Hepatobiliary Cancers Translational Advances And Molecular Medicine

Author : Anonim
Publisher : Academic Press
Page : 468 pages
File Size : 41,5 Mb
Release : 2022-08-10
Category : Science
ISBN : 9780323983938

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Hepatobiliary Cancers: Translational Advances and Molecular Medicine by Anonim Pdf

Hepatobiliary cancer refers to primary malignant tumors originating in cells of the liver, bile ducts, and gallbladder. Globally, primary liver cancer, which includes hepatocellular carcinoma (~75 % of all cases) and intrahepatic biliary cancer or cholangiocarcinoma (~10-15 % 0f all cases) is the 6th most commonly diagnosed cancer and 3rd leading cause of cancer deaths worldwide. The vast majority of these highly malignant cancers are diagnosed at an advanced stage where treatment options are limited and patient survival outcomes are poor. The biological and therapeutic challenges posed by hepatobililiary cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are daunting, emphasizing a critical need to review and assess current and evolving basic, translational, and clinical research focused on addressing the critical obstacles that continue to limit progress towards achieving significant improvements in HCC and CCA clinical management and patient survival outcomes. Towards this goal, this special edition of Advances in Cancer Research is focused on providing a comprehensive, timely and authoritative reviews covering such topics of significant scientific and clinical relevance, including hepatobiliary cancer risk mechanisms and risk-predictive molecular biomarkers; causes and functional intricacies of inter- and intratumor heterogeneity; novel insights into the role of tumor microenvironment and key signaling pathways in promoting hepatobiliary cancer progression, therapeutic resistance and immunosuppression; emerging biomarkers of HCC and CCA prognosis; advances in molecular genomics for personalizing tumor classification and targeted therapies; innovative preclinical cell culture modeling for hepatobiliary cancer drug discovery; and current and emerging trends in hepatobiliary cancer molecular therapeutic targeting and immunotherapies. Up-to date review of hepatobiliary cancers molecular genetics, novel predictive molecular biomarkers, and distinct mechanisms of inter-and intratumor heterogeneity Novel insights into the role of tumor microenvironment as a promoter of hepatobiliary cancer progression and therapeutic resistance, as well as an emerging therapeutic target Current and emerging approaches and strategies for advancing personalized molecular therapeutic targeting and immunotherapy of hepatobiliary cancers

Author : Paul H. Sugarbaker
Publisher : Springer Science & Business Media
Page : 455 pages
File Size : 41,8 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9781461526049

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Hepatobiliary Cancer by Paul H. Sugarbaker Pdf

When one deals with cancer, the hepatobiliary malignancies present a chal lenge to the oncologists that can be characterized as a series of unsolved clinical and biological dilemmas. Liver metastases from colorectal and other gastrointestinal malignancies, hepatocellular carcinoma, cholangiocar cinoma, and gall bladder cancer present an array of problems but have two features in common. These are high morbidity and mortality with an overall poor result from treatment. Why is it that hepatobiliary cancer carries with it such a dismal prognosis? First of all, these diseases present, for the most part, in an advanced state. To this point in time the oncologist has had no help from early diagnosis or screening. Only the occasional patient followed by ultrasound or a tumor marker has the disease diagnosed in an asymptomatic state. By the time these diseases become symptomatic, curative treatment options have usually disappeared. Evolution has placed the liver in a protected position in order to avoid injury to the soft parenchyma. As with many other internal organs, the nerve supply is extremely limited. These two anatomic features result in a great lack of early warning signs of cancer.

Author : Tim F. Greten
Publisher : Springer
Page : 167 pages
File Size : 47,9 Mb
Release : 2017-10-04
Category : Medical
ISBN : 9783319649580

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Immunotherapy of Hepatocellular Carcinoma by Tim F. Greten Pdf

In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.

Author : Anonim
Publisher : Academic Press
Page : 384 pages
File Size : 50,6 Mb
Release : 2021-04-13
Category : Medical
ISBN : 9780128241592

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Autophagy and Senescence in Cancer Therapy by Anonim Pdf

Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more. Addresses the relationship between autophagy and senescence in cancer therapy Covers autophagy and senescence in tumor dormancy Explores autophagy and senescence in disease recurrence

Author : Yujin Hoshida
Publisher : Springer
Page : 366 pages
File Size : 54,9 Mb
Release : 2019-08-05
Category : Medical
ISBN : 9783030215408

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Hepatocellular Carcinoma by Yujin Hoshida Pdf

This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.

Author : Daniele Regge,Giulia Zamboni
Publisher : Springer
Page : 122 pages
File Size : 41,5 Mb
Release : 2018-02-26
Category : Medical
ISBN : 9783319502960

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Hepatobiliary and Pancreatic Cancer by Daniele Regge,Giulia Zamboni Pdf

This book describes the pathways of dissemination of primary liver, biliary, and pancreatic neoplasms and proposes a practical and clinically driven approach to their imaging. The typical dissemination pathways for hepatocellular carcinoma, cholangiocarcinoma, exocrine pancreatic carcinoma, and neuroendocrine pancreatic tumors are systematically reviewed, and more unusual pathways are also documented. The content is presented in an extremely schematic way, with numerous high-quality graphical illustrations and multimodality images (US, CT, MRI, and PET) that are accompanied by clear explanatory text. The clinical significance of findings and potential therapeutic options are explained whenever appropriate. In addition, relevant background information is provided on the role of morphopathological drivers of cancer spread and anatomy.

Author : L. H. Blumgart
Publisher : Unknown
Page : 324 pages
File Size : 44,5 Mb
Release : 1982
Category : Medical
ISBN : UOM:39015009561906

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The Biliary Tract by L. H. Blumgart Pdf

Author : Gw Sledge,George W. Sledge (Jr.)
Publisher : Clinical Pub
Page : 0 pages
File Size : 41,8 Mb
Release : 2012-06
Category : Breast
ISBN : 1846920663

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Targeted Therapies in Breast Cancer by Gw Sledge,George W. Sledge (Jr.) Pdf

This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.

Author : Harvey Pass,David Ball,Giorgio Scagliotti
Publisher : Elsevier Health Sciences
Page : 960 pages
File Size : 49,6 Mb
Release : 2017-04-21
Category : Medical
ISBN : 9780323527842

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IASLC Thoracic Oncology E-Book by Harvey Pass,David Ball,Giorgio Scagliotti Pdf

Global experts, in conjunction with the International Association for the Study of Lung Cancer, bring you up to date with today’s best approaches to lung cancer diagnosis, treatment, and follow-up. IASLC Thoracic Oncology, 2nd Edition, keeps you abreast of the entire scope of this fast-changing field, from epidemiology to diagnosis to treatment to advocacy. Written in a straightforward, practical style for the busy clinician, this comprehensive, multidisciplinary title is a must-have for anyone involved in the care of patients with lung cancer and other thoracic malignancies. Offers practical, relevant coverage of basic science, epidemiology, pulmonology, medical and radiation oncology, surgery, pathology, palliative care, nursing, and advocacy. Provides authoritative guidance from the IASLC – the only global organization dedicated to the study of lung cancer. Includes new content on molecular testing, immunotherapy, early detection, staging and the IASLC staging system, surgical resection for stage I and stage II lung cancer, and stem cells in lung cancer. Features a new full-color design throughout, as well as updated diagnostic algorithms.

Author : Hugh A. Edmondson
Publisher : Unknown
Page : 248 pages
File Size : 47,9 Mb
Release : 1958
Category : Bile ducts
ISBN : COLUMBIA:HS64700674

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Tumors of the Liver and Intrahepatic Bile Ducts by Hugh A. Edmondson Pdf

Author : Mauro Monteiro Correia,Michael A. Choti,Flavio G. Rocha,Go Wakabayashi
Publisher : Springer Nature
Page : 597 pages
File Size : 44,8 Mb
Release : 2019-12-28
Category : Medical
ISBN : 9783030254865

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Colorectal Cancer Liver Metastases by Mauro Monteiro Correia,Michael A. Choti,Flavio G. Rocha,Go Wakabayashi Pdf

Colorectal cancer is the third most commonly diagnosed condition in oncology, affecting around 1.23 million individuals per year, according to recent statistics. Of these patients, about 50% will develop liver metastases and approximately 20% will present a stage IV disease at diagnosis. These statistics make colorectal liver metastases (CLM) an issue of major importance in current oncology. The area of CLM is subject to great and continuous advances, as its pathophysiologic mechanisms are better understood and more therapeutic and surgical options are developed. Consequently, all professionals involved with the diagnosis, treatment and follow up of CLM should be kept up to date with the latest advances on the field, to provide high standard medical care to their patients. This book is designed to present the state-of-the-art in CLM management and, in doing so, to review the current evidence on CLM, discussing all important topics in the field. Coverage is broad and comprehensive, encompassing introductory topics (history, definitions, epidemiology, etc.), basic science subjects (molecular biology, genetics, dissemination process, etc.) and practical clinical topics (tumor behavior, diagnosis, drug therapy, radiation therapy, surgery, ablation, multidisciplinary teams, etc.). Although comprehensive on the coverage and selection of topics, each chapter is concise and objective, dissecting topics in a practical and direct format. Evidences and recommendations are included. Chapters display a brief introduction of the common knowledge, go straight to the detailed revision of the most recent years of the literature, and end with practical closing observations. This book is a tool for professionals (general and cancer surgeons, HPB surgeons, clinical oncologists, gastroenterologists and medical residents) and interns who search for a qualified and reader friendly revision on topics concerning Colorectal Cancer Liver Metastases.

Author : Wen-Ming Cong
Publisher : Springer
Page : 372 pages
File Size : 49,9 Mb
Release : 2017-05-29
Category : Medical
ISBN : 9789811035364

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Surgical Pathology of Hepatobiliary Tumors by Wen-Ming Cong Pdf

This book focuses on the pathological diagnosis of primary hepatic and bile duct tumors, and introduces the “Three Types and Six Sub-types” classification of hepatobiliary tumors. With more than 600 figures, including photographs and microscopy images, it highlights morphology, immunology and molecular pathology and their correlations with hepatic surgery and hepatic oncology. The book reviews the pathobiological characteristics of hepatic tumors and reveals the latest developments in this field. It is a valuable reference resource for hepatologists, pathologists and researchers.

Author : Valerie Van Holten,Constance L. Percy
Publisher : Unknown
Page : 212 pages
File Size : 50,8 Mb
Release : 1991
Category : Government publications
ISBN : PURD:32754068903362

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Conversion of Neoplasms by Topography and Morphology from the International Classification of Diseases for Oncology (ICD-O), (first Edition and Field Trials) to International Classification of Diseases for Oncology, Second Edition (ICD-O-2) by Valerie Van Holten,Constance L. Percy Pdf

Epidemiologists, statisticians, oncologists as well as tumor registrars are interested in studying trends in both incidence and mortality. To be able to compare data from one period to another, it is essential that conversion tables be available. The following conversion (comparison or equivalency) tables are from ICD-O-1 and the Field Trial editions to ICD-0-2. These tables are divided into Topography and Morphology. There is only one conversion table for the topography since ICD-O-1 and the Field Trials used the same Topography section. However there are three tables for Morphology: one for ICD-O-1, one for the Field Trials, and one for special codes introduced by the Surveillance, Epidemiology, and End Results Program (SEER) of the National Cancer Institute (NCI).

Author : William R. Jarnagin
Publisher : Elsevier Health Sciences
Page : 2520 pages
File Size : 51,5 Mb
Release : 2016-10-10
Category : Medical
ISBN : 9780323340878

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Blumgart's Surgery of the Liver, Pancreas and Biliary Tract E-Book by William R. Jarnagin Pdf

Extensively revised with new illustrations, new clinical photos, this classic text remains the most comprehensive and up-to-date resource on surgery of the hepatobiliary and pancreatic region. Dr. William Jarnagin and his team of internationally recognized surgeons continue the Blumgart’s tradition of excellence, bringing you the latest advances in diagnostic and surgical techniques. You’ll find updates on the newest minimally invasive surgeries, new interventional diagnostic techniques, and complete coverage of all relevant diseases, including those seen in the tropics. Considers all worldwide opinions and approaches to management, and includes key data on surgical outcomes to better inform your clinical decision-making. Covers exactly what you need to know, balancing basic science with information on clinical practice. Presents cutting edge guidance on pathology, diagnostics, surgery and non-operative intervention of the liver, biliary tract, and pancreas in a single, comprehensive reference. Covers the most recent non-surgical therapies for pancreatic cancer, microwave ablation, and other emerging technologies. Brings you up to date with recent developments in transplantation, minimally invasive surgery, percutaneous devices, pre- and post-care, blood transfusion, and surgical techniques for the spleen. Features an extensively revised art and illustration program, with new anatomical line drawings (including hundreds now in color), more than 750 new clinical photos, more schematic diagrams that summarize information, and new graphs and algorithms throughout.

Author : Anonim
Publisher : Academic Press
Page : 486 pages
File Size : 40,9 Mb
Release : 2021-06-18
Category : Medical
ISBN : 9780128240793

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Novel Approaches to Colorectal Cancer by Anonim Pdf

Novel Approaches to Colorectal Cancer, Volume 151 in the Advances in Cancer Research series, is composed of 11 reviews covering state-of-the-art research relating to the etiology, diagnosis, prevention and treatment of colorectal cancer. The book's chapters were written by recognized experts in the field, and include sections on molecular biomarkers in diagnosis and therapy, the interplay of diet, lifestyle, and the microbiome, early-age onset disease, mutational signature analysis, challenges in early detection, immunotherapy, organoid technology, the role of epigenetic alterations, disparities in minority populations, field carcinogenesis, and cancer as an evolutionary process. Each of these topics provides novel insights and concepts on various aspects of the nature of colorectal cancer, offering new opportunities for the management of a major source of cancer incidence and mortality. Provides information on the timely nature of the included topics, which represent the most current concepts and approaches in cancer research Offers outstanding and original reviews on colorectal cancer research Provides the authority and expertise of the authors, all of whom are highly recognized and conducting state-of-the-art investigations in cancer, with this release focusing on colorectal cancer