Human Polyomaviruses

Author : Nasimul Ahsan
Publisher : Springer Science & Business Media
Page : 383 pages
File Size : 55,5 Mb
Release : 2007-06-25
Category : Medical
ISBN : 9780387329574

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Polyomaviruses and Human Diseases by Nasimul Ahsan Pdf

Science never solves apr oblem without creating ten more Geor ge Bernard Shaw How prophetic the above words prove to be when applied to the advances of 20th century medicine. Prior to Banting and Best, chnicians were unaware of the ravages of diabetes, patients simply wasted away and died. Following the purifica tion of insulin, clinicians now had to deal with diabetic retinopathy, diabetic neph ropathy and all the other complications of long-term diabetes. A little over 50 years ago, the first successful human kidney transplant was performed in Boston. The first 30 years of the experience had successes when compared to the alternative but were a constant struggle to get even 50% of the grafts from deceased donors to survive more than a year. However, the science continued to advance knowledge of the immune response. With this came more and increasingly powerful tools for the clinician. Suddenly, success rates of 80-90% at one year were attainable. With this success came new problems, new complications and clinicians now had to worry about the long-term consequences of their therapy as patients were surviving with functional grafts for extended periods. A particular infectious complication evolved with the application of ever more powerful immunosuppressant drugs. Astute clinicians noted that occasionally cellular rejections seemed to get worse with steroids. Despite their best efforts and the use of powerful drugs, patients lost their grafts to overwhelming interstitial infiltrates not seen before.

Author : Kamel Khalili,Gerald L. Stoner
Publisher : John Wiley & Sons
Page : 714 pages
File Size : 47,5 Mb
Release : 2004-03-24
Category : Science
ISBN : 9780471461029

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Human Polyomaviruses by Kamel Khalili,Gerald L. Stoner Pdf

Human Polyomaviruses Molecular and Clinical perspectives Edited by Kamel Khalili and Gerald L. Stoner Our understanding of human polyomaviruses has evolved profoundly in the last fifteen years, creating an urgent need for an updated resource. Drs. Khalili and Stoner have collected the contributions of renowned researchers and clinicians in this cutting-edge volume. Human Polyomaviruses: Molecular and Clinical Perspectives presents in-depth analyses, comprehensive reviews, and timely assessments of recent discoveries and ongoing controversies focused on these important viral pathogens. Beginning with an historical perspective, this book covers up-to-date investigations into the molecular biology and pathogenesis of human polyomaviruses. All aspects of these persistent infections are subsequently covered, including clinical issues, from diagnosis to information on treatment and drug trials. Central topics are: BK virus JC virus Simian virus 40 (SV40) and its potential as a human pathogen Progressive multifocal leukoencephalopathy (PML) This reference is a superb indoctrination for graduate students, medical students, high-level undergraduates, and anyone engaged in the study of DNA viruses and their molecular biology, evolution, transmission, and pathological potential.

Author : Ugo Moens,Marijke Van Gheule,Mona Johannessen
Publisher : Nova Science Pub Incorporated
Page : 95 pages
File Size : 47,6 Mb
Release : 2009
Category : Medical
ISBN : 1606928120

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Human Polyomaviruses by Ugo Moens,Marijke Van Gheule,Mona Johannessen Pdf

Human polyomaviruses are non-enveloped viruses with a circular double-stranded DNA genome of approximately 5,000 base pairs. The members BK virus and JC virus were first isolated in 1971 and are very common in the human population. Simian virus 40 (SV40), although originally isolated from rhesus macaques and accidentally introduced in the human population during massive poliovirus vaccination, may represent a third member of the polyomaviruses that can have man as a natural host. Primary infection with BK or/and JC virus occurs during early childhood. Subsequently, these viruses establish a seemingly life-long harmless latent infection. However, virus reactivation can occur especially in immunocompromised individuals and JC virus has been recognised as the cause of progressive multifocal leukoencephalopathy, while BK virus-associated interstitial nephritis has become an emerging complication in renal transplant patients. The genomes of human polyomaviruses encode two functional classes of proteins: the regulatory proteins large T-antigen, small t-antigen, and agnoprotein, and the structural proteins VP1, VP2 and VP3 that form the capsid. The regulatory proteins can modulate the expression and/or activity of cellular proteins involved in signal transduction, cell cycle regulation, and chromosomal functions. Therefore, they all possess oncogenic potential. Consistent with this, human polyomaviruses are capable of transforming human cells and inducing tumours in rodents, and are implicated in human malignancies. This book focuses on the etiological role of human polyomaviruses in cancer and highlights the mechanisms by which the viral regulatory proteins may contribute to neoplastic transformation of the infected host cells. Possible therapeutic strategies against these viruses will also be discussed.

Author : Ugo Moens
Publisher : MDPI
Page : 197 pages
File Size : 42,8 Mb
Release : 2018-09-21
Category : Electronic books
ISBN : 9783038972204

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Human Polyomaviruses and Papillomaviruses by Ugo Moens Pdf

This book is a printed edition of the Special Issue "Human Polyomaviruses and Papillomaviruses" that was published in IJMS

Author : John L. Sever,David Larry Madden
Publisher : Alan R. Liss
Page : 410 pages
File Size : 49,5 Mb
Release : 1983
Category : Medical
ISBN : UOM:39015004349505

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Polyomaviruses and Human Neurological Disease by John L. Sever,David Larry Madden Pdf

Author : Wang-Shick Ryu
Publisher : Academic Press
Page : 440 pages
File Size : 40,6 Mb
Release : 2016-03-30
Category : Science
ISBN : 9780128009994

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Molecular Virology of Human Pathogenic Viruses by Wang-Shick Ryu Pdf

Molecular Virology of Human Pathogenic Viruses presents robust coverage of the key principles of molecular virology while emphasizing virus family structure and providing key context points for topical advances in the field. The book is organized in a logical manner to aid in student discoverability and comprehension and is based on the author’s more than 20 years of teaching experience. Each chapter will describe the viral life cycle covering the order of classification, virion and genome structure, viral proteins, life cycle, and the effect on host and an emphasis on virus-host interaction is conveyed throughout the text. Molecular Virology of Human Pathogenic Viruses provides essential information for students and professionals in virology, molecular biology, microbiology, infectious disease, and immunology and contains outstanding features such as study questions and recommended journal articles with perspectives at the end of each chapter to assist students with scientific inquiries and in reading primary literature. Presents viruses within their family structure Contains recommended journal articles with perspectives to put primary literature in context Includes integrated recommended reading references within each chapter Provides access to online ancillary package inclusive of annotated PowerPoint images, instructor’s manual, study guide, and test bank

Author : Anonim
Publisher : ScholarlyEditions
Page : 49 pages
File Size : 43,6 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464905711

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Polyomavirus: New Insights for the Healthcare Professional: 2011 Edition by Anonim Pdf

Polyomavirus: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Polyomavirus in a concise format. The editors have built Polyomavirus: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Polyomavirus in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Polyomavirus: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Ugo Moens
Publisher : Unknown
Page : 95 pages
File Size : 45,8 Mb
Release : 2009
Category : HEALTH & FITNESS
ISBN : 1614700583

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Human Polyomaviruses by Ugo Moens Pdf

Author : Joseph Domachowske,Manika Suryadevara
Publisher : Springer Nature
Page : 357 pages
File Size : 43,7 Mb
Release : 2020-08-05
Category : Medical
ISBN : 9783030508739

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Clinical Infectious Diseases Study Guide by Joseph Domachowske,Manika Suryadevara Pdf

This book is meticulously designed for the busy student, trainee, or seasoned physician looking to enhance or refresh skills in infectious diseases. It is intended to provide a solid resource for students and physicians in need of a concise yet comprehensive background of the material. Each chapter begins with a summary of the topic, a brief case description, definitions, critical teaching points, and tables, figures, photos, and other visual materials to reinforce learning. The chapters take a systems based approach to infections before concluding with the essentials of diagnostic microbiology to leave users with a practical toolkit for real-world clinics. Authored by two expert educators and dual infectious diseases and pediatrics specialists, Clinical Infectious Diseases Study Guide is the only updated study guide designed for medical students, fellows, residents, and trainees who need a strong foundation in infectious diseases. This includes infectious disease specialists in both adult and pediatric care, various internal medicine subspecialists, and hospitalists.

Author : Christopher J. Burrell,Colin R. Howard,Frederick A. Murphy
Publisher : Academic Press
Page : 604 pages
File Size : 51,9 Mb
Release : 2016-11-09
Category : Science
ISBN : 9780123751577

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Fenner and White's Medical Virology by Christopher J. Burrell,Colin R. Howard,Frederick A. Murphy Pdf

Fenner and White's Medical Virology, Fifth Edition provides an integrated view of related sciences, from cell biology, to medical epidemiology and human social behavior. The perspective represented by this book, that of medical virology as an infectious disease science, is meant to provide a starting point, an anchor, for those who must relate the subject to clinical practice, public health practice, scholarly research, and other endeavors. The book presents detailed exposition on the properties of viruses, how viruses replicate, and how viruses cause disease. These chapters are then followed by an overview of the principles of diagnosis, epidemiology, and how virus infections can be controlled. The first section concludes with a discussion on emergence and attempts to predict the next major public health challenges. These form a guide for delving into the specific diseases of interest to the reader as described in Part II. This lucid and concise, yet comprehensive, text is admirably suited to the needs of not only advanced students of science and medicine, but also postgraduate students, teachers, and research workers in all areas of virology. Features updated and expanded coverage of pathogenesis and immunity Contains the latest laboratory diagnostic methods Provides insights into clinical features of human viral disease, vaccines, chemotherapy, epidemiology, and control

Author : International Agency for Research on Cancer
Publisher : IARC Monographs on the Evaluat
Page : 0 pages
File Size : 49,6 Mb
Release : 2015-03-31
Category : Medical
ISBN : 9283213270

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Malaria and Some Polyomaviruses (SV40, BK, JC, and Merkel Cell Viruses) by International Agency for Research on Cancer Pdf

This volume of the IARC Monographs provides evaluations of malaria (a disease caused by infection with Plasmodium parasites) and four polyomaviruses--simian virus 40 (SV40), and BK, JC and Merkel cell viruses. The global burden of malaria is enormous, with about 50% of the world's population at risk. In regions where malaria is highly endemic (holoendemic), such as sub-Saharan Africa and Papua New Guinea, a role for malaria has long been suspected in the etiology of endemic Burkitt lymphoma, which in these regions represents up to 70% of childhood cancers. In the 1950s and early 1960s, millions of people worldwide received vaccines against poliovirus that were contaminated with SV40, a polyomavirus whose natural host is the rhesus macaque. Infection with human polyomaviruses is widespread in the general population, with the proportion of adults infected ranging from 50% to more than 90% worldwide. BK and JC viruses, first isolated in 1971, are naturally human-tropic polymaviruses that are responsible for rare, lethal, nonmalignant diseases in immunosuppressed people. Merkel cell virus was discovered in 2008 in a rare skin cancer in humans. An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard to humans of these infections. -- Back cover.

Author : Institute of Medicine,Board on Health Promotion and Disease Prevention,Immunization Safety Review Committee
Publisher : National Academies Press
Page : 118 pages
File Size : 42,9 Mb
Release : 2003-12-26
Category : Medical
ISBN : 9780309086103

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Immunization Safety Review by Institute of Medicine,Board on Health Promotion and Disease Prevention,Immunization Safety Review Committee Pdf

The Immunization Safety Review Committee was established by the Institute of Medicine (IOM) to evaluate the evidence on possible causal associations between immunizations and certain adverse outcomes, and to then present conclusions and recommendations. The committee's mandate also includes assessing the broader societal significance of these immunization safety issues. While all the committee members share the view that immunization is generally beneficial, none of them has a vested interest in the specific immunization safety issues that come before the group. The committee reviews three immunization safety review topics each year, addressing each one at a time. In this fifth report in a series, the committee examines the hypothesis that exposure to polio vaccine contaminated with simian virus 40 (SV40), a virus that causes inapparent infection in some monkeys, can cause certain types of cancer.

Author : Arie J. Zuckerman,Jangu E. Banatvala,John R. Pattison,Paul Griffiths,Barry Schoub
Publisher : John Wiley & Sons
Page : 912 pages
File Size : 46,8 Mb
Release : 2004-08-13
Category : Medical
ISBN : 9780470020968

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Principles and Practice of Clinical Virology by Arie J. Zuckerman,Jangu E. Banatvala,John R. Pattison,Paul Griffiths,Barry Schoub Pdf

The knowledge and practice of clinical virology continues to expand. This new fifth edition has thirty-six comprehensive chapters, each of which has been extensively revised or rewritten, with the addition of new colour plates. This updated version takes into account knowledge accumulated in molecular biology with its applications for laboratory diagnosis, immunisation and antiviral chemotherapy. Each chapter highlights the clinical features and epidemiological patterns of infection. Similarly, in response to the global concern of the threat posed by new viruses, a new chapter on Emerging Infections is included. There is also new material on Hospital Acquired Infections, including some advice relating to SARS, that will be of benefit to those dealing with the day-to-day management of patients in hospital.

Author : Dongyou Liu
Publisher : CRC Press
Page : 704 pages
File Size : 55,5 Mb
Release : 2021-04-12
Category : Science
ISBN : 9781351120364

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Molecular Food Microbiology by Dongyou Liu Pdf

The elucidation of DNA double helix in 1953 and the publication of DNA cloning protocol in 1973 have put wings under the sail of molecular biology, which has since quietly revolutionized many fields of biological science, including food microbiology. Exploiting the power and versatility of molecular technologies, molecular food microbiology extends and greatly improves on phenotypically based food microbiology, leading to the development of better diagnostics for foodborne infections and intoxications, and contributing to the design of more effective therapeutics and prophylaxes against foodborne diseases. Forming part of the Food Microbiology series, Molecular Food Microbiology provides a state of art coverage on molecular techniques applicable to food microbiology. While the introductory chapter contains an overview on the principles of current DNA, RNA and protein techniques and discusses their utility in helping solve practical problems that food microbiology is facing now and in the future, the remaining chapters present detailed moleuclar analyses of selective foodborne viruses, bacteria, fungi and parasites. Key Features: Contains a state of art overview on moleuclar techniques applicable to food microbiology research and development Presents in-depth molecular analysis of selective foodborne viruses, bacteria, fungi and parasites Highlights the utility of molecular tecniques for accurate diagnosis and effective control of foodborne diseases Includes expert contributions from international scientists involved in molecular food microbiology research Represents a highly informative textbook for students majoring in food, medical, and veterinary microbiology Offers a contemporary reference for scholars and educators wishing to keep abreast with the latest developments in molecular food microbiology With contributions from international scientists involved in molecular food microbiology research, this book constitutes an informative textbook for undergraduates and postgraduates majoring in food, medical, and veterinary microbiology; represents an indispensable guide for food, medical, and veterinary scientists engaged in molecular food microbiology research and development; and offers a contemporary update for scholars and educators trying to keep in touch with the latest developments in molecular food microbiology.

Author : Van G. Wilson
Publisher : Springer Nature
Page : 359 pages
File Size : 52,6 Mb
Release : 2022-03-01
Category : Medical
ISBN : 9783030854874

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Viruses: Intimate Invaders by Van G. Wilson Pdf

This book guides through the fascinating world of viruses and makes readers enjoy science in an accessible way. Virologist and author Professor Van Wilson imparts knowledge about what viruses are, how they work, and how much they impact life on Earth. The book equips the reader with the scientific basics behind virus function and presents the historic milestones of virus research and discovery. Well-known viruses such as HIV or Influenza are tackled alongside novel pathogens like coronavirus SARS-CoV-2. Professor Wilson explores where they come from and how they impact our society. Last but not least the book provides exciting insights into how our immune system reacts to different viruses and how vaccines contribute to conquer pandemics. While scientifically informative, this book makes the field of virology understandable to a lay audience and encourages readers to further thinking. And more importantly, it conveys the wonder, beauty, and mystery of these ubiquitous, microscopic marvels. This book addresses anyone interested in understanding the principles of virology, viral diseases, or the impact of viruses on human societies.