Human Targets

Author : Victor M. Rios
Publisher : University of Chicago Press
Page : 220 pages
File Size : 51,8 Mb
Release : 2017-03-08
Category : Education
ISBN : 9780226090993

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Human Targets by Victor M. Rios Pdf

Victor Rios has a vibrant reputation as America s leading ethnographer of Latino youth. His personal storygoing from drug pusher (selling heroin on the streets as a teenager) to a hard worker at a mechanic shop within a matter of weeksshows how he stands in the place of the Latino youths he studies. His story underscores the degree to which delinquent urban youths can become adaptable, fluid, amenable individuals, able to shift their views of the world as well as their actions. Rios rejects the old storyline that said gangs are bad and they do bad things because they are bad people. Kids on the street, he argues, can drift between different identities, indeed, they can shift seamlessly between responsible and deviant displays within a few hours time. The key to understanding gang-associated youth lies in analysis of the way authority figures (teachers and police officers) interact with young people. The kids need caring adults who offer tangible resources. Story and characters are always front-and-center in Rios s narrative: Jorge, Mark, Wilson, and others, are boys we get to know as they negotiate day-to-day life on the streets and across institutional settings. We learn a great deal about Cholo subculture, the clothing and hairstyles, and the argot that are adopted by Latino youth in response to the forces that seek to marginalize or punish them. The crisis of a perceived epidemic of police brutality in our post-Ferguson era is a product of culture in Rios s view: contested symbols, negative interactions, and day-to-day encounters that freeze youth identities as gang-associated, and that freeze authority identities as negative shapers of youth attitudes and actions are the dynamic. Fear of young males of color leads to police misreading and dehumanizing of young black and Latino men. Rios raises our awareness of how this dynamic operates by studying his subjects whole: following young gang members into their schools, their homes, their community organizations, their detention facilities, and watching them interact with police, watching them grow up to become fathers, get jobs, get rap sheets. Get killed. This book will be a landmark contribution to the social psychology of poverty and crime."

Author : Edward D. Zanders
Publisher : John Wiley & Sons
Page : 454 pages
File Size : 48,8 Mb
Release : 2015-11-09
Category : Science
ISBN : 9781118849859

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Human Drug Targets by Edward D. Zanders Pdf

The identification of drug targets in a given disease has been central to pharmaceutical research from the latter half of the 20th century right up to the modern genomics era. Human Drug Targets provides an essential guide to one of the most important aspects of drug discovery – the identification of suitable protein and RNA targets prior to the creation of drug development candidates. The first part of the book consists of introductory chapters that provide the background to drug target discovery and highlight the way in which these targets have been organised into online databases. It also includes a user’s guide to the list of entries that forms the bulk of the book. Since this is not designed to be a compendium of drugs, the emphasis will be on the known (or speculated) biological role of the targets and not on the issues associated with pharmaceutical development. The objective is to provide just enough information to be informative and prompt further searches, while keeping the amount of text for each of the many entries to a minimum. Human Drug Targets will prove invaluable to those drug discovery professionals, in both industry and academia, who need to make some sense of the bewildering array of online information sources on current and potential human drug targets. As well as creating order out of a complex target landscape, the book will act as an ideas generator for potentially novel targets that might form the basis of future discovery projects.

Author : Carlos Alonso Escudero
Publisher : Frontiers Media SA
Page : 114 pages
File Size : 45,6 Mb
Release : 2015-04-15
Category : Science (General)
ISBN : 9782889194612

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New therapeutic targets for human placental angiogenesis diseases by Carlos Alonso Escudero Pdf

A large number of publications have described impaired angiogenesis and vasculogenesis present in the feto-placental circulation after pregnancy diseases such as pre-eclamptic pregnancies, gestational diabetes, and intrauterine growth restriction, among others. Results suggest impaired secretion and activity of pro-angiogenic factors such as vascular endothelial growth factor (VEGF), interleukin 8 (IL-8), adenosine and nitric oxide, associates with compromised secretion and activity of anti-angiogenic factors such as soluble receptor of VEGF (sFlt-1), thrombospondin 2, endostatin among others. More recent evidences include the participation of endothelial progenitor cells (EPC), which circulating number is reduced infeto-placental circulation in pregnancies such as pre-eclampsia. Despite this knowledge, therapies for placental angiogenesis recovery during pathological pregnancies are far to be tested. However, from the cardiovascular field, it has been described the administration of EPC, alone or used as gene-transfer therapy; or it has been described the potential role of statins (HMGCoA inhibitors), or angiotensin-converter enzyme (ACE) inhibitors for enhancing angiogenesis. Finally, feto-placental tissue is an exceptional source of progenitor and stem cells, which could be used for treated other human diseases such as stroke, myocardial infarction, hypertension, or even cancer. In this research topic, authors highlight physiopatological and clinical importance of the impaired placental angiogenesis, and suggest potential targets for developing innovative therapies.

Author : Takahiro Ochiya,Ryou-u Takahashi
Publisher : MDPI
Page : 273 pages
File Size : 54,6 Mb
Release : 2018-10-16
Category : Electronic books
ISBN : 9783038972525

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MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers by Takahiro Ochiya,Ryou-u Takahashi Pdf

This book is a printed edition of the Special Issue "MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers" that was published in JCM

Author : Madhathilkovilakathu Haridas
Publisher : Springer Nature
Page : 572 pages
File Size : 40,8 Mb
Release : 2024-06-28
Category : Electronic
ISBN : 9789819991839

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Drugs from Nature: Targets, Assay Systems and Leads by Madhathilkovilakathu Haridas Pdf

Author : Cameron H. Malin,Terry Gudaitis,Thomas Holt,Max Kilger
Publisher : Elsevier
Page : 284 pages
File Size : 51,6 Mb
Release : 2017-06-30
Category : Computers
ISBN : 9780124116399

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Deception in the Digital Age by Cameron H. Malin,Terry Gudaitis,Thomas Holt,Max Kilger Pdf

Deception in the Digital Age: Exploiting and Defending Human Targets Through Computer-Mediated Communication guides readers through the fascinating history and principles of deception—and how these techniques and stratagems are now being effectively used by cyber attackers. Users will find an in-depth guide that provides valuable insights into the cognitive, sensory and narrative bases of misdirection, used to shape the targeted audience’s perceptions and beliefs. The text provides a detailed analysis of the psychological, sensory, sociological, and technical precepts that reveal predictors of attacks—and conversely postmortem insight about attackers—presenting a unique resource that empowers readers to observe, understand and protect against cyber deception tactics. Written by information security experts with real-world investigative experience, the text is the most instructional book available on the subject, providing practical guidance to readers with rich literature references, diagrams and examples that enhance the learning process. Deeply examines the psychology of deception through the lens of misdirection and other techniques used by master magicians Explores cognitive vulnerabilities that cyber attackers use to exploit human targets Dissects the underpinnings and elements of deception narratives Examines group dynamics and deception factors in cyber attacker underground markets Provides deep coverage on how cyber attackers leverage psychological influence techniques in the trajectory of deception strategies Explores the deception strategies used in today’s threat landscape—phishing, watering hole, scareware and ransomware attacks Gives unprecedented insight into deceptive Internet video communications Delves into the history and deception pathways of nation-state and cyber terrorism attackers Provides unique insight into honeypot technologies and strategies Explores the future of cyber deception

Author : Tom King
Publisher : DC Comics
Page : 40 pages
File Size : 45,7 Mb
Release : 2022-02-22
Category : Comics & Graphic Novels
ISBN : PKEY:T2139300055001

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The Human Target (2021-) #5 by Tom King Pdf

Christopher Chance, a.k.a. the Human Target, will be dead in a few days, but nothing will stop him from solving his own murder. His investigation into the JLI intensifies, and he sets his sights on the Martian Manhunter…but what piece does J’onn J’onzz add to the puzzle?

Author : Gerhard F. Ecker,Rasmus P. Clausen,Harald H. Sitte
Publisher : John Wiley & Sons
Page : 354 pages
File Size : 48,6 Mb
Release : 2017-04-10
Category : Medical
ISBN : 9783527333844

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Transporters as Drug Targets by Gerhard F. Ecker,Rasmus P. Clausen,Harald H. Sitte Pdf

As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug targets, including neurotransmitter transporters, ABC transporters, glucose transporters and organic ion transporters. The final part discusses recent advances in structural studies of transport proteins, assay methods for transport activity, and the systems biology of transporters and their regulation. With its focus on drug development issues, this authoritative overview is required reading for researchers in industry and academia targeting transport proteins for the treatment of disease.

Author : Eve Ensler
Publisher : Dramatists Play Service Inc
Page : 52 pages
File Size : 46,9 Mb
Release : 2003
Category : Drama
ISBN : 082221895X

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Necessary Targets by Eve Ensler Pdf

THE STORY: In NECESSARY TARGETS, two American women, a Park Avenue psychiatrist and an ambitious young writer, travel to Bosnia to help women refugees confront their memories of war. Though the two have little in common beyond the methods they use

Author : Nicholas B. La Thangue,Lasantha R. Bandara
Publisher : Springer Science & Business Media
Page : 352 pages
File Size : 49,5 Mb
Release : 2002-04-03
Category : Medical
ISBN : 9781592591534

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Targets for Cancer Chemotherapy by Nicholas B. La Thangue,Lasantha R. Bandara Pdf

In Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins, a panel of leading basic researchers, pharmaceutical scientists, and clinical oncologists explain in detail the therapeutically-relevant protein targets that contribute to cancer pathology and spell out their implications for cancer drug discovery and clinical application. The authors identify and illuminate selected transcription factor oncoproteins and tumor suppressors, together with nuclear proteins that are central to the phenotype of the tumor cell involved in chromatin control. The emphasis is on new targets and approaches to cancer treatment derived from the cancer cell cycle, gene control targets, and angiogenesis.

Author : Mireille Alhouayek,Ester Pagano
Publisher : Frontiers Media SA
Page : 158 pages
File Size : 55,7 Mb
Release : 2022-08-31
Category : Science
ISBN : 9782889768752

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Colorectal Cancer: Targets, Treatment and Prevention by Mireille Alhouayek,Ester Pagano Pdf

Author : Nikki P. Lee,C.Y. Cheng,John M. Luk
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 43,5 Mb
Release : 2013-06-22
Category : Science
ISBN : 9781627034562

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New Advances on Disease Biomarkers and Molecular Targets in Biomedicine by Nikki P. Lee,C.Y. Cheng,John M. Luk Pdf

Rising occurrences of various diseases and epidemics have pressurized the already-burdened health system across the globe, and this imposes an unprecedented challenge on our current research in identifying disease-specific biomarkers and molecular targets, in particular for cancers, neurological disorders and unexplained infertility. Despite decades of efforts in deciphering the fundamental biology underlying various diseases at discrete levels using an array of advanced technologies, attempts to identify reliable and disease-indicating markers for detection and biomolecules or cellular structures for targeting are still in vain. This monograph describes and discusses the updated findings in this field with a specific aim to compile prior and recent literature and from there to acquire some insights to facilitate future research to expand options of understanding, detecting and treating diseases. Among the many possible areas of biomedical research, this content comprises two themes: disease biomarkers and molecular targets. The book also covers topics that are more advanced in development to emerging scientific discoveries. In particular, this monograph includes concepts on the renovated use of oncofetal molecules in cancer prediction and treatment, the evolving development in cancer biology at the cellular and molecular levels and the recent involvement on new classes of molecules in diseases. This book renews established concepts in the field, and at the same time leads to important insights for research and development of drugs, diagnostics, and interventions for managing diseases of unmet medical needs.

Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 107 pages
File Size : 40,6 Mb
Release : 2014-02-06
Category : Medical
ISBN : 9780309292498

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Improving and Accelerating Therapeutic Development for Nervous System Disorders by Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Author : Trevor T. Hansel,Peter J. Barnes
Publisher : Karger Medical and Scientific Publishers
Page : 326 pages
File Size : 54,6 Mb
Release : 2010-01-01
Category : Medical
ISBN : 9783805595667

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New Drugs and Targets for Asthma and COPD by Trevor T. Hansel,Peter J. Barnes Pdf

Asthma, allergy and chronic obstructive lung disease are common throughout the world and are increasing in incidence, particularly in the developing world. This volume provides a state-of-the-art account of the identification of new targets and the development of new therapies for these conditions. Some 40 chapters by clinical academics and senior members of the pharmaceutical industry detail the latest breakthroughs in research and development. In asthma, a promising approach is the use of therapy directed against specific Th2 responses through biological antagonists of IL-5, IL-4 and IL-13. There have also been major advances in our understanding of innate immune responses to pathogen-associated molecular patterns, and in the area of Toll-like receptors. Up to date and comprehensive, this book will be of particular relevance to those working in the pharmaceutical industry (in preclinical research and clinical development), to academic researchers in the field of respiratory medicine, and to respiratory health care specialists.

Author : Jinhang Gao,Enis Kostallari,Hua Wang
Publisher : Frontiers Media SA
Page : 186 pages
File Size : 47,8 Mb
Release : 2022-08-16
Category : Science
ISBN : 9782889767762

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Chronic Liver Disease: New Targets and New Mechanisms by Jinhang Gao,Enis Kostallari,Hua Wang Pdf