John Wiley & Sons
Page : 800 pages
File Size : 44,7 Mb
Release : 2013-12-18
Category : Medical
ISBN : 9783527676569

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Natural Products in Medicinal Chemistry by Stephen Hanessian Pdf

The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer

Development, Differentiation and Disease of the Para-Alimentary Tract

Anonim
Development Differentiation and Disease of the Para Alimentary Tract Book PDF

Author : Anonim
Publisher : Academic Press
Page : 301 pages
File Size : 47,8 Mb
Release : 2010-12-13
Category : Science
ISBN : 9780123852342

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Development, Differentiation and Disease of the Para-Alimentary Tract by Anonim Pdf

Understanding how digestive organs develop, their physiology and structure is important for determining new therapies to combat diseases of the digestive organs. This volume reviews the latest research and developments in this field. Discusses new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields

New Drugs for Malignancy, An Issue of Hematology/Oncology Clinics of North America - E-Book

Franco Muggia
New Drugs for Malignancy An Issue of Hematology Oncology Clinics of North America E Book Book PDF

Author : Franco Muggia
Publisher : Elsevier Health Sciences
Page : 1440 pages
File Size : 47,7 Mb
Release : 2012-05-08
Category : Medical
ISBN : 9781455744084

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New Drugs for Malignancy, An Issue of Hematology/Oncology Clinics of North America - E-Book by Franco Muggia Pdf

Topics include: Targeting IGF-1R, Tyrosine Kinase Inhibitors in Lung Cancer, Targeting mTOR, Targeting Hedgehog, Mitotic Inhibitors, Topoisomerase I Inhibitors , and New Strategies and Drugs Inhibiting Folate Pathways.

Issues in Cancer Epidemiology and Research: 2012 Edition

Anonim
Issues in Cancer Epidemiology and Research 2012 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 413 pages
File Size : 49,9 Mb
Release : 2013-01-10
Category : Medical
ISBN : 9781481645935

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Issues in Cancer Epidemiology and Research: 2012 Edition by Anonim Pdf

Issues in Cancer Epidemiology and Research / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer Research. The editors have built Issues in Cancer Epidemiology and Research: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Cancer Epidemiology and Research: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Oxford Textbook of Oncology

David J. Kerr,Daniel G. Haller,Cornelis J. H. van de Velde,Michael Baumann
Oxford Textbook of Oncology Book PDF

Author : David J. Kerr,Daniel G. Haller,Cornelis J. H. van de Velde,Michael Baumann
Publisher : Oxford University Press
Page : 832 pages
File Size : 43,9 Mb
Release : 2016-01-28
Category : Medical
ISBN : 9780191065118

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Oxford Textbook of Oncology by David J. Kerr,Daniel G. Haller,Cornelis J. H. van de Velde,Michael Baumann Pdf

Now in paperback, the Oxford Textbook of Oncology reflects current best practice in the multidisciplinary management of cancer, written and edited by internationally recognised leaders in the field. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.

Gastric Carcinoma

Mahmoud Lotfy
Gastric Carcinoma Book PDF

Author : Mahmoud Lotfy
Publisher : BoD – Books on Demand
Page : 370 pages
File Size : 52,5 Mb
Release : 2011-06-15
Category : Medical
ISBN : 9789533074122

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Gastric Carcinoma by Mahmoud Lotfy Pdf

Gastric cancer is one of the most common tumors worldwide. It has a heterogeneous milieu, where the genetic background, tumor immunology, oxidative stress, and microbial infections are key players in the multiple stages of tumorigenesis. These diverse factors are linked to the prognosis of the gastric cancer and the survival of gastric cancer patients. This book is appropriate for scientists and students in the field of oncology, gastroenterology, molecular biology, immunology, cell biology, biology, biochemistry, and pathology. This authoritative text carefully explains the fundamentals, providing a general overview of the principles followed by more detailed explanations of these recent topics efficiently. The topics presented herein contain the most recent knowledge in gastric cancer concerning the oncogenic signaling, genetic instability, the epigenetic aspect, molecular features and their clinical implications, miRNAs, integrin and E-cadherin, carbohydrate-associated-transferases, free radicals, immune cell responses, mucins, Helicobacter-pylori, neoadjuvant and adjuvant therapy, prophylactic strategy for peritoneal recurrence, and hepatic metastasis.

Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology

Sadegh Babashah
Cancer Stem Cells Emerging Concepts and Future Perspectives in Translational Oncology Book PDF

Author : Sadegh Babashah
Publisher : Springer
Page : 560 pages
File Size : 45,5 Mb
Release : 2015-11-12
Category : Medical
ISBN : 9783319210308

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Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology by Sadegh Babashah Pdf

The concept of cancer stem cells has great clinical implications. This is due to the fact that small subpopulations of these cells have been identified in a variety of neoplastic conditions ranging from solid tumors to liquid malignancies. Although there are some huge gaps in our current understanding of the role played by cancer stem cells in cancer biology, a growing body of evidence provides strong support for the principal functions of these cells in tumorigenesis. This has represented the potential of cancer stem cells in the development of novel and innovative tools for the treatment of metastatic tumors. This book aims to offer a broad framework for obtaining insight into the state-of-the-art knowledge on cancer stem cell biology and highlight the therapeutic implications of these cells in the future of clinical oncology.

The Smoothened Receptor in Cancer and Regenerative Medicine

Martial Ruat
The Smoothened Receptor in Cancer and Regenerative Medicine Book PDF

Author : Martial Ruat
Publisher : Springer
Page : 210 pages
File Size : 40,7 Mb
Release : 2015-06-23
Category : Science
ISBN : 9783319197555

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The Smoothened Receptor in Cancer and Regenerative Medicine by Martial Ruat Pdf

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Pancreatic Cancer: Basic Mechanisms and Therapies

Anonim
Pancreatic Cancer Basic Mechanisms and Therapies Book PDF

Author : Anonim
Publisher : Elsevier
Page : 392 pages
File Size : 49,8 Mb
Release : 2023-05-31
Category : Medical
ISBN : 9780443133558

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Pancreatic Cancer: Basic Mechanisms and Therapies by Anonim Pdf

Pancreatic Cancer: Basic Mechanisms and Therapies, Volume 159 in the Advances in Cancer Research, presents the latest release in this ongoing, well-regarded serial with invaluable information on the exciting and fast-moving field of cancer research. Pancreatic cancer (PC) is the third leading cause of cancer-related deaths in the United States. Greater than 90% PCs are Pancreatic ductal adenocarcinomas (PDAC) which have a dismal estimated 5-year overall survival of only 11%. PDAC is predicted to become the second leading cause of mortality in the United States by 2030. In the clinic, the PDAC patients often present with incurable disease at the time of first diagnosis. This cancer is particularly lethal because of its propensity to spread quickly to distant organs including the lymphatic system. PDAC metastasis occurs shortly after tumor initiation and is caused by a complex interaction between autonomous tumor cells and cellular elements of the tumor microenvironment. Although PDAC remains a challenging disease to treat and a leading cause of cancer-related deaths, progress is being made in disease etiology and pathogenesis, and intensive research is focused on developing optimal treatment approaches for patients. Considering the continuous progress being made in understanding PDAC pathogenesis and designing new therapies, it was considered timely to develop an up-to-date thematic issue of Advances in Cancer Research (ACR) focused on PDAC. In this thematic issue, we have included ten review articles by experts that cover cancer disparities, PDAC pathobiology, the roles of the tumor microenvironment, tumor heterogeneity, PC stem cells, genetic and signaling events critical for PDAC pathogenesis, Immunotherapy and chemoresistance in PDAC, and different PDAC mouse models. This special issue highlights recent research progress in PDAC, which bridges the gap between basic and clinical research. The recent overview of Racial Disparities in Pancreatic Cancer Clinical Trials; Overview the evolution of in vivo models for PDAC Up-to-date discussion of diverse genetic and molecular signaling changes in PDAC; Role of tumor heterogeneity in therapy resistance in PDAC; Chemoresistance in PDAC and how to overcome this challenge; Current and emerging approaches and strategies for advancing targeted therapy and immunotherapy for PDAC New insights into the role of epithelial-to-mesenchymal transition, tumor microenvironment (TME) and interactions of TME with cancer stem cells in PDAC pathogenesis, progression and therapeutic resistance

Ethnobotany and Ethnopharmacology of Medicinal and Aromatic Plants

Mohd Adnan,Mitesh Patel,Mejdi Snoussi
Ethnobotany and Ethnopharmacology of Medicinal and Aromatic Plants Book PDF

Author : Mohd Adnan,Mitesh Patel,Mejdi Snoussi
Publisher : CRC Press
Page : 668 pages
File Size : 44,9 Mb
Release : 2023-08-31
Category : Science
ISBN : 9781000923148

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Ethnobotany and Ethnopharmacology of Medicinal and Aromatic Plants by Mohd Adnan,Mitesh Patel,Mejdi Snoussi Pdf

Medicinal and aromatic plants are beneficial to human health. Plant-derived molecules possess biological activities that can be used to prevent many infectious diseases and metabolic disorders. Ethnobotany and Ethnopharmacology of Medicinal and Aromatic Plants summarizes techniques and methods used to study the biological activities of plant-derived extracts and compounds to study ethnobotanical and ethnopharmacological features of medicinal and aromatic plants. This book: Includes computational approaches to study the pharmacological properties of biomolecules in medicinal and aromatic plants. Details methods in ethnopharmacology including chromatographical and analytical techniques. Demonstrates trends in sustainable use and management of medicinal and aromatic plants. Features information on databases and tools used in computational phytochemistry for drug designing and discovery. Elucidates the importance of phytochemicals as immunomodulators in herbal drug development including their nanoformulations. A volume in the Exploring Medicinal Plants series, Ethnobotany and Ethnopharmacology of Medicinal and Aromatic Plants will be of interest to those working with plant extracts, including botanists and ethnobotanists, pharmacologists and ethnopharmacologists, as well as scientists and researchers interested in natural compounds and their potential applications.

Pancreatic Cancer

Sanjay Srivastava
Pancreatic Cancer Book PDF

Author : Sanjay Srivastava
Publisher : BoD – Books on Demand
Page : 328 pages
File Size : 49,9 Mb
Release : 2012-03-28
Category : Medical
ISBN : 9789535103943

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Pancreatic Cancer by Sanjay Srivastava Pdf

This book covers pancreatic cancer risk factors, treatment and clinical procedures. It provides an outline of pancreatic cancer genetic risk factors, biomarkers and systems biology for the better understanding of disease. As pancreatic cancer suffers from lack of early diagnosis or prognosis markers, this book encompasses stem cell and genetic makers to identify the disease in early stages. The book uncovers the rationale and effectiveness of monotherapy and combination therapy in combating the devastating disease. As immunotherapy is emerging as an attractive approach to cease pancreatic cancer progression, the present book covers various aspects of immunotherapy including innate, adaptive, active, passive and bacterial approaches. Management of anesthesia during surgery and pain after surgery has been discussed. Book also takes the reader through the role of endoscopy and fine needle guided biopsies in diagnosing and observing the disease progression.

Recent Trends in Medicinal Plants Research

Anonim
Recent Trends in Medicinal Plants Research Book PDF

Author : Anonim
Publisher : Academic Press
Page : 468 pages
File Size : 41,9 Mb
Release : 2012-11-13
Category : Science
ISBN : 9780123947994

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Recent Trends in Medicinal Plants Research by Anonim Pdf

Plants and other living organisms have great potential to treat human disease. There are two distinct types of biomedical research that seek to develop this potential. One type of research explores the value of medicinal plants as traditionally used and studies of these plants have the potential to determine which plants are most potent, optimize dosages and dose forms, and identify safety risks. Another type of research uses bioassays to identify single molecules from plants that have interesting bioactivities in isolation and might be useful lead compounds for the development of pharmaceutical drugs. This new volume of Advances in Botanical Research covers the recent trends in Medicinal Plants Research over 11 chapters. Topics that are covered include Development of Drugs from Plants – Regulation and Evaluation, Chinese Herbal Medicines for Rheumatoid Arthritis, and Taxol, camptothecin and beyond for cancer therapy. Covers the recent trends in medicinal plants research over 11 chapters Topics that are covered include Development of Drugs from Plants – Regulation and Evaluation, Chinese Herbal Medicines for Rheumatoid Arthritis, and Taxol, camptothecin and beyond for cancer therapy