Signal Transduction In Mast Cells And Basophils

Author : Ehud Razin,Juan Rivera
Publisher : Springer Science & Business Media
Page : 438 pages
File Size : 42,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461221548

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Signal Transduction in Mast Cells and Basophils by Ehud Razin,Juan Rivera Pdf

Focussing on the molecular mechanisms that govern mast cell and basophil cell biology and function, this book also provides a comprehensive summary of the field of signal transduction, giving insights into areas that have therapeutic potential. It gives detailed insights into mast cell and basophil growth and development, their activation by allergens, including details of receptor activation and downstream events, and the regulators of morphology and degranulation. The metabolic pathways involved in prostaglandin and leukotriene production are discussed as is the role of transcription factors in mast cell growth and cytokine production. Written by leaders in the field, this volume will provide readers with an up-to-date account of a topic whose rapid progress makes conventional information gathering difficult.

Author : Gianni Marone,Lawrence M. Lichtenstein,Federica J. Galli
Publisher : Academic Press
Page : 738 pages
File Size : 42,7 Mb
Release : 2000-05-25
Category : Medical
ISBN : 9780080535852

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Mast Cells and Basophils by Gianni Marone,Lawrence M. Lichtenstein,Federica J. Galli Pdf

Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.

Author : Majed M. Hamawy
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 40,9 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9783662220221

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IgE Receptor (FcεRI) Function in Mast Cells and Basophils by Majed M. Hamawy Pdf

The high affinity IgE receptor (FceRI) plays a central role in allergic diseases including asthma, allergic rhinitis, atopic dermatitis, food and drug allergy. Manipulating the function of this receptor is important for controlling the onset of allergic diseases. Written by leading scientists in the field, this book is the first comprehensive monograph to cover various aspects of FceRI structure, signal transduction and function. Thus, the book is valuable for researchers/students working on FceRI and on other receptors. In addition, clinicians who are concerned with broadening their knowledge of the FceRI role in allergic diseases will find this book useful.

Author : Gianni Marone
Publisher : Unknown
Page : 264 pages
File Size : 42,6 Mb
Release : 1995
Category : Basophils
ISBN : PURD:32754065290516

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Human Basophils and Mast Cells by Gianni Marone Pdf

Author : Hirohisa Saito,Yoshimichi Okayama
Publisher : Karger Medical and Scientific Publishers
Page : 233 pages
File Size : 48,7 Mb
Release : 2005-01-01
Category : Medical
ISBN : 9783805579483

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Mast Cells in Allergic Diseases by Hirohisa Saito,Yoshimichi Okayama Pdf

In this book, the editors have focused on the roles of mast cells in allergic diseases and discuss the future direction of discovering drugs. Another implication of this book is to understand mast cells at the system level. System biology is a research category to understand biology at the system level by examining the structure and dynamics of cellular and organismal functions, rather than the characteristics of isolated parts of a cell or organism.

Author : Ann M. Dvorak
Publisher : Springer Science & Business Media
Page : 418 pages
File Size : 44,5 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781475795257

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Basophil and Mast Cell Degranulation and Recovery by Ann M. Dvorak Pdf

Basophils and mast cells are similar but unique secretory cells with a well-documented role in immediate-hypersensitivity reactions. The presence of these cells in various cell mediated hypersensitivity reactions, in tissues of multiple diseases, and as a component of the host reaction to injury and repair in numerous circumstances is well known. Release of stored and newly generated mediators of inflammation from basophils and mast cells contributes to the cascade of pathogenetic events in circumstances under which these release reactions occur. Despite insights acquired through studies of these pathologic events, the role of basophils and mast cells and their secretory products in health is not known. In this book, I review much of the structural information regarding basophils and mast cells of multiple species. Ultrastructural studies of rat mast cells historically precede and quantitatively exceed similar studies of basophils and mast cells of other species. Therefore, I first review these background studies as an entity. Then I discuss the contents of two prominent organelles-granules and lipid bodies-in basophils and mast cells of several species. The ultrastructural morphology of basophils and mast cells in three species is presented in detail to establish appropriate guidelines for their recognition and to provide general rules for analysis which are appropriate for the identification of these cells in other species as well.

Author : Derek J. Chadwick,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 274 pages
File Size : 42,6 Mb
Release : 2006-01-04
Category : Medical
ISBN : 9780470030516

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Mast Cells and Basophils by Derek J. Chadwick,Jamie A. Goode Pdf

The book presents recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and basophils; discussion of new technologies used to study these cells, and integration of the basic scientific findings in the context of therapeutic possibilities for the treatment of diseases such as allergic inflammation and autoimmune disease which are mediated, in part, by these granulocytes.

Author : Guha Krishnaswamy,David S. Chi
Publisher : Springer Science & Business Media
Page : 434 pages
File Size : 52,6 Mb
Release : 2008-02-04
Category : Medical
ISBN : 9781592599677

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Mast Cells by Guha Krishnaswamy,David S. Chi Pdf

A cutting-edge collection of readily reproducible techniques for the isolation, culture, and study of activation and signaling in human mast cells. These methods take advantage of the latest advances in molecular biology, technology, and information science. They include methods for the identification of mast cells, the development of mast cells in vitro, the study of mast cell signaling and gene expression, and the measurement of mast cell expression of inflammatory mediators. Additional chapters cover methods for studying mast cell interactions with other cell types (endothelial cells, fibroblasts, and B cells), the roles of mast cells in host defense, and mast cell apoptosis.

Author : John C. Foreman
Publisher : Academic Press
Page : 264 pages
File Size : 50,9 Mb
Release : 1993-11-29
Category : Medical
ISBN : UOM:39015032906821

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Immunopharmacology of Mast Cells and Basophils by John C. Foreman Pdf

There has been a steady and continued research effort directed to understanding both the function and the role of mast cells and basophils ever since these cells were first described at the end of the nineteenth century. One of the most significant advances has perhaps been the appreciation of the fact that mast cells do not represent a single homogenous population of cells: they display heterogeneity at the morphological, biochemical and functional levels. The one characteristic that unites all types of mast cells and basophils appears to be the possession of the high affinity membrane receptor for immunoglobulin E, through which the cells may be stimulated. This volume begins with a review of the origin and development of mast cells and basophils. It continues by reviewing our knowledge of the stimuli to mast cells and basophils and the biochemical mechanisms which link the signal generated by stimulus to the response machinery of the cell. Further chapters deal with the drug control of mast cell and basophil responses, the heterogeneity of the cells' functions and the mediators' release by the cells, along with the morphological aspects of the cells' function. This book is completed by a selection of examples which examine the role of the mast cells or basophils in lung, skin and gastrointestinal tract. However, the role of the mast cell with regard to normal physiology, remains an open question. This book aims to provide an up-to-date account of mast cell and basophil biology, together with an insight into the functional relevance of these cells in some tissue types.

Author : Ann M. Dvorak
Publisher : Karger Medical and Scientific Publishers
Page : 377 pages
File Size : 47,7 Mb
Release : 2005-01-01
Category : Medical
ISBN : 9783805578646

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Ultrastructure of Mast Cells and Basophils by Ann M. Dvorak Pdf

In this book, the author reviews the ultrastructural studies of basophils and mast cells performed since the publication of an earlier monograph in 1991. These studies include the use of ultrastructural rules that allow identification of basophils and mast cells in new circumstances. Including more than 180 excellent micrographs, this book will be of interest to basic scientists in immunology, cell biology, secretion and angiogenesis research, and histochemistry. As mast cells and basophils play a crucial role in various diseases, it will be essential reading for allergists, immunologists, dermatologists, hematologists, gastroenterologists, rheumatologists, neurologists, pathologists, pulmonologists, and cardiologists.

Author : Bernhard F. Gibbs,Franco H. Falcone
Publisher : Springer Nature
Page : 379 pages
File Size : 46,5 Mb
Release : 2020-08-06
Category : Medical
ISBN : 9781071606964

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Basophils and Mast Cells by Bernhard F. Gibbs,Franco H. Falcone Pdf

This second edition provides updated and new chapters to build on and extend the strengths of the first edition. Chapters guide readers through basic biology of basophils, obtaining the cells by purification, culture of stem cells progenitors, peripheral CD34+ stem cell-derived mast cells, basophils from CD34+ progenitors, diagnostic applications, gene expression patterns in basophils, roles of basophils in different asthma phenotypes, knockout, and disease models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Basophils and Mast Cells: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

Author : Gianni Marone
Publisher : S. Karger AG (Switzerland)
Page : 290 pages
File Size : 43,9 Mb
Release : 1995
Category : Basophils
ISBN : PURD:32754065281549

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Human Basophils and Mast Cells by Gianni Marone Pdf

"Expert contributions cover disorders, such as mastocytosis and respiratory and cutaneous allergy, which are known to be associated with these cells. The less well-known involvement of the latter in atherosclerosis and gastrointestinal, cardiac, rheumatic and neoplastic diseases is emerging as an area of considerable interest as several informative chapters show. Written by clinical investigators specialising in diseases related to mast cells and basophils, this volume will be stimulating reading for those working in allergy, immunology, biochemistry, and respiration."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved

Author : Majed M. Hamawy
Publisher : Unknown
Page : 292 pages
File Size : 46,8 Mb
Release : 1997-01-01
Category : Fc receptors
ISBN : 1570593809

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IGE Receptor (FceRI) Function in Mast Cells and Basophils by Majed M. Hamawy Pdf

Author : Ulrich Blank,Marc Benhamou
Publisher : Frontiers E-books
Page : 135 pages
File Size : 44,6 Mb
Release : 2014-03-20
Category : Electronic
ISBN : 9782889191864

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Deciphering new molecular mechanisms of mast cell activation by Ulrich Blank,Marc Benhamou Pdf

Mast cells are tissue-localized cells that play an important role in immunity and inflammation. Following an offensive event they act as cellular sensors that via the activation of cell surface receptors launch a cellular response culminating in the release of a whole set of inflammatory mediators and products. This response is initially destined to restore tissue homeostasis, but in case of chronic injury or deregulation also promotes pathology. To further understand the action of mast cells in their environmental context it is necessary to decipher the molecular mechanisms of their activation as well as the ensuing cellular responses. This will allow identification of new strategies to promote their beneficial actions or, at the contrary, to interfere with their pathological consequences. While in the past many studies have focused on responses engaged by high affinity IgE receptor because of its implication in the allergic response, it has become clear that mast cells can be activated by multiple types of receptors initiating an intense molecular crosstalk between receptors and signaling pathways that can either synergize, antagonize and in some cases produce new types of responses. Mast cells can indeed react with an astounding diverse array of cellular responses that sometimes are engaged selectively. This Research Topic will focus on selected articles that shed some new light on the molecular mechanisms of mast cell activation, the possible crosstalk between signaling pathways and the ensuing cellular responses that allow mast cells to act as cellular sensors in tissues.

Author : Stephen J. Galli,Karl Frank Austen
Publisher : Raven Press (ID)
Page : 376 pages
File Size : 47,5 Mb
Release : 1989
Category : Medical
ISBN : UOM:39015014484169

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Mast Cell and Basophil Differentiation and Function in Health and Disease by Stephen J. Galli,Karl Frank Austen Pdf