Human Basophils And Mast Cells

Author : Gianni Marone
Publisher : S. Karger AG (Switzerland)
Page : 290 pages
File Size : 42,8 Mb
Release : 1995
Category : Basophils
ISBN : PURD:32754065281549

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Human Basophils and Mast Cells by Gianni Marone Pdf

"Expert contributions cover disorders, such as mastocytosis and respiratory and cutaneous allergy, which are known to be associated with these cells. The less well-known involvement of the latter in atherosclerosis and gastrointestinal, cardiac, rheumatic and neoplastic diseases is emerging as an area of considerable interest as several informative chapters show. Written by clinical investigators specialising in diseases related to mast cells and basophils, this volume will be stimulating reading for those working in allergy, immunology, biochemistry, and respiration."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved

Author : Gianni Marone,Lawrence M. Lichtenstein,Federica J. Galli
Publisher : Academic Press
Page : 738 pages
File Size : 48,9 Mb
Release : 2000-05-25
Category : Medical
ISBN : 9780080535852

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Mast Cells and Basophils by Gianni Marone,Lawrence M. Lichtenstein,Federica J. Galli Pdf

Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.

Author : Ann M. Dvorak
Publisher : Springer Science & Business Media
Page : 418 pages
File Size : 45,5 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781475795257

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Basophil and Mast Cell Degranulation and Recovery by Ann M. Dvorak Pdf

Basophils and mast cells are similar but unique secretory cells with a well-documented role in immediate-hypersensitivity reactions. The presence of these cells in various cell mediated hypersensitivity reactions, in tissues of multiple diseases, and as a component of the host reaction to injury and repair in numerous circumstances is well known. Release of stored and newly generated mediators of inflammation from basophils and mast cells contributes to the cascade of pathogenetic events in circumstances under which these release reactions occur. Despite insights acquired through studies of these pathologic events, the role of basophils and mast cells and their secretory products in health is not known. In this book, I review much of the structural information regarding basophils and mast cells of multiple species. Ultrastructural studies of rat mast cells historically precede and quantitatively exceed similar studies of basophils and mast cells of other species. Therefore, I first review these background studies as an entity. Then I discuss the contents of two prominent organelles-granules and lipid bodies-in basophils and mast cells of several species. The ultrastructural morphology of basophils and mast cells in three species is presented in detail to establish appropriate guidelines for their recognition and to provide general rules for analysis which are appropriate for the identification of these cells in other species as well.

Author : Gianni Marone
Publisher : Unknown
Page : 264 pages
File Size : 53,9 Mb
Release : 1995
Category : Basophils
ISBN : PURD:32754065290516

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Human Basophils and Mast Cells by Gianni Marone Pdf

Author : Bernhard F. Gibbs,Franco H. Falcone
Publisher : Springer Nature
Page : 379 pages
File Size : 49,8 Mb
Release : 2020-08-06
Category : Medical
ISBN : 9781071606964

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Basophils and Mast Cells by Bernhard F. Gibbs,Franco H. Falcone Pdf

This second edition provides updated and new chapters to build on and extend the strengths of the first edition. Chapters guide readers through basic biology of basophils, obtaining the cells by purification, culture of stem cells progenitors, peripheral CD34+ stem cell-derived mast cells, basophils from CD34+ progenitors, diagnostic applications, gene expression patterns in basophils, roles of basophils in different asthma phenotypes, knockout, and disease models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Basophils and Mast Cells: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

Author : Ehud Razin,Juan Rivera
Publisher : Springer Science & Business Media
Page : 438 pages
File Size : 48,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461221548

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Signal Transduction in Mast Cells and Basophils by Ehud Razin,Juan Rivera Pdf

Focussing on the molecular mechanisms that govern mast cell and basophil cell biology and function, this book also provides a comprehensive summary of the field of signal transduction, giving insights into areas that have therapeutic potential. It gives detailed insights into mast cell and basophil growth and development, their activation by allergens, including details of receptor activation and downstream events, and the regulators of morphology and degranulation. The metabolic pathways involved in prostaglandin and leukotriene production are discussed as is the role of transcription factors in mast cell growth and cytokine production. Written by leaders in the field, this volume will provide readers with an up-to-date account of a topic whose rapid progress makes conventional information gathering difficult.

Author : Ann M. Dvorak
Publisher : Karger Medical and Scientific Publishers
Page : 377 pages
File Size : 55,8 Mb
Release : 2005-01-01
Category : Medical
ISBN : 9783805578646

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Ultrastructure of Mast Cells and Basophils by Ann M. Dvorak Pdf

In this book, the author reviews the ultrastructural studies of basophils and mast cells performed since the publication of an earlier monograph in 1991. These studies include the use of ultrastructural rules that allow identification of basophils and mast cells in new circumstances. Including more than 180 excellent micrographs, this book will be of interest to basic scientists in immunology, cell biology, secretion and angiogenesis research, and histochemistry. As mast cells and basophils play a crucial role in various diseases, it will be essential reading for allergists, immunologists, dermatologists, hematologists, gastroenterologists, rheumatologists, neurologists, pathologists, pulmonologists, and cardiologists.

Author : Derek J. Chadwick,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 274 pages
File Size : 42,5 Mb
Release : 2006-01-04
Category : Medical
ISBN : 9780470030516

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Mast Cells and Basophils by Derek J. Chadwick,Jamie A. Goode Pdf

The book presents recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and basophils; discussion of new technologies used to study these cells, and integration of the basic scientific findings in the context of therapeutic possibilities for the treatment of diseases such as allergic inflammation and autoimmune disease which are mediated, in part, by these granulocytes.

Author : G. Mardne
Publisher : Unknown
Page : 470 pages
File Size : 44,7 Mb
Release : 1995-04-30
Category : Electronic
ISBN : 3805561296

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Chemical Immunology by G. Mardne Pdf

Author : Stephen T. Holgate
Publisher : Springer Science & Business Media
Page : 293 pages
File Size : 55,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400912878

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Mast Cells, Mediators and Disease by Stephen T. Holgate Pdf

In 1879 Paul Ehrlich first described the mast cell as a tissue fixed cell contain ing many granules which, when stained with basic dyes, such as toluidine blue, changed the colour spectrum of the dye in a process called meta chromasia. Since this early description, pathologists, physicians and pharmacologists have been fascinated by this cell on account of its central involvement in human allergic diseases. Approximately four decades after Ehrlich's first description of the mast cell, Prausnitz and Kiistner reported their pioneer experiment, demonstrating that the immediate skin wheal response to allergen could be passively transferred with serum. They named the antigen-specific serum factor reagin. A further four and one half decades had to pass before the connection between the mast cell and reagin could be made with the identification of reagin as an immunoglobulin E by Johansson and Ishizaka and its unique property to bind with high affinity to specific receptors on mast cells and basophils. Meanwhile in the 1920s Coca published a series of papers in which he described the clinical features of acute allergic responses and first used the term atopy. This, together with the fundamental pharmacological studies of Sir Henry Dale in identifying histamine as one mediator of the acute ana phylactic reaction, provided the second approach which eventually linked the mast cell to allergic tissue reactions. Indeed, it was Best, working in Dale's group who first showed that histamine was a chemical stored in mast cells.

Author : Judah A. Denburg
Publisher : Springer Science & Business Media
Page : 589 pages
File Size : 44,7 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9781475727760

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Allergy and Allergic Diseases by Judah A. Denburg Pdf

Allergy and Allergic Diseases has been organized to provide an up-to-date, clinically relevant compilation of one of the most exciting areas of investigation in medicine today-allergic disease, especially as it pertains to the skin, airways, and bowel. With the dramatic rise in the incidence of various allergic disorders worldwide, and the coming of age of the discipline of Clinical Immunology and Allergy, the interface between basic and clinical science in this arena demands highlighting in this comprehensive new syn thesis.1t is with the hope of filling this evident need that Allergy and Allergic Diseases: The New Mechanisms and Therapeutics has been put together. The book's content is divided into both basic and clinical sections, with emphasis on various components of the immune and inflammatory response as they relate to the development of allergic disease. Topics span the range from molecular biology to clinical symptomatology, with an effort to make this of interest to as broad a constituency as possible. This book will therefore be of substantial interest to specialists in Clinical Immunology and Allergy, scientists studying the cellular and molecular biology of in flammation and immunity, as well as internists, teachers, developers of medical school curricula, and members of industry focused on drug discovery and therapeutics. Indeed, a separate section has been added to deal with some specific issues in this latter field.

Author : John C. Foreman
Publisher : Academic Press
Page : 264 pages
File Size : 41,8 Mb
Release : 1993-11-29
Category : Medical
ISBN : UOM:39015032906821

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Immunopharmacology of Mast Cells and Basophils by John C. Foreman Pdf

There has been a steady and continued research effort directed to understanding both the function and the role of mast cells and basophils ever since these cells were first described at the end of the nineteenth century. One of the most significant advances has perhaps been the appreciation of the fact that mast cells do not represent a single homogenous population of cells: they display heterogeneity at the morphological, biochemical and functional levels. The one characteristic that unites all types of mast cells and basophils appears to be the possession of the high affinity membrane receptor for immunoglobulin E, through which the cells may be stimulated. This volume begins with a review of the origin and development of mast cells and basophils. It continues by reviewing our knowledge of the stimuli to mast cells and basophils and the biochemical mechanisms which link the signal generated by stimulus to the response machinery of the cell. Further chapters deal with the drug control of mast cell and basophil responses, the heterogeneity of the cells' functions and the mediators' release by the cells, along with the morphological aspects of the cells' function. This book is completed by a selection of examples which examine the role of the mast cells or basophils in lung, skin and gastrointestinal tract. However, the role of the mast cell with regard to normal physiology, remains an open question. This book aims to provide an up-to-date account of mast cell and basophil biology, together with an insight into the functional relevance of these cells in some tissue types.

Author : Stephen J. Galli,Karl Frank Austen
Publisher : Raven Press (ID)
Page : 376 pages
File Size : 44,5 Mb
Release : 1989
Category : Medical
ISBN : UOM:39015014484169

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Mast Cell and Basophil Differentiation and Function in Health and Disease by Stephen J. Galli,Karl Frank Austen Pdf

Author : Christophe Pellefigues,Hajime Karasuyama
Publisher : Frontiers Media SA
Page : 161 pages
File Size : 40,8 Mb
Release : 2023-11-07
Category : Medical
ISBN : 9782832538418

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The Fundamental Biology of Basophils in Health and Disease by Christophe Pellefigues,Hajime Karasuyama Pdf

Author : Ann M. Dvorak
Publisher : Springer Science & Business Media
Page : 173 pages
File Size : 41,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642741456

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Human Mast Cells by Ann M. Dvorak Pdf

This book looks in detail at human mast cells. It includes a review of previous and current ultrastructural studies, whereby the latter are illustrated with numerous high-quality electron micrographs obtained from a large number of structural and functional experiments using highly purified isolated human lung mast cells. Specifically, the book provides criteria for the identification of human mast cells, discusses the unique role in mast cell function of granules and lipid bodies, describes the ultrastructural anatomy of two release reactions - i.e., anaphylactic degranulation and piecemeal degranulation - and defines the recovery, cyclical and maturational properties of human mast cells. All of these new morphological-biochemical and functional studies are correlated with the author's wide experience in the visual properties of human mast cells as seen in biopsy material obtained from a diagnostic ultrastructural pathology service.