Hematopoietic Stem Cell Development

Hematopoietic Stem Cell Development Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Hematopoietic Stem Cell Development book. This book definitely worth reading, it is an incredibly well-written.

Hematopoietic Stem Cell Development

Isabelle Godin,Ana Cumano
Hematopoietic Stem Cell Development Book PDF

Author : Isabelle Godin,Ana Cumano
Publisher : Springer Science & Business Media
Page : 188 pages
File Size : 49,6 Mb
Release : 2010-05-27
Category : Medical
ISBN : 9780387335353

Get Book

Hematopoietic Stem Cell Development by Isabelle Godin,Ana Cumano Pdf

This book collects articles on the biology of hematopoietic stem cells during embryonic development, reporting on fly, fish, avian and mammalian models. The text invites a comparative overview of hematopoietic stem cell generation in the different classes, emphasizing conserved trends in development. The book reviews current knowledge on human hematopoietic development and discusses recent breakthroughs of relevance to both researchers and clinicians.

Hematopoietic Stem Cell Biology

Motonari Kondo
Hematopoietic Stem Cell Biology Book PDF

Author : Motonari Kondo
Publisher : Springer Science & Business Media
Page : 252 pages
File Size : 42,7 Mb
Release : 2009-12-04
Category : Medical
ISBN : 9781603273473

Get Book

Hematopoietic Stem Cell Biology by Motonari Kondo Pdf

In the summer of 1988, my developmental biology professor announced to the class that hematopoietic stem cells (HSCs) had finally been purified. Somehow, I never forgot the professor’s words. When I started working in Dr. Irv Weissman’s labo- tory at Stanford as a postdoctoral fellow, I realized that the findings mentioned by the professor were from Weissman’s laboratory and had been published in a 1988 edition of the journal Science. It has been over 20 years since the publication of that seminal paper, and since then tremendous advances in understanding the biology and maturation of HSCs, namely the process of hematopoiesis, which includes lymphocyte development, have been made. These discoveries were made possible in part by advancements in technology. For example, recent availability of user friendly fluorescence activated cell sorting (FACS) machines and monoclonal an- bodies with a variety of fluorescent labels has allowed more scientists to sort and analyze rare populations in the bone marrow, such as HSCs. All classes of hematopoietic cells are derived from HSCs. Stem cell biology draws enormous attention not only from scientists, but also from ordinary people because of the tremendous potential for development of new therapeutic application to diseases that currently lack any type of effective therapy. Thus, this type of “regenerative medicine” is a relatively new and attractive field in both basic science and clinical medicine.

Hematopoiesis

Leonard I. Zon
Hematopoiesis Book PDF

Author : Leonard I. Zon
Publisher : Oxford University Press
Page : 864 pages
File Size : 54,9 Mb
Release : 2001-04-12
Category : Medical
ISBN : 0199771758

Get Book

Hematopoiesis by Leonard I. Zon Pdf

Hematopoiesis, or the process of blood formation, has been extensively studied at both basic and clinical levels. Human diseases such as thalassemia, immunodeficiency, and leukemia represent defects in this process. Approaches to treat these disorders have required a basic understanding of the biology of blood cells. For instance, hemapoietic stem cell replacement or bone marrow transplantation has been used to ameliorate disease. This volume focuses on hematopoiesis at a cellular and molecular level, and establishes the basis for clinical manipulation of hematopoietic cells for therapeutic benefit. In Part I, the cellular characteristics of progenitors and stem cells are explored. Emphasis is placed on purification of stem cells and both in vitro and in vivo assays. The regulation of normal and leukemis stem cells is illustrated. An excellent discussion of potential use of these cells for gene therapy concludes this section. Hemapoiesis is easily studied during embryogenesis. Part II develops the concept of the waves of hemapoiesis during development. Comparative hematology is making a major comeback as a field in the 1990's. One hope is that general principles of hematopoiesis will be established by studying many models and systems. Part III delves into critical factors that regulate hematopoiesis, including both intracellular and extracellular signals. Part IV and V describe lineage programs for myeloid and lymphoid lineages. These chapters are meant to be illustrative of the different cell fates, but are not exhaustive. Part VI examines the genetics of hematopoisis, particularly in animal models. The hematopoietic system is in constant contact with stromal cells and endothelial cells during development and in the adult. Evidence suggests that endothelial cells and blood cells may arise from a common progenitor, the hemangioblast. Part VII and VIII discuss the stromal and endothelial cells with the emphasis on their interaction with hematopoietic cells.

Hematopoietic Stem Cells

Meng Zhao,Pengxu Qian
Hematopoietic Stem Cells Book PDF

Author : Meng Zhao,Pengxu Qian
Publisher : Springer Nature
Page : 218 pages
File Size : 55,8 Mb
Release : 2024-01-17
Category : Medical
ISBN : 9789819974719

Get Book

Hematopoietic Stem Cells by Meng Zhao,Pengxu Qian Pdf

This book renders a comprehensive understanding of hematopoietic stem cells (HSCs) from their embryonic development through adult maintenance to aging, in the studies conducted in zebrafish and mammals. Hematopoiesis provides a paradigm for understanding the development, maintenance, regeneration, aging and malignant transformation of mammalian organs. Sitting at the apex of the hematopoiesis hierarchy tree, HSCs orchestrate their proliferation, self-renewal, and differentiation to produce all the blood cell lineages throughout life, which represents the best example for somatic stem cell studies. In this book, key regulatory mechanisms for HSC self-renewal and differentiation are overviewed in an array of fields including epigenetics, metabolism and microenvironment regulation. It also highlights the HSC heterogeneity and clonal dynamics from the recent advanced single-cell technologies. This book elaborates on the research history of HSC studies and reveals how the insights from HSC studies shed light on their clinic application. It presents great value from the bench to the clinic.

Stem Cells and the Future of Regenerative Medicine

Institute of Medicine,Board on Neuroscience and Behavioral Health,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on the Biological and Biomedical Applications of Stem Cell Research
Stem Cells and the Future of Regenerative Medicine Book PDF

Author : Institute of Medicine,Board on Neuroscience and Behavioral Health,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on the Biological and Biomedical Applications of Stem Cell Research
Publisher : National Academies Press
Page : 112 pages
File Size : 41,7 Mb
Release : 2002-01-25
Category : Science
ISBN : 9780309170420

Get Book

Stem Cells and the Future of Regenerative Medicine by Institute of Medicine,Board on Neuroscience and Behavioral Health,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on the Biological and Biomedical Applications of Stem Cell Research Pdf

Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.

Hematopoietic Stem Cell Development

Isabelle Godin,Ana Cumano
Hematopoietic Stem Cell Development Book PDF

Author : Isabelle Godin,Ana Cumano
Publisher : Springer
Page : 178 pages
File Size : 50,6 Mb
Release : 2006-02-28
Category : Medical
ISBN : 0306478722

Get Book

Hematopoietic Stem Cell Development by Isabelle Godin,Ana Cumano Pdf

This book collects articles on the biology of hematopoietic stem cells during embryonic development, reporting on fly, fish, avian and mammalian models. The text invites a comparative overview of hematopoietic stem cell generation in the different classes, emphasizing conserved trends in development. The book reviews current knowledge on human hematopoietic development and discusses recent breakthroughs of relevance to both researchers and clinicians.

Molecular Basis of Hematopoiesis

Amittha Wickrema,Barbara Kee
Molecular Basis of Hematopoiesis Book PDF

Author : Amittha Wickrema,Barbara Kee
Publisher : Springer Science & Business Media
Page : 260 pages
File Size : 47,9 Mb
Release : 2008-12-26
Category : Medical
ISBN : 9780387858166

Get Book

Molecular Basis of Hematopoiesis by Amittha Wickrema,Barbara Kee Pdf

Although much is known with respect to blood cell formation and function, many new concepts in the areas of the regulation of hematopoietic stem cell commitment and the subsequent survival, proliferation, and differentiation of progenitors have been elucidated in the last five years. Our understanding of the microenvironment where stem cells reside and commit to distinct blood types (the niche) has grown significantly in recent years. Furthermore, blood cells have been used as the key model system to study microRNA function and the role of microRNAs in the transformation of normal cells into cancer cells. The current volume Molecular Basis of Hematopoiesis, edited by Amittha Wickrema & Barbara Kee, provides the most recent developments in the area in addition to a chapter on the utilization of basic science knowledge for the treatment of blood diseases. Each chapter in this book has been written and edited by faculty in major academic and research institutions around the world, who are pushing the frontiers of research in this important area.

Hematopoietic Stem Cell Protocols

Kevin D. Bunting
Hematopoietic Stem Cell Protocols Book PDF

Author : Kevin D. Bunting
Publisher : Springer Science & Business Media
Page : 306 pages
File Size : 45,7 Mb
Release : 2008-01-31
Category : Science
ISBN : 9781588298683

Get Book

Hematopoietic Stem Cell Protocols by Kevin D. Bunting Pdf

This revised edition provides up-to-date protocols developed in the HSC field. A team of leading researchers supply this volume with in-depth, readily reproducible methods for effective characterization of HSC and their developmental potential. The book provides detailed flow cytometry protocols for thorough analysis of enriched HSC populations, and offers a variety of transplantation approaches to measure HSC function in vivo. This is a much needed technical resource in the critically important field of stem cell investigation.

Hematopoietic Stem Cell Niche

Anonim
Hematopoietic Stem Cell Niche Book PDF

Author : Anonim
Publisher : Elsevier
Page : 186 pages
File Size : 43,5 Mb
Release : 2017-03-10
Category : Science
ISBN : 9780128113769

Get Book

Hematopoietic Stem Cell Niche by Anonim Pdf

Hematopoietic Stem Cell Niche focuses on an individual organ, looking at the stem cells in the organ itself (if they exist), their niches, and how to use them alongside relevant methods and protocols. This series addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Hematopoietic Stem Cell Transplantation

Anthony D. Ho,Rainer Haas,Richard E. Champlin
Hematopoietic Stem Cell Transplantation Book PDF

Author : Anthony D. Ho,Rainer Haas,Richard E. Champlin
Publisher : CRC Press
Page : 624 pages
File Size : 46,9 Mb
Release : 2000-07-25
Category : Medical
ISBN : 9780824741815

Get Book

Hematopoietic Stem Cell Transplantation by Anthony D. Ho,Rainer Haas,Richard E. Champlin Pdf

This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy-providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation, selection, and collection; minimal residual disease and purging; expansion

Advances in Hematopoietic Stem Cell Research

Rosana Pelayo
Advances in Hematopoietic Stem Cell Research Book PDF

Author : Rosana Pelayo
Publisher : BoD – Books on Demand
Page : 480 pages
File Size : 43,9 Mb
Release : 2012-01-27
Category : Science
ISBN : 9789533079301

Get Book

Advances in Hematopoietic Stem Cell Research by Rosana Pelayo Pdf

This book provides a comprehensive overview in our understanding of the biology and therapeutic potential of hematopoietic stem cells, and is aimed at those engaged in stem cell research: undergraduate and postgraduate science students, investigators and clinicians. Starting from fundamental principles in hematopoiesis, Advances in Hematopoietic Stem Cell Research assemble a wealth of information relevant to central mechanisms that may regulate differentiation, and expansion of hematopoietic stem cells in normal conditions and during disease.

Hematopoietic Stem Cells

Louis M. Pelus,Jonathan Hoggatt
Hematopoietic Stem Cells Book PDF

Author : Louis M. Pelus,Jonathan Hoggatt
Publisher : Humana
Page : 0 pages
File Size : 51,8 Mb
Release : 2022-11-17
Category : Science
ISBN : 1071626787

Get Book

Hematopoietic Stem Cells by Louis M. Pelus,Jonathan Hoggatt Pdf

This detailed volume collects updates on the technical advances in hematopoietic stem cell research and incorporates new techniques focused on the molecular/genetic, cellular, and whole organism levels. Exploring methods that apply stress to hematopoiesis, the book also contains chapters focused on better understanding the role of hematopoietic niches and their cellular components, as well as in vivo models that test and quantitate stem cell function and are key to further development of therapeutic applications. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Hematopoietic Stem Cells: Methods and Protocols serves as a valued addition to laboratories focused on understanding hematopoietic stem cell biology and the therapeutic advances that can be derived from it.

Stem Cells from Cord Blood, in Utero Stem Cell Development and Transplantation-Inclusive Gene Therapy

W. Holzgreve,M. Lessl
Stem Cells from Cord Blood in Utero Stem Cell Development and Transplantation Inclusive Gene Therapy Book PDF

Author : W. Holzgreve,M. Lessl
Publisher : Springer Science & Business Media
Page : 229 pages
File Size : 48,9 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9783662044698

Get Book

Stem Cells from Cord Blood, in Utero Stem Cell Development and Transplantation-Inclusive Gene Therapy by W. Holzgreve,M. Lessl Pdf

The title "Stem Cells from Cord Blood, In Utero Stem Cell Develop ment, and Transplantation-Inclusive Gene Therapy" suggests that more than one topic is combined in one workshop. Indeed, at first glance the recovery of stem cells from cord blood has to be seen as separate from the attempts to achieve effective in utero therapy by stem cell trans plantation, because the first issue deals with an innovative stem cell source as an alternative to bone marrow, which is already spreading rapidly in medical practice, whereas the second topic is still strictly ex perimental and only investigated in medical centers with the appropri ate background. It is, however, not only justified, but helpful to com bine the two topics in one workshop and consequently to cover them in the same volume of the Ernst Schering Research Foundation Work shop series, because they are intimately related and both based on the new insights into the biology of stem cells. Professor Werner Arber, the Nobel Laureate from the University of Basel, pointed out in his In- Professor Dr. W. Holzgreve VI Preface The participants of the workshop troductory Lecture that our understanding of hematopoietic stem cells as descendents of totipotent cells and our current approaches to using them in post-and prenatal therapy have been furthered significantly by genetic engineering technologies which are "artificial contributions to the process of biologic evolution".

Hematopoietic Stem Cells

Daniel Levitt,Roland Mertelsmann
Hematopoietic Stem Cells Book PDF

Author : Daniel Levitt,Roland Mertelsmann
Publisher : CRC Press
Page : 681 pages
File Size : 49,8 Mb
Release : 1995-02-15
Category : Medical
ISBN : 0824793056

Get Book

Hematopoietic Stem Cells by Daniel Levitt,Roland Mertelsmann Pdf

Presents preclinical and clinical investigations into the identification, isolation, expansion, and therapeutic applications of hematopoietic stem cells--providing up-to-the minute information on phenotype and characterization. Describes hematopoietic stem cell development into bone marrow and blood cells and shows how to isolate and expand them ex vivo.

Bone Marrow Niche

Takashi Nagasawa
Bone Marrow Niche Book PDF

Author : Takashi Nagasawa
Publisher : Springer Nature
Page : 138 pages
File Size : 54,7 Mb
Release : 2021-12-01
Category : Medical
ISBN : 9783030860165

Get Book

Bone Marrow Niche by Takashi Nagasawa Pdf

This volume summarizes recent advances in research on mesenchymal cell populations in the bone marrow. It explores how mesenchymal cells create niches for immune cells in extramedullary organs and it discusses new concepts of lympho-hematopoietic microenvironments. Readers are introduced to the fundamentals of hematopoietic stem cells (HSCs) differentiation to all types of blood cells, including immune cells, in the bone marrow. The book highlights how this process is supported and regulated by the individual microenvironments of stem cells, termed niches. The identity of HSC niches has been subject to longstanding debates. Recent studies identified the population of mesenchymal stem cells as the major cellular component of niches, for hematopoietic stem and progenitor cells (HSPCs) and their candidate developmental origin. Furthermore, candidate cellular niches for immune cells in lymph nodes and adipose and connective tissues were identified. The authors of this volume focus on shared features between those and HSPC niche cells in the bone marrow. Covering latest research results, this book serves as fascinating read for researchers and clinicians in hematology and immunology.