The Science Of Hormesis In Health And Longevity

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The Science of Hormesis in Health and Longevity

Suresh I. S. Rattan,Marios Kyriazi
The Science of Hormesis in Health and Longevity Book PDF

Author : Suresh I. S. Rattan,Marios Kyriazi
Publisher : Academic Press
Page : 326 pages
File Size : 52,9 Mb
Release : 2018-10-23
Category : Medical
ISBN : 9780128142547

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The Science of Hormesis in Health and Longevity by Suresh I. S. Rattan,Marios Kyriazi Pdf

The Science of Hormesis in Health and Longevity provides a comprehensive review of mild stress-induced physiological hormesis and its role in the maintenance and promotion of health. Coverage includes the underlying mechanisms of hormesis, including details of stress-response signaling, an enriched environment, positive challenges and dose-response mechanisms, amongst others. Research from top experts is presented to provide suggestions for developing novel therapeutic strategies, along with lifestyle interventions to promote health and homoeostasis. Researchers in aging and physiology, gerontologists, clinicians and medical students will find this a valuable addition for their work. Provides a comprehensive, scholarly review of the current state of hormesis in physiology, health, disease and aging Includes multiple perspectives and in-depth analysis by top experts involved in cutting-edge research to provide developing, novel therapeutic strategies, as well as lifestyle interventions Offers a clear understanding of hormesis’ underlying mechanisms, including details of stress-response signaling, an enriched environment, positive challenges, dose-response mechanisms, and more

Hormesis

Mark P. Mattson,Edward J. Calabrese
Hormesis Book PDF

Author : Mark P. Mattson,Edward J. Calabrese
Publisher : Springer Science & Business Media
Page : 219 pages
File Size : 44,9 Mb
Release : 2009-12-01
Category : Medical
ISBN : 9781607614951

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Hormesis by Mark P. Mattson,Edward J. Calabrese Pdf

Hormesis is a poorly understood phenomenon affecting all forms of life on earth. This groundbreaking book summarizes and analyzes the various positives of hormesis in an attempt to reveal hormesis as a fundamental principle of biomedical sciences as a whole.

Hormesis in Health and Disease

Suresh I. S. Rattan,Éric Le Bourg
Hormesis in Health and Disease Book PDF

Author : Suresh I. S. Rattan,Éric Le Bourg
Publisher : CRC Press
Page : 382 pages
File Size : 47,7 Mb
Release : 2014-05-16
Category : Medical
ISBN : 9781482205466

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Hormesis in Health and Disease by Suresh I. S. Rattan,Éric Le Bourg Pdf

Some mild stresses have positive effects on survival and aging as shown in animal models. There is also a large body of research that demonstrates these hormetic effects on aging, health, and resistance to severe stresses and diseases in human beings. However, the data are dispersed in the literature and are not always interpreted as hormetic effects. Hormesis in Health and Disease reviews the evidence for hormesis in humans as achieved through a variety of stresses or stimuli, and discusses mechanisms of hormesis and its ethical and legal issues. Divided into four sections, this book presents the current state of research, including questions, debates, doubts, and controversies in hormesis. Section I covers the history and terminology of hormesis, describing its main features and providing necessary background information. Section II shows that hormetic effects can be caused by various stresses—including physical exercise, nutritional components, fasting, micronutrients, irradiation, heat, ischemia, and mental challenge—and can be observed both in organs and at the organism level. Section III reviews possible mechanisms of hormesis that have been elucidated at this point. Section IV discusses the wider consequences hormesis may have for everyone. This book demonstrates that health beneficial hormetic effects do exist in human beings. It offers information to inspire key players to initiate new strategies to elucidate the strengths and limits of the dual nature of stress.

Explaining Health Across the Sciences

Jonathan Sholl,Suresh I.S. Rattan
Explaining Health Across the Sciences Book PDF

Author : Jonathan Sholl,Suresh I.S. Rattan
Publisher : Springer Nature
Page : 551 pages
File Size : 54,8 Mb
Release : 2020-08-28
Category : Medical
ISBN : 9783030526634

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Explaining Health Across the Sciences by Jonathan Sholl,Suresh I.S. Rattan Pdf

This edited volume aims to better understand the multifaceted phenomenon we call health. Going beyond simple views of health as the absence of disease or as complete well-being, this book unites scientists and philosophers. The contributions clarify the links between health and adaptation, robustness, resilience, or dynamic homeostasis, and discuss how to achieve health and healthy aging through practices such as hormesis. The book is divided into three parts and a conclusion: the first part explains health from within specific disciplines, the second part explores health from the perspective of a bodily part, system, function, or even the environment in which organisms live, and the final part looks at more clinical or practical perspectives. It thereby gathers, across 30 chapters, diverse perspectives from the broad fields of evolutionary and systems biology, immunology, and biogerontology, more specific areas such as odontology, cardiology, neurology, and public health, as well as philosophical reflections on mental health, sexuality, authenticity and medical theories. The overarching aim is to inform, inspire and encourage intellectuals from various disciplines to assess whether explanations in these disparate fields and across biological levels can be sufficiently systematized and unified to clarify the complexity of health. It will be particularly useful for medical graduates, philosophy graduates and research professionals in the life sciences and general medicine, as well as for upper-level graduate philosophy of science students.

The Longevity Code

Kris Verburgh
The Longevity Code Book PDF

Author : Kris Verburgh
Publisher : The Experiment
Page : 257 pages
File Size : 48,7 Mb
Release : 2018-01-23
Category : Health & Fitness
ISBN : 9781615194254

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The Longevity Code by Kris Verburgh Pdf

“Why do we grow old? . . . Verburgh tackles this age-old question . . . with practical suggestions for how to slow down our biological clock.” —David Ludwig, MD, PhD, #1 New York Times–bestselling author Do you know exactly how and why you age? And what you can do—whatever your current age—to slow that process and have a longer, healthier life? In The Longevity Code, medical doctor Kris Verburgh illuminates the biological mechanisms that make our bodies susceptible to heart attacks, dementia, diabetes, and other aging-related diseases. With the facts laid out, he provides the tools we need to slow down the aging process. His scientifically backed Longevity Staircase outlines a simple yet innovative step-by-step method offering better health and a longer life span– especially the crucial role of proper nutrition and exercise. But diet and exercise might not be the only way to crack the “longevity code”: With each passing day, advances in biotechnology that were once the stuff of science fiction are emerging. Dr. Verburgh discusses how new types of vaccines, mitochondrial DNA, CRISPR proteins, and stem cells may help us slow and even reverse aging—now and in the future—and when paired with the right lifestyle, lead to longer, healthier lives than we’ve ever imagined. “Verburgh examines how we age and takes a valuable look at ethical issues surrounding the prevention of aging.” —Library Journal

Mild Stress and Healthy Aging

Eric Le Bourg,Suresh I.S. Rattan
Mild Stress and Healthy Aging Book PDF

Author : Eric Le Bourg,Suresh I.S. Rattan
Publisher : Springer Science & Business Media
Page : 188 pages
File Size : 51,6 Mb
Release : 2008-01-24
Category : Medical
ISBN : 9781402068690

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Mild Stress and Healthy Aging by Eric Le Bourg,Suresh I.S. Rattan Pdf

Whereas chronic stress has well known harmful effects, recent research shows that intermittent exposure of cells and organisms to mild stress can improve various biological parameters. This book brings together some of the world leaders in this area of research who present a critical analysis of the ongoing research with respect to the effects and mechanisms of action of various types of mild stress. Novel approaches to improving health and longevity are introduced.

Explaining Health Across the Sciences

Jonathan Sholl,Suresh I.S. Rattan
Explaining Health Across the Sciences Book PDF

Author : Jonathan Sholl,Suresh I.S. Rattan
Publisher : Springer
Page : 555 pages
File Size : 46,6 Mb
Release : 2021-08-29
Category : Medical
ISBN : 3030526658

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Explaining Health Across the Sciences by Jonathan Sholl,Suresh I.S. Rattan Pdf

This edited volume aims to better understand the multifaceted phenomenon we call health. Going beyond simple views of health as the absence of disease or as complete well-being, this book unites scientists and philosophers. The contributions clarify the links between health and adaptation, robustness, resilience, or dynamic homeostasis, and discuss how to achieve health and healthy aging through practices such as hormesis. The book is divided into three parts and a conclusion: the first part explains health from within specific disciplines, the second part explores health from the perspective of a bodily part, system, function, or even the environment in which organisms live, and the final part looks at more clinical or practical perspectives. It thereby gathers, across 30 chapters, diverse perspectives from the broad fields of evolutionary and systems biology, immunology, and biogerontology, more specific areas such as odontology, cardiology, neurology, and public health, as well as philosophical reflections on mental health, sexuality, authenticity and medical theories. The overarching aim is to inform, inspire and encourage intellectuals from various disciplines to assess whether explanations in these disparate fields and across biological levels can be sufficiently systematized and unified to clarify the complexity of health. It will be particularly useful for medical graduates, philosophy graduates and research professionals in the life sciences and general medicine, as well as for upper-level graduate philosophy of science students.

The Longevity Seekers

Ted Anton
The Longevity Seekers Book PDF

Author : Ted Anton
Publisher : University of Chicago Press
Page : 224 pages
File Size : 45,9 Mb
Release : 2013-05-01
Category : Science
ISBN : 9780226020952

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The Longevity Seekers by Ted Anton Pdf

People have searched for the fountain of youth everywhere from Bimini to St. Augustine. But for a steadfast group of scientists, the secret to a long life lies elsewhere: in the lowly lab worm. By suppressing the function of just a few key genes, these scientists were able to lengthen worms’ lifespans up to tenfold, while also controlling the onset of many of the physical problems that beset old age. As the global population ages, the potential impact of this discovery on society is vast—as is the potential for profit. With The Longevity Seekers, science writer Ted Anton takes readers inside this tale that began with worms and branched out to snare innovative minds from California to Crete, investments from big biotech, and endorsements from TV personalities like Oprah and Dr. Oz. Some of the research was remarkable, such as the discovery of an enzyme in humans that stops cells from aging. And some, like an oft-cited study touting the compound resveratrol, found in red wine—proved highly controversial, igniting a science war over truth, credit, and potential profit. As the pace of discovery accelerated, so too did powerful personal rivalries and public fascination, driven by the hope that a longer, healthier life was right around the corner. Anton has spent years interviewing and working with the scientists at the frontier of longevity science, and this book offers a behind-the-scenes look at the state-of-the-art research and the impact it might have on global public health, society, and even our friends and family. With spectacular science and an unforgettable cast of characters, The Longevity Seekers has all the elements of a great story and sheds light on discoveriesthat could fundamentally reshape human life.

Calorie Restriction, Aging and Longevity

Arthur V. Everitt,Suresh I. S. Rattan,David G. Couteur,Rafael de Cabo
Calorie Restriction Aging and Longevity Book PDF

Author : Arthur V. Everitt,Suresh I. S. Rattan,David G. Couteur,Rafael de Cabo
Publisher : Springer Science & Business Media
Page : 323 pages
File Size : 48,8 Mb
Release : 2010-06-14
Category : Medical
ISBN : 9048185564

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Calorie Restriction, Aging and Longevity by Arthur V. Everitt,Suresh I. S. Rattan,David G. Couteur,Rafael de Cabo Pdf

Food or calorie restriction has been shown in many short-lived animals and the rhesus monkey to prolong life-span. Life-long nutrition studies are not possible in humans because of their long survival. Studies over two to six years in healthy adult humans have, however, shown that a 20% reduction in food or calorie intake slows many indices of normal and disease-related aging. Thus, it is widely believed that long-term reduction in calorie or food intake will delay the onset of age-related diseases such as heart disease, diabetes and cancer, and so prolong life. Over the last 20 or more years there has been a progressive rise in food intake in many countries of the world, accompanied by a rising incidence of obesity. Thus our increasing food and calorie intake has been linked to the rising incidence of cardiovascular disease and diabetes in early adult life. It is accepted that overeating, accompanied by reduced physical exercise, will lead to more age-related diseases and shortening of life-span. The answer is to reduce our calorie intake, improve our diet, and exercise more. But calorie restriction is extremely difficult to maintain for long periods. How then can we solve this problem? Edited by a team of highly distinguished academics, this book provides the latest information on the beneficial effects of calorie restriction on health and life-span. This book brings us closer to an understanding at the molecular, cellular and whole organism level of the way forward.

Nutrition, Food and Diet in Ageing and Longevity

Suresh I. S. Rattan,Gurcharan Kaur
Nutrition Food and Diet in Ageing and Longevity Book PDF

Author : Suresh I. S. Rattan,Gurcharan Kaur
Publisher : Springer Nature
Page : 643 pages
File Size : 46,7 Mb
Release : 2021-10-03
Category : Family & Relationships
ISBN : 9783030830175

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Nutrition, Food and Diet in Ageing and Longevity by Suresh I. S. Rattan,Gurcharan Kaur Pdf

This edited volume is a compilation of 30 articles discussing what constitutes food for health and longevity. The aim is to provide up-to-date information, insights, and future tendencies in the ongoing scientific research about nutritional components, food habits and dietary patterns in different cultures. The health-sustaining and health-promoting effects of food are certainly founded in its overall composition of macronutrients and micronutrients. However, the consumption of these nutrients is normally in the form of raw or prepared food from the animal and plant sources. The book is divided into four parts and a conclusion, and successfully convenes the well-established information and knowledge, along with the personal views of a diversified group of researchers and academicians on the multifaceted aspects of nutrition, food and diet. The first part reviews the scientific information about proteins, carbohydrates, fats and oils, micronutrients, pro- and pre-biotics, and hormetins, along with a discussion of the evolutionary principles and constraints about what is optimal food, if any. The second part discusses various kinds of foods and food supplements with respect to their claimed benefits for general health and prevention of some diseases. The third part brings in the cultural aspects, such as what are the principles of healthy eating according to the traditional Chinese and Indian systems, what is the importance of mealing times and daily rhythms, and how different cultures have developed different folk wisdoms for eating for health, longevity and immortality. In the part four, various approaches which are either already in practice or are still in the testing and research phases are discussed and evaluated critically, for example intermittent fasting and calorie restriction, food-based short peptides, senolytics, Ayurvedic compounds, optimal food for old people, and food for the prevention of obesity and other metabolic disorders. The overreaching aim of this book is to inform, inspire and encourage students, researchers, educators and medical health professionals thinking about food and food habits in a holistic context of our habits, cultures and patterns. Food cannot be reduced to a pill of nutritional components. Eating food is a complex human behavior culturally evolved over thousands of years. Perhaps the old adage “we are what we eat” needs to be modified to “we eat what we are”.

Age Later

Nir Barzilai, M.D.
Age Later Book PDF

Author : Nir Barzilai, M.D.
Publisher : St. Martin's Press
Page : 320 pages
File Size : 49,6 Mb
Release : 2020-06-16
Category : Health & Fitness
ISBN : 9781250230867

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Age Later by Nir Barzilai, M.D. Pdf

How do some people avoid the slowing down, deteriorating, and weakening that plagues many of their peers decades earlier? Are they just lucky? Or do they know something the rest of us don’t? Is it possible to grow older without getting sicker? What if you could look and feel fifty through your eighties and nineties? Founder of the Institute for Aging Research at the Albert Einstein College of Medicine and one of the leading pioneers of longevity research, Dr. Nir Barzilai’s life’s work is tackling the challenges of aging to delay and prevent the onset of all age-related diseases including “the big four”: diabetes, cancer, heart disease, and Alzheimer’s. One of Dr. Barzilai’s most fascinating studies features volunteers that include 750 SuperAgers—individuals who maintain active lives well into their nineties and even beyond—and, more importantly, who reached that ripe old age never having experienced cardiovascular disease, cancer, diabetes, or cognitive decline. In Age Later, Dr. Barzilai reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process. This eye-opening and inspirational book will help you think of aging not as a certainty, but as a phenomenon—like many other diseases and misfortunes—that can be targeted, improved, and even cured.

Successful Ageing

Clemens Tesch-Römer,Hans-Werner Wahl,Suresh I. S. Rattan,Liat Ayalon
Successful Ageing Book PDF

Author : Clemens Tesch-Römer,Hans-Werner Wahl,Suresh I. S. Rattan,Liat Ayalon
Publisher : Oxford University Press
Page : 129 pages
File Size : 43,6 Mb
Release : 2021-10-29
Category : Gerontology
ISBN : 9780192897534

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Successful Ageing by Clemens Tesch-Römer,Hans-Werner Wahl,Suresh I. S. Rattan,Liat Ayalon Pdf

This book argues that a narrow policy on successful ageing excludes a large portion of ageing individuals from the quest for a good life in old age. It explores various models defining successful ageing and argues that successful ageing in guiding policy will profit by following a pluralistic and holistic view.

Dietary Phytochemicals

Chukwuebuka Egbuna,Sadia Hassan
Dietary Phytochemicals Book PDF

Author : Chukwuebuka Egbuna,Sadia Hassan
Publisher : Springer Nature
Page : 262 pages
File Size : 45,6 Mb
Release : 2021-08-20
Category : Science
ISBN : 9783030729998

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Dietary Phytochemicals by Chukwuebuka Egbuna,Sadia Hassan Pdf

This book presents comprehensive coverage on the importance of good nutrition in the treatment and management of obesity, cancer and diabetes. Naturally occurring bioactive compounds are ubiquitous in most dietary plants available to humans and provide opportunities for the management of diseases. The text provides information about the major causes of these diseases and their association with nutrition. The text also covers the role of dietary phytochemicals in drug development and their pathways. Later chapters emphasize novel bioactive compounds as anti-diabetic, anti-cancer and anti-obesity agents and describe their mechanisms to regulate cell metabolism. Written by global team of experts, Dietary Phytochemicals: A Source of Novel Bioactive Compounds for the Treatment of Obesity, Cancer and Diabetes describes the potentials of novel phytochemicals, their sources, and underlying mechanism of action. The chapters were drawn systematically and incorporated sequentially to facilitate proper understanding. This book is intended for nutritionists, physicians, medicinal chemists, drug developers in research and development, postgraduate students and scientists in area of nutrition and life sciences.

How Not to Age

Michael Greger, M.D., FACLM
How Not to Age Book PDF

Author : Michael Greger, M.D., FACLM
Publisher : Flatiron Books
Page : 860 pages
File Size : 49,8 Mb
Release : 2023-12-05
Category : Health & Fitness
ISBN : 9781250796325

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How Not to Age by Michael Greger, M.D., FACLM Pdf

Instant New York Times Bestseller Uncover the evidence-based science to slowing the effects of aging, from the New York Times bestselling author of the How Not to Die series When Dr. Michael Greger, founder of NutritionFacts.org, dove into the top peer-reviewed anti-aging medical research, he realized that diet could regulate every one of the most promising strategies for combating the effects of aging. We don’t need Big Pharma to keep us feeling young—we already have the tools. In How Not to Age, the internationally renowned physician and nutritionist breaks down the science of aging and chronic illness and explains how to help avoid the diseases most commonly encountered in our journeys through life. Physicians have long treated aging as a malady, but getting older does not have to mean getting sicker. There are eleven pathways for aging in our bodies’ cells and we can disrupt each of them. Processes like autophagy, the upcycling of unusable junk, can be boosted with spermidine, a compound found in tempeh, mushrooms, and wheat germ. Senescent “zombie” cells that spew inflammation and are linked to many age-related diseases may be cleared in part with quercetin-rich foods like onions, apples, and kale. And we can combat effects of aging without breaking the bank. Why spend a small fortune on vitamin C and nicotinamide facial serums when you can make your own for up to 2,000 times cheaper? Inspired by the dietary and lifestyle patterns of centenarians and residents of “blue zone” regions where people live the longest, Dr. Greger presents simple, accessible, and evidence-based methods to preserve the body functions that keep you feeling youthful, both physically and mentally. Brimming with expertise and actionable takeaways, How Not to Age lays out practical strategies for achieving ultimate longevity.

Cracking the Aging Code

Josh Mitteldorf,Dorion Sagan
Cracking the Aging Code Book PDF

Author : Josh Mitteldorf,Dorion Sagan
Publisher : Flatiron Books
Page : 320 pages
File Size : 42,7 Mb
Release : 2016-06-14
Category : Science
ISBN : 9781250061720

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Cracking the Aging Code by Josh Mitteldorf,Dorion Sagan Pdf

A revolutionary examination of why we age, what it means for our health, and how we just might be able to fight it. In Cracking the Aging Code, theoretical biologist Josh Mitteldorf and award-winning writer and ecological philosopher Dorion Sagan reveal that evolution and aging are even more complex and breathtaking than we originally thought. Using meticulous multidisciplinary science, as well as reviewing the history of our understanding about evolution, this book makes the case that aging is not something that “just happens,” nor is it the result of wear and tear or a genetic inevitability. Rather, aging has a fascinating evolutionary purpose: to stabilize populations and ecosystems, which are ever-threatened by cyclic swings that can lead to extinction. When a population grows too fast it can put itself at risk of a wholesale wipeout. Aging has evolved to help us adjust our growth in a sustainable fashion as well as prevent an ecological crisis from starvation, predation, pollution, or infection. This dynamic new understanding of aging is provocative, entertaining, and pioneering, and will challenge the way we understand aging, death, and just what makes us human.