Hepatobiliary Cancer

Author : Paul H. Sugarbaker
Publisher : Springer Science & Business Media
Page : 326 pages
File Size : 42,9 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9781461526049

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Hepatobiliary Cancer by Paul H. Sugarbaker Pdf

When one deals with cancer, the hepatobiliary malignancies present a chal lenge to the oncologists that can be characterized as a series of unsolved clinical and biological dilemmas. Liver metastases from colorectal and other gastrointestinal malignancies, hepatocellular carcinoma, cholangiocar cinoma, and gall bladder cancer present an array of problems but have two features in common. These are high morbidity and mortality with an overall poor result from treatment. Why is it that hepatobiliary cancer carries with it such a dismal prognosis? First of all, these diseases present, for the most part, in an advanced state. To this point in time the oncologist has had no help from early diagnosis or screening. Only the occasional patient followed by ultrasound or a tumor marker has the disease diagnosed in an asymptomatic state. By the time these diseases become symptomatic, curative treatment options have usually disappeared. Evolution has placed the liver in a protected position in order to avoid injury to the soft parenchyma. As with many other internal organs, the nerve supply is extremely limited. These two anatomic features result in a great lack of early warning signs of cancer.

Author : Yuman Fong,Jia-Hong Dong
Publisher : PMPH USA
Page : 502 pages
File Size : 41,6 Mb
Release : 2014
Category : Medical
ISBN : 9781607950165

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Hepatobiliary Cancer by Yuman Fong,Jia-Hong Dong Pdf

Hepatobiliary Cancer addresses the field with contributions from talented practitioners from around the world in surgery, chemotherapy, radiation therapy, medical oncology, and integrative medicine. The text approaches these cancers by type – biliary and liver tumors – and in terms of diagnostic techniques and therapies: surgical, ablative, systemic and regional chemotherapies, biologic, and complementary. Hepatobiliary Cancer is essential reading for anyone expert in, or engaged in learning about, treating hepatobiliary cancers. Heavily illustrated with photomicrographs, photographs, drawings, and tables to support and illuminate the text, it is a concise, yet comprehensive guide to hepatobiliary cancer diagnosis and treatment.

Author : Tim Cross,Daniel H. Palmer
Publisher : Springer
Page : 312 pages
File Size : 52,7 Mb
Release : 2018-12-12
Category : Medical
ISBN : 9783319922164

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Liver Cancers by Tim Cross,Daniel H. Palmer Pdf

This book explores in detail the primary liver cancers of hepatocellular carcinoma and cholangiocarcinoma examining the pathogenesis of disease along with diagnosis and current management options together with exploration of future treatment strategies and areas of controversy. Furthermore, the book highlights management of the common secondary malignancies and touches on benign liver tumours and how to best manage these. Written in a clear and didactic style, this volume includes summaries of the key learning points and questions so that the reader can gauge their knowledge and understanding. This book is aimed to broaden the knowledge base of primary care physicians, general physicians along with specialists in hepatology, oncology and hepato-biliary surgery

Author : Steven A. Curley
Publisher : Springer Science & Business Media
Page : 274 pages
File Size : 53,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461216667

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Liver Cancer by Steven A. Curley Pdf

Liver Cancer provides the general surgeon, surgical oncologist, and medical oncologist with the most current standard of multimodality care for hepatobiliary cancer. Surgical approaches, chemotherapy, immunotherapy, gene therapy, and radiotherapy are all presented.

Author : Nima Rezaei
Publisher : Springer Nature
Page : 367 pages
File Size : 52,5 Mb
Release : 2024-01-01
Category : Medical
ISBN : 9783031445286

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Hepatobiliary Cancers: An Interdisciplinary Approach by Nima Rezaei Pdf

Hepatobiliary cancers, including hepatocellular carcinoma and biliary tract cancers, have high rate of mortality and low survival rate. The third volume of the “Interdisciplinary Cancer Research” series, entitled “Hepatobiliary Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of hepatobiliary cancers and therapeutic modalities and presents the most updated and peer-reviewed chapters on hepatobiliary cancers. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on hepatobiliary cancers.

Author : Anonim
Publisher : Academic Press
Page : 468 pages
File Size : 45,5 Mb
Release : 2022-08-10
Category : Science
ISBN : 9780323983938

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Hepatobiliary Cancers: Translational Advances and Molecular Medicine by Anonim Pdf

Hepatobiliary cancer refers to primary malignant tumors originating in cells of the liver, bile ducts, and gallbladder. Globally, primary liver cancer, which includes hepatocellular carcinoma (~75 % of all cases) and intrahepatic biliary cancer or cholangiocarcinoma (~10-15 % 0f all cases) is the 6th most commonly diagnosed cancer and 3rd leading cause of cancer deaths worldwide. The vast majority of these highly malignant cancers are diagnosed at an advanced stage where treatment options are limited and patient survival outcomes are poor. The biological and therapeutic challenges posed by hepatobililiary cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are daunting, emphasizing a critical need to review and assess current and evolving basic, translational, and clinical research focused on addressing the critical obstacles that continue to limit progress towards achieving significant improvements in HCC and CCA clinical management and patient survival outcomes. Towards this goal, this special edition of Advances in Cancer Research is focused on providing a comprehensive, timely and authoritative reviews covering such topics of significant scientific and clinical relevance, including hepatobiliary cancer risk mechanisms and risk-predictive molecular biomarkers; causes and functional intricacies of inter- and intratumor heterogeneity; novel insights into the role of tumor microenvironment and key signaling pathways in promoting hepatobiliary cancer progression, therapeutic resistance and immunosuppression; emerging biomarkers of HCC and CCA prognosis; advances in molecular genomics for personalizing tumor classification and targeted therapies; innovative preclinical cell culture modeling for hepatobiliary cancer drug discovery; and current and emerging trends in hepatobiliary cancer molecular therapeutic targeting and immunotherapies. Up-to date review of hepatobiliary cancers molecular genetics, novel predictive molecular biomarkers, and distinct mechanisms of inter-and intratumor heterogeneity Novel insights into the role of tumor microenvironment as a promoter of hepatobiliary cancer progression and therapeutic resistance, as well as an emerging therapeutic target Current and emerging approaches and strategies for advancing personalized molecular therapeutic targeting and immunotherapy of hepatobiliary cancers

Author : Arthur Zimmermann
Publisher : Springer
Page : 0 pages
File Size : 47,9 Mb
Release : 2016-11-02
Category : Medical
ISBN : 3319269542

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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract by Arthur Zimmermann Pdf

This book covers all liver tumors and lesions that clinically and radiologically mimic liver tumors. It provides readers with a comprehensive overview of this complex and rapidly evolving field. All aspects of surgical pathology are addressed, supplemented by detailed presentations of the lesions’ cell-biologic and molecular features. In addition, the methods employed for diagnosis and diagnostic algorithms are discussed. It appeals to pathologists and hepatologists and serves as an invaluable aid to diagnosis.The field of liver tumors and tumor-like lesions in adults and children has experienced tremendous advances in recent years. Specifically, the recognition of novel entities, deepened insights into known tumors, and refinement of classifications have necessitated continual updates and reappraisals. In addition, previous understanding of hepatic carcinogenesis and tumor progression has been transformed by the very rapid evolution of our understanding of cell biology, genomics, signaling pathways, cell interactions, and mechanisms of invasion and spread of hepatic tumor cells. These general pathology issues must be combined with surgical pathology if a comprehensive understanding of liver tumor pathology is to be achieved.

Author : Daniele Regge,Giulia Zamboni
Publisher : Springer
Page : 122 pages
File Size : 48,9 Mb
Release : 2018-02-26
Category : Medical
ISBN : 9783319502960

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Hepatobiliary and Pancreatic Cancer by Daniele Regge,Giulia Zamboni Pdf

This book describes the pathways of dissemination of primary liver, biliary, and pancreatic neoplasms and proposes a practical and clinically driven approach to their imaging. The typical dissemination pathways for hepatocellular carcinoma, cholangiocarcinoma, exocrine pancreatic carcinoma, and neuroendocrine pancreatic tumors are systematically reviewed, and more unusual pathways are also documented. The content is presented in an extremely schematic way, with numerous high-quality graphical illustrations and multimodality images (US, CT, MRI, and PET) that are accompanied by clear explanatory text. The clinical significance of findings and potential therapeutic options are explained whenever appropriate. In addition, relevant background information is provided on the role of morphopathological drivers of cancer spread and anatomy.

Author : Mauro Monteiro Correia,Michael A. Choti,Flavio G. Rocha,Go Wakabayashi
Publisher : Springer Nature
Page : 597 pages
File Size : 43,7 Mb
Release : 2019-12-28
Category : Medical
ISBN : 9783030254865

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Colorectal Cancer Liver Metastases by Mauro Monteiro Correia,Michael A. Choti,Flavio G. Rocha,Go Wakabayashi Pdf

Colorectal cancer is the third most commonly diagnosed condition in oncology, affecting around 1.23 million individuals per year, according to recent statistics. Of these patients, about 50% will develop liver metastases and approximately 20% will present a stage IV disease at diagnosis. These statistics make colorectal liver metastases (CLM) an issue of major importance in current oncology. The area of CLM is subject to great and continuous advances, as its pathophysiologic mechanisms are better understood and more therapeutic and surgical options are developed. Consequently, all professionals involved with the diagnosis, treatment and follow up of CLM should be kept up to date with the latest advances on the field, to provide high standard medical care to their patients. This book is designed to present the state-of-the-art in CLM management and, in doing so, to review the current evidence on CLM, discussing all important topics in the field. Coverage is broad and comprehensive, encompassing introductory topics (history, definitions, epidemiology, etc.), basic science subjects (molecular biology, genetics, dissemination process, etc.) and practical clinical topics (tumor behavior, diagnosis, drug therapy, radiation therapy, surgery, ablation, multidisciplinary teams, etc.). Although comprehensive on the coverage and selection of topics, each chapter is concise and objective, dissecting topics in a practical and direct format. Evidences and recommendations are included. Chapters display a brief introduction of the common knowledge, go straight to the detailed revision of the most recent years of the literature, and end with practical closing observations. This book is a tool for professionals (general and cancer surgeons, HPB surgeons, clinical oncologists, gastroenterologists and medical residents) and interns who search for a qualified and reader friendly revision on topics concerning Colorectal Cancer Liver Metastases.

Author : Ghassan K. Abou-Alfa,Celina Ang
Publisher : Jones & Bartlett Publishers
Page : 167 pages
File Size : 53,7 Mb
Release : 2012-12-23
Category : Medical
ISBN : 9781449686178

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Dx/Rx: Liver Cancer by Ghassan K. Abou-Alfa,Celina Ang Pdf

Dx/Rx: Liver Cancer is a quick and practical reference guide containing all aspects of the diagnosis and therapy of hepatocellular carcinoma (HCC), prognostic and staging systems, clinical management, molecular biology, current controversies, and future insights. Organized into a condensed, bulleted format, this concise reference offers precise and up-to-date information on the epidemiology, classification, diagnosis, treatment, and risk factors for cancers of the liver. Presented in a handy, easy-to-read format, Dx/Rx: Liver Cancer is a must-have resource for oncologists, internists, primary care physicians, and other health care professionals on the ward or in the clinic.

Author : Ghassan K. Abou-Alfa,Ronald DeMatteo
Publisher : Jones & Bartlett Publishers
Page : 137 pages
File Size : 47,7 Mb
Release : 2011-12-15
Category : Health & Fitness
ISBN : 9781449622893

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100 Questions and Answers about Liver Cancer by Ghassan K. Abou-Alfa,Ronald DeMatteo Pdf

100 Questions & Answers About Liver Cancer is a quick and practical reference guide containing all aspects of the diagnosis and therapy of hepatocellular carcinoma (HCC), prognostic and staging systems, clinical management, molecular biology, current controversies, and future insights. Organized into a condensed, bulleted format, this concise reference offers precise and up-to-date information on the epidemiology, classification, diagnosis, treatment, and risk factors for cancers of the liver.

Author : U. Metzger,F. Largiader,H.-J. Senn
Publisher : Springer Science & Business Media
Page : 170 pages
File Size : 52,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642824326

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Perioperative Chemotherapy by U. Metzger,F. Largiader,H.-J. Senn Pdf

One reason for failure to cure solid tumors by surgery appears to be the impossibility of controlling metastases that are present but latent at the time of operation. This failure is a common clinical experience with aggressive neoplasms. but it is not always appreciated in tumors with longer survival times. e. g .• breast and colon cancer. In addition. recent evidence indicates that after resection of a primary tumor micrometas tases from it might be enhanced by suppression of immune and reticu loendothelial functions of the host. Other factors, such as increase of coagulability and stress in the perioperative period, can also promote tumor growth. The development of new metastases might be facilitated by cells forced into the circulation during operative manipulations. Such events could be important for the outcome of treatment and it is suggested that preventive measures should be directed to this systemic component of solid tumors. Radical surgery can reduce the number of tumor cells to a subclinical 3 6 stage (10 to 10 cells) in which chemotherapy might be more effective than in advanced stages. Chemotherapy, on the other hand, might aggravate the surgical morbidity by influencing the wound healing pro cess, by decreasing the immune response, and/or by toxicity to the bone marrow and to the gastrointestinal tract, for example.

Author : Catherine M. Handy,Denise O'Dea
Publisher : Unknown
Page : 0 pages
File Size : 43,5 Mb
Release : 2013
Category : Biliary tract
ISBN : 1935864181

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Pancreatic and Hepatobiliary Cancers by Catherine M. Handy,Denise O'Dea Pdf

Part of the 'Site-specific Cancer Series', this volume looks at pancreatic and hepatobiliary cancers.

Author : Ghassan K. Abou-Alfa,Eileen O'Reilly
Publisher : Jones & Bartlett Publishers
Page : 144 pages
File Size : 44,8 Mb
Release : 2013-12-20
Category : Health & Fitness
ISBN : 9781284025385

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100 Questions & Answers About Biliary Cancer by Ghassan K. Abou-Alfa,Eileen O'Reilly Pdf

100 Questions & Answers About Biliary Cancer provides authoritative and practical answers to the most common questions asked by patients and their loved ones. Providing both doctor and patient perspectives, this easy-to-read book is a comprehensive guide to the basics of biliary cancer, risk factors and prevention, diagnosis, treatment, survivorship, and life after diagnosis. Written by Dr. Ghassan Abou-Alfa, a board-certified medical oncologist who specializes in primary liver cancer (hepatocellular carcinoma), pancreas, gallbladder, and bile duct tumors, 100 Questions & Answers About Biliary Cancer is an invaluable resource for anyone interested in learning what to expect after being diagnosed with biliary cancer.

Author : H. J. F. Hodgson,Stephen Robert Bloom
Publisher : Butterworth-Heinemann
Page : 458 pages
File Size : 55,6 Mb
Release : 1983
Category : Medical
ISBN : UOM:39015006003894

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Gastrointestinal and Hepatobiliary Cancer by H. J. F. Hodgson,Stephen Robert Bloom Pdf