Hormesis In Health And Disease

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Hormesis in Health and Disease

Suresh I. S. Rattan,Éric Le Bourg
Hormesis in Health and Disease Book PDF

Author : Suresh I. S. Rattan,Éric Le Bourg
Publisher : CRC Press
Page : 382 pages
File Size : 43,7 Mb
Release : 2014-05-16
Category : Medical
ISBN : 9781482205466

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Hormesis in Health and Disease by Suresh I. S. Rattan,Éric Le Bourg Pdf

Some mild stresses have positive effects on survival and aging as shown in animal models. There is also a large body of research that demonstrates these hormetic effects on aging, health, and resistance to severe stresses and diseases in human beings. However, the data are dispersed in the literature and are not always interpreted as hormetic effects. Hormesis in Health and Disease reviews the evidence for hormesis in humans as achieved through a variety of stresses or stimuli, and discusses mechanisms of hormesis and its ethical and legal issues. Divided into four sections, this book presents the current state of research, including questions, debates, doubts, and controversies in hormesis. Section I covers the history and terminology of hormesis, describing its main features and providing necessary background information. Section II shows that hormetic effects can be caused by various stresses—including physical exercise, nutritional components, fasting, micronutrients, irradiation, heat, ischemia, and mental challenge—and can be observed both in organs and at the organism level. Section III reviews possible mechanisms of hormesis that have been elucidated at this point. Section IV discusses the wider consequences hormesis may have for everyone. This book demonstrates that health beneficial hormetic effects do exist in human beings. It offers information to inspire key players to initiate new strategies to elucidate the strengths and limits of the dual nature of stress.

The Science of Hormesis in Health and Longevity

Suresh I. S. Rattan,Marios Kyriazi
The Science of Hormesis in Health and Longevity Book PDF

Author : Suresh I. S. Rattan,Marios Kyriazi
Publisher : Academic Press
Page : 326 pages
File Size : 44,7 Mb
Release : 2018-10-23
Category : Medical
ISBN : 9780128142547

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The Science of Hormesis in Health and Longevity by Suresh I. S. Rattan,Marios Kyriazi Pdf

The Science of Hormesis in Health and Longevity provides a comprehensive review of mild stress-induced physiological hormesis and its role in the maintenance and promotion of health. Coverage includes the underlying mechanisms of hormesis, including details of stress-response signaling, an enriched environment, positive challenges and dose-response mechanisms, amongst others. Research from top experts is presented to provide suggestions for developing novel therapeutic strategies, along with lifestyle interventions to promote health and homoeostasis. Researchers in aging and physiology, gerontologists, clinicians and medical students will find this a valuable addition for their work. Provides a comprehensive, scholarly review of the current state of hormesis in physiology, health, disease and aging Includes multiple perspectives and in-depth analysis by top experts involved in cutting-edge research to provide developing, novel therapeutic strategies, as well as lifestyle interventions Offers a clear understanding of hormesis’ underlying mechanisms, including details of stress-response signaling, an enriched environment, positive challenges, dose-response mechanisms, and more

Hormesis

Mark P. Mattson,Edward J. Calabrese
Hormesis Book PDF

Author : Mark P. Mattson,Edward J. Calabrese
Publisher : Springer Science & Business Media
Page : 219 pages
File Size : 40,8 Mb
Release : 2009-12-01
Category : Medical
ISBN : 9781607614951

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Hormesis by Mark P. Mattson,Edward J. Calabrese Pdf

Hormesis is a poorly understood phenomenon affecting all forms of life on earth. This groundbreaking book summarizes and analyzes the various positives of hormesis in an attempt to reveal hormesis as a fundamental principle of biomedical sciences as a whole.

Radiation Hormesis and the Linear-No-Threshold Assumption

Charles L. Sanders
Radiation Hormesis and the Linear No Threshold Assumption Book PDF

Author : Charles L. Sanders
Publisher : Springer Science & Business Media
Page : 217 pages
File Size : 46,8 Mb
Release : 2009-11-07
Category : Medical
ISBN : 9783642037207

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Radiation Hormesis and the Linear-No-Threshold Assumption by Charles L. Sanders Pdf

Current radiation protection standards are based upon the application of the linear no-threshold (LNT) assumption, which considers that even very low doses of ionizing radiation can cause cancer. The radiation hormesis hypothesis, by contrast, proposes that low-dose ionizing radiation is beneficial. In this book, the author examines all facets of radiation hormesis in detail, including the history of the concept and mechanisms, and presents comprehensive, up-to-date reviews for major cancer types. It is explained how low-dose radiation can in fact decrease all-cause and all-cancer mortality and help to control metastatic cancer. Attention is also drawn to biases in epidemiological research when using the LNT assumption. The author shows how proponents of the LNT assumption consistently reject, manipulate, and deliberately ignore an overwhelming abundance of published data and falsely claim that no reliable data are available at doses of less than 100 mSv.

Hormesis in Health and Disease

Suresh I. S. Rattan,Éric Le Bourg
Hormesis in Health and Disease Book PDF

Author : Suresh I. S. Rattan,Éric Le Bourg
Publisher : CRC Press
Page : 386 pages
File Size : 46,9 Mb
Release : 2014-05-16
Category : Medical
ISBN : 9781482205459

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Hormesis in Health and Disease by Suresh I. S. Rattan,Éric Le Bourg Pdf

Some mild stresses have positive effects on survival and aging as shown in animal models. There is also a large body of research that demonstrates these hormetic effects on aging, health, and resistance to severe stresses and diseases in human beings. However, the data are dispersed in the literature and are not always interpreted as hormetic effects. Hormesis in Health and Disease reviews the evidence for hormesis in humans as achieved through a variety of stresses or stimuli, and discusses mechanisms of hormesis and its ethical and legal issues. Divided into four sections, this book presents the current state of research, including questions, debates, doubts, and controversies in hormesis. Section I covers the history and terminology of hormesis, describing its main features and providing necessary background information. Section II shows that hormetic effects can be caused by various stresses—including physical exercise, nutritional components, fasting, micronutrients, irradiation, heat, ischemia, and mental challenge—and can be observed both in organs and at the organism level. Section III reviews possible mechanisms of hormesis that have been elucidated at this point. Section IV discusses the wider consequences hormesis may have for everyone. This book demonstrates that health beneficial hormetic effects do exist in human beings. It offers information to inspire key players to initiate new strategies to elucidate the strengths and limits of the dual nature of stress.

Explaining Health Across the Sciences

Jonathan Sholl,Suresh I.S. Rattan
Explaining Health Across the Sciences Book PDF

Author : Jonathan Sholl,Suresh I.S. Rattan
Publisher : Springer Nature
Page : 551 pages
File Size : 44,8 Mb
Release : 2020-08-28
Category : Medical
ISBN : 9783030526634

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Explaining Health Across the Sciences by Jonathan Sholl,Suresh I.S. Rattan Pdf

This edited volume aims to better understand the multifaceted phenomenon we call health. Going beyond simple views of health as the absence of disease or as complete well-being, this book unites scientists and philosophers. The contributions clarify the links between health and adaptation, robustness, resilience, or dynamic homeostasis, and discuss how to achieve health and healthy aging through practices such as hormesis. The book is divided into three parts and a conclusion: the first part explains health from within specific disciplines, the second part explores health from the perspective of a bodily part, system, function, or even the environment in which organisms live, and the final part looks at more clinical or practical perspectives. It thereby gathers, across 30 chapters, diverse perspectives from the broad fields of evolutionary and systems biology, immunology, and biogerontology, more specific areas such as odontology, cardiology, neurology, and public health, as well as philosophical reflections on mental health, sexuality, authenticity and medical theories. The overarching aim is to inform, inspire and encourage intellectuals from various disciplines to assess whether explanations in these disparate fields and across biological levels can be sufficiently systematized and unified to clarify the complexity of health. It will be particularly useful for medical graduates, philosophy graduates and research professionals in the life sciences and general medicine, as well as for upper-level graduate philosophy of science students.

Health Risks from Exposure to Low Levels of Ionizing Radiation

Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation,National Research Council
Health Risks from Exposure to Low Levels of Ionizing Radiation Book PDF

Author : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation,National Research Council
Publisher : National Academies Press
Page : 422 pages
File Size : 50,9 Mb
Release : 2006-03-23
Category : Science
ISBN : 9780309133340

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Health Risks from Exposure to Low Levels of Ionizing Radiation by Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation,National Research Council Pdf

This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.

Radiation Hormesis

T. D. Luckey
Radiation Hormesis Book PDF

Author : T. D. Luckey
Publisher : CRC Press
Page : 317 pages
File Size : 48,6 Mb
Release : 2020-10-28
Category : Law
ISBN : 9781000098723

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Radiation Hormesis by T. D. Luckey Pdf

Radiation Hormesis presents the only critical review of the effects of whole-body exposure to low doses of ionizing radiation in animals. This is a "must read" book for radiobiologists, health-conscious individuals, and serious environmentalists. Topics discussed include our radiation environment, radiation hormesis in cancer mortality, growth and development, reproduction and mutation, immunity, and cancer. Data is presented that indicates that low doses of ionizing radiation may actually be beneficial to human health. This information could invalidate the "zero thesis" and linear models used by most regulatory agencies. The implications regarding eliminating linear models and accepting radiation hormesis are also discussed.

Curcumin in Health and Disease

Beatrice E. Bachmeier
Curcumin in Health and Disease Book PDF

Author : Beatrice E. Bachmeier
Publisher : MDPI
Page : 274 pages
File Size : 51,6 Mb
Release : 2019-10-11
Category : Medical
ISBN : 9783039214495

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Curcumin in Health and Disease by Beatrice E. Bachmeier Pdf

The plant-derived polyphenol curcumin has been used in promoting health and combating disease for thousands of years. Its therapeutic effects have been successfully utilized in Ayurvedic and Traditional Chinese Medicine in order to treat inflammatory diseases. Current results from modern biomolecular research reveal the modulatory effects of curcumin on a variety of signal transduction pathways associated with inflammation and cancer. In this context, curcumin’s antioxidant, anti-inflammatory, anti-tumorigenic, and even anti-metastatic activities are discussed. On the cellular level, the reduced activity of several transcription factors (such as NFkB or AP-1) and the suppression of inflammatory cytokines, matrix degrading enzymes, metastasis related genes and even microRNAs are reported. On functional levels, these molecular effects translate into reduced proliferative, invasive, and metastatic capacity, as well as induced tumor cell apoptosis. All these effects have been observed not only in vitro but also in animal models. In combination with anti-neoplastic drugs like Taxol, kinase inhibitors, and radiation therapy, curcumin potentiates the drugs’ therapeutic power and can protect against undesired side effects. Natural plant-derived compounds like curcumin have one significant advantage: They do not usually cause side effects. This feature qualifies curcumin for primary prevention in healthy persons with a predisposition to cancer, arteriosclerosis, or chronic inflammatory diseases. Nonetheless, curcumin is considered safe, although potential toxic effects stemming from high dosages, long-term intake, and pharmacological interactions with other compounds have yet to be assessed. This Special Issue examines in detail and updates current research on the molecular targets, protective effects, and modes of action of natural plant-derived compounds and their roles in the prevention and treatment of human diseases.

Radiobiology and Radiation Hormesis

Charles L. Sanders
Radiobiology and Radiation Hormesis Book PDF

Author : Charles L. Sanders
Publisher : Springer
Page : 273 pages
File Size : 52,6 Mb
Release : 2017-08-08
Category : Medical
ISBN : 9783319563725

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Radiobiology and Radiation Hormesis by Charles L. Sanders Pdf

This book presents new information on radiobiology that more clearly refutes the linear no-threshold (LNT) assumption and supports radiation hormesis. Fresh light is cast on the mechanisms of radiation hormesis and the potential benefits of low-dose ionizing radiation in preventing and treating a wide variety of inflammatory and proliferative diseases. It is proposed that these effects may derive from cellular communication via electromagnetic waves directed by DNA, with each cell acting as a quantum computer. Readers will also find close analysis of the negative impacts of radiophobia on many aspects of modern life, including attitudes to imaging technologies, licensing of nuclear power reactors, and preparedness for survival of nuclear war. The book will be of interest to researchers and scientists in radiobiology, radiation protection, health physics, medical physics, and radiology. Specifically, it will provide medical physicians, radiation oncologists, radiation epidemiologists, gerontologists, cell biologists, toxicologists, and nuclear engineers with a wide range of interesting facts and enlightening novel perspectives.

Radiation and Health

Thormod Henriksen
Radiation and Health Book PDF

Author : Thormod Henriksen
Publisher : CRC Press
Page : 241 pages
File Size : 50,5 Mb
Release : 2002-09-05
Category : Science
ISBN : 9780203166352

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Radiation and Health by Thormod Henriksen Pdf

Radiation and the effects of radioactivity have been known for more than 100 years. International research spanning this period has yielded a great deal of information about radiation and its biological effects and this activity has resulted in the discovery of many applications in medicine and industry including cancer therapy, medical diagnostics

Diet and Exercise in Cognitive Function and Neurological Diseases

Akhlaq A. Farooqui,Tahira Farooqui
Diet and Exercise in Cognitive Function and Neurological Diseases Book PDF

Author : Akhlaq A. Farooqui,Tahira Farooqui
Publisher : John Wiley & Sons
Page : 405 pages
File Size : 53,8 Mb
Release : 2015-04-20
Category : Medical
ISBN : 9781118840559

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Diet and Exercise in Cognitive Function and Neurological Diseases by Akhlaq A. Farooqui,Tahira Farooqui Pdf

Diet and exercise have long been recognized as important components of a healthy lifestyle, as they have a great impact on improving cardiovascular and cerebrovascular functions, lowering the risk of metabolic disorders, and contributing to healthy aging. As a greater proportion of the world’s population is living longer, there has been increased interest in understanding the role of nutrition and exercise in long-term neurological health and cognitive function. Diet and Exercise in Cognitive Function and Neurological Diseases discusses the role and impact that nutrition and activity have on cognitive function and neurological health. The book is divided into two sections. The first section focuses on diet and its impact on neurobiological processes. Chapters focus on the impacts of specific diets, such as the Mediterranean, ketogenic and vegan diets, as well as the role of specific nutrients, fats, fatty acids, and calorie restriction on neurological health and cognitive function. The second section of the book focuses on exercise, and its role in maintaining cognitive function, reducing neuroinflammatory responses, regulating adult neurogenesis, and healthy brain aging. Other chapters look at the impact of exercise in the management of specific neurological disorders such Multiple Sclerosis and Parkinson’s Disease. Diet and Exercise in Cognitive Function and Neurological Diseases is a timely reference on the neurobiological interplay between diet and exercise on long-term brain health and cognitive function.

Calorie Restriction, Aging and Longevity

Arthur V. Everitt,Suresh I. S. Rattan,David G. Couteur,Rafael de Cabo
Calorie Restriction Aging and Longevity Book PDF

Author : Arthur V. Everitt,Suresh I. S. Rattan,David G. Couteur,Rafael de Cabo
Publisher : Springer Science & Business Media
Page : 323 pages
File Size : 41,6 Mb
Release : 2010-06-14
Category : Medical
ISBN : 9048185564

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Calorie Restriction, Aging and Longevity by Arthur V. Everitt,Suresh I. S. Rattan,David G. Couteur,Rafael de Cabo Pdf

Food or calorie restriction has been shown in many short-lived animals and the rhesus monkey to prolong life-span. Life-long nutrition studies are not possible in humans because of their long survival. Studies over two to six years in healthy adult humans have, however, shown that a 20% reduction in food or calorie intake slows many indices of normal and disease-related aging. Thus, it is widely believed that long-term reduction in calorie or food intake will delay the onset of age-related diseases such as heart disease, diabetes and cancer, and so prolong life. Over the last 20 or more years there has been a progressive rise in food intake in many countries of the world, accompanied by a rising incidence of obesity. Thus our increasing food and calorie intake has been linked to the rising incidence of cardiovascular disease and diabetes in early adult life. It is accepted that overeating, accompanied by reduced physical exercise, will lead to more age-related diseases and shortening of life-span. The answer is to reduce our calorie intake, improve our diet, and exercise more. But calorie restriction is extremely difficult to maintain for long periods. How then can we solve this problem? Edited by a team of highly distinguished academics, this book provides the latest information on the beneficial effects of calorie restriction on health and life-span. This book brings us closer to an understanding at the molecular, cellular and whole organism level of the way forward.

Integrative Preventive Medicine

Richard H. Carmona,Mark Liponis
Integrative Preventive Medicine Book PDF

Author : Richard H. Carmona,Mark Liponis
Publisher : Oxford University Press
Page : 585 pages
File Size : 44,6 Mb
Release : 2017-12-12
Category : Medical
ISBN : 9780190241254

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Integrative Preventive Medicine by Richard H. Carmona,Mark Liponis Pdf

For most clinicians, the science and evidence for many integrative therapies is largely unknown or considered suspect. Most physicians don't have time to learn integrative approaches and aren't sure what to recommend or which approaches have merit or improved outcomes. Here, clinicians have easy access to the best practices in integrative medicine and expectations for outcomes

Postharvest Pathology of Fresh Horticultural Produce

Lluís Palou,Joseph L. Smilanick
Postharvest Pathology of Fresh Horticultural Produce Book PDF

Author : Lluís Palou,Joseph L. Smilanick
Publisher : CRC Press
Page : 743 pages
File Size : 44,9 Mb
Release : 2019-10-28
Category : Technology & Engineering
ISBN : 9781351805889

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Postharvest Pathology of Fresh Horticultural Produce by Lluís Palou,Joseph L. Smilanick Pdf

Optimal distribution of fresh horticultural products entails prolonging their freshness and nutritional quality as long as possible after harvest. A major limitation to their marketing is decay after harvest, which is caused primarily by fungal pathogens. Postharvest Pathology of Fresh Horticultural Produce provides a comprehensive resource of information about the biology and control of postharvest diseases of many fresh horticultural products, citing sources from appropriate literature of any age, rather than only the most recent. The etiology and symptoms of postharvest diseases and the biology of postharvest pathogens are reviewed by leading experts, who are familiar with many of world’s most popular fresh fruits and vegetables and the diseases that affect them. Key aspects related to infection and epidemiology, methods to minimize postharvest decay losses, including use of conventional fungicides and alternative management strategies, harvest and handling practices, and other aspects are described for the most significant temperate, subtropical, and tropical fruits as well as fruit-like vegetables and leafy vegetables. Features: Provides comprehensive academic and practical reviews of postharvest diseases of fresh fruits and vegetables Discusses the economic importance, etiology, and epidemiology of the most significant postharvest diseases Includes quality color plates that allow the practical identification of disease symptoms Explains practical postharvest disease management actions, including the use of conventional fungicides and alternatives to their use The authors summarize a massive quantity of published information, and often apply their own considerable practical experience to identify and interpret the most significant information. This book is a valuable and comprehensive resource for industry professionals, academics, educators, students, consultants, pest control advisors, regulatory personnel, and others interested in this subject.